PSU Profiles
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Last Name
Institution

Adam Glick

Title
InstitutionCollege of Agricultural Sciences
DepartmentVeterinary and Biomedical Sciences
Address306C Life Sciences Bldg
University Park, PA 16802
Phone8148657170
Other Positions
TitleCo-Chair of the Molecular Medicine Graduate Program
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Associate Professor, Department of Veterinary and Biomedical Sciences
Co-Chair, Molecular Medicine Program

GRADUATE PROGRAM AFFILIATIONS:

Immunology and Infectious Diseases, Molecular Medicine, Molecular Toxicology

NARRATIVE:

Dr. Glick's research focuses on molecular mechanisms and signaling pathways that regulate progression of squamous tumors from a benign to malignant phenotype. He also works on analysis of the tumor suppressor and oncogenic roles of Transforming Growth Factor Beta in multistage skin carcinogenesis using novel transgenic and knockout mouse models.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhu B, Ferry CH, Markell LK, Blazanin N, Glick AB, Gonzalez FJ, Peters JM. The nuclear receptor peroxisome proliferator-activated receptor-ß/d (PPARß/d) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. J Biol Chem. 2014 Jul 18; 289(29):20102-19.
    View in: PubMed
  2. Ravindran A, Mohammed J, Gunderson AJ, Cui X, Glick AB. Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells. Carcinogenesis. 2014 Apr; 35(4):959-66.
    View in: PubMed
  3. Narola J, Pandey SN, Glick A, Chen YW. Conditional expression of TGF-ß1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy. PLoS One. 2013; 8(11):e79356.
    View in: PubMed
  4. Zhu B, Ferry CH, Blazanin N, Bility MT, Khozoie C, Kang BH, Glick AB, Gonzalez FJ, Peters JM. PPARß/d promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling. Oncogene. 2014 Nov 13; 33(46):5348-59.
    View in: PubMed
  5. Hogan KA, Ravindran A, Podolsky MA, Glick AB. The TGFß1 pathway is required for NF?B dependent gene expression in mouse keratinocytes. Cytokine. 2013 Dec; 64(3):652-9.
    View in: PubMed
  6. Glick AB. The Role of TGFß Signaling in Squamous Cell Cancer: Lessons from Mouse Models. J Skin Cancer. 2012; 2012:249063.
    View in: PubMed
  7. Gunderson AJ, Mohammed J, Horvath FJ, Podolsky MA, Anderson CR, Glick AB. CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-?. J Invest Dermatol. 2013 Apr; 133(4):955-63.
    View in: PubMed
  8. Plichta KA, Mathers JL, Gestl SA, Glick AB, Gunther EJ. Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth. Cancer Res. 2012 Nov 15; 72(22):5856-66.
    View in: PubMed
  9. Mohammed J, Gunderson AJ, Khong HH, Koubek RD, Udey MC, Glick AB. TGFß1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity. J Invest Dermatol. 2013 Jan; 133(1):135-43.
    View in: PubMed
  10. Shi C, Cooper TK, McCloskey DE, Glick AB, Shantz LM, Feith DJ. S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis. 2012 Jul; 33(7):1310-8.
    View in: PubMed
  11. Zhu B, Khozoie C, Bility MT, Ferry CH, Blazanin N, Glick AB, Gonzalez FJ, Peters JM. Peroxisome proliferator-activated receptor ß/d cross talks with E2F and attenuates mitosis in HRAS-expressing cells. Mol Cell Biol. 2012 Jun; 32(11):2065-82.
    View in: PubMed
  12. Glick A. A new xenotransplantation model reveals tumor-initiating cells in cutaneous squamous cell carcinoma. J Invest Dermatol. 2012 Feb; 132(2):261-2.
    View in: PubMed
  13. Markell LM, Masiuk KE, Blazanin N, Glick AB. Pharmacologic inhibition of ALK5 causes selective induction of terminal differentiation in mouse keratinocytes expressing oncogenic HRAS. Mol Cancer Res. 2011 Jun; 9(6):746-56.
    View in: PubMed
  14. Mordasky Markell L, Pérez-Lorenzo R, Masiuk KE, Kennett MJ, Glick AB. Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression. Carcinogenesis. 2010 Dec; 31(12):2127-35.
    View in: PubMed
  15. Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, Gebhardt R, Glick AB, Hähnel B, Hosser H, Gröne HJ, Kriz W. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am J Pathol. 2010 Aug; 177(2):632-43.
    View in: PubMed
  16. Mohammed J, Ryscavage A, Perez-Lorenzo R, Gunderson AJ, Blazanin N, Glick AB. TGFbeta1-induced inflammation in premalignant epidermal squamous lesions requires IL-17. J Invest Dermatol. 2010 Sep; 130(9):2295-303.
    View in: PubMed
  17. Pérez-Lorenzo R, Markell LM, Hogan KA, Yuspa SH, Glick AB. Transforming growth factor beta1 enhances tumor promotion in mouse skin carcinogenesis. Carcinogenesis. 2010 Jun; 31(6):1116-23.
    View in: PubMed
  18. Ponnamperuma RM, King KE, Elsir T, Glick AB, Wahl GM, Nister M, Weinberg WC. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol. 2009 Oct; 219(2):263-74.
    View in: PubMed
  19. Jabbar SF, Abrams L, Glick A, Lambert PF. Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene. Cancer Res. 2009 May 15; 69(10):4407-14.
    View in: PubMed
  20. Rozenberg J, Rishi V, Orosz A, Moitra J, Glick A, Vinson C. Inhibition of CREB function in mouse epidermis reduces papilloma formation. Mol Cancer Res. 2009 May; 7(5):654-64.
    View in: PubMed
  21. Bae DS, Blazanin N, Licata M, Lee J, Glick AB. Tumor suppressor and oncogene actions of TGFbeta1 occur early in skin carcinogenesis and are mediated by Smad3. Mol Carcinog. 2009 May; 48(5):441-53.
    View in: PubMed
  22. Vijayachandra K, Higgins W, Lee J, Glick A. Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes. Mol Carcinog. 2009 Mar; 48(3):181-6.
    View in: PubMed
  23. Zheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z. Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling. J Invest Dermatol. 2009 Mar; 129(3):742-51.
    View in: PubMed
  24. Bility MT, Devlin-Durante MK, Blazanin N, Glick AB, Ward JM, Kang BH, Kennett MJ, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis. Carcinogenesis. 2008 Dec; 29(12):2406-14.
    View in: PubMed
  25. Traykova-Brauch M, Schönig K, Greiner O, Miloud T, Jauch A, Bode M, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R. An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med. 2008 Sep; 14(9):979-84.
    View in: PubMed
  26. Shukla A, Ho Y, Liu X, Ryscavage A, Glick AB. Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis. Mol Cancer Res. 2008 Mar; 6(3):509-16.
    View in: PubMed
  27. Glick AB, Perez-Lorenzo R, Mohammed J. Context-dependent regulation of cutaneous immunological responses by TGFbeta1 and its role in skin carcinogenesis. Carcinogenesis. 2008 Jan; 29(1):9-14.
    View in: PubMed
  28. Sainte Marie Y, Toulon A, Paus R, Maubec E, Cherfa A, Grossin M, Descamps V, Clemessy M, Gasc JM, Peuchmaur M, Glick A, Farman N, Jaisser F. Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Am J Pathol. 2007 Sep; 171(3):846-60.
    View in: PubMed
  29. Glick A, Ryscavage A, Perez-Lorenzo R, Hennings H, Yuspa S, Darwiche N. The high-risk benign tumor: evidence from the two-stage skin cancer model and relevance for human cancer. Mol Carcinog. 2007 Aug; 46(8):605-10.
    View in: PubMed
  30. Garcia RJ, Ittah A, Mirabal S, Figueroa J, Lopez L, Glick AB, Kos L. Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. J Invest Dermatol. 2008 Jan; 128(1):131-42.
    View in: PubMed
  31. Darwiche N, Ryscavage A, Perez-Lorenzo R, Wright L, Bae DS, Hennings H, Yuspa SH, Glick AB. Expression profile of skin papillomas with high cancer risk displays a unique genetic signature that clusters with squamous cell carcinomas and predicts risk for malignant conversion. Oncogene. 2007 Oct 18; 26(48):6885-95.
    View in: PubMed
  32. Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 2006 Nov 15; 66(22):10861-9.
    View in: PubMed
  33. Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C. Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res. 2006 Aug 1; 66(15):7578-88.
    View in: PubMed
  34. Abdel-Fattah R, Glick A, Rehman I, Maiberger P, Hennings H. Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol. Int J Cancer. 2006 Feb 1; 118(3):527-31.
    View in: PubMed
  35. Glick AB, Yuspa SH. Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers. Semin Cancer Biol. 2005 Apr; 15(2):75-83.
    View in: PubMed
  36. Suh KS, Mutoh M, Gerdes M, Crutchley JM, Mutoh T, Edwards LE, Dumont RA, Sodha P, Cheng C, Glick A, Yuspa SH. Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth. Cancer Res. 2005 Jan 15; 65(2):562-71.
    View in: PubMed
  37. Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick A, Dlugosz AA. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 2005 Jan 15; 19(2):214-23.
    View in: PubMed
  38. Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A, Wysolmerski JJ, Millar SE. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development. 2004 Oct; 131(19):4819-29.
    View in: PubMed
  39. Sauer B, Vogler R, von Wenckstern H, Fujii M, Anzano MB, Glick AB, Schäfer-Korting M, Roberts AB, Kleuser B. Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. J Biol Chem. 2004 Sep 10; 279(37):38471-9.
    View in: PubMed
  40. Woodworth CD, Michael E, Smith L, Vijayachandra K, Glick A, Hennings H, Yuspa SH. Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. Carcinogenesis. 2004 Sep; 25(9):1771-8.
    View in: PubMed
  41. Glick AB. TGFbeta1, back to the future: revisiting its role as a transforming growth factor. Cancer Biol Ther. 2004 Mar; 3(3):276-83.
    View in: PubMed
  42. Liu X, Lee J, Cooley M, Bhogte E, Hartley S, Glick A. Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. Cancer Res. 2003 Nov 15; 63(22):7760-8.
    View in: PubMed
  43. Vijayachandra K, Lee J, Glick AB. Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Cancer Res. 2003 Jul 1; 63(13):3447-52.
    View in: PubMed
  44. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature. 2003 Mar 13; 422(6928):169-73.
    View in: PubMed
  45. Yamada H, Vijayachandra K, Penner C, Glick A. Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation. J Biol Chem. 2001 Jun 1; 276(22):19052-8.
    View in: PubMed
  46. Rutberg SE, Adams TL, Glick A, Bonovich MT, Vinson C, Yuspa SH. Activator protein 1 transcription factors are fundamental to v-rasHa-induced changes in gene expression in neoplastic keratinocytes. Cancer Res. 2000 Nov 15; 60(22):6332-8.
    View in: PubMed
  47. Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A. Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras. Oncogene. 2000 Mar 23; 19(13):1698-709.
    View in: PubMed
  48. Glick A, Popescu N, Alexander V, Ueno H, Bottinger E, Yuspa SH. Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14949-54.
    View in: PubMed
  49. Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Roberts AB. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol. 1999 Sep; 1(5):260-6.
    View in: PubMed
  50. Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, Tennant RW, Weinberg RA, Yuspa SH, Conti CJ. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev. 1998 Aug 15; 12(16):2469-74.
    View in: PubMed
  51. Rutberg SE, Lee EJ, Hansen LH, Glick AB, Yuspa SH. Identification of differentially expressed genes in chemically induced skin tumors. Mol Carcinog. 1997 Sep; 20(1):88-98.
    View in: PubMed
  52. Glick AB, Weinberg WC, Wu IH, Quan W, Yuspa SH. Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb. Cancer Res. 1996 Aug 15; 56(16):3645-50.
    View in: PubMed
  53. Rutberg SE, Saez E, Glick A, Dlugosz AA, Spiegelman BM, Yuspa SH. Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. Oncogene. 1996 Jul 4; 13(1):167-76.
    View in: PubMed
  54. Yuspa SH, Dlugosz AA, Denning MF, Glick AB. Multistage carcinogenesis in the skin. J Investig Dermatol Symp Proc. 1996 Apr; 1(2):147-50.
    View in: PubMed
  55. Tennenbaum T, Belanger AJ, Glick AB, Tamura R, Quaranta V, Yuspa SH. A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Proc Natl Acad Sci U S A. 1995 Jul 18; 92(15):7041-5.
    View in: PubMed
  56. Darwiche N, Celli G, Tennenbaum T, Glick AB, Yuspa SH, De Luca LM. Mouse skin tumor progression results in differential expression of retinoic acid and retinoid X receptors. Cancer Res. 1995 Jul 1; 55(13):2774-82.
    View in: PubMed
  57. Ueda M, Kawamura H, Sutter C, Glick A, Yuspa SH, Strickland JE. Analysis of v-Ha-ras and v-fos oncogene transduction into a mouse epidermal cell line with "initiated" phenotype in culture but normal skin phenotype in vivo. Mol Carcinog. 1995 Jun; 13(2):96-103.
    View in: PubMed
  58. Dlugosz AA, Glick AB, Tennenbaum T, Weinberg WC, Yuspa SH. Isolation and utilization of epidermal keratinocytes for oncogene research. Methods Enzymol. 1995; 254:3-20.
    View in: PubMed
  59. Yuspa SH, Hennings H, Dlugosz A, Tennenbaum T, Glick A. The role of growth factors in mouse skin tumor promotion and premalignant progression. Prog Clin Biol Res. 1995; 391:39-48.
    View in: PubMed
  60. Yuspa SH, Dlugosz AA, Cheng CK, Denning MF, Tennenbaum T, Glick AB, Weinberg WC. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J Invest Dermatol. 1994 Nov; 103(5 Suppl):90S-95S.
    View in: PubMed
  61. Glick AB, Lee MM, Darwiche N, Kulkarni AB, Karlsson S, Yuspa SH. Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma. Genes Dev. 1994 Oct 15; 8(20):2429-40.
    View in: PubMed
  62. Hennings H, Glick AB, Lowry DT, Krsmanovic LS, Sly LM, Yuspa SH. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis. 1993 Nov; 14(11):2353-8.
    View in: PubMed
  63. Tennenbaum T, Weiner AK, Belanger AJ, Glick AB, Hennings H, Yuspa SH. The suprabasal expression of alpha 6 beta 4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis. Cancer Res. 1993 Oct 15; 53(20):4803-10.
    View in: PubMed
  64. Glick AB, Kulkarni AB, Tennenbaum T, Hennings H, Flanders KC, O'Reilly M, Sporn MB, Karlsson S, Yuspa SH. Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):6076-80.
    View in: PubMed
  65. Hennings H, Glick AB, Greenhalgh DA, Morgan DL, Strickland JE, Tennenbaum T, Yuspa SH. Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis. Proc Soc Exp Biol Med. 1993 Jan; 202(1):1-8.
    View in: PubMed
  66. Yuspa SH, Punnonen K, Lee E, Hennings H, Strickland J, Cheng C, Glick A, Dlugosz A. The in vitro analysis of biochemical changes relevant to skin carcinogenesis. Recent Results Cancer Res. 1993; 128:299-308.
    View in: PubMed
  67. Lee E, Punnonen K, Cheng C, Glick A, Dlugosz A, Yuspa SH. Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype. Carcinogenesis. 1992 Dec; 13(12):2367-73.
    View in: PubMed
  68. Morgan D, Welty D, Glick A, Greenhalgh D, Hennings H, Yuspa SH. Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells. Cancer Res. 1992 Jun 1; 52(11):3145-56.
    View in: PubMed
  69. Yuspa SH, Punnonen K, Lee E, Hennings H, Strickland JE, Cheng C, Glick A, Dlugosz A. Alterations in the biology and biochemistry of keratinocytes induced by the ras oncogene. Prog Clin Biol Res. 1992; 376:103-15.
    View in: PubMed
  70. Fisher GJ, Tavakkol A, Griffiths CE, Elder JT, Zhang QY, Finkel L, Danielpour D, Glick AB, Higley H, Ellingsworth L, et al. Differential modulation of transforming growth factor-beta 1 expression and mucin deposition by retinoic acid and sodium lauryl sulfate in human skin. J Invest Dermatol. 1992 Jan; 98(1):102-8.
    View in: PubMed
  71. Glick AB, Sporn MB, Yuspa SH. Altered regulation of TGF-beta 1 and TGF-alpha in primary keratinocytes and papillomas expressing v-Ha-ras. Mol Carcinog. 1991; 4(3):210-9.
    View in: PubMed
  72. Roberts AB, Kim SJ, Noma T, Glick AB, Lafyatis R, Lechleider R, Jakowlew SB, Geiser A, O'Reilly MA, Danielpour D, et al. Multiple forms of TGF-beta: distinct promoters and differential expression. Ciba Found Symp. 1991; 157:7-15; discussion 15-28.
    View in: PubMed
  73. Glick AB, Danielpour D, Morgan D, Sporn MB, Yuspa SH. Induction and autocrine receptor binding of transforming growth factor-beta 2 during terminal differentiation of primary mouse keratinocytes. Mol Endocrinol. 1990 Jan; 4(1):46-52.
    View in: PubMed
  74. Glick AB, Flanders KC, Danielpour D, Yuspa SH, Sporn MB. Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. Cell Regul. 1989 Nov; 1(1):87-97.
    View in: PubMed
  75. Sporn MB, Roberts AB, Wakefield LM, Glick AB, Danielpour D. Transforming growth factor-beta and suppression of carcinogenesis. Princess Takamatsu Symp. 1989; 20:259-66.
    View in: PubMed
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