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Craig Cameron

TitlePaul Berg Professor of Biochemistry and Molecular Biology
InstitutionEberly College of Science
DepartmentBiochemistry and Molecular Biology
Address201 Althouse Lab
University Park, PA 16802
Phone8148638705
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Paul Berg Professor of Biochemistry and Molecular Biology
Associate Department Head for Research and Graduate Education

NARRATIVE:

Dr. Cameron's research focuses on defining the molecular details of genome replication in positive-strand RNA viruses and identifying components of this process suitable for antiviral drug development. Current projects areas include RNA-dependent RNA polymerase mechanisms, viral attenuation and vaccine development, picornavirus genome replication, biochemical mechanisms and biological functions of HCV, NS3, and NS5a proteins, mitochondrial transcription and disease, and lethal mutagenesis as an antiviral strategy.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee CA, August A, Arnold JJ, Cameron CE. Polymerase Mechanism-Based Method of Viral Attenuation. Methods Mol Biol. 2016; 1349:83-104.
    View in: PubMed
  2. Gajewski JP, Arnold JJ, Salminen TS, Kaguni LS, Cameron CE. Expression and Purification of Mitochondrial RNA Polymerase and Transcription Factor A from Drosophila melanogaster. Methods Mol Biol. 2016; 1351:199-210.
    View in: PubMed
  3. Moustafa IM, Gohara DW, Uchida A, Yennawar N, Cameron CE. Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome? Viruses. 2015; 7(11):5962-86.
    View in: PubMed
  4. Liu X, Musser DM, Lee CA, Yang X, Arnold JJ, Cameron CE, Boehr DD. Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase. Viruses. 2015; 7(10):5571-86.
    View in: PubMed
  5. Reynolds KA, Cameron CE, Raney KD. Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction. Biochemistry. 2015 Jul 14; 54(27):4248-58.
    View in: PubMed
  6. Van Slyke GA, Arnold JJ, Lugo AJ, Griesemer SB, Moustafa IM, Kramer LD, Cameron CE, Ciota AT. Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes. PLoS Pathog. 2015 Jun; 11(6):e1005009.
    View in: PubMed
  7. Moustafa IM, Uchida A, Wang Y, Yennawar N, Cameron CE. Structural models of mammalian mitochondrial transcription factor B2. Biochim Biophys Acta. 2015 Aug; 1849(8):987-1002.
    View in: PubMed
  8. Murugesapillai D, Lodeiro MF, James Maher L, Cameron CE, Williams MC. 26 Sequence-specific DNA looping by mitochondrial transcription factor A (TFAM). J Biomol Struct Dyn. 2015 May; 33 Suppl 1:15-6.
    View in: PubMed
  9. van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. PLoS Pathog. 2015 Mar; 11(3):e1004733.
    View in: PubMed
  10. Kolli S, Meng X, Wu X, Shengjuler D, Cameron CE, Xiang Y, Deng J. Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication. J Virol. 2015 Feb 15; 89(4):2209-19.
    View in: PubMed
  11. Li S, Ding X, Mao Z, Chen Y, Nama N, Guo F, Li P, Wang L, Cameron CE, Huang TJ. Standing surface acoustic wave (SSAW)-based cell washing. Lab Chip. 2014 Dec 3; 15(1):331-8.
    View in: PubMed
  12. Moustafa IM, Korboukh VK, Arnold JJ, Smidansky ED, Marcotte LL, Gohara DW, Yang X, Sánchez-Farrán MA, Filman D, Maranas JK, Boehr DD, Hogle JM, Colina CM, Cameron CE. Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase. J Biol Chem. 2014 Dec 26; 289(52):36229-48.
    View in: PubMed
  13. Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry. 2014 Oct 21; 53(41):6584-94.
    View in: PubMed
  14. Li S, Guo F, Chen Y, Ding X, Li P, Wang L, Cameron CE, Huang TJ. Standing surface acoustic wave based cell coculture. Anal Chem. 2014 Oct 7; 86(19):9853-9.
    View in: PubMed
  15. Korboukh VK, Lee CA, Acevedo A, Vignuzzi M, Xiao Y, Arnold JJ, Hemperly S, Graci JD, August A, Andino R, Cameron CE. RNA virus population diversity, an optimum for maximal fitness and virulence. J Biol Chem. 2014 Oct 24; 289(43):29531-44.
    View in: PubMed
  16. Cordek DG, Croom-Perez TJ, Hwang J, Hargittai MR, Subba-Reddy CV, Han Q, Lodeiro MF, Ning G, McCrory TS, Arnold JJ, Koc H, Lindenbach BD, Showalter SA, Cameron CE. Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein. J Biol Chem. 2014 Aug 29; 289(35):24397-416.
    View in: PubMed
  17. Liu YC, Kuo RL, Lin JY, Huang PN, Huang Y, Liu H, Arnold JJ, Chen SJ, Wang RY, Cameron CE, Shih SR. Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8. PLoS Pathog. 2014 Jun; 10(6):e1004199.
    View in: PubMed
  18. Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R. Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2. J Mol Biol. 2014 Jul 15; 426(14):2580-93.
    View in: PubMed
  19. Li S, Kiehne J, Sinoway LI, Cameron CE, Huang TJ. Microfluidic opportunities in the field of nutrition. Lab Chip. 2013 Oct 21; 13(20):3993-4003.
    View in: PubMed
  20. Liu X, Yang X, Lee CA, Moustafa IM, Smidansky ED, Lum D, Arnold JJ, Cameron CE, Boehr DD. Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity. J Biol Chem. 2013 Nov 8; 288(45):32753-65.
    View in: PubMed
  21. Panigrahi R, Hazari S, Chandra S, Chandra PK, Datta S, Kurt R, Cameron CE, Huang Z, Zhang H, Garry RF, Balart LA, Dash S. Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One. 2013; 8(8):e72791.
    View in: PubMed
  22. Li S, Ding X, Guo F, Chen Y, Lapsley MI, Lin SC, Wang L, McCoy JP, Cameron CE, Huang TJ. An on-chip, multichannel droplet sorter using standing surface acoustic waves. Anal Chem. 2013 Jun 4; 85(11):5468-74.
    View in: PubMed
  23. Nallagatla SR, Jones CN, Ghosh SK, Sharma SD, Cameron CE, Spremulli LL, Bevilacqua PC. Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One. 2013; 8(3):e57905.
    View in: PubMed
  24. Shen H, Moustafa IM, Cameron CE, Colina CM. Exploring the dynamics of four RNA-dependent RNA polymerases by a coarse-grained model. J Phys Chem B. 2012 Dec 20; 116(50):14515-24.
    View in: PubMed
  25. Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, Cho A, Perry J, Vela JE, Park Y, Xu Y, Tian Y, Babusis D, Barauskus O, Peterson BR, Gnatt A, Kashlev M, Zhong W, Cameron CE. Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. PLoS Pathog. 2012; 8(11):e1003030.
    View in: PubMed
  26. Raney VM, Reynolds KA, Harrison MK, Harrison DK, Cameron CE, Raney KD. Binding by the hepatitis C virus NS3 helicase partially melts duplex DNA. Biochemistry. 2012 Sep 25; 51(38):7596-607.
    View in: PubMed
  27. Cameron CE, Cline SD. Mitochondrial gene expression. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):913.
    View in: PubMed
  28. Weeks SA, Lee CA, Zhao Y, Smidansky ED, August A, Arnold JJ, Cameron CE. A Polymerase mechanism-based strategy for viral attenuation and vaccine development. J Biol Chem. 2012 Sep 14; 287(38):31618-22.
    View in: PubMed
  29. Yang X, Smidansky ED, Maksimchuk KR, Lum D, Welch JL, Arnold JJ, Cameron CE, Boehr DD. Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure. 2012 Sep 5; 20(9):1519-27.
    View in: PubMed
  30. Lim PJ, Chatterji U, Cordek D, Sharma SD, Garcia-Rivera JA, Cameron CE, Lin K, Targett-Adams P, Gallay PA. Correlation between NS5A dimerization and hepatitis C virus replication. J Biol Chem. 2012 Aug 31; 287(36):30861-73.
    View in: PubMed
  31. Trahey M, Oh HS, Cameron CE, Hay JC. Poliovirus infection transiently increases COPII vesicle budding. J Virol. 2012 Sep; 86(18):9675-82.
    View in: PubMed
  32. Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE. Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):948-60.
    View in: PubMed
  33. Lodeiro MF, Uchida A, Bestwick M, Moustafa IM, Arnold JJ, Shadel GS, Cameron CE. Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6513-8.
    View in: PubMed
  34. Davis WG, Bowzard JB, Sharma SD, Wiens ME, Ranjan P, Gangappa S, Stuchlik O, Pohl J, Donis RO, Katz JM, Cameron CE, Fujita T, Sambhara S. The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I. PLoS One. 2012; 7(3):e32661.
    View in: PubMed
  35. Graci JD, Gnädig NF, Galarraga JE, Castro C, Vignuzzi M, Cameron CE. Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J Virol. 2012 Mar; 86(5):2869-73.
    View in: PubMed
  36. Gazina EV, Smidansky ED, Holien JK, Harrison DN, Cromer BA, Arnold JJ, Parker MW, Cameron CE, Petrou S. Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase. J Virol. 2011 Oct; 85(19):10364-74.
    View in: PubMed
  37. Dutta A, Zheng S, Jain D, Cameron CE, Reese JC. Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo. J Biol Chem. 2011 Aug 5; 286(31):27454-70.
    View in: PubMed
  38. Smidansky ED, Arnold JJ, Reynolds SL, Cameron CE. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds. Biochemistry. 2011 Jun 7; 50(22):5016-32.
    View in: PubMed
  39. Moustafa IM, Shen H, Morton B, Colina CM, Cameron CE. Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelity. J Mol Biol. 2011 Jul 1; 410(1):159-81.
    View in: PubMed
  40. Wu R, Smidansky ED, Oh HS, Takhampunya R, Padmanabhan R, Cameron CE, Peterson BR. Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses. J Med Chem. 2010 Nov 25; 53(22):7958-66.
    View in: PubMed
  41. Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, Raney KD, Kao CC, Cameron CE. Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol. 2010 Dec; 84(24):12480-91.
    View in: PubMed
  42. Cline SD, Lodeiro MF, Marnett LJ, Cameron CE, Arnold JJ. Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG. Nucleic Acids Res. 2010 Nov; 38(21):7546-57.
    View in: PubMed
  43. Shutt TE, Lodeiro MF, Cotney J, Cameron CE, Shadel GS. Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27):12133-8.
    View in: PubMed
  44. Cameron CE, Oh HS, Moustafa IM. Expanding knowledge of P3 proteins in the poliovirus lifecycle. Future Microbiol. 2010 Jun; 5(6):867-81.
    View in: PubMed
  45. Hsu NY, Ilnytska O, Belov G, Santiana M, Chen YH, Takvorian PM, Pau C, van der Schaar H, Kaushik-Basu N, Balla T, Cameron CE, Ehrenfeld E, van Kuppeveld FJ, Altan-Bonnet N. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell. 2010 May 28; 141(5):799-811.
    View in: PubMed
  46. Raney KD, Sharma SD, Moustafa IM, Cameron CE. Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem. 2010 Jul 23; 285(30):22725-31.
    View in: PubMed
  47. Toroney R, Nallagatla SR, Boyer JA, Cameron CE, Bevilacqua PC. Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A. J Mol Biol. 2010 Jul 16; 400(3):393-412.
    View in: PubMed
  48. Chatterji U, Lim P, Bobardt MD, Wieland S, Cordek DG, Vuagniaux G, Chisari F, Cameron CE, Targett-Adams P, Parkinson T, Gallay PA. HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol. 2010 Jul; 53(1):50-6.
    View in: PubMed
  49. Lodeiro MF, Uchida AU, Arnold JJ, Reynolds SL, Moustafa IM, Cameron CE. Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J Biol Chem. 2010 May 21; 285(21):16387-402.
    View in: PubMed
  50. Matlock DL, Yeruva L, Byrd AK, Mackintosh SG, Langston C, Brown C, Cameron CE, Fischer CJ, Raney KD. Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase. Biochemistry. 2010 Mar 16; 49(10):2097-109.
    View in: PubMed
  51. Wang Q, Arnold JJ, Uchida A, Raney KD, Cameron CE. Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase. Nucleic Acids Res. 2010 Mar; 38(4):1312-24.
    View in: PubMed
  52. Cameron CE, Moustafa IM, Arnold JJ. Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase? Curr Opin Struct Biol. 2009 Dec; 19(6):768-74.
    View in: PubMed
  53. te Velthuis AJ, Arnold JJ, Cameron CE, van den Worm SH, Snijder EJ. The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. Nucleic Acids Res. 2010 Jan; 38(1):203-14.
    View in: PubMed
  54. Oh HS, Pathak HB, Goodfellow IG, Arnold JJ, Cameron CE. Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants. J Virol. 2009 Sep; 83(18):9370-87.
    View in: PubMed
  55. Castro C, Smidansky ED, Arnold JJ, Maksimchuk KR, Moustafa I, Uchida A, Götte M, Konigsberg W, Cameron CE. Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol. 2009 Feb; 16(2):212-8.
    View in: PubMed
  56. Jennings TA, Mackintosh SG, Harrison MK, Sikora D, Sikora B, Dave B, Tackett AJ, Cameron CE, Raney KD. NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations. J Biol Chem. 2009 Feb 20; 284(8):4806-14.
    View in: PubMed
  57. Arias A, Arnold JJ, Sierra M, Smidansky ED, Domingo E, Cameron CE. Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J Virol. 2008 Dec; 82(24):12346-55.
    View in: PubMed
  58. Pathak HB, Oh HS, Goodfellow IG, Arnold JJ, Cameron CE. Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylation. J Biol Chem. 2008 Nov 7; 283(45):30677-88.
    View in: PubMed
  59. Sun Q, Edathil JP, Wu R, Smidansky ED, Cameron CE, Peterson BR. One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates. Org Lett. 2008 May 1; 10(9):1703-6.
    View in: PubMed
  60. Sikora B, Chen Y, Lichti CF, Harrison MK, Jennings TA, Tang Y, Tackett AJ, Jordan JB, Sakon J, Cameron CE, Raney KD. Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro. J Biol Chem. 2008 Apr 25; 283(17):11516-25.
    View in: PubMed
  61. Jennings TA, Chen Y, Sikora D, Harrison MK, Sikora B, Huang L, Jankowsky E, Fairman ME, Cameron CE, Raney KD. RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase. Biochemistry. 2008 Jan 29; 47(4):1126-35.
    View in: PubMed
  62. Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM, Peterson BR, Loakes D, Brown DM, Cameron CE. Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrob Agents Chemother. 2008 Mar; 52(3):971-9.
    View in: PubMed
  63. Ng KK, Arnold JJ, Cameron CE. Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol. 2008; 320:137-56.
    View in: PubMed
  64. Moriyama K, Suzuki T, Negishi K, Graci JD, Thompson CN, Cameron CE, Watanabe M. Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity. J Med Chem. 2008 Jan 10; 51(1):159-66.
    View in: PubMed
  65. Nallagatla SR, Hwang J, Toroney R, Zheng X, Cameron CE, Bevilacqua PC. 5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science. 2007 Nov 30; 318(5855):1455-8.
    View in: PubMed
  66. Shen M, Reitman ZJ, Zhao Y, Moustafa I, Wang Q, Arnold JJ, Pathak HB, Cameron CE. Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex. J Biol Chem. 2008 Jan 11; 283(2):875-88.
    View in: PubMed
  67. Shen M, Wang Q, Yang Y, Pathak HB, Arnold JJ, Castro C, Lemon SM, Cameron CE. Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex. J Virol. 2007 Nov; 81(22):12485-95.
    View in: PubMed
  68. Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. Chembiochem. 2007 Aug 13; 8(12):1359-62.
    View in: PubMed
  69. Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE. Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. J Virol. 2007 Oct; 81(20):11256-66.
    View in: PubMed
  70. Korneeva VS, Cameron CE. Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J Biol Chem. 2007 Jun 1; 282(22):16135-45.
    View in: PubMed
  71. Pathak HB, Arnold JJ, Wiegand PN, Hargittai MR, Cameron CE. Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. J Biol Chem. 2007 Jun 1; 282(22):16202-13.
    View in: PubMed
  72. Castro C, Smidansky E, Maksimchuk KR, Arnold JJ, Korneeva VS, Götte M, Konigsberg W, Cameron CE. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4267-72.
    View in: PubMed
  73. Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM. Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol. 2007 Apr; 81(7):3583-96.
    View in: PubMed
  74. Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR. Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J Med Chem. 2006 Oct 19; 49(21):6166-9.
    View in: PubMed
  75. Takhampunya R, Ubol S, Houng HS, Cameron CE, Padmanabhan R. Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol. 2006 Jul; 87(Pt 7):1947-52.
    View in: PubMed
  76. D'Abramo CM, Deval J, Cameron CE, Cellai L, Götte M. Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase. J Biol Chem. 2006 Aug 25; 281(34):24991-8.
    View in: PubMed
  77. Huang L, Gledhill J, Cameron CE. An Assay for RNA-Dependent RNA Polymerase Activity. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  78. Huang L, Gledhill J, Cameron CE. Assay for Primed RNA-Dependent RNA Polymerase Transcription. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  79. Huang L, Gledhill J, Cameron CE. Preparation and Fractionation of Drosophila Embryo Extracts for the In Vitro Characterization of RNAi. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  80. Huang L, Gledhill J, Cameron CE. Preparation of siRNAs from Drosophila Embryo Extracts. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  81. Huang L, Gledhill J, Cameron CE. Protocol for siRNA-Primed RNA Synthesis. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  82. Lanzi G, de Miranda JR, Boniotti MB, Cameron CE, Lavazza A, Capucci L, Camazine SM, Rossi C. Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J Virol. 2006 May; 80(10):4998-5009.
    View in: PubMed
  83. van Ooij MJ, Vogt DA, Paul A, Castro C, Kuijpers J, van Kuppeveld FJ, Cameron CE, Wimmer E, Andino R, Melchers WJ. Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. J Gen Virol. 2006 Jan; 87(Pt 1):103-13.
    View in: PubMed
  84. Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol. 2006 Jan-Feb; 16(1):37-48.
    View in: PubMed
  85. Vignuzzi M, Stone JK, Arnold JJ, Cameron CE, Andino R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature. 2006 Jan 19; 439(7074):344-8.
    View in: PubMed
  86. Mackintosh SG, Lu JZ, Jordan JB, Harrison MK, Sikora B, Sharma SD, Cameron CE, Raney KD, Sakon J. Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J Biol Chem. 2006 Feb 10; 281(6):3528-35.
    View in: PubMed
  87. Franco D, Pathak HB, Cameron CE, Rombaut B, Wimmer E, Paul AV. Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. Virol J. 2005; 2:86.
    View in: PubMed
  88. Arnold JJ, Bernal A, Uche U, Sterner DE, Butt TR, Cameron CE, Mattern MR. Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal Biochem. 2006 Mar 15; 350(2):214-21.
    View in: PubMed
  89. Huang L, Hwang J, Sharma SD, Hargittai MR, Chen Y, Arnold JJ, Raney KD, Cameron CE. Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein. J Biol Chem. 2005 Oct 28; 280(43):36417-28.
    View in: PubMed
  90. Arnold JJ, Vignuzzi M, Stone JK, Andino R, Cameron CE. Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem. 2005 Jul 8; 280(27):25706-16.
    View in: PubMed
  91. Franco D, Pathak HB, Cameron CE, Rombaut B, Wimmer E, Paul AV. Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. J Virol. 2005 May; 79(10):6358-67.
    View in: PubMed
  92. Belliot G, Sosnovtsev SV, Chang KO, Babu V, Uche U, Arnold JJ, Cameron CE, Green KY. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J Virol. 2005 Feb; 79(4):2393-403.
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  93. Castro C, Arnold JJ, Cameron CE. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res. 2005 Feb; 107(2):141-9.
    View in: PubMed
  94. Tackett AJ, Chen Y, Cameron CE, Raney KD. Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro. J Biol Chem. 2005 Mar 18; 280(11):10797-806.
    View in: PubMed
  95. Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, Cameron CE. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif. 2004 Sep; 37(1):144-53.
    View in: PubMed
  96. Gohara DW, Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry. 2004 May 11; 43(18):5149-58.
    View in: PubMed
  97. Arnold JJ, Gohara DW, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Biochemistry. 2004 May 11; 43(18):5138-48.
    View in: PubMed
  98. Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry. 2004 May 11; 43(18):5126-37.
    View in: PubMed
  99. Freistadt MS, Meades GD, Cameron CE. Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance? Drug Resist Updat. 2004 Feb; 7(1):19-24.
    View in: PubMed
  100. Graci JD, Cameron CE. Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir Chem Chemother. 2004 Jan; 15(1):1-13.
    View in: PubMed
  101. Crotty S, Gohara D, Gilligan DK, Karelsky S, Cameron CE, Andino R. Manganese-dependent polioviruses caused by mutations within the viral polymerase. J Virol. 2003 May; 77(9):5378-88.
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  102. Gorbalenya AE, Pringle FM, Zeddam JL, Luke BT, Cameron CE, Kalmakoff J, Hanzlik TN, Gordon KH, Ward VK. The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J Mol Biol. 2002 Nov 15; 324(1):47-62.
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  103. Green KY, Mory A, Fogg MH, Weisberg A, Belliot G, Wagner M, Mitra T, Ehrenfeld E, Cameron CE, Sosnovtsev SV. Isolation of enzymatically active replication complexes from feline calicivirus-infected cells. J Virol. 2002 Sep; 76(17):8582-95.
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  104. Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry. 2002 Jul 23; 41(29):9026-33.
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  105. Graci JD, Cameron CE. Quasispecies, error catastrophe, and the antiviral activity of ribavirin. Virology. 2002 Jul 5; 298(2):175-80.
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  106. Pathak HB, Ghosh SK, Roberts AW, Sharma SD, Yoder JD, Arnold JJ, Gohara DW, Barton DJ, Paul AV, Cameron CE. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem. 2002 Aug 30; 277(35):31551-62.
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  107. Morris PD, Byrd AK, Tackett AJ, Cameron CE, Tanega P, Ott R, Fanning E, Raney KD. Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA. Biochemistry. 2002 Feb 19; 41(7):2372-8.
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  108. Hong Z, Cameron CE. Pleiotropic mechanisms of ribavirin antiviral activities. Prog Drug Res. 2002; 59:41-69.
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  109. Crotty S, Cameron C, Andino R. Ribavirin's antiviral mechanism of action: lethal mutagenesis? J Mol Med (Berl). 2002 Feb; 80(2):86-95.
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  110. Cameron CE, Castro C. The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase. Curr Opin Infect Dis. 2001 Dec; 14(6):757-64.
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