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Craig Cameron

TitlePaul Berg Professor of Biochemistry and Molecular Biology
InstitutionEberly College of Science
DepartmentBiochemistry and Molecular Biology
Address201 Althouse Lab
University Park, PA 16802
Phone8148638705
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Paul Berg Professor of Biochemistry and Molecular Biology
Associate Department Head for Research and Graduate Education

NARRATIVE:

Dr. Cameron's research focuses on defining the molecular details of genome replication in positive-strand RNA viruses and identifying components of this process suitable for antiviral drug development. Current projects areas include RNA-dependent RNA polymerase mechanisms, viral attenuation and vaccine development, picornavirus genome replication, biochemical mechanisms and biological functions of HCV, NS3, and NS5a proteins, mitochondrial transcription and disease, and lethal mutagenesis as an antiviral strategy.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Reynolds KA, Cameron CE, Raney KD. Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction. Biochemistry. 2015 Jul 14; 54(27):4248-58.
    View in: PubMed
  2. Van Slyke GA, Arnold JJ, Lugo AJ, Griesemer SB, Moustafa IM, Kramer LD, Cameron CE, Ciota AT. Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes. PLoS Pathog. 2015 Jun; 11(6):e1005009.
    View in: PubMed
  3. Murugesapillai D, Lodeiro MF, James Maher L, Cameron CE, Williams MC. 26 Sequence-specific DNA looping by mitochondrial transcription factor A (TFAM). J Biomol Struct Dyn. 2015 May; 33 Suppl 1:15-6.
    View in: PubMed
  4. van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. PLoS Pathog. 2015 Mar; 11(3):e1004733.
    View in: PubMed
  5. Li S, Ding X, Mao Z, Chen Y, Nama N, Guo F, Li P, Wang L, Cameron CE, Huang TJ. Standing surface acoustic wave (SSAW)-based cell washing. Lab Chip. 2014 Dec 3; 15(1):331-8.
    View in: PubMed
  6. Kolli S, Meng X, Wu X, Shengjuler D, Cameron CE, Xiang Y, Deng J. Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication. J Virol. 2015 Feb 15; 89(4):2209-19.
    View in: PubMed
  7. Moustafa IM, Korboukh VK, Arnold JJ, Smidansky ED, Marcotte LL, Gohara DW, Yang X, Sánchez-Farrán MA, Filman D, Maranas JK, Boehr DD, Hogle JM, Colina CM, Cameron CE. Structural Dynamics as a Contributor to Error-prone Replication by an RNA-dependent RNA Polymerase. J Biol Chem. 2014 Dec 26; 289(52):36229-48.
    View in: PubMed
  8. Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry. 2014 Oct 21; 53(41):6584-94.
    View in: PubMed
  9. Li S, Guo F, Chen Y, Ding X, Li P, Wang L, Cameron CE, Huang TJ. Standing surface acoustic wave based cell coculture. Anal Chem. 2014 Oct 7; 86(19):9853-9.
    View in: PubMed
  10. Korboukh VK, Lee CA, Acevedo A, Vignuzzi M, Xiao Y, Arnold JJ, Hemperly S, Graci JD, August A, Andino R, Cameron CE. RNA virus population diversity, an optimum for maximal fitness and virulence. J Biol Chem. 2014 Oct 24; 289(43):29531-44.
    View in: PubMed
  11. Cordek DG, Croom-Perez TJ, Hwang J, Hargittai MR, Subba-Reddy CV, Han Q, Lodeiro MF, Ning G, McCrory TS, Arnold JJ, Koc H, Lindenbach BD, Showalter SA, Cameron CE. Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein. J Biol Chem. 2014 Aug 29; 289(35):24397-416.
    View in: PubMed
  12. Liu YC, Kuo RL, Lin JY, Huang PN, Huang Y, Liu H, Arnold JJ, Chen SJ, Wang RY, Cameron CE, Shih SR. Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8. PLoS Pathog. 2014 Jun; 10(6):e1004199.
    View in: PubMed
  13. Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R. Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2. J Mol Biol. 2014 Jul 15; 426(14):2580-93.
    View in: PubMed
  14. Li S, Kiehne J, Sinoway LI, Cameron CE, Huang TJ. Microfluidic opportunities in the field of nutrition. Lab Chip. 2013 Oct 21; 13(20):3993-4003.
    View in: PubMed
  15. Liu X, Yang X, Lee CA, Moustafa IM, Smidansky ED, Lum D, Arnold JJ, Cameron CE, Boehr DD. Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity. J Biol Chem. 2013 Nov 8; 288(45):32753-65.
    View in: PubMed
  16. Panigrahi R, Hazari S, Chandra S, Chandra PK, Datta S, Kurt R, Cameron CE, Huang Z, Zhang H, Garry RF, Balart LA, Dash S. Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One. 2013; 8(8):e72791.
    View in: PubMed
  17. Li S, Ding X, Guo F, Chen Y, Lapsley MI, Lin SC, Wang L, McCoy JP, Cameron CE, Huang TJ. An on-chip, multichannel droplet sorter using standing surface acoustic waves. Anal Chem. 2013 Jun 4; 85(11):5468-74.
    View in: PubMed
  18. Nallagatla SR, Jones CN, Ghosh SK, Sharma SD, Cameron CE, Spremulli LL, Bevilacqua PC. Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One. 2013; 8(3):e57905.
    View in: PubMed
  19. Shen H, Moustafa IM, Cameron CE, Colina CM. Exploring the dynamics of four RNA-dependent RNA polymerases by a coarse-grained model. J Phys Chem B. 2012 Dec 20; 116(50):14515-24.
    View in: PubMed
  20. Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, Cho A, Perry J, Vela JE, Park Y, Xu Y, Tian Y, Babusis D, Barauskus O, Peterson BR, Gnatt A, Kashlev M, Zhong W, Cameron CE. Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. PLoS Pathog. 2012; 8(11):e1003030.
    View in: PubMed
  21. Raney VM, Reynolds KA, Harrison MK, Harrison DK, Cameron CE, Raney KD. Binding by the hepatitis C virus NS3 helicase partially melts duplex DNA. Biochemistry. 2012 Sep 25; 51(38):7596-607.
    View in: PubMed
  22. Cameron CE, Cline SD. Mitochondrial gene expression. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):913.
    View in: PubMed
  23. Weeks SA, Lee CA, Zhao Y, Smidansky ED, August A, Arnold JJ, Cameron CE. A Polymerase mechanism-based strategy for viral attenuation and vaccine development. J Biol Chem. 2012 Sep 14; 287(38):31618-22.
    View in: PubMed
  24. Yang X, Smidansky ED, Maksimchuk KR, Lum D, Welch JL, Arnold JJ, Cameron CE, Boehr DD. Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition. Structure. 2012 Sep 5; 20(9):1519-27.
    View in: PubMed
  25. Lim PJ, Chatterji U, Cordek D, Sharma SD, Garcia-Rivera JA, Cameron CE, Lin K, Targett-Adams P, Gallay PA. Correlation between NS5A dimerization and hepatitis C virus replication. J Biol Chem. 2012 Aug 31; 287(36):30861-73.
    View in: PubMed
  26. Trahey M, Oh HS, Cameron CE, Hay JC. Poliovirus infection transiently increases COPII vesicle budding. J Virol. 2012 Sep; 86(18):9675-82.
    View in: PubMed
  27. Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE. Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):948-60.
    View in: PubMed
  28. Lodeiro MF, Uchida A, Bestwick M, Moustafa IM, Arnold JJ, Shadel GS, Cameron CE. Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6513-8.
    View in: PubMed
  29. Davis WG, Bowzard JB, Sharma SD, Wiens ME, Ranjan P, Gangappa S, Stuchlik O, Pohl J, Donis RO, Katz JM, Cameron CE, Fujita T, Sambhara S. The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I. PLoS One. 2012; 7(3):e32661.
    View in: PubMed
  30. Graci JD, Gnädig NF, Galarraga JE, Castro C, Vignuzzi M, Cameron CE. Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis. J Virol. 2012 Mar; 86(5):2869-73.
    View in: PubMed
  31. Gazina EV, Smidansky ED, Holien JK, Harrison DN, Cromer BA, Arnold JJ, Parker MW, Cameron CE, Petrou S. Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase. J Virol. 2011 Oct; 85(19):10364-74.
    View in: PubMed
  32. Dutta A, Zheng S, Jain D, Cameron CE, Reese JC. Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo. J Biol Chem. 2011 Aug 5; 286(31):27454-70.
    View in: PubMed
  33. Smidansky ED, Arnold JJ, Reynolds SL, Cameron CE. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds. Biochemistry. 2011 Jun 7; 50(22):5016-32.
    View in: PubMed
  34. Moustafa IM, Shen H, Morton B, Colina CM, Cameron CE. Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelity. J Mol Biol. 2011 Jul 1; 410(1):159-81.
    View in: PubMed
  35. Bamford CV, Francescutti T, Cameron CE, Jenkinson HF, Dymock D. Characterization of a novel family of fibronectin-binding proteins with M23 peptidase domains from Treponema denticola. Mol Oral Microbiol. 2010 Dec; 25(6):369-83.
    View in: PubMed
  36. Wu R, Smidansky ED, Oh HS, Takhampunya R, Padmanabhan R, Cameron CE, Peterson BR. Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses. J Med Chem. 2010 Nov 25; 53(22):7958-66.
    View in: PubMed
  37. Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, Raney KD, Kao CC, Cameron CE. Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol. 2010 Dec; 84(24):12480-91.
    View in: PubMed
  38. Cline SD, Lodeiro MF, Marnett LJ, Cameron CE, Arnold JJ. Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG. Nucleic Acids Res. 2010 Nov; 38(21):7546-57.
    View in: PubMed
  39. Shutt TE, Lodeiro MF, Cotney J, Cameron CE, Shadel GS. Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27):12133-8.
    View in: PubMed
  40. Cameron CE, Oh HS, Moustafa IM. Expanding knowledge of P3 proteins in the poliovirus lifecycle. Future Microbiol. 2010 Jun; 5(6):867-81.
    View in: PubMed
  41. Hsu NY, Ilnytska O, Belov G, Santiana M, Chen YH, Takvorian PM, Pau C, van der Schaar H, Kaushik-Basu N, Balla T, Cameron CE, Ehrenfeld E, van Kuppeveld FJ, Altan-Bonnet N. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell. 2010 May 28; 141(5):799-811.
    View in: PubMed
  42. Raney KD, Sharma SD, Moustafa IM, Cameron CE. Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem. 2010 Jul 23; 285(30):22725-31.
    View in: PubMed
  43. Toroney R, Nallagatla SR, Boyer JA, Cameron CE, Bevilacqua PC. Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A. J Mol Biol. 2010 Jul 16; 400(3):393-412.
    View in: PubMed
  44. Chatterji U, Lim P, Bobardt MD, Wieland S, Cordek DG, Vuagniaux G, Chisari F, Cameron CE, Targett-Adams P, Parkinson T, Gallay PA. HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol. 2010 Jul; 53(1):50-6.
    View in: PubMed
  45. Lodeiro MF, Uchida AU, Arnold JJ, Reynolds SL, Moustafa IM, Cameron CE. Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J Biol Chem. 2010 May 21; 285(21):16387-402.
    View in: PubMed
  46. Matlock DL, Yeruva L, Byrd AK, Mackintosh SG, Langston C, Brown C, Cameron CE, Fischer CJ, Raney KD. Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase. Biochemistry. 2010 Mar 16; 49(10):2097-109.
    View in: PubMed
  47. Wang Q, Arnold JJ, Uchida A, Raney KD, Cameron CE. Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase. Nucleic Acids Res. 2010 Mar; 38(4):1312-24.
    View in: PubMed
  48. Cameron CE, Moustafa IM, Arnold JJ. Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase? Curr Opin Struct Biol. 2009 Dec; 19(6):768-74.
    View in: PubMed
  49. te Velthuis AJ, Arnold JJ, Cameron CE, van den Worm SH, Snijder EJ. The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. Nucleic Acids Res. 2010 Jan; 38(1):203-14.
    View in: PubMed
  50. Oh HS, Pathak HB, Goodfellow IG, Arnold JJ, Cameron CE. Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants. J Virol. 2009 Sep; 83(18):9370-87.
    View in: PubMed
  51. Castro C, Smidansky ED, Arnold JJ, Maksimchuk KR, Moustafa I, Uchida A, Götte M, Konigsberg W, Cameron CE. Nucleic acid polymerases use a general acid for nucleotidyl transfer. Nat Struct Mol Biol. 2009 Feb; 16(2):212-8.
    View in: PubMed
  52. Jennings TA, Mackintosh SG, Harrison MK, Sikora D, Sikora B, Dave B, Tackett AJ, Cameron CE, Raney KD. NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations. J Biol Chem. 2009 Feb 20; 284(8):4806-14.
    View in: PubMed
  53. Arias A, Arnold JJ, Sierra M, Smidansky ED, Domingo E, Cameron CE. Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. J Virol. 2008 Dec; 82(24):12346-55.
    View in: PubMed
  54. Pathak HB, Oh HS, Goodfellow IG, Arnold JJ, Cameron CE. Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylation. J Biol Chem. 2008 Nov 7; 283(45):30677-88.
    View in: PubMed
  55. Sun Q, Edathil JP, Wu R, Smidansky ED, Cameron CE, Peterson BR. One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates. Org Lett. 2008 May 1; 10(9):1703-6.
    View in: PubMed
  56. Amero CD, Arnold JJ, Moustafa IM, Cameron CE, Foster MP. Identification of the oriI-binding site of poliovirus 3C protein by nuclear magnetic resonance spectroscopy. J Virol. 2008 May; 82(9):4363-70.
    View in: PubMed
  57. Sikora B, Chen Y, Lichti CF, Harrison MK, Jennings TA, Tang Y, Tackett AJ, Jordan JB, Sakon J, Cameron CE, Raney KD. Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro. J Biol Chem. 2008 Apr 25; 283(17):11516-25.
    View in: PubMed
  58. Jennings TA, Chen Y, Sikora D, Harrison MK, Sikora B, Huang L, Jankowsky E, Fairman ME, Cameron CE, Raney KD. RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase. Biochemistry. 2008 Jan 29; 47(4):1126-35.
    View in: PubMed
  59. Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM, Peterson BR, Loakes D, Brown DM, Cameron CE. Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrob Agents Chemother. 2008 Mar; 52(3):971-9.
    View in: PubMed
  60. Ng KK, Arnold JJ, Cameron CE. Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol. 2008; 320:137-56.
    View in: PubMed
  61. Moriyama K, Suzuki T, Negishi K, Graci JD, Thompson CN, Cameron CE, Watanabe M. Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity. J Med Chem. 2008 Jan 10; 51(1):159-66.
    View in: PubMed
  62. Nallagatla SR, Hwang J, Toroney R, Zheng X, Cameron CE, Bevilacqua PC. 5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. Science. 2007 Nov 30; 318(5855):1455-8.
    View in: PubMed
  63. Shen M, Reitman ZJ, Zhao Y, Moustafa I, Wang Q, Arnold JJ, Pathak HB, Cameron CE. Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex. J Biol Chem. 2008 Jan 11; 283(2):875-88.
    View in: PubMed
  64. Shen M, Wang Q, Yang Y, Pathak HB, Arnold JJ, Castro C, Lemon SM, Cameron CE. Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex. J Virol. 2007 Nov; 81(22):12485-95.
    View in: PubMed
  65. Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. Chembiochem. 2007 Aug 13; 8(12):1359-62.
    View in: PubMed
  66. Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE. Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. J Virol. 2007 Oct; 81(20):11256-66.
    View in: PubMed
  67. Korneeva VS, Cameron CE. Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. J Biol Chem. 2007 Jun 1; 282(22):16135-45.
    View in: PubMed
  68. Pathak HB, Arnold JJ, Wiegand PN, Hargittai MR, Cameron CE. Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. J Biol Chem. 2007 Jun 1; 282(22):16202-13.
    View in: PubMed
  69. Castro C, Smidansky E, Maksimchuk KR, Arnold JJ, Korneeva VS, Götte M, Konigsberg W, Cameron CE. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4267-72.
    View in: PubMed
  70. Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM. Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. J Virol. 2007 Apr; 81(7):3583-96.
    View in: PubMed
  71. Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR. Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. J Med Chem. 2006 Oct 19; 49(21):6166-9.
    View in: PubMed
  72. Takhampunya R, Ubol S, Houng HS, Cameron CE, Padmanabhan R. Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol. 2006 Jul; 87(Pt 7):1947-52.
    View in: PubMed
  73. D'Abramo CM, Deval J, Cameron CE, Cellai L, Götte M. Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase. J Biol Chem. 2006 Aug 25; 281(34):24991-8.
    View in: PubMed
  74. Huang L, Gledhill J, Cameron CE. An Assay for RNA-Dependent RNA Polymerase Activity. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  75. Huang L, Gledhill J, Cameron CE. Assay for Primed RNA-Dependent RNA Polymerase Transcription. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  76. Huang L, Gledhill J, Cameron CE. Preparation and Fractionation of Drosophila Embryo Extracts for the In Vitro Characterization of RNAi. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  77. Huang L, Gledhill J, Cameron CE. Preparation of siRNAs from Drosophila Embryo Extracts. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  78. Huang L, Gledhill J, Cameron CE. Protocol for siRNA-Primed RNA Synthesis. CSH Protoc. 2006; 2006(1).
    View in: PubMed
  79. Lanzi G, de Miranda JR, Boniotti MB, Cameron CE, Lavazza A, Capucci L, Camazine SM, Rossi C. Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.). J Virol. 2006 May; 80(10):4998-5009.
    View in: PubMed
  80. van Ooij MJ, Vogt DA, Paul A, Castro C, Kuijpers J, van Kuppeveld FJ, Cameron CE, Wimmer E, Andino R, Melchers WJ. Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. J Gen Virol. 2006 Jan; 87(Pt 1):103-13.
    View in: PubMed
  81. Graci JD, Cameron CE. Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol. 2006 Jan-Feb; 16(1):37-48.
    View in: PubMed
  82. Vignuzzi M, Stone JK, Arnold JJ, Cameron CE, Andino R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature. 2006 Jan 19; 439(7074):344-8.
    View in: PubMed
  83. Mackintosh SG, Lu JZ, Jordan JB, Harrison MK, Sikora B, Sharma SD, Cameron CE, Raney KD, Sakon J. Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J Biol Chem. 2006 Feb 10; 281(6):3528-35.
    View in: PubMed
  84. Franco D, Pathak HB, Cameron CE, Rombaut B, Wimmer E, Paul AV. Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. Virol J. 2005; 2:86.
    View in: PubMed
  85. Arnold JJ, Bernal A, Uche U, Sterner DE, Butt TR, Cameron CE, Mattern MR. Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal Biochem. 2006 Mar 15; 350(2):214-21.
    View in: PubMed
  86. Huang L, Hwang J, Sharma SD, Hargittai MR, Chen Y, Arnold JJ, Raney KD, Cameron CE. Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein. J Biol Chem. 2005 Oct 28; 280(43):36417-28.
    View in: PubMed
  87. Arnold JJ, Vignuzzi M, Stone JK, Andino R, Cameron CE. Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. J Biol Chem. 2005 Jul 8; 280(27):25706-16.
    View in: PubMed
  88. Franco D, Pathak HB, Cameron CE, Rombaut B, Wimmer E, Paul AV. Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro. J Virol. 2005 May; 79(10):6358-67.
    View in: PubMed
  89. Belliot G, Sosnovtsev SV, Chang KO, Babu V, Uche U, Arnold JJ, Cameron CE, Green KY. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J Virol. 2005 Feb; 79(4):2393-403.
    View in: PubMed
  90. Castro C, Arnold JJ, Cameron CE. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. Virus Res. 2005 Feb; 107(2):141-9.
    View in: PubMed
  91. Tackett AJ, Chen Y, Cameron CE, Raney KD. Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro. J Biol Chem. 2005 Mar 18; 280(11):10797-806.
    View in: PubMed
  92. Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, Cameron CE. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif. 2004 Sep; 37(1):144-53.
    View in: PubMed
  93. de Miranda JR, Drebot M, Tyler S, Shen M, Cameron CE, Stoltz DB, Camazine SM. Complete nucleotide sequence of Kashmir bee virus and comparison with acute bee paralysis virus. J Gen Virol. 2004 Aug; 85(Pt 8):2263-70.
    View in: PubMed
  94. Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. Biochemistry. 2004 May 11; 43(18):5126-37.
    View in: PubMed
  95. Arnold JJ, Gohara DW, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. Biochemistry. 2004 May 11; 43(18):5138-48.
    View in: PubMed
  96. Gohara DW, Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. Biochemistry. 2004 May 11; 43(18):5149-58.
    View in: PubMed
  97. Freistadt MS, Meades GD, Cameron CE. Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance? Drug Resist Updat. 2004 Feb; 7(1):19-24.
    View in: PubMed
  98. Graci JD, Cameron CE. Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. Antivir Chem Chemother. 2004 Jan; 15(1):1-13.
    View in: PubMed
  99. Crotty S, Gohara D, Gilligan DK, Karelsky S, Cameron CE, Andino R. Manganese-dependent polioviruses caused by mutations within the viral polymerase. J Virol. 2003 May; 77(9):5378-88.
    View in: PubMed
  100. Gorbalenya AE, Pringle FM, Zeddam JL, Luke BT, Cameron CE, Kalmakoff J, Hanzlik TN, Gordon KH, Ward VK. The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage. J Mol Biol. 2002 Nov 15; 324(1):47-62.
    View in: PubMed
  101. Green KY, Mory A, Fogg MH, Weisberg A, Belliot G, Wagner M, Mitra T, Ehrenfeld E, Cameron CE, Sosnovtsev SV. Isolation of enzymatically active replication complexes from feline calicivirus-infected cells. J Virol. 2002 Sep; 76(17):8582-95.
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  102. Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry. 2002 Jul 23; 41(29):9026-33.
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  103. Graci JD, Cameron CE. Quasispecies, error catastrophe, and the antiviral activity of ribavirin. Virology. 2002 Jul 5; 298(2):175-80.
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  104. Pathak HB, Ghosh SK, Roberts AW, Sharma SD, Yoder JD, Arnold JJ, Gohara DW, Barton DJ, Paul AV, Cameron CE. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem. 2002 Aug 30; 277(35):31551-62.
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  105. Morris PD, Byrd AK, Tackett AJ, Cameron CE, Tanega P, Ott R, Fanning E, Raney KD. Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA. Biochemistry. 2002 Feb 19; 41(7):2372-8.
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  106. Hong Z, Cameron CE. Pleiotropic mechanisms of ribavirin antiviral activities. Prog Drug Res. 2002; 59:41-69.
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  107. Crotty S, Cameron C, Andino R. Ribavirin's antiviral mechanism of action: lethal mutagenesis? J Mol Med (Berl). 2002 Feb; 80(2):86-95.
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  108. Cameron CE, Castro C. The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase. Curr Opin Infect Dis. 2001 Dec; 14(6):757-64.
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  109. Maag D, Castro C, Hong Z, Cameron CE. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J Biol Chem. 2001 Dec 7; 276(49):46094-8.
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  110. Hong Z, Cameron CE, Walker MP, Castro C, Yao N, Lau JY, Zhong W. A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology. 2001 Jun 20; 285(1):6-11.
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  111. Crotty S, Cameron CE, Andino R. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci U S A. 2001 Jun 5; 98(12):6895-900.
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  112. Wei L, Huhn JS, Mory A, Pathak HB, Sosnovtsev SV, Green KY, Cameron CE. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase. J Virol. 2001 Feb; 75(3):1211-9.
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  113. Tackett AJ, Wei L, Cameron CE, Raney KD. Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex. Nucleic Acids Res. 2001 Jan 15; 29(2):565-72.
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  114. Crotty S, Maag D, Arnold JJ, Zhong W, Lau JY, Hong Z, Andino R, Cameron CE. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med. 2000 Dec; 6(12):1375-9.
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  115. Zhong W, Ferrari E, Lesburg CA, Maag D, Ghosh SK, Cameron CE, Lau JY, Hong Z. Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase. J Virol. 2000 Oct; 74(19):9134-43.
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  116. Gohara DW, Crotty S, Arnold JJ, Yoder JD, Andino R, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B. J Biol Chem. 2000 Aug 18; 275(33):25523-32.
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  117. Cameron CE, Lukehart SA, Castro C, Molini B, Godornes C, Van Voorhis WC. Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92. J Infect Dis. 2000 Apr; 181(4):1401-13.
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  118. Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub). J Biol Chem. 2000 Feb 25; 275(8):5329-36.
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  119. Arnold JJ, Ghosh SK, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection. J Biol Chem. 1999 Dec 24; 274(52):37060-9.
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  120. Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao JX, Macaulay C, Willer D, Evans D, McFadden G. The complete DNA sequence of myxoma virus. Virology. 1999 Nov 25; 264(2):298-318.
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  121. Gohara DW, Ha CS, Kumar S, Ghosh B, Arnold JJ, Wisniewski TJ, Cameron CE. Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli. Protein Expr Purif. 1999 Oct; 17(1):128-38.
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  122. Arnold JJ, Ghosh SK, Bevilacqua PC, Cameron CE. Single-nucleotide resolution of RNA strands in the presence of their RNA complements. Biotechniques. 1999 Sep; 27(3):450-2, 454, 456.
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  123. Cameron CE, Castro C, Lukehart SA, Van Voorhis WC. Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains. Infect Immun. 1999 Jun; 67(6):3168-70.
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  124. Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA. Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response. J Exp Med. 1999 Feb 15; 189(4):647-56.
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  125. Arnold JJ, Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro. J Biol Chem. 1999 Jan 29; 274(5):2706-16.
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  126. Cameron CE, Castro C, Lukehart SA, Van Voorhis WC. Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase. Infect Immun. 1998 Dec; 66(12):5763-70.
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  127. Cameron CE, Benkovic SJ. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant. Biochemistry. 1997 Dec 16; 36(50):15792-800.
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  128. Cameron CE, Ghosh M, Le Grice SF, Benkovic SJ. Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6700-5.
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  129. Shao H, Robek MD, Threadgill DS, Mankowski LS, Cameron CE, Fuller FJ, Payne SL. Characterization and mutational studies of equine infectious anemia virus dUTPase. Biochim Biophys Acta. 1997 May 23; 1339(2):181-91.
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  130. Xiang Y, Cameron CE, Wills JW, Leis J. Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain. J Virol. 1996 Aug; 70(8):5695-700.
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  131. Ridky TW, Bizub-Bender D, Cameron CE, Weber IT, Wlodawer A, Copeland T, Skalka AM, Leis J. Programming the Rous sarcoma virus protease to cleave new substrate sequences. J Biol Chem. 1996 May 3; 271(18):10538-44.
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  132. Ridky TW, Cameron CE, Cameron J, Leis J, Copeland T, Wlodawer A, Weber IT, Harrison RW. Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites. J Biol Chem. 1996 Mar 1; 271(9):4709-17.
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  133. Cirino NM, Cameron CE, Smith JS, Rausch JW, Roth MJ, Benkovic SJ, Le Grice SF. Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase. Biochemistry. 1995 Aug 8; 34(31):9936-43.
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  134. Ghosh M, Howard KJ, Cameron CE, Benkovic SJ, Hughes SH, Le Grice SF. Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer. J Biol Chem. 1995 Mar 31; 270(13):7068-76.
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  135. Cameron CE, Burstein H, Bizub-Bender D, Ridky T, Weber IT, Wlodawer A, Skalka AM, Leis J. Identification of amino acid residues of the retroviral aspartic proteinases important for substrate specificity and catalytic efficiency. Adv Exp Med Biol. 1995; 362:399-406.
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  136. Le Grice SF, Cameron CE, Benkovic SJ. Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase. Methods Enzymol. 1995; 262:130-44.
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  137. Benkovic SJ, Cameron CE. Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I. Methods Enzymol. 1995; 262:257-69.
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  138. Wills JW, Cameron CE, Wilson CB, Xiang Y, Bennett RP, Leis J. An assembly domain of the Rous sarcoma virus Gag protein required late in budding. J Virol. 1994 Oct; 68(10):6605-18.
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  139. Leis JP, Cameron CE. Engineering proteases with altered specificity. Curr Opin Biotechnol. 1994 Aug; 5(4):403-8.
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  140. Cameron CE, Ridky TW, Shulenin S, Leis J, Weber IT, Copeland T, Wlodawer A, Burstein H, Bizub-Bender D, Skalka AM. Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus-1 proteases. J Biol Chem. 1994 Apr 15; 269(15):11170-7.
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  141. Cameron CE, Grinde B, Jacques P, Jentoft J, Leis J, Wlodawer A, Weber IT. Comparison of the substrate-binding pockets of the Rous sarcoma virus and human immunodeficiency virus type 1 proteases. J Biol Chem. 1993 Jun 5; 268(16):11711-20.
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  142. Cameron CE, Grinde B, Jentoft J, Leis J, Weber IT, Copeland TD, Wlodawer A. Mechanism of inhibition of the retroviral protease by a Rous sarcoma virus peptide substrate representing the cleavage site between the gag p2 and p10 proteins. J Biol Chem. 1992 Nov 25; 267(33):23735-41.
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  143. Grinde B, Cameron CE, Leis J, Weber IT, Wlodawer A, Burstein H, Bizub D, Skalka AM. Mutations that alter the activity of the Rous sarcoma virus protease. J Biol Chem. 1992 May 15; 267(14):9481-90.
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  144. Grinde B, Cameron CE, Leis J, Weber IT, Wlodawer A, Burstein H, Skalka AM. Analysis of substrate interactions of the Rous sarcoma virus wild type and mutant proteases and human immunodeficiency virus-1 protease using a set of systematically altered peptide substrates. J Biol Chem. 1992 May 15; 267(14):9491-8.
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  145. Bizub D, Weber IT, Cameron CE, Leis JP, Skalka AM. A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains. J Biol Chem. 1991 Mar 15; 266(8):4951-8.
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