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Patricia Silveyra

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive, Hershey, PA 17033
Mailbox: H085
Phone7175316973
Email
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    Collapse Biography 
    Collapse awards and honors
    2018Respiration Section New Investigator Award, American Physiological Society
    2017Inspired Award: Community, Penn State College of Medicine
    2017Distinguished Early Stage Investigator Award, Penn State College of Medicine
    2017All In at Penn State: An Achievement Award for Commitment to Diversity and Inclusion, Penn State University
    2017Dale J. Benos Early Career Professional Service Award, American Physiological Society
    2017OSSD-BSD prize for best paper published in Biology of Sex Differences in 2016, Organization for the Study of Sex Differences
    2017The Extra Mile Award, Leadership Harrisburg Area
    2017Respiration Section Outstanding Trainee Award, American Physiological Society
    2016 - 2019NIH K01 Career Development Award, NIH - NHLBI
    2016Rotary Community Service Award, Hershey Rotary Club
    2016YWCA Tribute to Women of Excellence Award, YWCA Harrisburg
    2015 - 2016Programs to Increase Diversity in Health-Related Research (PRIDE) , NIH - NHLBI
    2015Travel Award, Network of Minority Health Research Investigators, NIH NMRI
    2015Travel Award, Gordon Research Conference "Lung Development, Injury and Repair", Gordon Research Conference
    2014Penn State University Achieving Women Award, Penn State Commision for Women
    2014FASEB MARC Professional Skills Training Travel Award, FASEB MARC
    2013 - 2014CROWN Research Grant, Center for Research on Women and Newborn Health
    2013 - 2014CMN Research Grant, Children’s Miracle Network
    2013 - 2015BIRCWH (Building Interdisciplinary Research Careers on Women's Health) K12, National Institutes of Health
    2013Carl Storm Underrepresented Minority Fellowship, Gordon Research Conferences Minority Diversity Initiative
    2012 - 2013SDE/GWIS Adele Lewis Grant Fellowship, Graduate Women in Science
    2012 - 2013CMN Research Grant, Children’s Miracle Network
    2012ATS Minority Trainee Travel Award, American Thoracic Society
    2011Bond and Bradley Outstanding Postdoctoral Award , Penn State Hershey Postdoctoral Society
    2009ASCB Postdoctoral Travel Award, American Society for Cell Biology
    2008 - 2009Rotary International Ambassadorial Scholarship, The Rotary Foundation - Rotary International

    Collapse Overview 
    Collapse overview
    EDUCATION

    1999-2002, BS, MSc
    Licenciada en Ciencias Biológicas. University of Buenos Aires, Argentina (Magna cum laude)
    U.S. Equivalence: Bachelor of Science degree with a major in Biological Sciences plus a Master of Science degree in Biological Sciences

    2003-2007, PhD
    Doctora en Ciencias Químicas. University of Buenos Aires, Argentina (Summa cum laude)
    U.S. Equivalence: Doctor of Philosophy degree in Biological Chemistry.

    2008-2011, Postdoctoral Research Fellow (Pulmonary Molecular Biology)
    CHILD Research, Pediatrics, Penn State College of Medicine.

    2015 - 2016 Graduate Certificate in Applied Bioinformatics
    Pennsylvania State University World Campus


    NARRATIVE

    I am a research scientist with expertise in several disciplines including endocrinology, molecular biology, and respiratory physiology. My research is primarily focused on the study of lung inflammation associated with air pollution, with particular emphasis in sex differences and the role of sex hormones. My laboratory uses a combination of molecular biology, immunology, and endocrinology approaches to study hormonal regulation of gene expression networks in response to environmental insults. I also lead an interdisciplinary research project focused on the identification of miRNA and proteomic biomarkers for pediatric inflammatory lung disease, including bronchopulmonary dysplasia and pulmonary hypertension.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Vargas Pelaez AF, Ramirez SI, Valdes Sanchez C, Piedra Abusharar S, Romeu JC, Carmichael C, Bascoy S, Baron R, Pichardo-Lowden A, Albarracin N, Jones CC, Silveyra P. Implementing a medical student interpreter training program as a strategy to developing humanism. BMC Med Educ. 2018 Jun 18; 18(1):141. PMID: 29914460.
      View in: PubMed
    2. Fuentes N, Roy A, Mishra V, Cabello N, Silveyra P. Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation. Biol Sex Differ. 2018 May 08; 9(1):18. PMID: 29739446.
      View in: PubMed
    3. Silveyra GR, Silveyra P, Vatnick I, Medesani DA, Rodríguez EM. Effects of atrazine on vitellogenesis, steroid levels and lipid peroxidation, in female red swamp crayfish Procambarus clarkii. Aquat Toxicol. 2018 Apr; 197:136-142. PMID: 29482076.
      View in: PubMed
    4. Halstead ES, Umstead TM, Davies ML, Kawasawa YI, Silveyra P, Howyrlak J, Yang L, Guo W, Hu S, Hewage EK, Chroneos ZC. GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization. Respir Res. 2018 Jan 05; 19(1):3. PMID: 29304863.
      View in: PubMed
    5. Silveyra P, Zeldin DC. It All Begins In Utero: Cord Blood Bacterial DNA and T Cell Immunity. Am J Respir Cell Mol Biol. 2017 Oct; 57(4):379-380. PMID: 28960102.
      View in: PubMed
    6. Mishra V, Banga J, Silveyra P. Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets. Pharmacol Ther. 2018 01; 181:169-182. PMID: 28842273.
      View in: PubMed
    7. Fino KK, Yang L, Silveyra P, Hu S, Umstead TM, DiAngelo S, Halstead ES, Cooper TK, Abraham T, Takahashi Y, Zhou Z, Wang HG, Chroneos ZC. SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection. Sci Rep. 2017 Aug 04; 7(1):7262. PMID: 28779131.
      View in: PubMed
    8. Carney MC, Tarasiuk A, DiAngelo SL, Silveyra P, Podany A, Birch LL, Paul IM, Kelleher S, Hicks SD. Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery. Pediatr Res. 2017 Aug; 82(2):226-236. PMID: 28422941.
      View in: PubMed
    9. Rivera L, Siddaiah R, Oji-Mmuo C, Silveyra GR, Silveyra P. Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant. Front Pediatr. 2016; 4:33. PMID: 27065351; PMCID: PMC4814627.
    10. Mishra V, DiAngelo SL, Silveyra P. Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation. Biol Sex Differ. 2016; 7:16. PMID: 26949510; PMCID: PMC4779258.
    11. Cabello N, Mishra V, Sinha U, DiAngelo SL, Chroneos ZC, Ekpa NA, Cooper TK, Caruso CR, Silveyra P. Sex differences in the expression of lung inflammatory mediators in response to ozone. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15; 309(10):L1150-63. PMID: 26342085; PMCID: PMC4652152 [Available on 11/15/16].
    12. Yang L, Carrillo M, Wu YM, DiAngelo SL, Silveyra P, Umstead TM, Halstead ES, Davies ML, Hu S, Floros J, McCormack FX, Christensen ND, Chroneos ZC. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS One. 2015; 10(5):e0126576. PMID: 25965346; PMCID: PMC4428707.
    13. Grageda M, Silveyra P, Thomas NJ, DiAngelo SL, Floros J. DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. Exp Lung Res. 2015 Mar; 41(2):93-102. PMID: 25514367; PMCID: PMC4336205.
    14. Tsotakos N, Silveyra P, Lin Z, Thomas N, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 01; 308(1):L58-75. PMID: 25326576; PMCID: PMC4281701.
    15. Silveyra P, Chroneos ZC, DiAngelo SL, Thomas NJ, Noutsios GT, Tsotakos N, Howrylak JA, Umstead TM, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study. Exp Lung Res. 2014 Sep; 40(7):354-66. PMID: 25058539; PMCID: PMC4197128.
    16. Silveyra P, DiAngelo SL, Floros J. An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 01; 307(1):L106-19. PMID: 24793167; PMCID: PMC4080286.
    17. Olmeda B, Umstead TM, Silveyra P, Pascual A, López-Barneo J, Phelps DS, Floros J, Pérez-Gil J. Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response. J Proteomics. 2014 Apr 14; 101:179-91. PMID: 24576641; PMCID: PMC4017078.
    18. Phelps DS, Umstead TM, Silveyra P, Hu S, Wang G, Floros J. Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2. J Proteom Genom Res. 2013 Apr 01; 1(2):2-26. PMID: 24729982.
      View in: PubMed
    19. Noutsios GT, Silveyra P, Bhatti F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L722-35. PMID: 23525782; PMCID: PMC3680765.
    20. Yang W, Ni L, Silveyra P, Wang G, Noutsios GT, Singh A, Diangelo SL, Sanusi O, Raval M, Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. J Mol Biochem. 2013 Feb 20; 2(1):40-55. PMID: 23687636.
      View in: PubMed
    21. Silveyra P, Floros J. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. Gene. 2013 Dec 01; 531(2):126-32. PMID: 23069847; PMCID: PMC3570704.
    22. Silveyra P, Floros J. Air pollution and epigenetics: effects on SP-A and innate host defence in the lung. Swiss Med Wkly. 2012 May 02; 142:w13579. PMID: 22553125; PMCID: PMC3601480.
    23. Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection. Exp Lung Res. 2012 May; 38(4):165-72. PMID: 22394250; PMCID: PMC3651915.
    24. Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 2012 Jan; 71(1):107-14. PMID: 22289858; PMCID: PMC3610412.
    25. Silveyra P, Floros J. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci (Landmark Ed). 2012 Jan 01; 17:407-29. PMID: 22201752; PMCID: PMC3635489.
    26. Silveyra P, Raval M, Simmons B, Diangelo S, Wang G, Floros J. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L795-803. PMID: 21840962; PMCID: PMC3290452.
    27. Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L523-34. PMID: 20693318; PMCID: PMC2957414.
    28. Silveyra P, Cataldi NI, Lux-Lantos VA, Libertun C. Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol (Oxf). 2010 Mar; 198(3):355-60. PMID: 19796256.
      View in: PubMed
    29. Silveyra P, Cataldi NI, Lux-Lantos V, Libertun C. Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner. Regul Pept. 2009 Nov 27; 158(1-3):121-6. PMID: 19699765.
      View in: PubMed
    30. García-Tornadú I, Díaz-Torga G, Risso GS, Silveyra P, Cataldi N, Ramirez MC, Low MJ, Libertun C, Becu-Villalobos D. Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. 2009 Aug; 43(4):267-74. PMID: 19570576.
      View in: PubMed
    31. Wang G, Guo X, Silveyra P, Kimball SR, Floros J. Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol. 2009 Apr; 296(4):L635-47. PMID: 19181744; PMCID: PMC2670766.
    32. Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007 Oct; 293(4):E977-85. PMID: 17638707.
      View in: PubMed
    33. Silveyra P, Catalano PN, Lux-Lantos V, Libertun C. Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E820-8. PMID: 17122088.
      View in: PubMed
    34. Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function. Neuroendocrinology. 2005; 82(5-6):294-305. PMID: 16682806.
      View in: PubMed
    35. Bianchi MS, Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression. Neuroendocrinology. 2004; 80(3):129-42. PMID: 15591793.
      View in: PubMed
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