PSU Profiles
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Patricia Silveyra

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive, Hershey, PA 17033
Mailbox: H085
Phone7175316973
Email

 Biography 
 awards and honors
2016 - Community Service Award
2016 - YWCA Tribute to Women of Excellence Award
2015 - 2016Programs to Increase Diversity in Health-Related Research (PRIDE)
2015 - Travel Award, Network of Minority Health Research Investigators
2015 - Travel Award, Gordon Research Conference "Lung Development, Injury and Repair"
2014 - Penn State University Achieving Women Award
2014 - FASEB MARC Professional Skills Training Travel Award
2013 - 2014CROWN Research Grant
2013 - 2014CMN Research Grant
2013 - 2015BIRCWH (Building Interdisciplinary Research Careers on Women's Health) K12
2013 - Carl Storm Underrepresented Minority Fellowship
2012 - 2013SDE/GWIS Adele Lewis Grant Fellowship
2012 - 2013CMN Research Grant
2012 - ATS Minority Trainee Travel Award
2011 - Bond and Bradley Outstanding Postdoctoral Award
2009 - ASCB Postdoctoral Travel Award
2008 - 2009Rotary International Ambassadorial Scholarship

 Overview 
 overview
EDUCATION

1999-2002, BS, MSc
Licenciada en Ciencias Biológicas. University of Buenos Aires, Argentina (Magna cum laude)
U.S. Equivalence: Bachelor of Science degree with a major in Biological Sciences plus a Master of Science degree in Biological Sciences

2003-2007, PhD
Doctora en Ciencias Químicas. University of Buenos Aires, Argentina (Summa cum laude)
U.S. Equivalence: Doctor of Philosophy degree in Biological Chemistry.

2008-2011, Postdoctoral Research Fellow (Pulmonary Molecular Biology)
CHILD Research, Pediatrics, Penn State College of Medicine.

2015 - 2016 Graduate Certificate in Applied Bioinformatics
Pennsylvania State University World Campus


NARRATIVE

I am a research scientist with expertise in several disciplines including endocrinology, molecular biology, and respiratory physiology. My research is primarily focused on the study of lung inflammation associated with air pollution, with particular emphasis in sex differences and the role of sex hormones. My laboratory uses a combination of molecular biology, immunology, and endocrinology approaches to study hormonal regulation of gene expression networks in response to environmental insults. I also lead an interdisciplinary research project focused on the identification of miRNA and proteomic biomarkers for pediatric inflammatory lung disease, including bronchopulmonary dysplasia and pulmonary hypertension.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rivera L, Siddaiah R, Oji-Mmuo C, Silveyra GR, Silveyra P. Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant. Front Pediatr. 2016; 4:33.
    View in: PubMed
  2. Mishra V, DiAngelo SL, Silveyra P. Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation. Biol Sex Differ. 2016; 7:16.
    View in: PubMed
  3. Cabello N, Mishra V, Sinha U, DiAngelo SL, Chroneos ZC, Ekpa NA, Cooper TK, Caruso CR, Silveyra P. Sex differences in the expression of lung inflammatory mediators in response to ozone. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15; 309(10):L1150-63.
    View in: PubMed
  4. Yang L, Carrillo M, Wu YM, DiAngelo SL, Silveyra P, Umstead TM, Halstead ES, Davies ML, Hu S, Floros J, McCormack FX, Christensen ND, Chroneos ZC. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS One. 2015; 10(5):e0126576.
    View in: PubMed
  5. Grageda M, Silveyra P, Thomas NJ, DiAngelo SL, Floros J. DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. Exp Lung Res. 2015 Mar; 41(2):93-102.
    View in: PubMed
  6. Tsotakos N, Silveyra P, Lin Z, Thomas N, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1; 308(1):L58-75.
    View in: PubMed
  7. Silveyra P, Chroneos ZC, DiAngelo SL, Thomas NJ, Noutsios GT, Tsotakos N, Howrylak JA, Umstead TM, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study. Exp Lung Res. 2014 Sep; 40(7):354-66.
    View in: PubMed
  8. Silveyra P, DiAngelo SL, Floros J. An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1; 307(1):L106-19.
    View in: PubMed
  9. Olmeda B, Umstead TM, Silveyra P, Pascual A, López-Barneo J, Phelps DS, Floros J, Pérez-Gil J. Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response. J Proteomics. 2014 Apr 14; 101:179-91.
    View in: PubMed
  10. Phelps DS, Umstead TM, Silveyra P, Hu S, Wang G, Floros J. Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2. J Proteom Genom Res. 2013 Apr 1; 1(2):2-26.
    View in: PubMed
  11. Noutsios GT, Silveyra P, Bhatti F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1; 304(11):L722-35.
    View in: PubMed
  12. Yang W, Ni L, Silveyra P, Wang G, Noutsios GT, Singh A, Diangelo SL, Sanusi O, Raval M, Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. J Mol Biochem. 2013 Feb 20; 2(1):40-55.
    View in: PubMed
  13. Silveyra P, Floros J. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. Gene. 2013 Dec 1; 531(2):126-32.
    View in: PubMed
  14. Silveyra P, Floros J. Air pollution and epigenetics: effects on SP-A and innate host defence in the lung. Swiss Med Wkly. 2012; 142:w13579.
    View in: PubMed
  15. Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection. Exp Lung Res. 2012 May; 38(4):165-72.
    View in: PubMed
  16. Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 2012 Jan; 71(1):107-14.
    View in: PubMed
  17. Silveyra P, Floros J. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci (Landmark Ed). 2012; 17:407-29.
    View in: PubMed
  18. Silveyra P, Raval M, Simmons B, Diangelo S, Wang G, Floros J. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L795-803.
    View in: PubMed
  19. Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L523-34.
    View in: PubMed
  20. Silveyra P, Cataldi NI, Lux-Lantos VA, Libertun C. Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol (Oxf). 2010 Mar; 198(3):355-60.
    View in: PubMed
  21. Silveyra P, Cataldi NI, Lux-Lantos V, Libertun C. Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner. Regul Pept. 2009 Nov 27; 158(1-3):121-6.
    View in: PubMed
  22. García-Tornadú I, Díaz-Torga G, Risso GS, Silveyra P, Cataldi N, Ramirez MC, Low MJ, Libertun C, Becu-Villalobos D. Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. 2009 Aug; 43(4):267-74.
    View in: PubMed
  23. Wang G, Guo X, Silveyra P, Kimball SR, Floros J. Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol. 2009 Apr; 296(4):L635-47.
    View in: PubMed
  24. Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007 Oct; 293(4):E977-85.
    View in: PubMed
  25. Silveyra P, Catalano PN, Lux-Lantos V, Libertun C. Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E820-8.
    View in: PubMed
  26. Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function. Neuroendocrinology. 2005; 82(5-6):294-305.
    View in: PubMed
  27. Bianchi MS, Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression. Neuroendocrinology. 2004; 80(3):129-42.
    View in: PubMed
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