|Institution||College of Medicine|
|Address||500 University Drive, Hershey, PA 17033|
2014||CROWN Research Grant|
2014||CMN Research Grant|
2015||BIRCWH (Building Interdisciplinary Research Careers on Women's Health) K12|
||Carl Storm Underrepresented Minority Fellowship|
2013||SDE/GWIS Adele Lewis Grant Fellowship|
2013||CMN Research Grant|
||Minority Trainee Travel Award|
||Bond and Bradley Outstanding Postdoctoral Award |
||Postdoctoral Travel Award|
1999-2002, BS, MSc
Licenciada en Ciencias Biológicas. University of Buenos Aires, Argentina (Magna cum laude)
U.S. Equivalence: Bachelor of Science degree with a major in Biological Sciences plus a Master of Science degree in Biological Sciences
Doctora en Ciencias Químicas. University of Buenos Aires, Argentina (Summa cum laude)
U.S. Equivalence: Doctor of Philosophy degree in Biological Chemistry.
Thesis Advisor: Dr. Carlos Libertun
Thesis dissertation: “Orexins and Orexin Receptors in the Neuroendocrine Integration of Appetite and Reproduction”
2008-2011, Postdoctoral Research Fellow (Pulmonary Molecular Biology)
CHILD Research, Pediatrics, Penn State College of Medicine.
Postdoctoral Advisor: Dr. Joanna Floros
Project: Regulation of expression of variants of the human SP-A genes
Dr. Silveyra’s research is primarily focused on the study of the role of microRNAs (miRNAs) in the development and resolution of lung disease and injury caused by environmental stressors and acute inflammation, with particular emphasis in gender and inter-individual differences. Her lab is also interested in the identification of miRNA biomarkers for pediatric inflammatory lung disease, including bronchopulmonary dysplasia, cystic fibrosis, and pulmonary hypertension.
There are currently five main areas of investigation in the Silveyra laboratory:
1) Hormonal regulation of pulmonary miRNA expression and function: we use a combination of molecular biology, immunology, and endocrinology approaches to study the role of female sex hormones in the miRNA-mediated control of gene expression in response to environmental insults such as acute exposure to ozone, hyperoxia, and infection.
2) The role of interleukin-6 in acute lung inflammation and injury: our recent work has identified an exacerbated increase in lung interleukin-6 expression in response to acute ozone exposure in female vs. male mice. We are currently interested in elucidating the molecular mechanisms and intracellular signaling pathways activated in this response.
3) Effects of ozone toxicity on the female reproductive axis: work from our laboratory has identified alterations in the circulating levels of hormones of the hypothalamic-pituitary-gonadal axis in females in response to acute ozone exposure. We are currently investigating the effects ozone toxicity on reproductive function using mouse models.
4) Co-morbid effects of ozone and alcohol induced oxidative damage: based on our recent findings, there is an apparent correlation in the level of antioxidants and ozone associated oxidative damage. We are currently developing a model to further explore this hypothesis by introducing alcohol as a secondary oxidative insult. We will study sex differences in the effects of alcohol and ozone exposure on pulmonary microvascular injury, and evaluate the mechanisms of mitochondrial damage induced by ozone and alcohol in lung function of male and female mice.
5) Identification of miRNA biomarkers for pediatric lung disease: We are currently profiling miRNA expression in clinical samples from a cohort of pediatric patients receiving mechanical ventilation in our NICU and PICU. Our goal is to identify miRNA signatures that can serve as non-invasive biomarkers for identifying children at risk for developing inflammatory lung disease (ILD). We are also interested in studying miRNA regulatory networks that will help us elucidate the molecular mechanisms involved in the development and progression of pediatric ILD.
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