PSU Profiles
Last Name

Patricia Silveyra

TitleAssistant Professor
InstitutionCollege of Medicine
Address500 University Drive, Hershey, PA 17033
Mailbox: H085

 awards and honors
2014 - Penn State University Achieving Women Award
2014 - FASEB MARC Professional Skills Training Travel Award
2013 - 2014CROWN Research Grant
2013 - 2014CMN Research Grant
2013 - 2015BIRCWH (Building Interdisciplinary Research Careers on Women's Health) K12
2013 - Carl Storm Underrepresented Minority Fellowship
2012 - 2013SDE/GWIS Adele Lewis Grant Fellowship
2012 - 2013CMN Research Grant
2012 - Minority Trainee Travel Award
2011 - Bond and Bradley Outstanding Postdoctoral Award
2009 - Postdoctoral Travel Award
2008 - 2009Ambassadorial Scholarship


1999-2002, BS, MSc
Licenciada en Ciencias Biológicas. University of Buenos Aires, Argentina (Magna cum laude)
U.S. Equivalence: Bachelor of Science degree with a major in Biological Sciences plus a Master of Science degree in Biological Sciences

2003-2007, PhD
Doctora en Ciencias Químicas. University of Buenos Aires, Argentina (Summa cum laude)
U.S. Equivalence: Doctor of Philosophy degree in Biological Chemistry.
Thesis Advisor: Dr. Carlos Libertun
Thesis dissertation: “Orexins and Orexin Receptors in the Neuroendocrine Integration of Appetite and Reproduction”

2008-2011, Postdoctoral Research Fellow (Pulmonary Molecular Biology)
CHILD Research, Pediatrics, Penn State College of Medicine.
Postdoctoral Advisor: Dr. Joanna Floros
Project: Regulation of expression of variants of the human SP-A genes


Dr. Silveyra’s research is primarily focused on the study of the role of microRNAs (miRNAs) in the development and resolution of lung disease and injury caused by environmental stressors and acute inflammation, with particular emphasis in gender and inter-individual differences. Her lab is also interested in the identification of miRNA biomarkers for pediatric inflammatory lung disease, including bronchopulmonary dysplasia, cystic fibrosis, and pulmonary hypertension.

There are currently five main areas of investigation in the Silveyra laboratory:

1) Hormonal regulation of pulmonary miRNA expression and function: we use a combination of molecular biology, immunology, and endocrinology approaches to study the role of female sex hormones in the miRNA-mediated control of gene expression in response to environmental insults such as acute exposure to ozone, hyperoxia, and infection.

2) The role of interleukin-6 in acute lung inflammation and injury: our recent work has identified an exacerbated increase in lung interleukin-6 expression in response to acute ozone exposure in female vs. male mice. We are currently interested in elucidating the molecular mechanisms and intracellular signaling pathways activated in this response.

3) Effects of ozone toxicity on the female reproductive axis: work from our laboratory has identified alterations in the circulating levels of hormones of the hypothalamic-pituitary-gonadal axis in females in response to acute ozone exposure. We are currently investigating the effects ozone toxicity on reproductive function using mouse models.

4) Co-morbid effects of ozone and alcohol induced oxidative damage: based on our recent findings, there is an apparent correlation in the level of antioxidants and ozone associated oxidative damage. We are currently developing a model to further explore this hypothesis by introducing alcohol as a secondary oxidative insult. We will study sex differences in the effects of alcohol and ozone exposure on pulmonary microvascular injury, and evaluate the mechanisms of mitochondrial damage induced by ozone and alcohol in lung function of male and female mice.

5) Identification of miRNA biomarkers for pediatric lung disease: We are currently profiling miRNA expression in clinical samples from a cohort of pediatric patients receiving mechanical ventilation in our NICU and PICU. Our goal is to identify miRNA signatures that can serve as non-invasive biomarkers for identifying children at risk for developing inflammatory lung disease (ILD). We are also interested in studying miRNA regulatory networks that will help us elucidate the molecular mechanisms involved in the development and progression of pediatric ILD.

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yang L, Carrillo M, Wu YM, DiAngelo SL, Silveyra P, Umstead TM, Halstead ES, Davies ML, Hu S, Floros J, McCormack FX, Christensen ND, Chroneos ZC. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS One. 2015; 10(5):e0126576.
    View in: PubMed
  2. Grageda M, Silveyra P, Thomas NJ, DiAngelo SL, Floros J. DNA methylation profile and expression of surfactant protein A2 gene in lung cancer. Exp Lung Res. 2015 Mar; 41(2):93-102.
    View in: PubMed
  3. Tsotakos N, Silveyra P, Lin Z, Thomas N, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1; 308(1):L58-75.
    View in: PubMed
  4. Silveyra P, Chroneos ZC, DiAngelo SL, Thomas NJ, Noutsios GT, Tsotakos N, Howrylak JA, Umstead TM, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study. Exp Lung Res. 2014 Sep; 40(7):354-66.
    View in: PubMed
  5. Silveyra P, DiAngelo SL, Floros J. An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1; 307(1):L106-19.
    View in: PubMed
  6. Olmeda B, Umstead TM, Silveyra P, Pascual A, López-Barneo J, Phelps DS, Floros J, Pérez-Gil J. Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response. J Proteomics. 2014 Apr 14; 101:179-91.
    View in: PubMed
  7. Phelps DS, Umstead TM, Silveyra P, Hu S, Wang G, Floros J. Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2. J Proteom Genom Res. 2013 Apr 1; 1(2):2-26.
    View in: PubMed
  8. Noutsios GT, Silveyra P, Bhatti F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1; 304(11):L722-35.
    View in: PubMed
  9. Yang W, Ni L, Silveyra P, Wang G, Noutsios GT, Singh A, Diangelo SL, Sanusi O, Raval M, Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. J Mol Biochem. 2013 Feb 20; 2(1):40-55.
    View in: PubMed
  10. Silveyra P, Floros J. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. Gene. 2013 Dec 1; 531(2):126-32.
    View in: PubMed
  11. Silveyra P, Floros J. Air pollution and epigenetics: effects on SP-A and innate host defence in the lung. Swiss Med Wkly. 2012; 142:w13579.
    View in: PubMed
  12. Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection. Exp Lung Res. 2012 May; 38(4):165-72.
    View in: PubMed
  13. Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 2012 Jan; 71(1):107-14.
    View in: PubMed
  14. Silveyra P, Floros J. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci (Landmark Ed). 2012; 17:407-29.
    View in: PubMed
  15. Silveyra P, Raval M, Simmons B, Diangelo S, Wang G, Floros J. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L795-803.
    View in: PubMed
  16. Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L523-34.
    View in: PubMed
  17. Silveyra P, Cataldi NI, Lux-Lantos VA, Libertun C. Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol (Oxf). 2010 Mar; 198(3):355-60.
    View in: PubMed
  18. Silveyra P, Cataldi NI, Lux-Lantos V, Libertun C. Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner. Regul Pept. 2009 Nov 27; 158(1-3):121-6.
    View in: PubMed
  19. García-Tornadú I, Díaz-Torga G, Risso GS, Silveyra P, Cataldi N, Ramirez MC, Low MJ, Libertun C, Becu-Villalobos D. Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. 2009 Aug; 43(4):267-74.
    View in: PubMed
  20. Wang G, Guo X, Silveyra P, Kimball SR, Floros J. Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol. 2009 Apr; 296(4):L635-47.
    View in: PubMed
  21. Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007 Oct; 293(4):E977-85.
    View in: PubMed
  22. Silveyra P, Catalano PN, Lux-Lantos V, Libertun C. Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E820-8.
    View in: PubMed
  23. Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function. Neuroendocrinology. 2005; 82(5-6):294-305.
    View in: PubMed
  24. Bianchi MS, Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression. Neuroendocrinology. 2004; 80(3):129-42.
    View in: PubMed
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