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W. Brian Reeves

TitleProfessor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive, Hershey, PA 17033
Mailbox: H040
Phone7175318156
Fax7175316776
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    Collapse Overview 
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    Dr. Reeves research is focused on elucidating the mechanisms of both acute and chronic kidney injury. His laboratory research uses mouse models of kidney injury, such as ischemia, drug toxicity, diabetes and sepsis, and a wide variety of genetically manipulated mice and pharmacologic and immunologic agents to define pathways which are important mediators of kidney injury or repair. Most of his recent work has centered on the innate immune system in acute kidney injury. In work supported by the NIH, his lab has shown that tumor necrosis factor, toll-like receptor 4, dendritic cells and IL-10 modulate, either in a positive or negative fashion, drug-induced and ischemic injury. In collaboration with Dr. Alaa Awad, his lab is now exploring the role of these pathways in chroinc diabetic kidney disease.



    Dr. Reeves also participates in translational research, also focused on acute kidney injury. With colleagues in the Department of Public Health Sciences, he is a member of the ASSESS-AKI study, a multicenter NIH-funded study of patients after acute kidney injury. With Dr. Jay Raman in the Division of Urology he is determining the value of urine biomarkers in detecting kidney injury in patients undergoing partial nephrectomy or shock wave lithotripsy. He also collaborates with engineers in developing novel methods of determining kidney function and kidney injury.



    Dr. Reeves is co-director of the Novel Methodologies section of the Penn State Clinical and Translational Research Institute. He also directs an NIH-funded program which provides summer research experiences to undergraduate students from under-represented minorities.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H, Reeves WB. Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia/reperfusion-induced acute kidney injury. Kidney Int. 2018 Feb; 93(2):365-374. PMID: 29061334.
      View in: PubMed
    2. Tadagavadi R, Reeves WB. Neutrophils in cisplatin AKI-mediator or marker? Kidney Int. 2017 Jul; 92(1):11-13. PMID: 28646989.
      View in: PubMed
    3. Raup-Konsavage WM, Gao T, Cooper TK, Morris SM, Reeves WB, Awad AS. Arginase-2 mediates renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F522-F534. PMID: 28515179.
      View in: PubMed
    4. Wyatt CM, Reeves WB. The sweetest thing: blocking fructose metabolism to prevent acute kidney injury? Kidney Int. 2017 05; 91(5):998-1000. PMID: 28407885.
      View in: PubMed
    5. Singh M, Truong J, Reeves WB, Hahm JI. Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement. Sensors (Basel). 2017 Feb 22; 17(2). PMID: 28241443.
      View in: PubMed
    6. You H, Gao T, Raup-Konsavage WM, Cooper TK, Bronson SK, Reeves WB, Awad AS. Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice. Kidney Int. 2017 Mar; 91(3):671-682. PMID: 27914709.
      View in: PubMed
    7. Wyatt CM, Coates PT, Reeves WB. Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans? Kidney Int. 2016 07; 90(1):10-3. PMID: 27312438.
      View in: PubMed
    8. Singh M, Alabanza A, Gonzalez LE, Wang W, Reeves WB, Hahm JI. Ultratrace level determination and quantitative analysis of kidney injury biomarkers in patient samples attained by zinc oxide nanorods. Nanoscale. 2016 Feb 28; 8(8):4613-22. PMID: 26846189; PMCID: PMC4760885.
    9. Gaddes DE, Demirel MC, Reeves WB, Tadigadapa S. Remote calorimetric detection of urea via flow injection analysis. Analyst. 2015 Dec 07; 140(23):8033-40. PMID: 26479269.
      View in: PubMed
    10. Tadagavadi RK, Gao G, Wang WW, Gonzalez MR, Reeves WB. Dendritic Cell Protection from Cisplatin Nephrotoxicity Is Independent of Neutrophils. Toxins (Basel). 2015 Aug 19; 7(8):3245-56. PMID: 26295408; PMCID: PMC4549748.
    11. Tadagavadi RK, Reeves WB. NODding off in acute kidney injury with progranulin? Kidney Int. 2015 May; 87(5):873-5. PMID: 25951064; PMCID: PMC4425217.
    12. Gao G, Wang W, Tadagavadi RK, Briley NE, Love MI, Miller BA, Reeves WB. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. J Clin Invest. 2014 Nov; 124(11):4989-5001. PMID: 25295536; PMCID: PMC4347231.
    13. Lin L, Jin Y, Mars WM, Reeves WB, Hu K. Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. Am J Pathol. 2014 Oct; 184(10):2757-67. PMID: 25131752; PMCID: PMC4715214.
    14. Awad AS, Gao T, Gvritishvili A, You H, Liu Y, Cooper TK, Reeves WB, Tombran-Tink J. Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury. Am J Physiol Renal Physiol. 2013 Sep 15; 305(6):F891-900. PMID: 23884140; PMCID: PMC3761290.
    15. Gao G, Zhang B, Ramesh G, Betterly D, Tadagavadi RK, Wang W, Reeves WB. TNF-a mediates increased susceptibility to ischemic AKI in diabetes. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F515-21. PMID: 23283990; PMCID: PMC3602710.
    16. Abdel-Rahman EM, Alhamad T, Reeves WB, Awad AS. Management of Diabetic Nephropathy in the Elderly: Special Considerations. J Nephrol Ther. 2012 Oct; 2(5). PMID: 24010011.
      View in: PubMed
    17. Reeves WB, Rawal BB, Abdel-Rahman EM, Awad AS. Therapeutic Modalities in Diabetic Nephropathy: Future Approaches. Open J Nephrol. 2012 Jun 25; 2(2):5-18. PMID: 23293752.
      View in: PubMed
    18. Abdel-Rahman EM, Saadulla L, Reeves WB, Awad AS. Therapeutic modalities in diabetic nephropathy: standard and emerging approaches. J Gen Intern Med. 2012 Apr; 27(4):458-68. PMID: 22005942; PMCID: PMC3304033.
    19. Ongeri EM, Anyanwu O, Reeves WB, Bond JS. Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion. Am J Physiol Renal Physiol. 2011 Oct; 301(4):F871-82. PMID: 21795642; PMCID: PMC3191804.
    20. Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of Cisplatin nephrotoxicity. Toxins (Basel). 2010 11; 2(11):2490-518. PMID: 22069563; PMCID: PMC3153174.
    21. Tadagavadi RK, Reeves WB. Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cells. J Immunol. 2010 Oct 15; 185(8):4904-11. PMID: 20844196; PMCID: PMC3169908.
    22. Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu KD, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB. The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol. 2010 Aug 27; 11:22. PMID: 20799966; PMCID: PMC2944247.
    23. Lin L, Bu G, Mars WM, Reeves WB, Tanaka S, Hu K. tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway. Am J Pathol. 2010 Oct; 177(4):1687-96. PMID: 20724593; PMCID: PMC2947266.
    24. Saadulla L, Reeves WB, Irey B, Ghahramani N. Impact of computerized order entry and pre-mixed dialysis solutions for continuous veno-venous hemodiafiltration on selection of therapy for acute renal failure. J Med Syst. 2012 Feb; 36(1):223-31. PMID: 20703723.
      View in: PubMed
    25. Wang H, Malvadkar N, Koytek S, Bylander J, Reeves WB, Demirel MC. Quantitative analysis of creatinine in urine by metalized nanostructured parylene. J Biomed Opt. 2010 Mar-Apr; 15(2):027004. PMID: 20459278.
      View in: PubMed
    26. Tadagavadi RK, Reeves WB. Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol. 2010 Jan; 21(1):53-63. PMID: 19875815; PMCID: PMC2799272.
    27. Wang W, Reeves WB, Pays L, Mehlen P, Ramesh G. Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol. 2009 Sep; 175(3):1010-8. PMID: 19700747; PMCID: PMC2731120.
    28. Wang W, Reeves WB, Ramesh G. Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F723-9. PMID: 19211685.
      View in: PubMed
    29. Yura RE, Bradley SG, Ramesh G, Reeves WB, Bond JS. Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge. Am J Physiol Renal Physiol. 2009 Jan; 296(1):F135-44. PMID: 18971209; PMCID: PMC2636909.
    30. Ghahramani N, Reeves WB, Hollenbeak C. Association between increased body mass index, calcineurin inhibitor use, and renal graft survival. Exp Clin Transplant. 2008 Sep; 6(3):199-202. PMID: 18954297.
      View in: PubMed
    31. Adalsteinsson V, Parajuli O, Kepics S, Gupta A, Reeves WB, Hahm JI. Ultrasensitive detection of cytokines enabled by nanoscale ZnO arrays. Anal Chem. 2008 Sep 01; 80(17):6594-601. PMID: 18681455.
      View in: PubMed
    32. Zhang B, Ramesh G, Uematsu S, Akira S, Reeves WB. TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity. J Am Soc Nephrol. 2008 May; 19(5):923-32. PMID: 18256356; PMCID: PMC2386719.
    33. Reeves WB, Kwon O, Ramesh G. Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F731-8. PMID: 18234954.
      View in: PubMed
    34. Wang W, Reeves WB, Ramesh G. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F739-47. PMID: 18216145; PMCID: PMC3713074.
    35. Bylander J, Li Q, Ramesh G, Zhang B, Reeves WB, Bond JS. Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F480-90. PMID: 18172000.
      View in: PubMed
    36. Ramesh G, Zhang B, Uematsu S, Akira S, Reeves WB. Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Am J Physiol Renal Physiol. 2007 Jul; 293(1):F325-32. PMID: 17494092.
      View in: PubMed
    37. Zhang B, Ramesh G, Norbury CC, Reeves WB. Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells. Kidney Int. 2007 Jul; 72(1):37-44. PMID: 17396112.
      View in: PubMed
    38. Ramesh G, Kimball SR, Jefferson LS, Reeves WB. Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F812-9. PMID: 17032936.
      View in: PubMed
    39. Ramesh G, Reeves WB. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am J Physiol Renal Physiol. 2005 Jul; 289(1):F166-74. PMID: 15701814.
      View in: PubMed
    40. Ramesh G, Reeves WB. Inflammatory cytokines in acute renal failure. Kidney Int Suppl. 2004 Oct; (91):S56-61. PMID: 15461705.
      View in: PubMed
    41. Ramesh G, Reeves WB. Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha. Kidney Int. 2004 Feb; 65(2):490-9. PMID: 14717919.
      View in: PubMed
    42. Ramesh G, Reeves WB. TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. Am J Physiol Renal Physiol. 2003 Oct; 285(4):F610-8. PMID: 12865254.
      View in: PubMed
    43. Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest. 2002 Sep; 110(6):835-42. PMID: 12235115; PMCID: PMC151130.
    44. Reeves WB, Winters CJ, Andreoli TE. Chloride channels in the loop of Henle. Annu Rev Physiol. 2001; 63:631-45. PMID: 11181970.
      View in: PubMed
    45. Winters CJ, Zimniak L, Mikhailova MV, Reeves WB, Andreoli TE. Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels. J Membr Biol. 2000 Oct 01; 177(3):221-30. PMID: 11014860.
      View in: PubMed
    46. Reeves WB, Andreoli TE. Transforming growth factor beta contributes to progressive diabetic nephropathy. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7667-9. PMID: 10884396; PMCID: PMC33997.
    47. Meng X, Reeves WB. Effects of chloride channel inhibitors on H(2)O(2)-induced renal epithelial cell injury. Am J Physiol Renal Physiol. 2000 Jan; 278(1):F83-90. PMID: 10644658.
      View in: PubMed
    48. Filipovic DM, Meng X, Reeves WB. Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells. Am J Physiol. 1999 Sep; 277(3 Pt 2):F428-36. PMID: 10484526.
      View in: PubMed
    49. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral TAL membranes. XIV. Kinetic properties of a basolateral MTAL Cl- channel. Kidney Int. 1999 Apr; 55(4):1444-9. PMID: 10201009.
      View in: PubMed
    50. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral TAL membranes: XIII. Heterogeneity between basolateral MTAL and CTAL Cl- channels. Kidney Int. 1999 Feb; 55(2):593-601. PMID: 9987083.
      View in: PubMed
    51. Sadikot R, Shaver MJ, Reeves WB. Ehrlichia chaffeensis in a renal transplant recipient. Am J Nephrol. 1999; 19(6):674-6. PMID: 10592362.
      View in: PubMed
    52. Filipovic DM, Adebanjo OA, Zaidi M, Reeves WB. Functional and molecular evidence for P2X receptors in LLC-PK1 cells. Am J Physiol. 1998 Jun; 274(6 Pt 2):F1070-7. PMID: 9841498.
      View in: PubMed
    53. Reeves WB, Winters CJ, Zimniak L, Andreoli TE. Properties and regulation of medullary thick limb basolateral Cl- channels. Kidney Int Suppl. 1998 Apr; 65:S24-8. PMID: 9551428.
      View in: PubMed
    54. Winters CJ, Zimniak L, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary membranes. XII. Anti-rbClC-Ka antibody blocks MTAL Cl- channels. Am J Physiol. 1997 Dec; 273(6 Pt 2):F1030-8. PMID: 9435693.
      View in: PubMed
    55. Reeves WB, Winters CJ, Zimniak L, Andreoli TE. Medullary thick limb basolateral Cl- channels. Wien Klin Wochenschr. 1997 Jun 27; 109(12-13):465-70. PMID: 9261987.
      View in: PubMed
    56. Reeves WB. Effects of chloride channel blockers on hypoxic injury in rat proximal tubules. Kidney Int. 1997 May; 51(5):1529-34. PMID: 9150469.
      View in: PubMed
    57. Filipovic DM, Reeves WB. Hydrogen peroxide activates glibenclamide-sensitive K+ channels in LLC-PK1 cells. Am J Physiol. 1997 Feb; 272(2 Pt 1):C737-43. PMID: 9124318.
      View in: PubMed
    58. Reeves WB, Winters CJ, Zimniak L, Andreoli TE. Medullary thick limbs: renal concentrating segments. Kidney Int Suppl. 1996 Dec; 57:S154-64. PMID: 8941937.
      View in: PubMed
    59. Reeves WB, Andreoli TE. Chloride channels in renal epithelial cells. Curr Opin Nephrol Hypertens. 1996 Sep; 5(5):406-10. PMID: 8937808.
      View in: PubMed
    60. Zimniak L, Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary vesicles XI. rbClC-Ka cDNA encodes basolateral MTAL Cl- channels. Am J Physiol. 1996 Jun; 270(6 Pt 2):F1066-72. PMID: 8764326.
      View in: PubMed
    61. Kyossev Z, Walker PD, Reeves WB. Immunolocalization of NAD-dependent 11 beta-hydroxysteroid dehydrogenase in human kidney and colon. Kidney Int. 1996 Jan; 49(1):271-81. PMID: 8770980.
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    62. Zimniak L, Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary vesicles. X. Cloning of a Cl- channel from rabbit outer medulla. Kidney Int. 1995 Dec; 48(6):1828-36. PMID: 8587242.
      View in: PubMed
    63. Reeves WB, Winters CJ, Filipovic DM, Andreoli TE. Cl- channels in basolateral renal medullary vesicles. IX. Channels from mouse MTAL cell patches and medullary vesicles. Am J Physiol. 1995 Nov; 269(5 Pt 2):F621-7. PMID: 7503227.
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    64. Reeves WB. NAD-dependent 11 beta-hydroxysteroid dehydrogenase in cultured human colonic epithelial cells. Am J Physiol. 1995 Jun; 268(6 Pt 1):C1467-73. PMID: 7611367.
      View in: PubMed
    65. Reeves WB, Shah SV. Activation of potassium channels contributes to hypoxic injury in proximal tubules. J Clin Invest. 1994 Dec; 94(6):2289-94. PMID: 7989584; PMCID: PMC330056.
    66. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary vesicles. VIII. Partial purification and functional reconstitution of basolateral mTAL Cl- channels. Kidney Int. 1994 Mar; 45(3):803-10. PMID: 8196282.
      View in: PubMed
    67. Reeves WB, Gurich RW. Calcium-dependent chloride channels in endosomes from rabbit kidney cortex. Am J Physiol. 1994 Mar; 266(3 Pt 1):C741-50. PMID: 8166237.
      View in: PubMed
    68. Reeves WB. Conductive properties of papillary surface epithelium. Am J Physiol. 1994 Feb; 266(2 Pt 2):F259-65. PMID: 8141326.
      View in: PubMed
    69. Reeves WB, Winters CJ, Zimniak L, Andreoli TE. Epithelial chloride channels, from kidney to airway cells. Adv Nephrol Necker Hosp. 1994; 23:177-90. PMID: 8154351.
      View in: PubMed
    70. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary membranes: VII. Characterization of the intracellular anion binding sites. J Membr Biol. 1993 Aug; 135(2):145-52. PMID: 8411136.
      View in: PubMed
    71. Zimniak L, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary membranes, VI. Cl- conductance expression in Xenopus oocytes. Am J Physiol. 1992 Nov; 263(5 Pt 2):F979-84. PMID: 1332508.
      View in: PubMed
    72. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary vesicles: V. Comparison of basolateral mTALH Cl- channels with apical Cl- channels from jejunum and trachea. J Membr Biol. 1992 May; 128(1):27-39. PMID: 1380090.
      View in: PubMed
    73. Reeves WB, Andreoli TE. Renal epithelial chloride channels. Annu Rev Physiol. 1992; 54:29-50. PMID: 1314040.
      View in: PubMed
    74. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary membrane vesicles: IV. Analogous channel activation by Cl- or cAMP-dependent protein kinase. J Membr Biol. 1991 May; 122(1):89-95. PMID: 1714961.
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    75. Winters CJ, Reeves WB, Andreoli TE. A survey of transport properties of the thick ascending limb. Semin Nephrol. 1991 Mar; 11(2):236-47. PMID: 2034927.
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    76. Winters CJ, Reeves WB, Andreoli TE. Cl- channels in basolateral renal medullary membranes: III. Determinants of single-channel activity. J Membr Biol. 1990 Dec; 118(3):269-78. PMID: 1706434.
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    77. Bayliss JM, Reeves WB, Andreoli TE. Cl- transport in basolateral renal medullary vesicles: I. Cl- transport in intact vesicles. J Membr Biol. 1990 Jan; 113(1):49-56. PMID: 2304071.
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    78. Reeves WB, Andreoli TE. Modulation of in vitro diluting power of the medullary thick ascending limb. Contrib Nephrol. 1990; 77:115-22. PMID: 2344741.
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    79. Reeves WB, Andreoli TE. Cl- transport in basolateral renal medullary vesicles: II. Cl- channels in planar lipid bilayers. J Membr Biol. 1990 Jan; 113(1):57-65. PMID: 1689386.
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    80. Molony DA, Reeves WB, Andreoli TE. Na+:K+:2Cl- cotransport and the thick ascending limb. Kidney Int. 1989 Sep; 36(3):418-26. PMID: 2687569.
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    81. Reeves WB, McDonald GA, Mehta P, Andreoli TE. Activation of K+ channels in renal medullary vesicles by cAMP-dependent protein kinase. J Membr Biol. 1989 Jul; 109(1):65-72. PMID: 2769736.
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    82. Reeves WB, Molony DA, Andreoli TE. Diluting power of thick limbs of Henle. III. Modulation of in vitro diluting power. Am J Physiol. 1988 Dec; 255(6 Pt 2):F1145-54. PMID: 3202179.
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    83. Reeves WB, Dudley MA, Mehta P, Andreoli TE. Diluting power of thick limbs of Henle. II. Bumetanide-sensitive 22Na+ influx in medullary vesicles. Am J Physiol. 1988 Dec; 255(6 Pt 2):F1138-44. PMID: 2849317.
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    84. Hebert SC, Reeves WB, Molony DA, Andreoli TE. The medullary thick limb: function and modulation of the single-effect multiplier. Kidney Int. 1987 Feb; 31(2):580-9. PMID: 3550227.
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    85. Molony DA, Reeves WB, Andreoli TE. Some transport characteristics of mammalian renal diluting segments. Miner Electrolyte Metab. 1987; 13(6):442-50. PMID: 3320725.
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    86. Molony DA, Reeves WB, Hebert SC, Andreoli TE. ADH increases apical Na+, K+, 2Cl- entry in mouse medullary thick ascending limbs of Henle. Am J Physiol. 1987 Jan; 252(1 Pt 2):F177-87. PMID: 3812700.
      View in: PubMed
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