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Ross Shiman

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentBiochemistry and Molecular Biology
Address500 University Drive, Hershey, PA 17033
Mailbox: H171
Phone7175318588
Fax7175317072

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor Emeritus of Biochemistry and Molecular Biology



 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lambert D, Leipply D, Shiman R, Draper DE. The influence of monovalent cation size on the stability of RNA tertiary structures. J Mol Biol. 2009 Jul 24; 390(4):791-804.
    View in: PubMed
  2. Misra VK, Shiman R, Draper DE. A thermodynamic framework for the magnesium-dependent folding of RNA. Biopolymers. 2003 May; 69(1):118-36.
    View in: PubMed
  3. Opresko PL, Shiman R, Eckert KA. Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis. Biochemistry. 2000 Sep 19; 39(37):11399-407.
    View in: PubMed
  4. Shiman R, Draper DE. Stabilization of RNA tertiary structure by monovalent cations. J Mol Biol. 2000 Sep 8; 302(1):79-91.
    View in: PubMed
  5. Shiman R, Gray DW. Formation and fate of tyrosine. Intracellular partitioning of newly synthesized tyrosine in mammalian liver. J Biol Chem. 1998 Dec 25; 273(52):34760-9.
    View in: PubMed
  6. Mitnaul LJ, Shiman R. Coordinate regulation of tetrahydrobiopterin turnover and phenylalanine hydroxylase activity in rat liver cells. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):885-9.
    View in: PubMed
  7. Shiman R, Xia T, Hill MA, Gray DW. Regulation of rat liver phenylalanine hydroxylase. II. Substrate binding and the role of activation in the control of enzymatic activity. J Biol Chem. 1994 Oct 7; 269(40):24647-56.
    View in: PubMed
  8. Shiman R, Gray DW, Hill MA. Regulation of rat liver phenylalanine hydroxylase. I. Kinetic properties of the enzyme's iron and enzyme reduction site. J Biol Chem. 1994 Oct 7; 269(40):24637-46.
    View in: PubMed
  9. Xia T, Gray DW, Shiman R. Regulation of rat liver phenylalanine hydroxylase. III. Control of catalysis by (6R)-tetrahydrobiopterin and phenylalanine. J Biol Chem. 1994 Oct 7; 269(40):24657-65.
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  10. Appelbaum PC, Spangler SK, Pankuch GA, Philippon A, Jacobs MR, Shiman R, Goldstein EJ, Citron DM. Characterization of a beta-lactamase from Clostridium clostridioforme. J Antimicrob Chemother. 1994 Jan; 33(1):33-40.
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  11. Appelbaum PC, Spangler SK, Shiman R, Jacobs MR. Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin. Antimicrob Agents Chemother. 1992 May; 36(5):1140-3.
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  12. Shiman R, Jones SH, Gray DW. Mechanism of phenylalanine regulation of phenylalanine hydroxylase. J Biol Chem. 1990 Jul 15; 265(20):11633-42.
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  13. Hill MA, Marota JJ, Shiman R. Reaction of rat liver phenylalanine hydroxylase with fatty acid hydroperoxides. Characterization and mechanism. J Biol Chem. 1988 Apr 25; 263(12):5646-55.
    View in: PubMed
  14. Hutson SM, Stinson-Fisher C, Shiman R, Jefferson LS. Regulation of albumin synthesis by hormones and amino acids in primary cultures of rat hepatocytes. Am J Physiol. 1987 Mar; 252(3 Pt 1):E291-8.
    View in: PubMed
  15. Shiman R. Purification and assay of rat liver phenylalanine 4-monooxygenase. Methods Enzymol. 1987; 142:17-27.
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  16. Flaim KE, Hutson SM, Lloyd CE, Taylor JM, Shiman R, Jefferson LS. Direct effect of insulin on albumin gene expression in primary cultures of rat hepatocytes. Am J Physiol. 1985 Nov; 249(5 Pt 1):E447-53.
    View in: PubMed
  17. Marota JJ, Shiman R. Stoichiometric reduction of phenylalanine hydroxylase by its cofactor: a requirement for enzymatic activity. Biochemistry. 1984 Mar 13; 23(6):1303-11.
    View in: PubMed
  18. Shiman R, Mortimore GE, Schworer CM, Gray DW. Regulation of phenylalanine hydroxylase activity by phenylalanine in vivo, in vitro, and in perfused rat liver. J Biol Chem. 1982 Oct 10; 257(19):11213-6.
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  19. Lazarus RA, Wallick DE, Dietrich RF, Gottschall DW, Benkovic SJ, Gaffney BJ, Shiman R. The mechanism of phenylalanine hydroxylase. Fed Proc. 1982 Jul; 41(9):2605-7.
    View in: PubMed
  20. Shiman R, Jefferson LS. Iron-dependent regulation of rat liver phenylalanine hydroxylase activity in vivo, in vitro, and in perfused liver. J Biol Chem. 1982 Jan 25; 257(2):839-44.
    View in: PubMed
  21. Gottschall DW, Dietrich RF, Benkovic SJ, Shiman R. Phenylalanine hydroxylase. Correlation of the iron content with activity and the preparation and reconstitution of the apoenzyme. J Biol Chem. 1982 Jan 25; 257(2):845-9.
    View in: PubMed
  22. Baker RE, Jefferson LS, Shiman R. Immunocytochemical identification of phenylalanine hydroxylase and albumin in cultured hepatoma cells and isolated rat hepatocytes. J Cell Biol. 1981 Jul; 90(1):145-52.
    View in: PubMed
  23. Shiman R. Relationship between the substrate activation site and catalytic site of phenylalanine hydroxylase. J Biol Chem. 1980 Nov 10; 255(21):10029-32.
    View in: PubMed
  24. Shiman R, Gray DW. Substrate activation of phenylalanine hydroxylase. A kinetic characterization. J Biol Chem. 1980 May 25; 255(10):4793-800.
    View in: PubMed
  25. Shiman R, Gray DW, Pater A. A simple purification of phenylalanine hydroxylase by substrate-induced hydrophobic chromatography. J Biol Chem. 1979 Nov 25; 254(22):11300-6.
    View in: PubMed
  26. Baker RE, Shiman R. Measurement of phenylalanine hydroxylase turnover in cultured hepatoma cells. J Biol Chem. 1979 Oct 10; 254(19):9633-9.
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  27. Breakefield XO, Castiglione CM, Halaban R, Pawelek J, Shiman R. Phenylalanine hydroxylase in melanoma cells. J Cell Physiol. 1978 Mar; 94(3):307-14.
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  28. Miller MR, McClure D, Shiman R. Mechanism of inactivation of phenylalanine hydroxylase by p-chlorophenylalanine in hepatome cells in culture. Two possible models. J Biol Chem. 1976 Jun 25; 251(12):3677-84.
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  29. Miller MR, Shiman R. Reversible inactivation of phenylalanine hydroxylase by catecholamines in cultured hepatoma cells. J Biol Chem. 1976 Jun 25; 251(12):3671-6.
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  30. McClure D, Miller MR, Shiman R. Cell density dependent regulation of phenylalanine hydroxylase activity in hepatoma cells. Evidence for both an active and inactive enzyme form. Exp Cell Res. 1976 Mar 15; 98(2):223-36.
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  31. Miller MR, Shiman R. Hydrocortisone induction of phenylalanine hydroxylase isozymes in cultured hepatoma cells. Biochem Biophys Res Commun. 1976 Feb 9; 68(3):740-5.
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  32. Koontz WA, Shiman R. Beef kidney 3-hydroxyanthranilic acid oxygenase. Purification, characterization, and analysis of the assay. J Biol Chem. 1976 Jan 25; 251(2):368-77.
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  33. Miller MR, McClure D, Shiman R. p-Chlorphenylalanine effect on phenylalanine hydroxylase in hepatoma cells in culture. J Biol Chem. 1975 Feb 10; 250(3):1132-40.
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  34. McClure D, Miller M, Shiman R. Correlation of phenylalanine hydroxylase activity with cell density in cultured hepatoma cells. Exp Cell Res. 1975 Jan; 90(1):31-9.
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  35. Rosenthal MH, Kreider JW, Shiman R. Quantitative assay of melanin in melanoma cells in culture and in tumors. Anal Biochem. 1973 Nov; 56(1):91-9.
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  36. Ogino T, Shiman R, Rapp F. Deoxythymidine kinase from rabbit kidney cells infected with herpes simplex virus types 1 and 2. Intervirology. 1973; 1(2):80-95.
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  37. Shiman R, Akino M, Kaufman S. Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla. J Biol Chem. 1971 Mar 10; 246(5):1330-40.
    View in: PubMed
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