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Anthony Kales

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentPsychiatry
Address500 University Drive, Hershey, PA 17033
Mailbox: MB073
Phone7175318515

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab. 2005 Aug; 90(8):4510-5.
    View in: PubMed
  2. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Follett H, Kales A, Chrousos GP. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab. 2004 May; 89(5):2119-26.
    View in: PubMed
  3. Papanicolaou DA, Amsterdam JD, Levine S, McCann SM, Moore RC, Newbrand CH, Allen G, Nisenbaum R, Pfaff DW, Tsokos GC, Vgontzas AN, Kales A. Neuroendocrine aspects of chronic fatigue syndrome. Neuroimmunomodulation. 2004; 11(2):65-74.
    View in: PubMed
  4. Vgontzas AN, Zoumakis M, Bixler EO, Lin HM, Prolo P, Vela-Bueno A, Kales A, Chrousos GP. Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab. 2003 May; 88(5):2087-95.
    View in: PubMed
  5. Bixler EO, Vgontzas AN, Lin HM, Vela-Bueno A, Kales A. Insomnia in central Pennsylvania. J Psychosom Res. 2002 Jul; 53(1):589-92.
    View in: PubMed
  6. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P, Lin HM, Vela-Bueno A, Kales A, Chrousos GP. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 2002 Jul; 51(7):887-92.
    View in: PubMed
  7. Vgontzas AN, Bixler EO, Lin HM, Prolo P, Mastorakos G, Vela-Bueno A, Kales A, Chrousos GP. Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab. 2001 Aug; 86(8):3787-94.
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  8. Vgontzas AN, Bixler EO, Wittman AM, Zachman K, Lin HM, Vela-Bueno A, Kales A, Chrousos GP. Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications. J Clin Endocrinol Metab. 2001 Apr; 86(4):1489-95.
    View in: PubMed
  9. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, Kales A. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):608-13.
    View in: PubMed
  10. Vgontzas AN, Legro RS, Bixler EO, Grayev A, Kales A, Chrousos GP. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab. 2001 Feb; 86(2):517-20.
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  11. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Leiby BE, Vela-Bueno A, Kales A. Association of hypertension and sleep-disordered breathing. Arch Intern Med. 2000 Aug 14-28; 160(15):2289-95.
    View in: PubMed
  12. Vgontzas AN, Bixler EO, Kales A, Criley C, Vela-Bueno A. Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications. Psychosom Med. 2000 Mar-Apr; 62(2):220-6.
    View in: PubMed
  13. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, Kales A, Chrousos GP. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab. 2000 Mar; 85(3):1151-8.
    View in: PubMed
  14. Vgontzas AN, Papanicolaou DA, Bixler EO, Lotsikas A, Zachman K, Kales A, Prolo P, Wong ML, Licinio J, Gold PW, Hermida RC, Mastorakos G, Chrousos GP. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab. 1999 Aug; 84(8):2603-7.
    View in: PubMed
  15. Vgontzas AN, Mastorakos G, Bixler EO, Kales A, Gold PW, Chrousos GP. Sleep deprivation effects on the activity of the hypothalamic-pituitary-adrenal and growth axes: potential clinical implications. Clin Endocrinol (Oxf). 1999 Aug; 51(2):205-15.
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  16. Vgontzas AN, Kales A. Sleep and its disorders. Annu Rev Med. 1999; 50:387-400.
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  17. Vgontzas AN, Tsigos C, Bixler EO, Stratakis CA, Zachman K, Kales A, Vela-Bueno A, Chrousos GP. Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res. 1998 Jul; 45(1):21-31.
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  18. Vgontzas AN, Bixler EO, Tan TL, Kantner D, Martin LF, Kales A. Obesity without sleep apnea is associated with daytime sleepiness. Arch Intern Med. 1998 Jun 22; 158(12):1333-7.
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  19. Bixler EO, Vgontzas AN, Ten Have T, Tyson K, Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med. 1998 Jan; 157(1):144-8.
    View in: PubMed
  20. Vgontzas AN, Bixler EO, Papanicolaou DA, Kales A, Stratakis CA, Vela-Bueno A, Gold PW, Chrousos GP. Rapid eye movement sleep correlates with the overall activities of the hypothalamic-pituitary-adrenal axis and sympathetic system in healthy humans. J Clin Endocrinol Metab. 1997 Oct; 82(10):3278-80.
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  21. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 1997 May; 82(5):1313-6.
    View in: PubMed
  22. Vgontzas AN, Bixler EO, Kales A, Centurione A, Rogan PK, Mascari M, Vela-Bueno A. Daytime sleepiness and REM abnormalities in Prader-Willi syndrome: evidence of generalized hypoarousal. Int J Neurosci. 1996 Nov; 87(3-4):127-39.
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  23. Vgontzas AN, Kales A, Seip J, Mascari MJ, Bixler EO, Myers DC, Vela-Bueno AV, Rogan PK. Relationship of sleep abnormalities to patient genotypes in Prader-Willi syndrome. Am J Med Genet. 1996 Sep 20; 67(5):478-82.
    View in: PubMed
  24. Vgontzas AN, Sollenberger SE, Kales A, Bixler EO, Vela-Bueno A. Narcolepsy-cataplexy and loss of sphincter control. Postgrad Med J. 1996 Aug; 72(850):493-4.
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  25. Vgontzas AN, Kales A, Bixler EO. Benzodiazepine side effects: role of pharmacokinetics and pharmacodynamics. Pharmacology. 1995 Oct; 51(4):205-23.
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  26. Vgontzas AN, Bixler EO, Kales A, Vela-Bueno A. Prader-Willi syndrome: effects of weight loss on sleep-disordered breathing, daytime sleepiness and REM sleep disturbance. Acta Paediatr. 1995 Jul; 84(7):813-4.
    View in: PubMed
  27. Vgontzas AN, Kales A, Bixler EO, Manfredi RL, Vela-Bueno A. Usefulness of polysomnographic studies in the differential diagnosis of insomnia. Int J Neurosci. 1995 May; 82(1-2):47-60.
    View in: PubMed
  28. Vgontzas AN, Friedman TC, Chrousos GP, Bixler EO, Vela-Bueno A, Kales A. Delta sleep-inducing peptide in normal humans and in patients with sleep apnea and narcolepsy. Peptides. 1995; 16(6):1153-6.
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  29. Vgontzas AN, Tan TL, Bixler EO, Martin LF, Shubert D, Kales A. Sleep apnea and sleep disruption in obese patients. Arch Intern Med. 1994 Aug 8; 154(15):1705-11.
    View in: PubMed
  30. Vgontzas AN, Bixler EO, Kales A, Manfredi RL, Tyson K. Validity and clinical utility of sleep laboratory criteria for insomnia. Int J Neurosci. 1994 Jul; 77(1-2):11-21.
    View in: PubMed
  31. Vgontzas AN, Kales A, Bixler EO, Manfredi RL, Tyson KL. Effects of lovastatin and pravastatin on sleep efficiency and sleep stages. Clin Pharmacol Ther. 1991 Dec; 50(6):730-7.
    View in: PubMed
  32. Manfredi RL, Kales A, Vgontzas AN, Bixler EO, Isaac MA, Falcone CM. Buspirone: sedative or stimulant effect? Am J Psychiatry. 1991 Sep; 148(9):1213-7.
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  33. Bixler EO, Kales A, Manfredi RL, Vgontzas AN, Tyson KL, Kales JD. Next-day memory impairment with triazolam use. Lancet. 1991 Apr 6; 337(8745):827-31.
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  34. Kales A, Manfredi RL, Vgontzas AN, Bixler EO, Vela-Bueno A, Fee EC. Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines. Clin Pharmacol Ther. 1991 Apr; 49(4):468-76.
    View in: PubMed
  35. Kales A. Benzodiazepine hypnotics and insomnia. Hosp Pract (Off Ed). 1990 Sep; 25 Suppl 3:7-21; discussion 22-3.
    View in: PubMed
  36. Stauffer JL, Buick MK, Bixler EO, Sharkey FE, Abt AB, Manders EK, Kales A, Cadieux RJ, Barry JD, Zwillich CW. Morphology of the uvula in obstructive sleep apnea. Am Rev Respir Dis. 1989 Sep; 140(3):724-8.
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  37. Kales A, Soldatos CR, Bixler EO, Kales JD, Vela-Bueno A. Diazepam: effects on sleep and withdrawal phenomena. J Clin Psychopharmacol. 1988 Oct; 8(5):340-6.
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  38. Bixler EO, Kales A, Vela-Bueno A, Niklaus DE, Shubert DD, Soldatos CR. Nocturnal sleep and blood pressure in essential hypertension. Int J Neurosci. 1988 May; 40(1-2):1-11.
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  39. Fedok FG, Strauss M, Houck JR, Cadieux RJ, Kales A. Further clinical experience with the silicone tracheal cannula in obstructive sleep apnea. Otolaryngol Head Neck Surg. 1987 Sep; 97(3):313-8.
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  40. Kales A, Kales JD. Evaluation and diagnosis of sleep disorders patients. Semin Neurol. 1987 Sep; 7(3):243-9.
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  41. Manfredi RL, Kales A. Clinical neuropharmacology of sleep disorders. Semin Neurol. 1987 Sep; 7(3):286-95.
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  42. Kales A, Bixler EO, Vela-Bueno A, Soldatos CR, Manfredi RL. Alprazolam: effects on sleep and withdrawal phenomena. J Clin Pharmacol. 1987 Jul; 27(7):508-15.
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  43. Bixler EO, Kales A, Brubaker BH, Kales JD. Adverse reactions to benzodiazepine hypnotics: spontaneous reporting system. Pharmacology. 1987; 35(5):286-300.
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  44. Kales JD, Kales A. Clinical selection of benzodiazepine hypnotics. Psychiatr Med. 1986; 4(2):229-41.
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  45. Kales JD, Soldatos CR, Kales A. Treatment of sleep disorders. Psychiatr Med. 1986; 4(2):209-27.
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  46. Kales AN, Phang JM. The effect of divided calcium intake on calcium metabolism. J Clin Endocrinol Metab. 1971 Jan; 32(1):83-7.
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  47. Kales AN, Phang JM. Dietary calcium perturbations in patients with abnormal calcium deposition. J Clin Endocrinol Metab. 1970 Aug; 31(2):204-12.
    View in: PubMed
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