PSU Profiles
Keywords
Last Name
Institution

Zachary Simmons

TitleProfessor
InstitutionCollege of Medicine
DepartmentNeurology
Address500 University Drive Hershey PA 17033
Phone7175311802

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Professor of Neurology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Humanities

GRADUATE PROGRAM AFFILIATIONS:

Neuroscience

EDUCATION:

Fellowship, Neuromuscular Diseases, University of Michigan Hospitals & Health Centers (1992)
Residency, Neurology, University of Iowa Hospitals and Clinics (1986)
Internship, Internal Medicine, University of Iowa Hospitals and Clinics (1983)
M.D., University of Florida, College of Medicine (1982)

NARRATIVE:

Clinical Research - ALS
Clinical Trials: We are involved in a clinical trials that change frequently. For updated information, contact our clinical nurse manager at 717-531-0003, ext 289123.

Brain-Computer Interface Technology: Brain-computer interface (BCI) devices have the potential to enhance the quality of life for those living with ALS, and can aid in basic forms of motor control and communication. In collaboration with Dr. Steven Schiff, our research aims to show how the success of BCI deployment is complicated by the high level of disease heterogeneity, and how we can use engineering principles to adapt our systems to optimize BCI use for each user.

Longitudinal Outcomes Research: A new strength measurement device called Accurate Test of Limb Isometric Strength (ATLIS) was developed to precisely and conveniently measure static limb strength in patients with ALS. We will compare ATLIS data with data from two commonly used ALS outcomes measures, the ALS Functional Rating Scale-Revised (ALSFRS-R) and slow vital capacity (SVC) in a prospective, longitudinal study. All three outcome measures will be performed on subjects collected preferably at clinic visits during the study period.

Understanding Falls: We are investigating the characteristics and circumstances of falls in people diagnosed with ALS in order to identify risk factors and prevent injuries from falls.
Understanding Pain in ALS: ALS has generally been considered a painless disorder, but recent studies have shown that pain is a frequently underestimated and under-reported symptom in ALS. We are conducting a study of pain experienced by ALS patients in Pennsylvania to better understand the nature of the pain and how it is currently treated. We will simultaneously survey ALS physicians in the U.S. and Canada on their experiences with pain management in the ALS population. From this study, we hope to contribute to the development of better pain management for people living with ALS.

Quality of Life: We have a longstanding interest in quality of life (QOL) in patients with ALS. Our group has developed a QOL questionnaire specific for those with ALS, the ALS-Specific Quality of Life Instrument - Revised, or ALSSQOL-R. The ALS-Specific Quality of Life-Revised (ALSSQOL-R) is available free of charge to those wishing to use it. We welcome collaboration from other ALS centers for projects using this instrument. We are currently working with investigators in US centers and International centers to understand QOL in patients with different cultural and ethnic backgrounds. We have recently constructed a short form of the tool (ALSSQOL-SF) which includes 18 items. We are in the process of validating the ALSSQOL-SF in a multicenter study.

Turning Research into Practice: Evidence-Based Practice is a method of providing clinical care to patients, by systematically incorporating solid research evidence with clinician expertise. This process has inspired several collaborative teams, made up of clinicians and researchers alike. Each group focuses on a particular aspect of patient care, in order to better meet the needs of our patients. Topics include:
• Support for Caregivers
• ALS and Frontotemporal Dementia (FTD)
• Improving End of Life Care and Decision Making

Basic Science Research - ALS
Discovery of a Genetic Risk Factor for ALS: Under the leadership of Dr. James Connor, a potential genetic risk factor for ALS has been identified. Termed the H63D HFE genetic variant, this is a variation of the hemochromatosis gene, a gene involved in iron metabolism, the immune system, and inflammatory responses. Studies now support that the presence of the H63D HFE gene is a four-fold risk factor for ALS.

Developing Innovative Mouse Models of ALS: We have successfully developed a mouse model that expresses the HFE risk factor gene and mated that mouse line with the established ALS mouse model. The resulting mice have a faster and more aggressive disease. This is an exciting breakthrough and will provide opportunities to understand how the risk factor we identified impacts the disease. This also provides a new model in which to test therapeutic strategies under consideration for ALS and hopefully improve the currently poor success rate for drugs that tested well in animal models but failed in human trials.

Understanding Cellular Stress and ALS: Studies to understand the relationship between H63D and cellular stress and between H63D and two other mutations known to be associated with ALS - TDP-43 and SOD1 - are in progress. Human cells that carry the H63D mutation have elevated levels of stress and mitochondrial dysfunction and alterations in glutamate metabolism and increased TDP-43 that are thought to contribute to ALS. These models will help us to understand the impact of the mutations on cell function and how the mutations combine to cause cell death, permitting the development of therapeutic strategies around that knowledge.

Biomarker Research: We have made progress with a novel biomarker-panel based approach to model ALS disease prognosis. We found that several important biomarkers involved in inflammation, iron metabolism, and immune responses may predict ALS disease course. Because current methods to predict prognosis are limited, these results have direct impact on clinical management and trials of novel therapies. We are currently establishing a repository of samples to be used for biomarker research.

Personalized Medicine: Since the creation of Penn State Hershey's new Institute for Personalized Medicine, this game-changing medical model is driving opportunities for greater collaborations across the institution to advance medical science. In collaboration with Drs. James Broach and Glenn Gerhard, and with patient and family member consent, blood and saliva samples will be taken and used to conduct highly sophisticated genetic sequencing. The process will identify known or new genetic mutations that are associated with ALS.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Eisenbruch AB, Simmons ZL, Roney JR. Lady in Red: Hormonal Predictors of Women's Clothing Choices. Psychol Sci. 2015 Aug; 26(8):1332-8.
    View in: PubMed
  2. Bandyopadhyay S, Simmons Z. Optimizing the clinical examination of the tongue. J Clin Neuromuscul Dis. 2015 Jun; 16(4):226-8.
    View in: PubMed
  3. Graham CD, Simmons Z, Stuart SR, Rose MR. The potential of psychological interventions to improve quality of life and mood in muscle disorders. Muscle Nerve. 2015 Jul; 52(1):131-6.
    View in: PubMed
  4. Simmons Z. Patient-Perceived Outcomes and Quality of Life in ALS. Neurotherapeutics. 2015 Apr; 12(2):394-402.
    View in: PubMed
  5. Ahmed A, Simmons Z. Isaacs syndrome: A review. Muscle Nerve. 2015 Jul; 52(1):5-12.
    View in: PubMed
  6. Stephens HE, Felgoise S, Young J, Simmons Z. Multidisciplinary ALS clinics in the USA: A comparison of those who attend and those who do not. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Jun; 16(3-4):196-201.
    View in: PubMed
  7. Liu Y, Neely E, Simmons Z, Connor JR. Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu. J Neurosci Res. 2015 May; 93(5):766-76.
    View in: PubMed
  8. Su XW, Clardy SL, Stephens HE, Simmons Z, Connor JR. Serum ferritin is elevated in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Mar; 16(1-2):102-7.
    View in: PubMed
  9. Raheja D, Specht C, Simmons Z. Paraproteinemic neuropathies. Muscle Nerve. 2015 Jan; 51(1):1-13.
    View in: PubMed
  10. Geronimo A, Stephens HE, Schiff SJ, Simmons Z. Acceptance of brain-computer interfaces in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Jun; 16(3-4):258-64.
    View in: PubMed
  11. Nandar W, Neely EB, Simmons Z, Connor JR. H63D HFE genotype accelerates disease progression in animal models of amyotrophic lateral sclerosis. Biochim Biophys Acta. 2014 Dec; 1842(12 Pt A):2413-26.
    View in: PubMed
  12. Simmons Z. Loss and well-being in ALS: a different perspective on the challenge. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun; 15(3-4):163-4.
    View in: PubMed
  13. Su XW, Broach JR, Connor JR, Gerhard GS, Simmons Z. Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research. Muscle Nerve. 2014 Jun; 49(6):786-803.
    View in: PubMed
  14. Meadowcroft MD, Mutic NJ, Bigler DC, Wang JL, Simmons Z, Connor JR, Yang QX. Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis. J Magn Reson Imaging. 2015 Mar; 41(3):665-75.
    View in: PubMed
  15. Kasarskis EJ, Mendiondo MS, Matthews DE, Mitsumoto H, Tandan R, Simmons Z, Bromberg MB, Kryscio RJ. Estimating daily energy expenditure in individuals with amyotrophic lateral sclerosis. Am J Clin Nutr. 2014 Apr; 99(4):792-803.
    View in: PubMed
  16. Su XW, Simmons Z, Mitchell RM, Kong L, Stephens HE, Connor JR. Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis. JAMA Neurol. 2013 Dec; 70(12):1505-11.
    View in: PubMed
  17. Ahmed A, Simmons Z. Pseudobulbar affect: prevalence and management. Ther Clin Risk Manag. 2013; 9:483-9.
    View in: PubMed
  18. Su XW, Lee SY, Mitchell RM, Stephens HE, Simmons Z, Connor JR. H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients. Muscle Nerve. 2013 Aug; 48(2):242-6.
    View in: PubMed
  19. Roney JR, Simmons ZL. Hormonal predictors of sexual motivation in natural menstrual cycles. Horm Behav. 2013 Apr; 63(4):636-45.
    View in: PubMed
  20. Houseman G, Walsh S, Brothers A, Lyter J, Simmons Z, Klapper J. Frontotemporal degeneration in the patient with amyotrophic lateral sclerosis: helping the caregiver cope. J Neurosci Nurs. 2013 Apr; 45(2):96-100.
    View in: PubMed
  21. Simmons Z. Rehabilitation of motor neuron disease. Handb Clin Neurol. 2013; 110:483-98.
    View in: PubMed
  22. Simmons Z. Electrodiagnosis of brachial plexopathies and proximal upper extremity neuropathies. Phys Med Rehabil Clin N Am. 2013 Feb; 24(1):13-32.
    View in: PubMed
  23. Roney JR, Simmons ZL. Men smelling women: null effects of exposure to ovulatory sweat on men's testosterone. Evol Psychol. 2012; 10(4):703-13.
    View in: PubMed
  24. Burns TM, Graham CD, Rose MR, Simmons Z. Quality of life and measures of quality of life in patients with neuromuscular disorders. Muscle Nerve. 2012 Jul; 46(1):9-25.
    View in: PubMed
  25. Simmons Z. What's in the literature? J Clin Neuromuscul Dis. 2012 Mar; 13(3):162-7.
    View in: PubMed
  26. Pagnini F, Simmons Z, Corbo M, Molinari E. Amyotrophic lateral sclerosis: time for research on psychological intervention? Amyotroph Lateral Scler. 2012 Sep; 13(5):416-7.
    View in: PubMed
  27. Zamietra K, Lehman EB, Felgoise SH, Walsh SM, Stephens HE, Simmons Z. Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS. Amyotroph Lateral Scler. 2012 Jan; 13(1):55-8.
    View in: PubMed
  28. Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, Ó Brannagáin D, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives. BMJ Support Palliat Care. 2011 Dec; 1(3):343-8.
    View in: PubMed
  29. Isackson PJ, Ochs-Balcom HM, Ma C, Harley JB, Peltier W, Tarnopolsky M, Sripathi N, Wortmann RL, Simmons Z, Wilson JD, Smith SA, Barboi A, Fine E, Baer A, Baker S, Kaufman K, Cobb B, Kilpatrick JR, Vladutiu GD. Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS. Muscle Nerve. 2011 Oct; 44(4):531-8.
    View in: PubMed
  30. Simmons ZL, Roney JR. Variation in CAG repeat length of the androgen receptor gene predicts variables associated with intrasexual competitiveness in human males. Horm Behav. 2011 Aug; 60(3):306-12.
    View in: PubMed
  31. McAllister MW, Hsi RS, Torrey RR, Simmons Z, Baldwin BD, Baldwin DD. In vitro comparison of changes in effective patient weight between purely laparoscopic and hand-assisted laparoscopic surgery. J Endourol. 2011 Apr; 25(4):651-5.
    View in: PubMed
  32. Flaherty-Craig CV, Brothers A, Yang C, Svoboda R, Simmons Z. Declines in problem solving and anosognosia in amyotrophic lateral sclerosis: application of Guilford's structure of intellect theory. Cogn Behav Neurol. 2011 Mar; 24(1):26-34.
    View in: PubMed
  33. Liu Y, Lee SY, Neely E, Nandar W, Moyo M, Simmons Z, Connor JR. Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J Biol Chem. 2011 Apr 15; 286(15):13161-70.
    View in: PubMed
  34. Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, O Brannagáin D, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives. J Neurol Neurosurg Psychiatry. 2011 Apr; 82(4):413-8.
    View in: PubMed
  35. Cupp J, Simmons Z, Berg A, Felgoise SH, Walsh SM, Stephens HE. Psychological health in patients with ALS is maintained as physical function declines. Amyotroph Lateral Scler. 2011 Jul; 12(4):290-6.
    View in: PubMed
  36. Roney JR, Simmons ZL, Gray PB. Changes in estradiol predict within-women shifts in attraction to facial cues of men's testosterone. Psychoneuroendocrinology. 2011 Jun; 36(5):742-9.
    View in: PubMed
  37. Hossler C, Levi BH, Simmons Z, Green MJ. Advance care planning for patients with ALS: feasibility of an interactive computer program. Amyotroph Lateral Scler. 2011 May; 12(3):172-7.
    View in: PubMed
  38. Felgoise SH, Chakraborty BH, Bond E, Rodriguez J, Bremer BA, Walsh SM, Lai EC, McCluskey L, Simmons Z. Psychological morbidity in ALS: the importance of psychological assessment beyond depression alone. Amyotroph Lateral Scler. 2010 Aug; 11(4):351-8.
    View in: PubMed
  39. Mitchell RM, Simmons Z, Beard JL, Stephens HE, Connor JR. Plasma biomarkers associated with ALS and their relationship to iron homeostasis. Muscle Nerve. 2010 Jul; 42(1):95-103.
    View in: PubMed
  40. Sundaram AN, Simmons Z, Towfighi J, Sheehan J, Reichwein R. Contralateral cranial polyneuropathy due to perineural invasion by a cutaneous squamous cell carcinoma. J Clin Neuromuscul Dis. 2010 Mar; 11(3):132-6.
    View in: PubMed
  41. Simmons Z, Specht CS. The neuromuscular manifestations of amyloidosis. J Clin Neuromuscul Dis. 2010 Mar; 11(3):145-57.
    View in: PubMed
  42. Hall EC, Lee SY, Simmons Z, Neely EB, Nandar W, Connor JR. Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D. Biochim Biophys Acta. 2010 Apr; 1802(4):389-95.
    View in: PubMed
  43. Felgoise SH, Stewart JL, Bremer BA, Walsh SM, Bromberg MB, Simmons Z. The SEIQoL-DW for assessing quality of life in ALS: strengths and limitations. Amyotroph Lateral Scler. 2009 Oct-Dec; 10(5-6):456-62.
    View in: PubMed
  44. Roney JR, Simmons ZL, Lukaszewski AW. Androgen receptor gene sequence and basal cortisol concentrations predict men's hormonal responses to potential mates. Proc Biol Sci. 2010 Jan 7; 277(1678):57-63.
    View in: PubMed
  45. Hall EC, Lee SY, Mairuae N, Simmons Z, Connor JR. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011 Aug; 32(8):1409-19.
    View in: PubMed
  46. Ahmed A, Simmons Z. Electrodiagnostic findings in a patient with Waardenburg syndrome. J Clin Neuromuscul Dis. 2009 Sep; 11(1):54-6.
    View in: PubMed
  47. Mitchell RM, Lee SY, Simmons Z, Connor JR. HFE polymorphisms affect cellular glutamate regulation. Neurobiol Aging. 2011 Jun; 32(6):1114-23.
    View in: PubMed
  48. Murphy V, Felgoise SH, Walsh SM, Simmons Z. Problem solving skills predict quality of life and psychological morbidity in ALS caregivers. Amyotroph Lateral Scler. 2009 Jun; 10(3):147-53.
    View in: PubMed
  49. Simmons Z. Can we eliminate placebo in ALS clinical Trials? Muscle Nerve. 2009 Jun; 39(6):861-5.
    View in: PubMed
  50. Simmons Z. What's in the Literature? J Clin Neuromuscul Dis. 2009 Jun; 10(4):202-7.
    View in: PubMed
  51. Flaherty-Craig C, Brothers A, Dearman B, Eslinger P, Simmons Z. Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: application to ALS. Amyotroph Lateral Scler. 2009 Apr; 10(2):107-12.
    View in: PubMed
  52. Mitchell RM, Lee SY, Randazzo WT, Simmons Z, Connor JR. Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. J Neuroinflammation. 2009; 6:6.
    View in: PubMed
  53. Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2009 Apr 15; 18(8):1524-32.
    View in: PubMed
  54. Landsverk ML, Ruzzo EK, Mefford HC, Buysse K, Buchan JG, Eichler EE, Petty EM, Peterson EA, Knutzen DM, Barnett K, Farlow MR, Caress J, Parry GJ, Quan D, Gardner KL, Hong M, Simmons Z, Bird TD, Chance PF, Hannibal MC. Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy. Hum Mol Genet. 2009 Apr 1; 18(7):1200-8.
    View in: PubMed
  55. Simmons ZL, Roney JR. Androgens and energy allocation: quasi-experimental evidence for effects of influenza vaccination on men's testosterone. Am J Hum Biol. 2009 Jan-Feb; 21(1):133-5.
    View in: PubMed
  56. Mitchell RM, Freeman WM, Randazzo WT, Stephens HE, Beard JL, Simmons Z, Connor JR. A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis. Neurology. 2009 Jan 6; 72(1):14-9.
    View in: PubMed
  57. Groh WJ, Groh MR, Saha C, Kincaid JC, Simmons Z, Ciafaloni E, Pourmand R, Otten RF, Bhakta D, Nair GV, Marashdeh MM, Zipes DP, Pascuzzi RM. Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1. N Engl J Med. 2008 Jun 19; 358(25):2688-97.
    View in: PubMed
  58. Roney JR, Simmons ZL. Women's estradiol predicts preference for facial cues of men's testosterone. Horm Behav. 2008 Jan; 53(1):14-9.
    View in: PubMed
  59. Zimmerman EK, Eslinger PJ, Simmons Z, Barrett AM. Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol. 2007 Jun; 20(2):79-82.
    View in: PubMed
  60. Roney JR, Lukaszewski AW, Simmons ZL. Rapid endocrine responses of young men to social interactions with young women. Horm Behav. 2007 Sep; 52(3):326-33.
    View in: PubMed
  61. Vender RL, Mauger D, Walsh S, Alam S, Simmons Z. Respiratory systems abnormalities and clinical milestones for patients with amyotrophic lateral sclerosis with emphasis upon survival. Amyotroph Lateral Scler. 2007 Feb; 8(1):36-41.
    View in: PubMed
  62. Flaherty-Craig C, Eslinger P, Stephens B, Simmons Z. A rapid screening battery to identify frontal dysfunction in patients with ALS. Neurology. 2006 Dec 12; 67(11):2070-2.
    View in: PubMed
  63. Wang XS, Simmons Z, Liu W, Boyer PJ, Connor JR. Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex. Amyotroph Lateral Scler. 2006 Dec; 7(4):201-10.
    View in: PubMed
  64. Simmons Z, Felgoise SH, Bremer BA, Walsh SM, Hufford DJ, Bromberg MB, David W, Forshew DA, Heiman-Patterson TD, Lai EC, McCluskey L. The ALSSQOL: balancing physical and nonphysical factors in assessing quality of life in ALS. Neurology. 2006 Nov 14; 67(9):1659-64.
    View in: PubMed
  65. Vladutiu GD, Simmons Z, Isackson PJ, Tarnopolsky M, Peltier WL, Barboi AC, Sripathi N, Wortmann RL, Phillips PS. Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve. 2006 Aug; 34(2):153-62.
    View in: PubMed
  66. Fisher J, Towfighi J, Darvish D, Simmons Z. A case of hereditary inclusion body myopathy: 1 patient, 2 novel mutations. J Clin Neuromuscul Dis. 2006 Jun; 7(4):179-84.
    View in: PubMed
  67. Chaisson KM, Walsh S, Simmons Z, Vender RL. A clinical pilot study: high frequency chest wall oscillation airway clearance in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2006 Jun; 7(2):107-11.
    View in: PubMed
  68. Scott KR, Kothari MJ, Venkatesh YS, Murphy T, Simmons Z. Parotid gland injections of botulinum toxin a are effective in treating sialorrhea in amyotrophic lateral sclerosis. J Clin Neuromuscul Dis. 2005 Dec; 7(2):62-5.
    View in: PubMed
  69. Simmons Z. Management strategies for patients with amyotrophic lateral sclerosis from diagnosis through death. Neurologist. 2005 Sep; 11(5):257-70.
    View in: PubMed
  70. Groh WJ, Lowe MR, Simmons Z, Bhakta D, Pascuzzi RM. Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1. Muscle Nerve. 2005 Jun; 31(6):719-24.
    View in: PubMed
  71. Wang XS, Lee S, Simmons Z, Boyer P, Scott K, Liu W, Connor J. Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. J Neurol Sci. 2004 Dec 15; 227(1):27-33.
    View in: PubMed
  72. Bremer BA, Simone AL, Walsh S, Simmons Z, Felgoise SH. Factors supporting quality of life over time for individuals with amyotrophic lateral sclerosis: the role of positive self-perception and religiosity. Ann Behav Med. 2004 Oct; 28(2):119-25.
    View in: PubMed
  73. You H, Simmons Z, Freivalds A, Kothari M, Naidu S, Young R. The development of risk assessment models for carpal tunnel syndrome: a case-referent study. Ergonomics. 2004 May 15; 47(6):688-709.
    View in: PubMed
  74. Walsh SM, Bremer BA, Felgoise SH, Simmons Z. Religiousness is related to quality of life in patients with ALS. Neurology. 2003 May 13; 60(9):1527-9.
    View in: PubMed
  75. Scott K, Simmons Z, Kothari MJ. A comparison of quantitative sensory testing with skin biopsy in small fiber neuropathy. J Clin Neuromuscul Dis. 2003 Mar; 4(3):129-32.
    View in: PubMed
  76. Simmons Z, Peterlin BL, Boyer PJ, Towfighi J. Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels. Muscle Nerve. 2003 Feb; 27(2):242-4.
    View in: PubMed
  77. Simmons Z, Feldman EL. Update on diabetic neuropathy. Curr Opin Neurol. 2002 Oct; 15(5):595-603.
    View in: PubMed
  78. Scott KR, Simmons Z, Boyer PJ. Hypothyroid myopathy with a strikingly elevated serum creatine kinase level. Muscle Nerve. 2002 Jul; 26(1):141-4.
    View in: PubMed
  79. Simmons Z, Towfighi J. Sporadic inclusion body myositis and hereditary inclusion body myopathy. J Clin Neuromuscul Dis. 2002 Mar; 3(3):122-32.
    View in: PubMed
  80. Kovach MJ, Waggoner B, Leal SM, Gelber D, Khardori R, Levenstien MA, Shanks CA, Gregg G, Al-Lozi MT, Miller T, Rakowicz W, Lopate G, Florence J, Glosser G, Simmons Z, Morris JC, Whyte MP, Pestronk A, Kimonis VE. Clinical delineation and localization to chromosome 9p13.3-p12 of a unique dominant disorder in four families: hereditary inclusion body myopathy, Paget disease of bone, and frontotemporal dementia. Mol Genet Metab. 2001 Dec; 74(4):458-75.
    View in: PubMed
  81. Simmons Z, Epstein DK, Borg B, Mauger DT, Kothari MJ, Shefner JM. Reproducibility of motor unit number estimation in individual subjects. Muscle Nerve. 2001 Apr; 24(4):467-73.
    View in: PubMed
  82. Robbins RA, Simmons Z, Bremer BA, Walsh SM, Fischer S. Quality of life in ALS is maintained as physical function declines. Neurology. 2001 Feb 27; 56(4):442-4.
    View in: PubMed
  83. Simmons Z, Bremer BA, Robbins RA, Walsh SM, Fischer S. Quality of life in ALS depends on factors other than strength and physical function. Neurology. 2000 Aug 8; 55(3):388-92.
    View in: PubMed
  84. Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA. Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci. 2000 Jul-Aug; 18(4-5):433-7.
    View in: PubMed
  85. Kothari MJ, Heistand M, Simmons Z. Side to side difference of nerve conduction amplitudes. Electromyogr Clin Neurophysiol. 2000 Mar; 40(2):81-2.
    View in: PubMed
  86. Simmons Z. Chronic inflammatory demyelinating polyradiculoneuropathy. J Clin Neuromuscul Dis. 1999 Dec; 1(2):90-8.
    View in: PubMed
  87. Simmons Z. Paraproteinemia and neuropathy. Curr Opin Neurol. 1999 Oct; 12(5):589-95.
    View in: PubMed
  88. You H, Simmons Z, Freivalds A, Kothari MJ, Naidu SH. Relationships between clinical symptom severity scales and nerve conduction measures in carpal tunnel syndrome. Muscle Nerve. 1999 Apr; 22(4):497-501.
    View in: PubMed
  89. Simmons Z, Mahadeen ZI, Kothari MJ, Powers S, Wise S, Towfighi J. Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. Muscle Nerve. 1999 Jan; 22(1):28-36.
    View in: PubMed
  90. Kothari MJ, Blakeslee MA, Reichwein R, Simmons Z, Logigian EL. Electrodiagnostic studies: are they useful in clinical practice? Arch Phys Med Rehabil. 1998 Dec; 79(12):1510-1.
    View in: PubMed
  91. Simmons Z, Thornton CA, Seltzer WK, Richards CS. Relative stability of a minimal CTG repeat expansion in a large kindred with myotonic dystrophy. Neurology. 1998 May; 50(5):1501-4.
    View in: PubMed
  92. Simmons Z, Nicholson T, Wilde C, Manders EK. Variation of calculated ulnar motor conduction velocity across the elbow with body mass index. Muscle Nerve. 1997 Dec; 20(12):1607-8.
    View in: PubMed
  93. Simmons Z, Wald JJ, Albers JW. Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long-term follow-up, with comparison to adults. Muscle Nerve. 1997 Dec; 20(12):1569-75.
    View in: PubMed
  94. Thornton CA, Wymer JP, Simmons Z, McClain C, Moxley RT. Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene. Nat Genet. 1997 Aug; 16(4):407-9.
    View in: PubMed
  95. Simmons Z, Wald JJ, Albers JW. Chronic inflammatory demyelinating polyradiculoneuropathy in children: I. Presentation, electrodiagnostic studies, and initial clinical course, with comparison to adults. Muscle Nerve. 1997 Aug; 20(8):1008-15.
    View in: PubMed
  96. Simmons Z, Tivakaran S. Acquired demyelinating polyneuropathy presenting as a pure clinical sensory syndrome. Muscle Nerve. 1996 Sep; 19(9):1174-6.
    View in: PubMed
  97. Kluin KJ, Bromberg MB, Feldman EL, Simmons Z. Dysphagia in elderly men with myasthenia gravis. J Neurol Sci. 1996 Jun; 138(1-2):49-52.
    View in: PubMed
  98. Doherty T, Simmons Z, O'Connell B, Felice KJ, Conwit R, Chan KM, Komori T, Brown T, Stashuk DW, Brown WF. Methods for estimating the numbers of motor units in human muscles. J Clin Neurophysiol. 1995 Nov; 12(6):565-84.
    View in: PubMed
  99. Simmons Z, Albers JW, Bromberg MB, Feldman EL. Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy. Brain. 1995 Apr; 118 ( Pt 2):359-68.
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  100. Simmons Z, Wald J, Albers JW, Feldman EL. The natural history of a "benign" rib lesion in a patient with a demyelinating polyneuropathy and an unusual variant of POEMS syndrome. Muscle Nerve. 1994 Sep; 17(9):1055-9.
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  101. Simmons Z, Blaivas M, Aguilera AJ, Feldman EL, Bromberg MB, Towfighi J. Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis. J Neurol Sci. 1993 Dec 1; 120(1):60-3.
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  102. Bromberg MB, Forshew DA, Nau KL, Bromberg J, Simmons Z, Fries TJ. Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis. Muscle Nerve. 1993 Nov; 16(11):1213-9.
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  103. Simmons Z, Albers JW, Bromberg MB, Feldman EL. Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy: comparison of patients without and with monoclonal gammopathy. Neurology. 1993 Nov; 43(11):2202-9.
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  104. Simmons Z, Bromberg MB, Feldman EL, Blaivas M. Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance. Muscle Nerve. 1993 Jan; 16(1):77-83.
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  105. Simmons Z, Albers JW, Sima AA. Case-of-the-month: perineuritis presenting as mononeuritis multiplex. Muscle Nerve. 1992 May; 15(5):630-5.
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  106. Simmons Z, Biller J, Beck DW, Keyes W. Painless compressive cervical myelopathy with false localizing sensory findings. Spine (Phila Pa 1976). 1986 Nov; 11(9):869-72.
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  107. Biller J, Adams HP, Dunn V, Simmons Z, Jacoby CG. Dichotomy between clinical findings and MR abnormalities in pontine infarction. J Comput Assist Tomogr. 1986 May-Jun; 10(3):379-85.
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  108. Simmons Z, Biller J, Adams HP, Dunn V, Jacoby CG. Cerebellar infarction: comparison of computed tomography and magnetic resonance imaging. Ann Neurol. 1986 Mar; 19(3):291-3.
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  109. Trumpower BL, Simmons Z. Diminished inhibition of mitochondrial electron transfer from succinate to cytochrome c by thenoyltrifluoroacetone induced by antimycin. J Biol Chem. 1979 Jun 10; 254(11):4608-16.
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  110. Lusby AF, Simmons Z, McGuire PM. Variation in mutagenicity of s-triazine compounds tested on four Salmonella strains. Environ Mutagen. 1979; 1(3):287-90.
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