PSU Profiles
Last Name

Zhaohai Yang

TitleAssistant Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033
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    Attending Pathologist and Associate Professor of Pathology
    Medical Director, Autopsy and Decedent Care Services


    Fellowship, Oncologic Surgical Pathology, Memorial Sloan-Kettering Cancer Center (New York) (2010)
    Fellowship, Gastrointestinal Pathology, University of Alabama Medical Center (Birmingham) (2009)
    Residency, Anatomic and Clinical Pathology, University of Alabama Medical Center (Birmingham) (2009)
    Ph.D., Cell and Molecular Biology, University of Pennsylvania (Philadelphia) (2001)
    Postgraduate, Pathology, Beijing Medical University / Peking University Health Science Center (Beijing) (1996)
    M.D., Beijing Medical University / Peking University Health Science Center (Beijing) (1993)


    Dr. Yang joined PSU Hershey Medical Center / College of Medicine in July 2010. His main clinical and research interest centers on the neoplasm of the digestive system, in particular, the classification, diagnosis and prognosis of neuroendocrine tumors and adenocarcinomas. He also maintains a broad interest in oncologic surgical pathology and is involved in breast, lung and genitourinary subspecialty sign-out and multidisciplinary tumor boards. He has published more than 40 peer-reviewed articles and presented more than 40 abstracts at national meetings. In addition, he enjoys teaching medical students, residents and fellows.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schieffer KM, Wright JR, Harris LR, Deiling S, Yang Z, Lamendella R, Yochum GS, Koltun WA. NOD2 Genetic Variants Predispose One of Two Familial Adenomatous Polyposis Siblings to Pouchitis Through Microbiome Dysbiosis. J Crohns Colitis. 2017 Oct 27; 11(11):1393-1397. PMID: 28633443.
      View in: PubMed
    2. Scrobola JF, McClune JR, Harriott AJ, Yang Z, Gilbert CR. Endobronchial Sarcoidosis. J Bronchology Interv Pulmonol. 2017 Oct; 24(4):303-306. PMID: 28195966.
      View in: PubMed
    3. Yang Z, Klimstra DS, Hruban RH, Tang LH. Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver. Am J Surg Pathol. 2017 Jul; 41(7):915-922. PMID: 28498280.
      View in: PubMed
    4. Ainechi S, Mann SA, Lin J, Patil D, Sheehan CE, Yang Z, Zuo C, Lee H. Paired Box 5 (PAX5) Expression in Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal and Pancreatobiliary Tract: Diagnostic and Potentially Therapeutic Implications. Appl Immunohistochem Mol Morphol. 2016 Dec 09. PMID: 27941564.
      View in: PubMed
    5. Chen G, Yang Z, Eshleman JR, Netto GJ, Lin MT. Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective. Biomed Res Int. 2016; 2016:9850690. PMID: 27699178.
      View in: PubMed
    6. Desai M, Reiprich A, Khov N, Yang Z, Mathew A, Levenick J. Crystal-Associated Colitis with Ulceration Leading to Hematochezia and Abdominal Pain. Case Rep Gastroenterol. 2016 May-Aug; 10(2):332-7. PMID: 27482192; PMCID: PMC4945809.
    7. Raman JD, Warrick JI, Caruso C, Yang Z, Shuman L, Bruggeman RD, Shariat S, Karam JA, Wood C, Weizer AZ, Remzi M, Haitel A, Bensalah K, Rioux-Leclerq N, Bolenz C, Roscigno M, Krabbe LM, Kapur P, Lotan Y, Margulis V, DeGraff DJ. Altered Expression of the Transcription Factor Forkhead Box A1 (FOXA1) Is Associated With Poor Prognosis in Urothelial Carcinoma of the Upper Urinary Tract. Urology. 2016 Aug; 94:314.e1-7. PMID: 27215483.
      View in: PubMed
    8. Chintanaboina J, Yang Z, Mathew A. Autoimmune Pancreatitis: A Diagnostic Challenge for the Clinician. South Med J. 2015 Sep; 108(9):579-89. PMID: 26332485.
      View in: PubMed
    9. Basturk O, Yang Z, Tang LH, Hruban RH, Adsay V, McCall CM, Krasinskas AM, Jang KT, Frankel WL, Balci S, Sigel C, Klimstra DS. The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol. 2015 May; 39(5):683-90. PMID: 25723112; PMCID: PMC4398606.
    10. Yee NS, Kazi AA, Li Q, Yang Z, Berg A, Yee RK. Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis. Biol Open. 2015 Mar 13; 4(4):507-14. PMID: 25770184; PMCID: PMC4400593.
    11. Das A, Kunkel M, Joudeh J, Dicker DT, Scicchitano A, Allen JE, Sarwani N, Yang Z, Kaifi J, Zhu J, Liao J, El-Deiry WS. Clinico-pathological correlation of serial measurement of circulating tumor cells in 24 metastatic colorectal cancer patients receiving chemotherapy reveals interpatient heterogeneity correlated with CEA levels but independent of KRAS and BRAF mutation. Cancer Biol Ther. 2015; 16(5):709-13. PMID: 25806877; PMCID: PMC4622543.
    12. Marks EI, Tan C, Zhang J, Zhou L, Yang Z, Scicchitano A, El-Deiry WS. Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy. Cancer Biol Ther. 2015; 16(12):1710-9. PMID: 26561209; PMCID: PMC4847811 [Available on 11/11/16].
    13. Yang Z. The utility of villin and mammaglobin in the differential diagnosis between intrahepatic cholangiocarcinoma and breast cancer. Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):19-25. PMID: 25153498.
      View in: PubMed
    14. Voss SM, Riley MP, Lokhandwala PM, Wang M, Yang Z. Mitotic count by phosphohistone H3 immunohistochemical staining predicts survival and improves interobserver reproducibility in well-differentiated neuroendocrine tumors of the pancreas. Am J Surg Pathol. 2015 Jan; 39(1):13-24. PMID: 25353284.
      View in: PubMed
    15. Marks E, Rizvi SM, Sarwani N, Yang Z, El-Deiry WS. A case of heterogeneous sensitivity to panitumumab in cetuximab-refractory colorectal adenocarcinoma metastases. Cancer Biol Ther. 2015; 16(3):377-82. PMID: 25695537; PMCID: PMC4622001.
    16. Yee NS, Li Q, Kazi AA, Yang Z, Berg A, Yee RK. Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion. Cells. 2014 May 23; 3(2):500-16. PMID: 24861976; PMCID: PMC4092867.
    17. Basturk O, Tang L, Hruban RH, Adsay V, Yang Z, Krasinskas AM, Vakiani E, La Rosa S, Jang KT, Frankel WL, Liu X, Zhang L, Giordano TJ, Bellizzi AM, Chen JH, Shi C, Allen P, Reidy DL, Wolfgang CL, Saka B, Rezaee N, Deshpande V, Klimstra DS. Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases. Am J Surg Pathol. 2014 Apr; 38(4):437-47. PMID: 24503751; PMCID: PMC3977000.
    18. Yang Z, Tang LH, Klimstra DS. Gastroenteropancreatic neuroendocrine neoplasms: historical context and current issues. Semin Diagn Pathol. 2013 Aug; 30(3):186-96. PMID: 24144288.
      View in: PubMed
    19. Lim B, Scicchitano A, Beachler C, Gusani N, Sarwani N, Yang Z, Staveley-O'Carroll K, Ashkenazi A, Portera C, El-Deiry WS. FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer. Cancer Biol Ther. 2013 Aug; 14(8):711-9. PMID: 23792567; PMCID: PMC3841210.
    20. Al-Marrawi MY, Saroya BS, Brennan MC, Yang Z, Dykes TM, El-Deiry WS. Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer. Cancer Biol Ther. 2013 Aug; 14(8):703-10. PMID: 23792568; PMCID: PMC3841209.
    21. Lamparella NE, Saroya BS, Yang Z, Sarwani NE, El-Deiry WS. Contradictory KRAS mutation test results in a patient with metastatic colon cancer: a clinical dilemma in the era of personalized medicine. Cancer Biol Ther. 2013 Aug; 14(8):699-702. PMID: 23792572; PMCID: PMC3841208.
    22. Gallant JN, Matthew EM, Cheng H, Harouaka R, Lamparella NE, Kunkel M, Yang Z, Harvey HA, Cream LV, Kumar SM, Robertson GP, Zheng S, Drabick JJ, Truica CI, El-Deiry WS. Predicting therapy response in live tumor cells isolated with the flexible micro spring array device. Cell Cycle. 2013 Jul 01; 12(13):2132-43. PMID: 23759587; PMCID: PMC3737315.
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