PSU Profiles
Last Name

Victor Ruiz-Velasco

InstitutionCollege of Medicine
DepartmentAnesthesiology and Perioperative Medicine
Address500 University Drive Hershey PA 17033
Mailbox: H187
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    Associate Vice Chairman for Basic Science Research


    Neural and Behavioral Sciences


    Ph.D., Tulane University School of Medicine
    Postdoctoral Training, University of Nevada at Reno 1995-1997
    Postdoctoral Training, Guthrie Research Institute, 1997-2002

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Carr ZJ, Van De Louw A, Fehr G, Li JD, Kunselman A, Ruiz-Velasco V. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis. BMC Res Notes. 2018 Jan 16; 11(1):41. PMID: 29338778.
      View in: PubMed
    2. Janicki PK, Eyileten C, Ruiz-Velasco V, Sedeek KA, Pordzik J, Czlonkowska A, Kurkowska-Jastrzebska I, Sugino S, Imamura-Kawasawa Y, Mirowska-Guzel D, Postula M. Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients. Int J Mol Sci. 2017 Dec 11; 18(12). PMID: 29232918.
      View in: PubMed
    3. Farrag M, Drobish JK, Puhl HL, Kim JS, Herold PB, Kaufman MP, Ruiz-Velasco V. Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. J Physiol. 2017 Dec 01; 595(23):7167-7183. PMID: 29044528.
      View in: PubMed
    4. Freet CS, Alexander DN, Imperio CG, Ruiz-Velasco V, Grigson PS. Heroin-induced suppression of saccharin intake in OPRM1 A118G mice. Brain Res Bull. 2017 Sep 20. PMID: 28939474.
      View in: PubMed
    5. Singbartl K, Miller L, Ruiz-Velasco V, Kellum JA. Reversal of Acute Kidney Injury-Induced Neutrophil Dysfunction: A Critical Role for Resistin. Crit Care Med. 2016 Jul; 44(7):e492-501. PMID: 26646460; PMCID: PMC4896858 [Available on 07/01/17].
    6. Mahmoud S, Farrag M, Ruiz-Velasco V. G?7 proteins contribute to coupling of nociceptin/orphanin FQ peptide (NOP) opioid receptors and voltage-gated Ca(2+) channels in rat stellate ganglion neurons. Neurosci Lett. 2016 Aug 03; 627:77-83. PMID: 27238748; PMCID: PMC4939115 [Available on 08/03/17].
    7. Copp SW, Kim JS, Ruiz-Velasco V, Kaufman MP. The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in rats with ligated femoral arteries. Am J Physiol Heart Circ Physiol. 2016 May 01; 310(9):H1233-41. PMID: 26921442; PMCID: PMC4867390 [Available on 05/01/17].
    8. Sugino S, Farrag M, Ruiz-Velasco V. Ga14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons. J Neurophysiol. 2016 Mar; 115(3):1577-86. PMID: 26843606; PMCID: PMC4808095 [Available on 03/01/17].
    9. Copp SW, Kim JS, Ruiz-Velasco V, Kaufman MP. The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats. J Physiol. 2016 Feb 01; 594(3):641-55. PMID: 26608396; PMCID: PMC4930067 [Available on 02/01/17].
    10. Farrag M, Laufenberg LJ, Steiner JL, Weller GE, Lang CH, Ruiz-Velasco V. Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats. PLoS One. 2015; 10(5):e0125566. PMID: 26017846; PMCID: PMC4446366.
    11. Freet CS, Ballard SM, Alexander DN, Cox TA, Imperio CG, Anosike N, Carter AB, Mahmoud S, Ruiz-Velasco V, Grigson PS. Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²? channel currents in sensory neurons of OPRM1 A118G mice. Physiol Behav. 2015 Feb; 139:216-23. PMID: 25449401; PMCID: PMC4275353.
    12. Hassan B, Kim JS, Farrag M, Kaufman MP, Ruiz-Velasco V. Alteration of the mu opioid receptor: Ca2+ channel signaling pathway in a subset of rat sensory neurons following chronic femoral artery occlusion. J Neurophysiol. 2014 Dec 15; 112(12):3104-15. PMID: 25231620; PMCID: PMC4269709.
    13. Leal AK, Yamauchi K, Kim J, Ruiz-Velasco V, Kaufman MP. Peripheral d-opioid receptors attenuate the exercise pressor reflex. Am J Physiol Heart Circ Physiol. 2013 Oct 15; 305(8):H1246-55. PMID: 23934854; PMCID: PMC3798785.
    14. Ramachandra R, Hassan B, McGrew SG, Dompor J, Farrag M, Ruiz-Velasco V, Elmslie KS. Identification of CaV channel types expressed in muscle afferent neurons. J Neurophysiol. 2013 Oct; 110(7):1535-43. PMID: 23843437; PMCID: PMC4042423.
    15. Laufenberg LJ, Weller GE, Lang CH, Ruiz-Velasco V. Nociceptin receptor signaling in sympathetic neurons from septic rats. J Surg Res. 2013 Oct; 184(2):973-80. PMID: 23608620; PMCID: PMC3728175.
    16. Yamauchi K, Kim JS, Stone AJ, Ruiz-Velasco V, Kaufman MP. Endoperoxide 4 receptors play a role in evoking the exercise pressor reflex in rats with simulated peripheral artery disease. J Physiol. 2013 Jun 01; 591(11):2949-62. PMID: 23568893; PMCID: PMC3690697.
    17. Stone AJ, Kim JS, Yamauchi K, Ruiz-Velasco V, Kaufman MP. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Neurosci Lett. 2013 May 24; 543:177-82. PMID: 23523647; PMCID: PMC3661189.
    18. Hassan B, Ruiz-Velasco V. The ?-opioid receptor agonist U-50488 blocks Ca2+ channels in a voltage- and G protein-independent manner in sensory neurons. Reg Anesth Pain Med. 2013 Jan-Feb; 38(1):21-7. PMID: 23222359; PMCID: PMC3530143.
    19. Mahmoud S, Yun JK, Ruiz-Velasco V. Gß2 and Gß4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons. J Physiol. 2012 Oct 01; 590(19):4673-89. PMID: 22711958; PMCID: PMC3487030.
    20. Mahmoud S, Thorsell A, Sommer WH, Heilig M, Holgate JK, Bartlett SE, Ruiz-Velasco V. Pharmacological consequence of the A118G µ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²? channels in humanized mouse sensory neurons. Anesthesiology. 2011 Nov; 115(5):1054-62. PMID: 21926562; PMCID: PMC3203255.
    21. Bezinover D, Ramamoorthy S, Uemura T, Kadry Z, McQuillan PM, Mets B, Falcucci O, Rannels S, Ruiz-Velasco V, Spiess B, Liang J, Mani H, Lou X, Janicki PK. Use of a third-generation perfluorocarbon for preservation of rat DCD liver grafts. J Surg Res. 2012 Jun 01; 175(1):131-7. PMID: 21543088.
      View in: PubMed
    22. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M. A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry. 2011 Aug; 16(8):809-17. PMID: 20479755; PMCID: PMC2925052.
    23. Mahmoud S, Margas W, Trapella C, Caló G, Ruiz-Velasco V. Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. Mol Pharmacol. 2010 May; 77(5):804-17. PMID: 20159949; PMCID: PMC2872970.
    24. Margas W, Mahmoud S, Ruiz-Velasco V. Muscarinic acetylcholine receptor modulation of mu (mu) opioid receptors in adult rat sphenopalatine ganglion neurons. J Neurophysiol. 2010 Jan; 103(1):172-82. PMID: 19889856; PMCID: PMC2807216.
    25. Kester M, Heakal Y, Fox T, Sharma A, Robertson GP, Morgan TT, Altinoglu EI, Tabakovic A, Parette MR, Rouse SM, Ruiz-Velasco V, Adair JH. Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells. Nano Lett. 2008 Dec; 8(12):4116-21. PMID: 19367878; PMCID: PMC3735173.
    26. Margas W, Sedeek K, Ruiz-Velasco V. Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA. J Neurophysiol. 2008 Sep; 100(3):1420-32. PMID: 18562551; PMCID: PMC2544458.
    27. Margas W, Ruiz-Velasco V. Electrophysiological and immunofluorescence characterization of Ca(2+) channels of acutely isolated rat sphenopalatine ganglion neurons. Neurosci Lett. 2007 Jun 04; 419(3):207-12. PMID: 17507162; PMCID: PMC1945817.
    28. Margas W, Zubkoff I, Schuler HG, Janicki PK, Ruiz-Velasco V. Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism. J Neurophysiol. 2007 Feb; 97(2):1058-67. PMID: 17151221.
      View in: PubMed
    29. Janicki PK, Schuler G, Francis D, Bohr A, Gordin V, Jarzembowski T, Ruiz-Velasco V, Mets B. A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain. Anesth Analg. 2006 Oct; 103(4):1011-7. PMID: 17000822.
      View in: PubMed
    30. Yang Q, Sumner AD, Puhl HL, Ruiz-Velasco V. M(1) and M(2) muscarinic acetylcholine receptor subtypes mediate Ca(2+) channel current inhibition in rat sympathetic stellate ganglion neurons. J Neurophysiol. 2006 Nov; 96(5):2479-87. PMID: 17005606.
      View in: PubMed
    31. Ruiz-Velasco V, Puhl HL, Fuller BC, Sumner AD. Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle. J Pharmacol Exp Ther. 2005 Sep; 314(3):987-94. PMID: 15937148.
      View in: PubMed
    32. Fuller BC, Sumner AD, Kutzler MA, Ruiz-Velasco V. A novel approach employing ultrasound guidance for percutaneous cardiac muscle injection to retrograde label rat stellate ganglion neurons. Neurosci Lett. 2004 Jun 17; 363(3):252-6. PMID: 15182954.
      View in: PubMed
    33. Ruiz-Velasco V, Ikeda SR. A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels. Physiol Genomics. 2003 Apr 16; 13(2):85-95. PMID: 12595577.
      View in: PubMed
    34. Ruiz-Velasco V, Ikeda SR, Puhl HL. Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit. Physiol Genomics. 2002 Feb 11; 8(1):41-50. PMID: 11842130.
      View in: PubMed
    35. Ruiz-Velasco V, Ikeda SR. Functional expression and FRET analysis of green fluorescent proteins fused to G-protein subunits in rat sympathetic neurons. J Physiol. 2001 Dec 15; 537(Pt 3):679-92. PMID: 11744747; PMCID: PMC2278994.
    36. Kammermeier PJ, Ruiz-Velasco V, Ikeda SR. A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma. J Neurosci. 2000 Aug 01; 20(15):5623-9. PMID: 10908599.
      View in: PubMed
    37. Ruiz-Velasco V, Ikeda SR. Multiple G-protein betagamma combinations produce voltage-dependent inhibition of N-type calcium channels in rat superior cervical ganglion neurons. J Neurosci. 2000 Mar 15; 20(6):2183-91. PMID: 10704493.
      View in: PubMed
    38. Ikeda SR, Jeong SW, Kammermeier PJ, Ruiz-Velasco V, King MM. Heterologous expression of a green fluorescent protein-pertussis toxin S1 subunit fusion construct disrupts calcium channel modulation in rat superior cervical ganglion neurons. Neurosci Lett. 1999 Aug 27; 271(3):163-6. PMID: 10507694.
      View in: PubMed
    39. Ruiz-Velasco V, Ikeda SR. Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons. J Physiol. 1998 Dec 15; 513 ( Pt 3):761-73. PMID: 9824716; PMCID: PMC2231322.
    40. Ruiz-Velasco V, Zhong J, Hume JR, Keef KD. Modulation of Ca2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein. Circ Res. 1998 Mar 23; 82(5):557-65. PMID: 9529160.
      View in: PubMed
    41. Ruiz-Velasco V, Mayer MB, Hymel LJ. Dihydropyridine-sensitive Ca2+ influx modulated by stretch in A7r5 vascular smooth muscle cells. Eur J Pharmacol. 1996 Feb 05; 296(3):327-34. PMID: 8904085.
      View in: PubMed
    42. Ruiz-Velasco V, Mayer MB, Inscho EW, Hymel LJ. Modulation of dihydropyridine receptors in vascular smooth muscle cells by membrane potential and cell proliferation. Eur J Pharmacol. 1994 Aug 16; 268(3):311-8. PMID: 7805757.
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    43. Fritz KL, Nelson TL, Ruiz-Velasco V, Mercurio SD. Acute intramuscular injection of oils or the oleic acid component protects mice against paraquat lethality. J Nutr. 1994 Mar; 124(3):425-9. PMID: 8120662.
      View in: PubMed
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