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Urs Leuenberger

TitleProfessor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Phone7175316853

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Professor of Medicine

EDUCATION:

M.D., University of Bern Medical School, 1977
Residency, Penn State Milton S. Hershey Medical Center
Fellowship, Penn State Milton S. Hershey Medical Center




 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ross AJ, Gao Z, Pollock JP, Leuenberger UA, Sinoway LI, Muller MD. ß-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1497-503.
    View in: PubMed
  2. Pollock JP, Patel HM, Randolph BJ, Heffernan MJ, Leuenberger UA, Muller MD. Ascorbic acid does not enhance hypoxia-induced vasodilation in healthy older men. Physiol Rep. 2014 Jul 1; 2(7).
    View in: PubMed
  3. Muller MD, Gao Z, McQuillan PM, Leuenberger UA, Sinoway LI. Coronary responses to cold air inhalation following afferent and efferent blockade. Am J Physiol Heart Circ Physiol. 2014 Jul 15; 307(2):H228-35.
    View in: PubMed
  4. Li S, Koerner MM, El-Banayosy A, Soleimani B, Pae WE, Leuenberger UA. Takotsubo's syndrome after mitral valve repair and rescue with extracorporeal membrane oxygenation. Ann Thorac Surg. 2014 May; 97(5):1777-8.
    View in: PubMed
  5. Solaiman AZ, Feehan RP, Chabitnoy AM, Leuenberger UA, Monahan KD. Ventilatory responses to chemoreflex stimulation are not enhanced by angiotensin II in healthy humans. Auton Neurosci. 2014 Jul; 183:72-9.
    View in: PubMed
  6. Muller MD, Gao Z, Patel HM, Heffernan MJ, Leuenberger UA, Sinoway LI. ß-Adrenergic blockade enhances coronary vasoconstrictor response to forehead cooling. Am J Physiol Heart Circ Physiol. 2014 Mar; 306(6):H910-7.
    View in: PubMed
  7. Gao Z, Muller MD, Sinoway LI, Leuenberger UA. Intravenous phentolamine abolishes coronary vasoconstriction in response to mild central hypovolemia. J Appl Physiol (1985). 2014 Jan 15; 116(2):216-21.
    View in: PubMed
  8. Spilk S, Herr MD, Sinoway LI, Leuenberger UA. Endothelium-derived hyperpolarizing factor contributes to hypoxia-induced skeletal muscle vasodilation in humans. Am J Physiol Heart Circ Physiol. 2013 Dec 1; 305(11):H1639-45.
    View in: PubMed
  9. Muller MD, Reed AB, Leuenberger UA, Sinoway LI. Physiology in medicine: peripheral arterial disease. J Appl Physiol (1985). 2013 Nov 1; 115(9):1219-26.
    View in: PubMed
  10. Puyana JC, Pinsky M, Leuenberger U, Berkow J. Model-based prediction of autoregulatory exhaustion in response to lower-body negative pressure-induced shock. J Trauma Acute Care Surg. 2013 Aug; 75(2 Suppl 2):S190-6.
    View in: PubMed
  11. Gao Z, Novick M, Muller MD, Williams RJ, Spilk S, Leuenberger UA, Sinoway LI. Exercise and diet-induced weight loss attenuates oxidative stress related-coronary vasoconstriction in obese adolescents. Eur J Appl Physiol. 2013 Feb; 113(2):519-28.
    View in: PubMed
  12. Muller MD, Gao Z, Mast JL, Blaha CA, Drew RC, Leuenberger UA, Sinoway LI. Aging attenuates the coronary blood flow response to cold air breathing and isometric handgrip in healthy humans. Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8):H1737-46.
    View in: PubMed
  13. Muller MD, Gao Z, Drew RC, Herr MD, Leuenberger UA, Sinoway LI. Effect of cold air inhalation and isometric exercise on coronary blood flow and myocardial function in humans. J Appl Physiol (1985). 2011 Dec; 111(6):1694-702.
    View in: PubMed
  14. Cui J, Leuenberger UA, Gao Z, Sinoway LI. Sympathetic and cardiovascular responses to venous distension in an occluded limb. Am J Physiol Regul Integr Comp Physiol. 2011 Dec; 301(6):R1831-7.
    View in: PubMed
  15. Gao Z, Spilk S, Momen A, Muller MD, Leuenberger UA, Sinoway LI. Vitamin C prevents hyperoxia-mediated coronary vasoconstriction and impairment of myocardial function in healthy subjects. Eur J Appl Physiol. 2012 Feb; 112(2):483-92.
    View in: PubMed
  16. Krishnan A, Lucassen EB, Hogeman C, Blaha C, Leuenberger UA. Effects of limb posture on reactive hyperemia. Eur J Appl Physiol. 2011 Jul; 111(7):1415-20.
    View in: PubMed
  17. Cui J, Leuenberger UA, Blaha C, King NC, Sinoway LI. Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans. J Physiol. 2011 Feb 1; 589(Pt 3):685-95.
    View in: PubMed
  18. Momen A, Gao Z, Cohen A, Khan T, Leuenberger UA, Sinoway LI. Coronary vasoconstrictor responses are attenuated in young women as compared with age-matched men. J Physiol. 2010 Oct 15; 588(Pt 20):4007-16.
    View in: PubMed
  19. Leuenberger UA. The muscle metaboreflex: reining in the heart? J Appl Physiol (1985). 2010 Aug; 109(2):263-4.
    View in: PubMed
  20. Cui J, Leuenberger UA, Blaha C, Yoder J, Gao Z, Sinoway LI. Local adenosine receptor blockade accentuates the sympathetic responses to fatiguing exercise. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2130-7.
    View in: PubMed
  21. Moradkhan R, Spitnale B, McQuillan P, Hogeman C, Gray KS, Leuenberger UA. Hypoxia-induced vasodilation and effects of regional phentolamine in awake patients with sleep apnea. J Appl Physiol (1985). 2010 May; 108(5):1234-40.
    View in: PubMed
  22. Herr MD, Hogeman CS, Koch DW, Krishnan A, Momen A, Leuenberger UA. A real-time device for converting Doppler ultrasound audio signals into fluid flow velocity. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1626-32.
    View in: PubMed
  23. Momen A, Kozak M, Leuenberger UA, Ettinger S, Blaha C, Mascarenhas V, Lendel V, Herr MD, Sinoway LI. Transthoracic Doppler echocardiography to noninvasively assess coronary vasoconstrictor and dilator responses in humans. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H524-9.
    View in: PubMed
  24. Momen A, Mascarenhas V, Gahremanpour A, Gao Z, Moradkhan R, Kunselman A, Boehmer JP, Sinoway LI, Leuenberger UA. Coronary blood flow responses to physiological stress in humans. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H854-61.
    View in: PubMed
  25. Lydakis C, Momen A, Blaha C, Gugoff S, Gray K, Herr M, Leuenberger UA, Sinoway LI. Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise. J Hum Hypertens. 2008 May; 22(5):320-8.
    View in: PubMed
  26. Lydakis C, Momen A, Blaha C, Herr M, Leuenberger UA, Sinoway LI. Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure. Eur J Appl Physiol. 2008 Apr; 102(6):633-41.
    View in: PubMed
  27. Leuenberger UA, Johnson D, Loomis J, Gray KS, MacLean DA. Venous but not skeletal muscle interstitial nitric oxide is increased during hypobaric hypoxia. Eur J Appl Physiol. 2008 Mar; 102(4):457-61.
    View in: PubMed
  28. Moradkhan R, McQuillan P, Hogeman C, Leuenberger A, Linton-Frazier L, Leuenberger UA. Metabolic forearm vasodilation is enhanced following Bier block with phentolamine. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2289-95.
    View in: PubMed
  29. Wilson TE, Sauder CL, Kearney ML, Kuipers NT, Leuenberger UA, Monahan KD, Ray CA. Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans. J Appl Physiol (1985). 2007 Oct; 103(4):1257-62.
    View in: PubMed
  30. Leuenberger UA, Hogeman CS, Quraishi SA, Quraishi S, Linton-Frazier L, Gray KS. Short-term intermittent hypoxia enhances sympathetic responses to continuous hypoxia in humans. J Appl Physiol (1985). 2007 Sep; 103(3):835-42.
    View in: PubMed
  31. Imadojemu VA, Mawji Z, Kunselman A, Gray KS, Hogeman CS, Leuenberger UA. Sympathetic chemoreflex responses in obstructive sleep apnea and effects of continuous positive airway pressure therapy. Chest. 2007 May; 131(5):1406-13.
    View in: PubMed
  32. Momen A, Gahremanpour A, Mansoor A, Kunselman A, Blaha C, Pae W, Leuenberger UA, Sinoway LI. Vasoconstriction seen in coronary bypass grafts during handgrip in humans. J Appl Physiol (1985). 2007 Feb; 102(2):735-9.
    View in: PubMed
  33. Monahan KD, Leuenberger UA, Ray CA. Aldosterone impairs baroreflex sensitivity in healthy adults. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H190-7.
    View in: PubMed
  34. Monahan KD, Leuenberger UA, Ray CA. Effect of repetitive hypoxic apnoeas on baroreflex function in humans. J Physiol. 2006 Jul 15; 574(Pt 2):605-13.
    View in: PubMed
  35. Momen A, Thomas K, Blaha C, Gahremanpour A, Mansoor A, Leuenberger UA, Sinoway LI. Renal vasoconstrictor responses to static exercise during orthostatic stress in humans: effects of the muscle mechano- and the baroreflexes. J Physiol. 2006 Jun 15; 573(Pt 3):819-25.
    View in: PubMed
  36. Momen A, Handly B, Kunselman A, Leuenberger UA, Sinoway LI. Influence of sex and active muscle mass on renal vascular responses during static exercise. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H121-6.
    View in: PubMed
  37. Leuenberger UA, Brubaker D, Quraishi S, Hogeman CS, Imadojemu VA, Gray KS. Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans. Auton Neurosci. 2005 Aug 31; 121(1-2):87-93.
    View in: PubMed
  38. Momen A, Bower D, Leuenberger UA, Boehmer J, Lerner S, Alfrey EJ, Handly B, Sinoway LI. Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1770-6.
    View in: PubMed
  39. Newcomer SC, Leuenberger UA, Hogeman CS, Proctor DN. Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H308-15.
    View in: PubMed
  40. Momen A, Bower D, Boehmer J, Kunselman AR, Leuenberger UA, Sinoway LI. Renal blood flow in heart failure patients during exercise. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2834-9.
    View in: PubMed
  41. Proctor DN, Koch DW, Newcomer SC, Le KU, Smithmyer SL, Leuenberger UA. Leg blood flow and VO2 during peak cycle exercise in younger and older women. Med Sci Sports Exerc. 2004 Apr; 36(4):623-31.
    View in: PubMed
  42. Momen A, Leuenberger UA, Handly B, Sinoway LI. Effect of aging on renal blood flow velocity during static exercise. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H735-40.
    View in: PubMed
  43. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN. Different vasodilator responses of human arms and legs. J Physiol. 2004 May 1; 556(Pt 3):1001-11.
    View in: PubMed
  44. Imadojemu VA, Sinoway LI, Leuenberger UA. Vascular dysfunction in sleep apnea: a reversible link to cardiovascular disease? Am J Respir Crit Care Med. 2004 Feb 1; 169(3):328-9.
    View in: PubMed
  45. Leuenberger UA, Mostoufi-Moab S, Herr M, Gray K, Kunselman A, Sinoway LI. Control of skin sympathetic nerve activity during intermittent static handgrip exercise. Circulation. 2003 Nov 11; 108(19):2329-35.
    View in: PubMed
  46. Proctor DN, Koch DW, Newcomer SC, Le KU, Leuenberger UA. Impaired leg vasodilation during dynamic exercise in healthy older women. J Appl Physiol (1985). 2003 Nov; 95(5):1963-70.
    View in: PubMed
  47. Koch DW, Leuenberger UA, Proctor DN. Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation. J Physiol. 2003 Aug 15; 551(Pt 1):337-44.
    View in: PubMed
  48. Momen A, Leuenberger UA, Ray CA, Cha S, Handly B, Sinoway LI. Renal vascular responses to static handgrip: role of muscle mechanoreflex. Am J Physiol Heart Circ Physiol. 2003 Sep; 285(3):H1247-53.
    View in: PubMed
  49. Proctor DN, Newcomer SC, Koch DW, Le KU, MacLean DA, Leuenberger UA. Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men. J Appl Physiol (1985). 2003 May; 94(5):1859-69.
    View in: PubMed
  50. Khan MH, Kunselman AR, Leuenberger UA, Davidson WR, Ray CA, Gray KS, Hogeman CS, Sinoway LI. Attenuated sympathetic nerve responses after 24 hours of bed rest. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2210-5.
    View in: PubMed
  51. Imadojemu VA, Gleeson K, Quraishi SA, Kunselman AR, Sinoway LI, Leuenberger UA. Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med. 2002 Apr 1; 165(7):950-3.
    View in: PubMed
  52. Imadojemu VA, Gleeson K, Gray KS, Sinoway LI, Leuenberger UA. Obstructive apnea during sleep is associated with peripheral vasoconstriction. Am J Respir Crit Care Med. 2002 Jan 1; 165(1):61-6.
    View in: PubMed
  53. Leuenberger UA, Hardy JC, Herr MD, Gray KS, Sinoway LI. Hypoxia augments apnea-induced peripheral vasoconstriction in humans. J Appl Physiol (1985). 2001 Apr; 90(4):1516-22.
    View in: PubMed
  54. Mostoufi-Moab S, Herr MD, Silber DH, Gray KS, Leuenberger UA, Sinoway LI. Limb congestion enhances the synchronization of sympathetic outflow with muscle contraction. Am J Physiol Regul Integr Comp Physiol. 2000 Aug; 279(2):R478-83.
    View in: PubMed
  55. Silber DH, Sinoway LI, Leuenberger UA, Amassian VE. Magnetic stimulation of the human motor cortex evokes skin sympathetic nerve activity. J Appl Physiol (1985). 2000 Jan; 88(1):126-34.
    View in: PubMed
  56. Leuenberger UA, Gray K, Herr MD. Adenosine contributes to hypoxia-induced forearm vasodilation in humans. J Appl Physiol (1985). 1999 Dec; 87(6):2218-24.
    View in: PubMed
  57. MacLean DA, Sinoway LI, Leuenberger U. Systemic hypoxia elevates skeletal muscle interstitial adenosine levels in humans. Circulation. 1998 Nov 10; 98(19):1990-2.
    View in: PubMed
  58. Kasravi B, Boehmer JP, Leuenberger UA. A noninvasive method for estimating cardiac output using lung to finger circulation time of oxygen. Am J Cardiol. 1998 Oct 1; 82(7):915-7.
    View in: PubMed
  59. Fritsch-Yelle JM, Leuenberger UA, D'Aunno DS, Rossum AC, Brown TE, Wood ML, Josephson ME, Goldberger AL. An episode of ventricular tachycardia during long-duration spaceflight. Am J Cardiol. 1998 Jun 1; 81(11):1391-2.
    View in: PubMed
  60. Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol (1985). 1998 May; 84(5):1551-9.
    View in: PubMed
  61. Sturtz CL, Abt AB, Leuenberger UA, Damiano R. Hamartoma of mature cardiac myocytes: a case report. Mod Pathol. 1998 May; 11(5):496-9.
    View in: PubMed
  62. Shoemaker JK, Hogeman CS, Leuenberger UA, Herr MD, Gray K, Silber DH, Sinoway LI. Sympathetic discharge and vascular resistance after bed rest. J Appl Physiol (1985). 1998 Feb; 84(2):612-7.
    View in: PubMed
  63. Sinoway L, Shenberger J, Leaman G, Zelis R, Gray K, Baily R, Leuenberger U. Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. J Appl Physiol (1985). 1996 Oct; 81(4):1778-84.
    View in: PubMed
  64. Leuenberger U, Gaul L, Noack H, Gubin S, Zelis R. Angiotensin-converting enzyme inhibition and the norepinephrine spillover response to dynamic exercise. J Appl Physiol (1985). 1996 Sep; 81(3):1138-42.
    View in: PubMed
  65. Luck JC, Hoover RJ, Biederman RW, Ettinger SM, Sinoway LI, Leuenberger UA. Observations on carotid sinus hypersensitivity from direct intraneural recordings of sympathetic nerve traffic. Am J Cardiol. 1996 Jun 15; 77(15):1362-5.
    View in: PubMed
  66. Waradekar NV, Sinoway LI, Zwillich CW, Leuenberger UA. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med. 1996 Apr; 153(4 Pt 1):1333-8.
    View in: PubMed
  67. Haque WA, Boehmer J, Clemson BS, Leuenberger UA, Silber DH, Sinoway LI. Hemodynamic effects of supplemental oxygen administration in congestive heart failure. J Am Coll Cardiol. 1996 Feb; 27(2):353-7.
    View in: PubMed
  68. Leuenberger U, Jacob E, Sweer L, Waravdekar N, Zwillich C, Sinoway L. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol (1985). 1995 Aug; 79(2):581-8.
    View in: PubMed
  69. Stylos L, Parilak L, Green MH, Leuenberger U, Zelis R. Compartmental analysis of norepinephrine kinetics in congestive heart failure. Am J Cardiol. 1995 Feb 1; 75(4):299-301.
    View in: PubMed
  70. Hardy JC, Gray K, Whisler S, Leuenberger U. Sympathetic and blood pressure responses to voluntary apnea are augmented by hypoxemia. J Appl Physiol (1985). 1994 Nov; 77(5):2360-5.
    View in: PubMed
  71. Sinoway LI, Smith MB, Enders B, Leuenberger U, Dzwonczyk T, Gray K, Whisler S, Moore RL. Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol. 1994 Aug; 267(2 Pt 2):H770-8.
    View in: PubMed
  72. Batman BA, Hardy JC, Leuenberger UA, Smith MB, Yang QX, Sinoway LI. Sympathetic nerve activity during prolonged rhythmic forearm exercise. J Appl Physiol (1985). 1994 Mar; 76(3):1077-81.
    View in: PubMed
  73. Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol (1985). 1993 Aug; 75(2):668-74.
    View in: PubMed
  74. Leuenberger U, Kenney G, Davis D, Clemson B, Zelis R. Comparison of norepinephrine and isoproterenol clearance in congestive heart failure. Am J Physiol. 1992 Jul; 263(1 Pt 2):H56-60.
    View in: PubMed
  75. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, Sinoway L. Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1659-64.
    View in: PubMed
  76. Zelis R, Sinoway LI, Leuenberger U, Clemson BS, Davis D. Time-constant adaptations in heart failure. Eur Heart J. 1991 Aug; 12 Suppl C:2-7.
    View in: PubMed
  77. Baily RG, Leuenberger U, Leaman G, Silber D, Sinoway LI. Norepinephrine kinetics and cardiac output during nonhypotensive lower body negative pressure. Am J Physiol. 1991 May; 260(5 Pt 2):H1708-12.
    View in: PubMed
  78. Goldhirsch A, Joss RA, Leuenberger U, Cavalli F, Ryssel HJ, Brunner KW. An evaluation of tamoxifen dose escalation in advanced breast cancer. Am J Clin Oncol. 1982 Oct; 5(5):501-3.
    View in: PubMed
  79. Goldhirsch A, Leuenberger U, Ryssel HJ, Cavalli F, Sonntag RW, Joss RA, Brunner KW. Combination hormonotherapy with tamoxifen and fluoxymesterone in patients with advanced breast cancer relapsing on hormonotherapy. Oncology. 1982; 39(5):284-6.
    View in: PubMed
  80. Goldhirsch A, Leuenberger U, Cavalli F. [Hormone receptors and breast cancer]. Gynakol Rundsch. 1981; 21(1):18-23.
    View in: PubMed
  81. Salzmann C, Althaus U, Hugentobler B, Leuenberger U, Merki H. [Surgery of mitral valve stenosis: open or closed commissurotomy?]. Schweiz Med Wochenschr. 1976 Nov 6; 106(45):1579-83.
    View in: PubMed
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