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Thyagarajan Subramanian

TitleProfessor
InstitutionCollege of Medicine
DepartmentNeurology
Address500 University Drive Hershey PA 17033
Phone7175311804

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Neurology and Neural and Behavioral Sciences
Director, Central PA APDA Referral and Information Center

Preferred email: tsubram@yahoo.com

EDUCATION:

Fellowship, Neurology, Emory University Hospital (1997)
Residency, Neurology, University of Pittsburgh Medical Center Presbyterian (1994)
Internship, Medicine, Shadyside Hospital/UPMC (1991)
M.B., B.S., University of Calicut (1985)



 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit. JAMA Neurol. 2014 Mar 24.
    View in: PubMed
  2. Lieu CA, Venkiteswaran K, Gilmour TP, Rao AN, Petticoffer AC, Gilbert EV, Deogaonkar M, Manyam BV, Subramanian T. The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate. Evid Based Complement Alternat Med. 2012; 2012:840247.
    View in: PubMed
  3. Piquet AL, Venkiteswaran K, Marupudi NI, Berk M, Subramanian T. The immunological challenges of cell transplantation for the treatment of Parkinson's disease. Brain Res Bull. 2012 Jul 1; 88(4):320-31.
    View in: PubMed
  4. Gilmour TP, Subramanian T, Lagoa C, Jenkins WK. Multiscale autoregressive identification of neuroelectrophysiological systems. Comput Math Methods Med. 2012; 2012:580795.
    View in: PubMed
  5. Roopnariane, CA., Ryu, Y-C., Tofighi, M-R, Miller, PA., Oh, S., Wang, J., Park, BS, Ansel, L., Lieu, CA., Subramanian, T., Yang, QX., Collins, CM. . Concepts in Magnetic Resonance Part B (Magnetic Resonance Engineering). Quadrature RF coil for in vivo brain MRI of a macaque monkey in a stereotaxic head frame. 2012; (41B):22-27.
  6. Lieu CA, Subramanian T. The interhemispheric connections of the striatum: Implications for Parkinson's disease and drug-induced dyskinesias. Brain Res Bull. 2012 Jan 4; 87(1):1-9.
    View in: PubMed
  7. Gilmour TP, Piallat B, Lieu CA, Venkiteswaran K, Ramachandra R, Rao AN, Petticoffer AC, Berk MA, Subramanian T. The effect of striatal dopaminergic grafts on the neuronal activity in the substantia nigra pars reticulata and subthalamic nucleus in hemiparkinsonian rats. Brain. 2011 Nov; 134(Pt 11):3276-89.
    View in: PubMed
  8. Schwarzschild MA, Marek K, Eberly S, Oakes D, Shoulson I, Jennings D, Seibyl J, Ascherio A. Serum urate and probability of dopaminergic deficit in early "Parkinson's disease". Mov Disord. 2011 Aug 15; 26(10):1864-8.
    View in: PubMed
  9. Subramanian T. A small light at the end of a long tunnel: long-term magnetic resonance imaging of stem cells in neonatal ischemic injury. Ann Neurol. 2011 Feb; 69(2):232-3.
    View in: PubMed
  10. Marras C, McDermott MP, Marek K, Rochon P, Naglie G, Tanner CM, Rudolph A, Shoulson I, Lang AE. Predictors of time to requiring dopaminergic treatment in 2 Parkinson's disease cohorts. Mov Disord. 2011 Mar; 26(4):608-13.
    View in: PubMed
  11. Gilmour TP, Subramanian T. Three-dimensional reconstruction of transcranial ultrasound images obtained through the temporal bone window using a helmet-mounted mechanical beam-steering device. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:413-6.
    View in: PubMed
  12. Gilmour TP, Subramanian T. Multiscale autoregressive identification of neuro-electrophysiological systems. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:7071-4.
    View in: PubMed
  13. Gilmour TP, Lieu CA, Nolt MJ, Piallat B, Deogaonkar M, Subramanian T. The effects of chronic levodopa treatments on the neuronal firing properties of the subthalamic nucleus and substantia nigra reticulata in hemiparkinsonian rhesus monkeys. Exp Neurol. 2011 Mar; 228(1):53-8.
    View in: PubMed
  14. Lieu CA, Deogaonkar M, Bakay RA, Subramanian T. Dyskinesias do not develop after chronic intermittent levodopa therapy in clinically hemiparkinsonian rhesus monkeys. Parkinsonism Relat Disord. 2011 Jan; 17(1):34-9.
    View in: PubMed
  15. Kieburtz K. Twice-daily, low-dose pramipexole in early Parkinson's disease: a randomized, placebo-controlled trial. Mov Disord. 2011 Jan; 26(1):37-44.
    View in: PubMed
  16. Schwid SR, Bausch J, Oakes D, Schuchter L, Tanner C, Forrest M, Lang AE, Shoulson I. Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease. Mov Disord. 2010 Sep 15; 25(12):1801-8.
    View in: PubMed
  17. Lieu CA, Kunselman AR, Manyam BV, Venkiteswaran K, Subramanian T. A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias. Parkinsonism Relat Disord. 2010 Aug; 16(7):458-65.
    View in: PubMed
  18. Abbi KK, Rizvi SM, Sivik J, Thyagarajan S, Loughran T, Drabick JJ. Guillain-Barré syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. Leuk Res. 2010 Jul; 34(7):e154-6.
    View in: PubMed
  19. Subramanian T, Lieu CA, Guttalu K, Berg D. Detection of MPTP-induced substantia nigra hyperechogenicity in Rhesus monkeys by transcranial ultrasound. Ultrasound Med Biol. 2010 Apr; 36(4):604-9.
    View in: PubMed
  20. Marras C, Lang AE, Eberly SW, Oakes D, Fahn S, Schwid SR, Hyson C, Shoulson I. A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts. Mov Disord. 2009 Dec 15; 24(16):2370-8.
    View in: PubMed
  21. Gilmour TP, Fang J, Guan Z, Subramanian T. Manual rat sleep classification in principal component space. Neurosci Lett. 2010 Jan 18; 469(1):97-101.
    View in: PubMed
  22. Ravina B, Tanner C, Dieuliis D, Eberly S, Flagg E, Galpern WR, Fahn S, Goetz CG, Grate S, Kurlan R, Lang AE, Marek K, Kieburtz K, Oakes D, Elliott R, Shoulson I. A longitudinal program for biomarker development in Parkinson's disease: a feasibility study. Mov Disord. 2009 Oct 30; 24(14):2081-90.
    View in: PubMed
  23. Brin MF, Comella CL, Jankovic J, Lai F, Naumann M. Long-term treatment with botulinum toxin type A in cervical dystonia has low immunogenicity by mouse protection assay. Mov Disord. 2008 Jul 30; 23(10):1353-60.
    View in: PubMed
  24. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol. 2008 Jun; 65(6):716-23.
    View in: PubMed
  25. Ivanhoe CB, Francisco GE, McGuire JR, Subramanian T, Grissom SP. Intrathecal baclofen management of poststroke spastic hypertonia: implications for function and quality of life. Arch Phys Med Rehabil. 2006 Nov; 87(11):1509-15.
    View in: PubMed
  26. Goetz CG, Schwid SR, Eberly SW, Oakes D, Shoulson I. Safety of rasagiline in elderly patients with Parkinson disease. Neurology. 2006 May 9; 66(9):1427-9.
    View in: PubMed
  27. Zhao Z, Krishnaney A, Teng Q, Yang J, Garrity-Moses M, Liu JK, Venkiteswaran K, Subramanian T, Davis M, Boulis NM. Anatomically discrete functional effects of adenoviral clostridial light chain gene-based synaptic inhibition in the midbrain. Gene Ther. 2006 Jun; 13(12):942-52.
    View in: PubMed
  28. Stover NP, Bakay RA, Subramanian T, Raiser CD, Cornfeldt ML, Schweikert AW, Allen RC, Watts RL. Intrastriatal implantation of human retinal pigment epithelial cells attached to microcarriers in advanced Parkinson disease. Arch Neurol. 2005 Dec; 62(12):1833-7.
    View in: PubMed
  29. Deogaonkar M, Heers M, Mahajan S, Brummer M, Subramanian T. Method of construction of a MRI-based tabular database of 3D stereotaxic co-ordinates for individual structures in the basal ganglia of Macaca mulatta. J Neurosci Methods. 2005 Dec 15; 149(2):154-63.
    View in: PubMed
  30. Tousi B, Subramanian T. The effect of levetiracetam on levodopa induced dyskinesia in patients with Parkinson's disease. Parkinsonism Relat Disord. 2005 Aug; 11(5):333-4.
    View in: PubMed
  31. Deogaonkar M, Subramanian T. Pathophysiological basis of drug-induced dyskinesias in Parkinson's disease. Brain Res Brain Res Rev. 2005 Dec 1; 50(1):156-68.
    View in: PubMed
  32. Subramanian T, Deogaonkar M, Brummer M, Bakay R. MRI guidance improves accuracy of stereotaxic targeting for cell transplantation in parkinsonian monkeys. Exp Neurol. 2005 May; 193(1):172-80.
    View in: PubMed
  33. A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: the PRESTO study. Arch Neurol. 2005 Feb; 62(2):241-8.
    View in: PubMed
  34. Tousi B, Schuele SU, Subramanian T. A 46-year-old woman with rigidity and frequent falls. Cleve Clin J Med. 2005 Jan; 72(1):57-63.
    View in: PubMed
  35. Tousi B, Perumal JS, Ahuja K, Ahmed A, Subramanian T. Effects of botulinum toxin-B (BTX-B) injections for hemifacial spasm. Parkinsonism Relat Disord. 2004 Oct; 10(7):455-6.
    View in: PubMed
  36. Bakay RA, Raiser CD, Stover NP, Subramanian T, Cornfeldt ML, Schweikert AW, Allen RC, Watts R. Implantation of Spheramine in advanced Parkinson's disease (PD). Front Biosci. 2004 Jan 1; 9:592-602.
    View in: PubMed
  37. Watts RL, Raiser CD, Stover NP, Cornfeldt ML, Schweikert AW, Allen RC, Subramanian T, Doudet D, Honey CR, Bakay RA. Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson's disease. J Neural Transm Suppl. 2003; (65):215-27.
    View in: PubMed
  38. Brashear A, Gordon MF, Elovic E, Kassicieh VD, Marciniak C, Do M, Lee CH, Jenkins S, Turkel C. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke. N Engl J Med. 2002 Aug 8; 347(6):395-400.
    View in: PubMed
  39. Subramanian T, Marchionini D, Potter EM, Cornfeldt ML. Striatal xenotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response. Cell Transplant. 2002; 11(3):207-14.
    View in: PubMed
  40. Okun MS, Stover NP, Subramanian T, Gearing M, Wainer BH, Holder CA, Watts RL, Juncos JL, Freeman A, Evatt ML, Schuele SU, Vitek JL, DeLong MR. Complications of gamma knife surgery for Parkinson disease. Arch Neurol. 2001 Dec; 58(12):1995-2002.
    View in: PubMed
  41. Fowler KA, Huerkamp MJ, Pullium JK, Subramanian T. Anesthetic protocol: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application. Brain Res Brain Res Protoc. 2001 Jun; 7(2):87-93.
    View in: PubMed
  42. Subramanian T. Cell transplantation for the treatment of Parkinson's disease. Semin Neurol. 2001; 21(1):103-15.
    View in: PubMed
  43. Starr PA, Subramanian T, Bakay RA, Wichmann T. Electrophysiological localization of the substantia nigra in the parkinsonian nonhuman primate. J Neurosurg. 2000 Oct; 93(4):704-10.
    View in: PubMed
  44. Kellstein DE, Lipton RB, Geetha R, Koronkiewicz K, Evans FT, Stewart WF, Wilkes K, Furey SA, Subramanian T, Cooper SA. Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study. Cephalalgia. 2000 May; 20(4):233-43.
    View in: PubMed
  45. Xing D, Chen P, Keil R, Kilts CD, Shi B, Camp VM, Malveaux G, Ely T, Owens MJ, Votaw J, Davis M, Hoffman JM, BaKay RA, Subramanian T, Watts RL, Goodman MM. Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography. J Med Chem. 2000 Feb 24; 43(4):639-48.
    View in: PubMed
  46. Wichmann T, Bergman H, Starr PA, Subramanian T, Watts RL, DeLong MR. Comparison of MPTP-induced changes in spontaneous neuronal discharge in the internal pallidal segment and in the substantia nigra pars reticulata in primates. Exp Brain Res. 1999 Apr; 125(4):397-409.
    View in: PubMed
  47. Watts RL, Subramanian T, Freeman A, Goetz CG, Penn RD, Stebbins GT, Kordower JH, Bakay RA. Effect of stereotaxic intrastriatal cografts of autologous adrenal medulla and peripheral nerve in Parkinson's disease: two-year follow-up study. Exp Neurol. 1997 Oct; 147(2):510-7.
    View in: PubMed
  48. Subramanian T, Emerich DF, Bakay RA, Hoffman JM, Goodman MM, Shoup TM, Miller GW, Levey AI, Hubert GW, Batchelor S, Winn SR, Saydoff JA, Watts RL. Polymer-encapsulated PC-12 cells demonstrate high-affinity uptake of dopamine in vitro and 18F-Dopa uptake and metabolism after intracerebral implantation in nonhuman primates. Cell Transplant. 1997 Sep-Oct; 6(5):469-77.
    View in: PubMed
  49. Subramanian T, Pollack IF, Lund RD. Rejection of mesencephalic retinal xenografts in the rat induced by systemic administration of recombinant interferon-gamma. Exp Neurol. 1995 Jan; 131(1):157-62.
    View in: PubMed
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