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Timothy K. Cooper, DVM, PhD, Diplomate ACVP

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentComparative Medicine
Address500 University Drive Hershey PA 17033
Mailbox: H054
Phone7175318460
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    Collapse Overview 
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    PREFERRED TITLE/ROLE:



    Associate Professor of Comparative Medicine



    GRADUATE PROGRAM AFFILIATIONS:



    Lab Animal Medicine



    EDUCATION:



    PhD, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2011

    Diplomate, American College of Veterinary Pathologists, 2007

    Post-Doctoral Training, Johns Hopkins University School of Medicine, 2002-2007

    DVM, University of Illinois Urbana-Champaign, 1999



    NARRATIVE:



    Dr. Cooper received his DVM from University of Illinois Urbana-Champaign in 1999. Following three years in private clinical practice as an ambulatory food animal veterinarian, he began a combined pathology residency/PhD program in the Department of Molecular and Comparative Pathobiology at the Johns Hopkins University School of Medicine. Training in comparative pathology of laboratory animals, with a focus on rodents and non-human primates, was augmented by zoo pathology and human autopsy and surgical pathology experience. This culminated in board certification by the American College of Veterinary Pathologists in 2007. Dr. Cooper was also accepted into the Cellular and Molecular Medicine graduate training program at JHUSOM and did his thesis research on the pathogenesis of Marfan syndrome and vascular Ehlers-Danlos syndrome (type IV) in the laboratory of Dr. Hal Dietz. Dr. Cooper was granted his PhD in 2011. Since 2007 he has been an assistant professor in the Department of Comparative Medicine with an adjunct appointment in the Department of Pathology.



    As a veterinary and comparative pathologist, Dr. Cooper provides diagnostic and experimental pathology support for the animal based research mission at HMC. Diagnostic necropsies are performed free of charge to researchers to investigate unexpected morbidity and/or mortality in research animals related to infectious or non-infectious disease or experimental manipulations. Dr. Cooper has extensive experience in a number of rodent and non-rodent models of human diseases, including background pathology and infectious disease co-morbidities. Current research collaborations include mouse and rat models of diabetes mellitus and cancer of the breast, liver, skin, pancreas, prostate, colon, and hemolymphatic system; zebrafish models of human disease [http://zfatlas.psu.edu/]; and large animal models of blood pumps, extracorporeal life support, and other medical devices. Present research investigations include antibiotic associated arteritis in cattle, urinary biomarkers of renal ischemia, and a novel viral agent of pneumonia in rabbits. As evidenced below, Dr. Cooper has demonstrated expertise in a number of animal models and organ systems.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Brendle SA, Christensen ND, Schell TD, Hu J. Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer. Sci Rep. 2017 Dec 05; 7(1):16932. PMID: 29208932.
      View in: PubMed
    2. Chen KM, Guttenplan JB, Sun YW, Cooper T, Shalaby NA, Kosinska W, Benitez G, Aliaga C, Zhu J, Liao J, Gowda K, Amin S, Stoner G, El-Bayoumy K. Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis and Tumorigenesis in the Mouse Oral Cavity. Cancer Prev Res (Phila). 2017 Nov 20. PMID: 29158340.
      View in: PubMed
    3. Wu W, Tang SN, Zhang Y, Puppala M, Cooper TK, Xing C, Jiang C, Lü J. Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica gigas Pyranocoumarins, in Mouse Models. Am J Chin Med. 2017; 45(8):1773-1792. PMID: 29121805.
      View in: PubMed
    4. Schell SL, Soni C, Fasnacht MJ, Domeier PP, Cooper TK, Rahman ZSM. Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers. J Immunol. 2017 12 15; 199(12):4001-4015. PMID: 29118245.
      View in: PubMed
    5. Sun YW, Chen KM, Imamura Kawasawa Y, Salzberg AC, Cooper TK, Caruso C, Aliaga C, Zhu J, Gowda K, Amin S, El-Bayoumy K. Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene. PLoS One. 2017; 12(10):e0186873. PMID: 29073177.
      View in: PubMed
    6. Imamura F, Cooper TK, Hasegawa-Ishii S, Sonobe T, Haouzi P. Hydrogen Sulfide Specifically Alters NAD(P)H Quinone Dehydrogenase 1 (NQO1) Olfactory Neurons in the Rat. Neuroscience. 2017 Dec 16; 366:105-112. PMID: 29054567.
      View in: PubMed
    7. Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Christensen ND, Myers R, Majerciak V, Gotte D, Zheng ZM, Hu J. Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy. J Gen Virol. 2017 Sep 25. PMID: 28942760.
      View in: PubMed
    8. Fino KK, Yang L, Silveyra P, Hu S, Umstead TM, DiAngelo S, Halstead ES, Cooper TK, Abraham T, Takahashi Y, Zhou Z, Wang HG, Chroneos ZC. SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection. Sci Rep. 2017 Aug 04; 7(1):7262. PMID: 28779131.
      View in: PubMed
    9. Cooper TK, Garner MM, Baccon J, Mani H. Coati Bodies: Cytoplasmic Hyaline Globules in the Ganglionic Neurons of Aging Captive Coatis. Vet Pathol. 2017 Sep; 54(5):851-854. PMID: 28578627.
      View in: PubMed
    10. Cooper TK. Membranous ventricular septal aneurysm in a black-tailed prairie dog ( Cynomys ludovicianus). J Vet Diagn Invest. 2017 Jul; 29(4):583-585. PMID: 28548023.
      View in: PubMed
    11. Raup-Konsavage WM, Gao T, Cooper TK, Morris SM, Reeves WB, Awad AS. Arginase-2 mediates renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F522-F534. PMID: 28515179.
      View in: PubMed
    12. Hernon KM, Whitcomb TL, Davis L, Cooper TK. Presumptive Spontaneous Lysosomal Storage-Like Disease in a Crl:CD1(ICR) Mouse. Comp Med. 2017 Feb 01; 67(1):28-33. PMID: 28222836.
      View in: PubMed
    13. You H, Gao T, Raup-Konsavage WM, Cooper TK, Bronson SK, Reeves WB, Awad AS. Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice. Kidney Int. 2017 Mar; 91(3):671-682. PMID: 27914709.
      View in: PubMed
    14. Bitzer ZT, Wopperer AL, Chrisfield BJ, Tao L, Cooper TK, Vanamala J, Elias RJ, Hayes JE, Lambert JD. Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo. J Nutr Biochem. 2017 Feb; 40:201-208. PMID: 27951472.
      View in: PubMed
    15. Besecker EM, Deiter GM, Pironi N, Cooper TK, Holmes GM. Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury. Am J Physiol Regul Integr Comp Physiol. 2017 01 01; 312(1):R146-R156. PMID: 27834292.
      View in: PubMed
    16. Cooper TK, Griffith JW, Chroneos ZC, Izer JM, Willing LB, Peng X. Spontaneous Lung Lesions in Aging Laboratory Rabbits ( Oryctolagus cuniculus). Vet Pathol. 2017 01; 54(1):178-187. PMID: 27507806.
      View in: PubMed
    17. Li G, Liu D, Cooper TK, Kimchi ET, Qi X, Avella DM, Li N, Yang QX, Kester M, Rountree CB, Kaifi JT, Cole DJ, Rockey DC, Schell TD, Staveley-O'Carroll KF. Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model. J Hepatol. 2017 Jan; 66(1):75-85. PMID: 27520877.
      View in: PubMed
    18. Abdulghani J, Gokare P, Gallant JN, Dicker D, Whitcomb T, Cooper T, Liao J, Derr J, Liu J, Goldenberg D, Finnberg NK, El-Deiry WS. Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC). Clin Cancer Res. 2016 Dec 15; 22(24):6192-6203. PMID: 27307592.
      View in: PubMed
    19. Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone CE, Orentreich D. Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer. 2016 06 03; 16:349. PMID: 27255182; PMCID: PMC4891836.
    20. Domeier PP, Chodisetti SB, Soni C, Schell SL, Elias MJ, Wong EB, Cooper TK, Kitamura D, Rahman ZS. IFN-? receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity. J Exp Med. 2016 May 02; 213(5):715-32. PMID: 27069112; PMCID: PMC4854731 [Available on 11/02/16].
    21. Sundberg JP, Berndt A, Sundberg BA, Silva KA, Kennedy V, Smith RS, Cooper TK, Schofield PN. Approaches to Investigating Complex Genetic Traits in a Large-Scale Inbred Mouse Aging Study. Vet Pathol. 2016 Mar; 53(2):456-67. PMID: 26936752.
      View in: PubMed
    22. Hu J, Budgeon LR, Cladel NM, Balogh K, Myers R, Cooper TK, Christensen ND. Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model. J Gen Virol. 2015 Dec; 96(12):3554-65. PMID: 26399579; PMCID: PMC4804763 [Available on 12/01/16].
    23. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Hu J, Christensen ND. Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue. Virology. 2016 Jan 15; 488:73-80. PMID: 26609937; PMCID: PMC4744521 [Available on 01/15/17].
    24. Cooper TK. Letter to the Editor regarding the article "Left ventricular assist devices: a kidney's perspective". Heart Fail Rev. 2015 Nov; 20(6):751-2. PMID: 26387095.
      View in: PubMed
    25. Cabello N, Mishra V, Sinha U, DiAngelo SL, Chroneos ZC, Ekpa NA, Cooper TK, Caruso CR, Silveyra P. Sex differences in the expression of lung inflammatory mediators in response to ozone. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15; 309(10):L1150-63. PMID: 26342085; PMCID: PMC4652152 [Available on 11/15/16].
    26. Raup-Konsavage WM, Cooper TK, Yochum GS. A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice. Dig Dis Sci. 2016 Feb; 61(2):410-22. PMID: 26320084.
      View in: PubMed
    27. Awad AS, You H, Gao T, Gvritishvili A, Cooper TK, Tombran-Tink J. Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury. PLoS One. 2015; 10(7):e0133777. PMID: 26207369; PMCID: PMC4514848.
    28. Cooper TK, Spitsbergen JM. Valvular and Mural Endocardiosis in Aging Zebrafish (Danio rerio). Vet Pathol. 2016 Mar; 53(2):504-9. PMID: 26169384.
      View in: PubMed
    29. Soni C, Domeier PP, Wong EB. Distinct and synergistic roles of Fc?RIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity. J Autoimmun. 2015 Sep; 63:31-46. PMID: 26162758; PMCID: PMC4564365.
    30. Sonobe T, Chenuel B, Cooper TK, Haouzi P. Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue. PLoS One. 2015; 10(6):e0131340. PMID: 26115032; PMCID: PMC4482667.
    31. Awad AS, You H, Gao T, Cooper TK, Nedospasov SA, Vacher J, Wilkinson PF, Farrell FX, Brian Reeves W. Macrophage-derived tumor necrosis factor-a mediates diabetic renal injury. Kidney Int. 2015 Oct; 88(4):722-33. PMID: 26061548; PMCID: PMC4589442.
    32. You H, Gao T, Cooper TK, Morris SM, Awad AS. Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F447-55. PMID: 26041444; PMCID: PMC4556892.
    33. Wang S, Izer JM, Clark JB, Patel S, Pauliks L, Kunselman AR, Leach D, Cooper TK, Wilson RP, Ündar A. In Vivo Hemodynamic Performance Evaluation of Novel Electrocardiogram-Synchronized Pulsatile and Nonpulsatile Extracorporeal Life Support Systems in an Adult Swine Model. Artif Organs. 2015 Jul; 39(7):E90-E101. PMID: 25866125.
      View in: PubMed
    34. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Hu J, Christensen ND. A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections. PLoS One. 2015; 10(3):e0120128. PMID: 25803616; PMCID: PMC4372414.
    35. Haakenson JK, Khokhlatchev AV, Choi YJ, Linton SS, Zhang P, Zaki PM, Fu C, Cooper TK, Manni A, Zhu J, Fox TE, Dong C, Kester M. Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells. J Biol Chem. 2015 Mar 27; 290(13):8632-43. PMID: 25681441; PMCID: PMC4375512.
    36. Booth JL, Umstead TM, Hu S, Dybvig KF, Cooper TK, Wilson RP, Chroneos ZC. Housing conditions modulate the severity of Mycoplasma pulmonis infection in mice deficient in class A scavenger receptor. Comp Med. 2014 Dec; 64(6):424-39. PMID: 25527023; PMCID: PMC4275078.
    37. Cozza EM, Cooper TK, Budgeon LR, Christensen ND, Schell TD. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. Cancer Immunol Immunother. 2015 Mar; 64(3):325-36. PMID: 25408469; PMCID: PMC4344424.
    38. You H, Gao T, Cooper TK, Morris SM, Awad AS. Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1292-301. PMID: 25320354; PMCID: PMC4254967.
    39. Villano JS, Fann MK, Suckow CE, Cooper TK. Diagnostic Exercise: Metastatic Calcification in Guinea Pigs. Vet Pathol. 2015 Jul; 52(4):757-9. PMID: 25281653.
      View in: PubMed
    40. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. PMID: 25058882; PMCID: PMC4161619.
    41. Sinha R, Cooper TK, Rogers CJ, Sinha I, Turbitt WJ, Calcagnotto A, Perrone CE, Richie JP. Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice. Prostate. 2014 Dec; 74(16):1663-73. PMID: 25250521.
      View in: PubMed
    42. Izer JM, Wilson RP, Cooper TK. Fatal clostridium septicum myonecrosis in a captive canada lynx (Lynx canadensis). J Zoo Wildl Med. 2014 Sep; 45(3):638-41. PMID: 25314833.
      View in: PubMed
    43. Peng X, Roshwalb S, Cooper TK, Zimmerman H, Christensen ND. High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain. Vet Ophthalmol. 2015 May; 18(3):186-90. PMID: 25123814; PMCID: PMC4329106.
    44. Cooper TK, Murray KN, Spagnoli S, Spitsbergen JM. Primary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio). Vet Pathol. 2015 Mar; 52(2):388-92. PMID: 24913269; PMCID: PMC4261063.
    45. Matters GL, Cooper TK, McGovern CO, Gilius EL, Liao J, Barth BM, Kester M, Smith JP. Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat. Dig Dis Sci. 2014 Jun; 59(6):1180-91. PMID: 24817409; PMCID: PMC4096234.
    46. Ward-Kavanagh LK, Zhu J, Cooper TK, Schell TD. Whole-body irradiation increases the magnitude and persistence of adoptively transferred T cells associated with tumor regression in a mouse model of prostate cancer. Cancer Immunol Res. 2014 Aug; 2(8):777-88. PMID: 24801834; PMCID: PMC4125439.
    47. Berry GJ, Budgeon LR, Cooper TK, Christensen ND, Waldner H. The type 1 diabetes resistance locus B10 Idd9.3 mediates impaired B-cell lymphopoiesis and implicates microRNA-34a in diabetes protection. Eur J Immunol. 2014 Jun; 44(6):1716-27. PMID: 24752729.
      View in: PubMed
    48. Villano JS, Rong F, Cooper TK. Bacterial infections in Myd88-deficient mice. Comp Med. 2014 Apr; 64(2):110-4. PMID: 24674585; PMCID: PMC3997288.
    49. You H, Gao T, Cooper TK, Brian Reeves W, Awad AS. Macrophages directly mediate diabetic renal injury. Am J Physiol Renal Physiol. 2013 Dec 15; 305(12):F1719-27. PMID: 24173355; PMCID: PMC3882451.
    50. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Bruggeman R, Cooper TK, Prokopczyk B, Trushin N, Calcagnotto A, Das A, Liao J, El-Bayoumy K. Influence of omega-3 fatty acids on Tamoxifen-induced suppression of rat mammary carcinogenesis. Int J Cancer. 2014 Apr 01; 134(7):1549-57. PMID: 24122252.
      View in: PubMed
    51. Cooper TK, Dumpala PR, Whitcomb TL. Diagnostic exercise: ascites, abdominal masses, and diffuse peritoneal nodules in a rat. Vet Pathol. 2014 May; 51(3):659-62. PMID: 23912713.
      View in: PubMed
    52. Booth JL, Peng X, Baccon J, Cooper TK. Multiple complex congenital malformations in a rabbit kit (Oryctolagus cuniculi). Comp Med. 2013 Aug; 63(4):342-7. PMID: 24209970; PMCID: PMC3750670.
    53. Goodwin EM, Zhong Q, Abendroth CS, Ward-Kavanagh LK, Schell TD, Cooper TK. Anaplastic renal carcinoma expressing SV40 T antigen in a female TRAMP mouse. Comp Med. 2013 Aug; 63(4):338-41. PMID: 24209969; PMCID: PMC3750669.
    54. Awad AS, Gao T, Gvritishvili A, You H, Liu Y, Cooper TK, Reeves WB, Tombran-Tink J. Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury. Am J Physiol Renal Physiol. 2013 Sep 15; 305(6):F891-900. PMID: 23884140; PMCID: PMC3761290.
    55. Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Hu J, Christensen ND. Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus. J Virol. 2013 Aug; 87(16):9391-5. PMID: 23785210; PMCID: PMC3754027.
    56. You H, Gao T, Cooper TK, Morris SM, Awad AS. Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism. Kidney Int. 2013 Dec; 84(6):1189-97. PMID: 23760286; PMCID: PMC3783645.
    57. Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, DelTondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K. Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent. Int J Cancer. 2013 Sep 15; 133(6):1300-9. PMID: 23483552; PMCID: PMC3707976.
    58. Sun YW, Guttenplan JB, Cooper T, Krzeminski J, Aliaga C, Boyiri T, Kosinska W, Zhao ZL, Chen KM, Berg A, Amin S, El-Bayoumy K. Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat. Chem Res Toxicol. 2013 Apr 15; 26(4):547-54. PMID: 23461617; PMCID: PMC3714335.
    59. Tiwari A, Hadley JA, Hendricks GL, Elkin RG, Cooper T, Ramachandran R. Characterization of ascites-derived ovarian tumor cells from spontaneously occurring ovarian tumors of the chicken: evidence for E-cadherin upregulation. PLoS One. 2013; 8(2):e57582. PMID: 23460878; PMCID: PMC3583847.
    60. Villano JS, Cooper TK. Mandibular fracture and necrotizing sialometaplasia in a rabbit. Comp Med. 2013 Feb; 63(1):67-70. PMID: 23561940; PMCID: PMC3567379.
    61. Takahashi Y, Hori T, Cooper TK, Liao J, Desai N, Serfass JM, Young MM, Park S, Izu Y, Wang HG. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Blood. 2013 Feb 28; 121(9):1622-32. PMID: 23287860; PMCID: PMC3587325.
    62. Villano JS, Boehm CA, Carney EL, Cooper TK. Complications of elastase-induced arterial saccular aneurysm in rabbits: case reports and literature review. Comp Med. 2012 Dec; 62(6):480-6. PMID: 23561881; PMCID: PMC3527752.
    63. Cooper TK, Griffith JW, Reibson J, Peterson R, Roush EP, Zhong Q, Weiss WJ, Rosenberg G. Antibiotic-associated eosinophilic and occlusive arteritis in calves complicating preclinical studies of left ventricular assist devices. Toxicol Pathol. 2013; 41(3):519-27. PMID: 22700648.
      View in: PubMed
    64. Shi C, Cooper TK, McCloskey DE, Glick AB, Shantz LM, Feith DJ. S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis. 2012 Jul; 33(7):1310-8. PMID: 22610166; PMCID: PMC3499050.
    65. Cooper TK, Zhong Q, Nabity M, Rosenberg G, Weiss WJ. Use of urinary biomarkers of renal ischemia in a lamb preclinical left ventricular assist device model. Artif Organs. 2012 Sep; 36(9):820-4. PMID: 22428807.
      View in: PubMed
    66. Koya V, Campbell AM, McLaughlin PJ, Tewari D, Wilson RP, Cooper TK. Outbreak of abdominal distension and obstipation in a C57BL/6J experimental autoimmune encephalomyelitis study. Vet Pathol. 2012 May; 49(3):528-31. PMID: 22262350.
      View in: PubMed
    67. Chen KM, Zhang SM, Aliaga C, Sun YW, Cooper T, Gowdahalli K, Zhu J, Amin S, El-Bayoumy K. Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse. Chem Res Toxicol. 2012 Feb 20; 25(2):374-80. PMID: 22107356; PMCID: PMC3288413.
    68. Weiss WJ, Carney EL, Clark JB, Peterson R, Cooper TK, Nifong TP, Siedlecki CA, Hicks D, Doxtater B, Lukic B, Yeager E, Reibson J, Cysyk J, Rosenberg G, Pierce WS. Chronic in vivo testing of the Penn State infant ventricular assist device. ASAIO J. 2012 Jan-Feb; 58(1):65-72. PMID: 22157073; PMCID: PMC3263523.
    69. Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, DelTondo J, Cooper T, Sun YW, Zhang SM, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K. Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. Int J Cancer. 2012 Jun 15; 130(12):2783-90. PMID: 21815141; PMCID: PMC3596885.
    70. Morris SM, Gao T, Cooper TK, Kepka-Lenhart D, Awad AS. Arginase-2 mediates diabetic renal injury. Diabetes. 2011 Nov; 60(11):3015-22. PMID: 21926276; PMCID: PMC3198072.
    71. Mikerov AN, Cooper TK, Wang G, Hu S, Umstead TM, Phelps DS, Floros J. Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions. Int J Physiol Pathophysiol Pharmacol. 2011 Sep 30; 3(3):176-90. PMID: 21941609; PMCID: PMC3175744.
    72. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59. PMID: 21769696.
      View in: PubMed
    73. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K. Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Int J Oncol. 2011 Nov; 39(5):1153-64. PMID: 21892590.
      View in: PubMed
    74. Leocadio DE, Kunselman AR, Cooper T, Barrantes JH, Trussell JC. Anatomical and histological equivalence of the human, canine, and bull vas deferens. Can J Urol. 2011 Jun; 18(3):5699-704. PMID: 21703043.
      View in: PubMed
    75. Pandey MK, Liu G, Cooper TK, Mulder KM. Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice. Int J Cancer. 2012 Jan 01; 130(1):213-22. PMID: 21344377; PMCID: PMC3163111.
    76. Briest W, Cooper TK, Tae HJ, Krawczyk M, McDonnell NB, Talan MI. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun; 337(3):621-7. PMID: 21363928; PMCID: PMC3101011.
    77. Cooper TK, Zhong Q, Krawczyk M, Tae HJ, Müller GA, Schubert R, Myers LA, Dietz HC, Talan MI, Briest W. The haploinsufficient Col3a1 mouse as a model for vascular Ehlers-Danlos syndrome. Vet Pathol. 2010 Nov; 47(6):1028-39. PMID: 20587693; PMCID: PMC2970629.
    78. Manni A, Xu H, Washington S, Aliaga C, Cooper T, Richie JP, Bruggeman R, Prokopczyk B, Calcagnotto A, Trushin N, Mauger D, Verderame MF, El-Bayoumy K. The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Cancer Prev Res (Phila). 2010 Mar; 3(3):322-30. PMID: 20179301.
      View in: PubMed
    79. Spitsbergen JM, Blazer VS, Bowser PR, Cheng KC, Cooper KR, Cooper TK, Frasca S, Groman DB, Harper CM, Law JM, Marty GD, Smolowitz RM, St Leger J, Wolf DC, Wolf JC. Finfish and aquatic invertebrate pathology resources for now and the future. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Mar; 149(2):249-57. PMID: 18948226; PMCID: PMC2680143.
    80. Xie J, Bessling SL, Cooper TK, Dietz HC, McCallion AS, Fisher S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 2007 Jun; 176(2):1339-42. PMID: 17483412; PMCID: PMC1894594.
    81. Cooper TK, Gabrielson KL. Spontaneous lesions in the reproductive tract and mammary gland of female non-human primates. Birth Defects Res B Dev Reprod Toxicol. 2007 Apr; 80(2):149-70. PMID: 17342758.
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    82. Helke KL, Cooper TK, Mankowski JL, Poynton SL. Disseminated visceral coccidiosis in Indo-gangetic flap-shelled turtles, Lissemys punctata andersonii. J Wildl Dis. 2006 Oct; 42(4):788-96. PMID: 17255445.
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    83. Cooper TK, Ronnett BM, Ruben DS, Zink MC. Uterine myxoid leiomyosarcoma with widespread metastases in a cat. Vet Pathol. 2006 Jul; 43(4):552-6. PMID: 16846999.
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    84. Cooper TK, Adelsohn D, Gilbertson SR. Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus). Vet Pathol. 2006 May; 43(3):377-80. PMID: 16672589.
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    85. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006 Apr 07; 312(5770):117-21. PMID: 16601194; PMCID: PMC1482474.
    86. Cooper TK, Shih IM, Gabrielson KL. Uterine epithelioid trophoblastic tumour in a red-tailed guenon (Cercopithecus ascanius). J Comp Pathol. 2005 Aug-Oct; 133(2-3):218-22. PMID: 16026797.
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    87. Pisharath HR, Cooper TK, Brice AK, Cianciolo RE, Pistorio AL, Wachtman LM, Mankowski JL, Newcomer CE. Septicemia and peritonitis in a colony of common marmosets (Callithrix jacchus) secondary to Klebsiella pneumoniae infection. Contemp Top Lab Anim Sci. 2005 Jan; 44(1):35-7. PMID: 15697197.
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    88. Chen W, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, Karp JE, Gokgoz N, Wunder JS, Andrulis IL, Levine AJ, Mankowski JL, Baylin SB. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell. 2004 Oct; 6(4):387-98. PMID: 15488761.
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    89. Whittem T, Hogan D, Sisson D, Cooper T. The population pharmacokinetics of digoxin in dogs with heart disease. J Vet Pharmacol Ther. 2000 Aug; 23(4):261-3. PMID: 11126326.
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    90. Whittem TL, Johnson AL, Smith CW, Schaeffer DJ, Coolman BR, Averill SM, Cooper TK, Merkin GR. Effect of perioperative prophylactic antimicrobial treatment in dogs undergoing elective orthopedic surgery. J Am Vet Med Assoc. 1999 Jul 15; 215(2):212-6. PMID: 10416474.
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