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Sang Lee

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentNeurosurgery
Address500 University Drive Hershey PA 17033
Mailbox: H110
Phone7175310003 x285546

 Overview 
 overview
PREFERRED TITLE/ROLE:



Assistant Professor of Neurosurgery



EDUCATION:



Ph.D., Kyungpook University (Korea), 1997



NARRATIVE:



We are investigating the cellular mechanisms of neurodegenerative disorders and brain tumors mediated by oxidative stress and iron mismanagement. Iron is tightly regulated for normal function. When iron imbalance occurs by dysfunction of iron regulatory mechanisms, cells are subjected to a pro-oxidative stress and a pro-inflammatory environment. HFE is one of several iron regulatory proteins and polymorphisms in the HFE gene are prevalent in Caucasians. HFE gene variants have been traditionally associated with the iron overload disorder known as Hereditary Hemochromatosis. Recently, it has become clear that the two most common variants in the HFE gene, H63D and C282Y, may be risk modifiers for neurodegenerative disorders (Alzheimer's disease, Amyotrophic Lateral Sclerosis) and cancer, respectively. The following lists are my research interests. First, understand the cellular consequences of carrying variant forms of HFE in brain tumors and neurodegenerative disorders. Second, determine the frequency of HFE polymorphisms in brain tumor patients and neurodegenerative disorders. Third, determine the chemotherapy resistance mechanism in the C282Y-expressing tumor cells. Fourth, develop a new chemotherapeutic agent to treat brain tumors, especially Temodar-resistant brain tumors, and neurodegenerative disorders that express HFE gene variants. For these studies, we utilize both cell culture and animal models. We are using stably-transfected human neuroblastoma cell lines that express different forms of HFE, and human astrocytoma cell lines expressing different HFE variants to determine the cellular consequences of the variants forms of HFE. We are also using H63D and C282Y knock-in mice to determine the consequence of HFE variants in in vivo.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mairuae N, Connor JR, Lee SY, Cheepsunthorn P, Tongjaroenbuangam W. The effects of okra (Abelmoschus esculentus Linn.) on the cellular events associated with Alzheimer's disease in a stably expressed HFE neuroblastoma SH-SY5Y cell line. Neurosci Lett. 2015 Aug 31; 603:6-11.
    View in: PubMed
  2. Lee SY, Slagle-Webb B, Sheehan JM, Zhu J, Muscat JE, Glantz M, Connor JR. HFE polymorphisms affect survival of brain tumor patients. J Neurooncol. 2015 Mar; 122(1):97-104.
    View in: PubMed
  3. Lee SY, Slagle-Webb B, Rizk E, Patel A, Miller PA, Sung SS, Connor JR. Characterization of a novel anti-cancer compound for astrocytomas. PLoS One. 2014; 9(9):e108166.
    View in: PubMed
  4. Ali-Rahmani F, Huang MA, Schengrund CL, Connor JR, Lee SY. C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells. PLoS One. 2014; 9(2):e88724.
    View in: PubMed
  5. Ali-Rahmani F, Grigson PS, Lee S, Neely E, Connor JR, Schengrund CL. H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment. Neurobiol Aging. 2014 Jun; 35(6):1511.e1-12.
    View in: PubMed
  6. Su XW, Lee SY, Mitchell RM, Stephens HE, Simmons Z, Connor JR. H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients. Muscle Nerve. 2013 Aug; 48(2):242-6.
    View in: PubMed
  7. Zhang Y, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun. 2011 Oct 14; 414(1):129-34.
    View in: PubMed
  8. Lee SY, Liu S, Mitchell RM, Slagle-Webb B, Hong YS, Sheehan JM, Connor JR. HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A. Int J Cancer. 2011 Nov 1; 129(9):2104-14.
    View in: PubMed
  9. Liu Y, Lee SY, Neely E, Nandar W, Moyo M, Simmons Z, Connor JR. Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J Biol Chem. 2011 Apr 15; 286(15):13161-70.
    View in: PubMed
  10. Mairuae N, Hall Ii EC, Cheepsunthorn P, Lee SY, Connor JR. The H63D HFE gene variant promotes activation of the intrinsic apoptotic pathway via mitochondria dysfunction following ß-amyloid peptide exposure. J Neurosci Res. 2010 Nov 1; 88(14):3079-89.
    View in: PubMed
  11. Hall EC, Lee SY, Simmons Z, Neely EB, Nandar W, Connor JR. Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D. Biochim Biophys Acta. 2010 Apr; 1802(4):389-95.
    View in: PubMed
  12. Hall EC, Lee SY, Mairuae N, Simmons Z, Connor JR. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011 Aug; 32(8):1409-19.
    View in: PubMed
  13. Mitchell RM, Lee SY, Simmons Z, Connor JR. HFE polymorphisms affect cellular glutamate regulation. Neurobiol Aging. 2011 Jun; 32(6):1114-23.
    View in: PubMed
  14. Mitchell RM, Lee SY, Randazzo WT, Simmons Z, Connor JR. Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. J Neuroinflammation. 2009; 6:6.
    View in: PubMed
  15. Lee SY, Patton SM, Henderson RJ, Connor JR. Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE. FASEB J. 2007 Feb; 21(2):564-76.
    View in: PubMed
  16. Connor JR, Lee SY. HFE mutations and Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):267-76.
    View in: PubMed
  17. Lee SY, Connor JR. Regulation of Hfe by stress factors in BV-2 cells. Neurobiol Aging. 2005 Jun; 26(6):803-12.
    View in: PubMed
  18. Wang XS, Lee S, Simmons Z, Boyer P, Scott K, Liu W, Connor J. Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. J Neurol Sci. 2004 Dec 15; 227(1):27-33.
    View in: PubMed
  19. Chiueh C, Lee S, Andoh T, Murphy D. Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen. Endocrine. 2003 Jun; 21(1):27-31.
    View in: PubMed
  20. Lee SY, Andoh T, Murphy DL, Chiueh CC. 17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection. FASEB J. 2003 May; 17(8):947-8.
    View in: PubMed
  21. Andoh T, Lee SY, Chiueh CC. Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress. FASEB J. 2000 Nov; 14(14):2144-6.
    View in: PubMed
  22. Kim HS, Band HJ, Lee SY, Yoo OJ, Yoo JC, Kim YH, Lee JJ. 44-Homooligomycin E, a new cytotoxic macrolide antibiotic from Streptomyces ostreogriseus. Biosci Biotechnol Biochem. 1997 Feb; 61(2):378-80.
    View in: PubMed
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