PSU Profiles
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Last Name
Institution

Song Tan

Title
InstitutionEberly College of Science
DepartmentBiochemistry and Molecular Biology
Address468A Frear North Lab
University Park, PA 16802
Phone8148653355
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Biochemistry and Molecular Biology

GRADUATE PROGRAM AFFILIATIONS:

Cell and Developmental Biology, Molecular Medicine

NARRATIVE:

Dr. Tan's research focuses on understanding how genes are regulated by combining genetic, biochemical and structural descriptions. His expectation is that such information will contribute to the development of future therapeutic agents against cancer and other human diseases.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim SA, Chatterjee N, Jennings MJ, Bartholomew B, Tan S. Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex. Nucleic Acids Res. 2015 May 26; 43(10):4868-80.
    View in: PubMed
  2. McGinty RK, Tan S. Nucleosome structure and function. Chem Rev. 2015 Mar 25; 115(6):2255-73.
    View in: PubMed
  3. McGinty RK, Henrici RC, Tan S. Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature. 2014 Oct 30; 514(7524):591-6.
    View in: PubMed
  4. Lalonde ME, Avvakumov N, Glass KC, Joncas FH, Saksouk N, Holliday M, Paquet E, Yan K, Tong Q, Klein BJ, Tan S, Yang XJ, Kutateladze TG, Côté J. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. Genes Dev. 2013 Sep 15; 27(18):2009-24.
    View in: PubMed
  5. Makde RD, Tan S. Strategies for crystallizing a chromatin protein in complex with the nucleosome core particle. Anal Biochem. 2013 Nov 15; 442(2):138-45.
    View in: PubMed
  6. Wu L, Lee SY, Zhou B, Nguyen UT, Muir TW, Tan S, Dou Y. ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes. Mol Cell. 2013 Mar 28; 49(6):1108-20.
    View in: PubMed
  7. Huang J, Tan S. Piccolo NuA4-catalyzed acetylation of nucleosomal histones: critical roles of an Esa1 Tudor/chromo barrel loop and an Epl1 enhancer of polycomb A (EPcA) basic region. Mol Cell Biol. 2013 Jan; 33(1):159-69.
    View in: PubMed
  8. Tan S. Deciphering how the chromatin factor RCC1 recognizes the nucleosome: the importance of individuals in the scientific discovery process. Biochem Soc Trans. 2012 Apr; 40(2):351-6.
    View in: PubMed
  9. Chittuluru JR, Chaban Y, Monnet-Saksouk J, Carrozza MJ, Sapountzi V, Selleck W, Huang J, Utley RT, Cramet M, Allard S, Cai G, Workman JL, Fried MG, Tan S, Côté J, Asturias FJ. Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes. Nat Struct Mol Biol. 2011 Nov; 18(11):1196-203.
    View in: PubMed
  10. Chatterjee N, Sinha D, Lemma-Dechassa M, Tan S, Shogren-Knaak MA, Bartholomew B. Histone H3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms. Nucleic Acids Res. 2011 Oct; 39(19):8378-91.
    View in: PubMed
  11. Tan S, Davey CA. Nucleosome structural studies. Curr Opin Struct Biol. 2011 Feb; 21(1):128-36.
    View in: PubMed
  12. Makde RD, England JR, Yennawar HP, Tan S. Structure of RCC1 chromatin factor bound to the nucleosome core particle. Nature. 2010 Sep 30; 467(7315):562-6.
    View in: PubMed
  13. England JR, Huang J, Jennings MJ, Makde RD, Tan S. RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex. J Mol Biol. 2010 May 14; 398(4):518-29.
    View in: PubMed
  14. Psathas JN, Zheng S, Tan S, Reese JC. Set2-dependent K36 methylation is regulated by novel intratail interactions within H3. Mol Cell Biol. 2009 Dec; 29(24):6413-26.
    View in: PubMed
  15. Reese J, Tan S. Preface to special issue on epigenetics. Biochim Biophys Acta. 2009 Jan; 1789(1):1-2.
    View in: PubMed
  16. Selleck W, Tan S. Recombinant protein complex expression in E. coli. Curr Protoc Protein Sci. 2008 May; Chapter 5:Unit 5.21.
    View in: PubMed
  17. Altaf M, Utley RT, Lacoste N, Tan S, Briggs SD, Côté J. Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol Cell. 2007 Dec 28; 28(6):1002-14.
    View in: PubMed
  18. Barrios A, Selleck W, Hnatkovich B, Kramer R, Sermwittayawong D, Tan S. Expression and purification of recombinant yeast Ada2/Ada3/Gcn5 and Piccolo NuA4 histone acetyltransferase complexes. Methods. 2007 Mar; 41(3):271-7.
    View in: PubMed
  19. Berndsen CE, Selleck W, McBryant SJ, Hansen JC, Tan S, Denu JM. Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. Biochemistry. 2007 Feb 27; 46(8):2091-9.
    View in: PubMed
  20. Berndsen CE, Albaugh BN, Tan S, Denu JM. Catalytic mechanism of a MYST family histone acetyltransferase. Biochemistry. 2007 Jan 23; 46(3):623-9.
    View in: PubMed
  21. Sermwittayawong D, Tan S. SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment. EMBO J. 2006 Aug 23; 25(16):3791-800.
    View in: PubMed
  22. Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 2006 Jan 6; 21(1):51-64.
    View in: PubMed
  23. Selleck W, Fortin I, Sermwittayawong D, Côté J, Tan S. The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. Mol Cell Biol. 2005 Jul; 25(13):5535-42.
    View in: PubMed
  24. Lichty JJ, Malecki JL, Agnew HD, Michelson-Horowitz DJ, Tan S. Comparison of affinity tags for protein purification. Protein Expr Purif. 2005 May; 41(1):98-105.
    View in: PubMed
  25. Tan S, Kern RC, Selleck W. The pST44 polycistronic expression system for producing protein complexes in Escherichia coli. Protein Expr Purif. 2005 Apr; 40(2):385-95.
    View in: PubMed
  26. Doyon Y, Selleck W, Lane WS, Tan S, Côté J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol. 2004 Mar; 24(5):1884-96.
    View in: PubMed
  27. Bleichenbacher M, Tan S, Richmond TJ. Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J Mol Biol. 2003 Sep 26; 332(4):783-93.
    View in: PubMed
  28. Boudreault AA, Cronier D, Selleck W, Lacoste N, Utley RT, Allard S, Savard J, Lane WS, Tan S, Côté J. Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev. 2003 Jun 1; 17(11):1415-28.
    View in: PubMed
  29. Boyer LA, Langer MR, Crowley KA, Tan S, Denu JM, Peterson CL. Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Mol Cell. 2002 Oct; 10(4):935-42.
    View in: PubMed
  30. Balasubramanian R, Pray-Grant MG, Selleck W, Grant PA, Tan S. Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation. J Biol Chem. 2002 Mar 8; 277(10):7989-95.
    View in: PubMed
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