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Sinisa Dovat

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive Hershey PA 17033
Phone7175310003 x280286
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    Collapse Overview 
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    PREFERRED TITLE/ROLE:

    Physician, Associate Professor, M.D., Ph.D.

    EDUCATION:

    Fellowship, Pediatric Hematology/Oncology, University of California - Los Angeles (1999) Residency, Pediatrics, Penn State Milton S. Hershey Medical Center (1996) Residency, Pediatrics, Institute for Health Care of Mother & Child (1993) M.D., University of Novi Sad Medical School, Serbia (1988)



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ge Z, Gu Y, Han Q, Sloane J, Ge Q, Gao G, Ma J, Song H, Hu J, Chen B, Dovat S, Song C. Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. Epigenomics. 2018 Jan; 10(1):59-69. PMID: 28994305.
      View in: PubMed
    2. Pandey MK, Gowda K, Sung SS, Abraham T, Budak-Alpdogan T, Talamo G, Dovat S, Amin S. A novel dual inhibitor of microtubule and Bruton's tyrosine kinase inhibits survival of multiple myeloma and osteoclastogenesis. Exp Hematol. 2017 Sep; 53:31-42. PMID: 28647392.
      View in: PubMed
    3. Gowda C, Soliman M, Kapadia M, Ding Y, Payne K, Dovat S. Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia. Adv Biol Regul. 2017 08; 65:16-25. PMID: 28623166.
      View in: PubMed
    4. Dovat S, Payne KJ. STAT5 alters the state of transcriptional networks, driving aggressive leukemia. Nat Immunol. 2017 05 18; 18(6):597-598. PMID: 28518152.
      View in: PubMed
    5. Ge Z, Zhou X, Gu Y, Han Q, Li J, Chen B, Ge Q, Dovat E, Payne JL, Sun T, Song C, Dovat S. Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia. Oncotarget. 2017 Jan 31; 8(5):8022-8034. PMID: 28030830.
      View in: PubMed
    6. Yoshida N, Sakaguchi H, Muramatsu H, Okuno Y, Song C, Dovat S, Shimada A, Ozeki M, Ohnishi H, Teramoto T, Fukao T, Kondo N, Takahashi Y, Matsumoto K, Kato K, Kojima S. Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia. Leukemia. 2017 May; 31(5):1221-1223. PMID: 28096536.
      View in: PubMed
    7. Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C. Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. Sci Rep. 2017 Jan 11; 7:40457. PMID: 28074872.
      View in: PubMed
    8. Gowda C, Sachdev M, Muthusami S, Kapadia M, Petrovic-Dovat L, Hartman M, Ding Y, Song C, Payne JL, Tan BH, Dovat S. Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies. Curr Pharm Des. 2017; 23(1):95-107. PMID: 27719640.
      View in: PubMed
    9. Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C. Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. Sci Rep. 2016 11 25; 6:38004. PMID: 27885263.
      View in: PubMed
    10. Bao L, Chen SJ, Conrad K, Keefer K, Abraham T, Lee JP, Wang J, Zhang XQ, Hirschler-Laszkiewicz I, Wang HG, Dovat S, Gans B, Madesh M, Cheung JY, Miller BA. Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics. J Biol Chem. 2016 Nov 18; 291(47):24449-24464. PMID: 27694440.
      View in: PubMed
    11. Gowda C, Song C, Kapadia M, Payne JL, Hu T, Ding Y, Dovat S. Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros. Adv Biol Regul. 2017 Jan; 63:71-80. PMID: 27666503.
      View in: PubMed
    12. Ge Z, Li M, Zhao G, Xiao L, Gu Y, Zhou X, Yu MD, Li J, Dovat S, Song C. Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia. Oncol Lett. 2016 Oct; 12(4):2746-2751. PMID: 27698851.
      View in: PubMed
    13. Ge Z, Gu Y, Zhao G, Li J, Chen B, Han Q, Guo X, Liu J, Li H, Yu MD, Olson J, Steffens S, Payne KJ, Song C, Dovat S. High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement. Oncotarget. 2016 Aug 02; 7(31):49722-49732. PMID: 27391346.
      View in: PubMed
    14. Ge Z, Gu Y, Xiao L, Han Q, Li J, Chen B, Yu J, Kawasawa YI, Payne KJ, Dovat S, Song C. Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction. Oncotarget. 2016 Jul 19; 7(29):46014-46027. PMID: 27322554.
      View in: PubMed
    15. Milford TA, Su RJ, Francis OL, Baez I, Martinez SR, Coats JS, Weldon AJ, Calderon MN, Nwosu MC, Botimer AR, Suterwala BT, Zhang XB, Morris CL, Weldon DJ, Dovat S, Payne KJ. TSLP or IL-7 provide an IL-7Ra signal that is critical for human B lymphopoiesis. Eur J Immunol. 2016 09; 46(9):2155-61. PMID: 27325567.
      View in: PubMed
    16. Ge Z, Song EJ, Kawasawa YI, Li J, Dovat S, Song C. WDR5 high expression and its effect on tumorigenesis in leukemia. Oncotarget. 2016 Jun 21; 7(25):37740-37754. PMID: 27192115.
      View in: PubMed
    17. Xiang M, Su H, Shu G, Wan D, He F, Loaec M, Ding Y, Li J, Dovat S, Yang G, Song C. Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer. Oncotarget. 2016 Apr 05; 7(14):18521-30. PMID: 26943775; PMCID: PMC4951306.
    18. Gowda CS, Song C, Ding Y, Kapadia M, Dovat S. Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis. J Investig Med. 2016 Mar; 64(3):735-9. PMID: 26912004.
      View in: PubMed
    19. Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S. Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem. 2016 Feb 19; 291(8):4004-18. PMID: 26655717; PMCID: PMC4759178 [Available on 02/19/17].
    20. Ge Z, Guo X, Li J, Hartman M, Kawasawa YI, Dovat S, Song C. Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia. Oncotarget. 2015 Dec 08; 6(39):42300-11. PMID: 26517351; PMCID: PMC4747226.
    21. Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S. Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia. Leukemia. 2016 Jun; 30(6):1436-40. PMID: 26639180; PMCID: PMC4889471.
    22. Francis OL, Milford TA, Martinez SR, Baez I, Coats JS, Mayagoitia K, Concepcion KR, Ginelli E, Beldiman C, Benitez A, Weldon AJ, Arogyaswamy K, Shiraz P, Fisher R, Morris CL, Zhang XB, Filippov V, Van Handel B, Ge Z, Song C, Dovat S, Su RJ, Payne KJ. A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica. 2016 Apr; 101(4):417-26. PMID: 26611474; PMCID: PMC5004401.
    23. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. PMID: 26219304; PMCID: PMC4600018.
    24. Guo X, Zhang R, Liu J, Li M, Song C, Dovat S, Li J, Ge Z. Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia. PLoS One. 2015; 10(5):e0125429. PMID: 25942645; PMCID: PMC4420493.
    25. Hu RM, Tan BH, Tester DJ, Song C, He Y, Dovat S, Peterson BZ, Ackerman MJ, Makielski JC. Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis. PLoS One. 2015; 10(4):e0124921. PMID: 25923670; PMCID: PMC4414567.
    26. Payne KJ, Benitez A, Dovat S. Translating basic science discoveries to clinical practice-Let us not repeat the naiveté of the pre-omics era. Ann Transl Med. 2015 Mar; 3(4):46. PMID: 25861601; PMCID: PMC4381468.
    27. Wang H, Song C, Gurel Z, Song N, Ma J, Ouyang H, Lai L, Payne KJ, Dovat S. Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia. Pediatr Blood Cancer. 2014 Dec; 61(12):2230-5. PMID: 25214003; PMCID: PMC4205270.
    28. Pandey MK, Kale VP, Song C, Sung SS, Sharma AK, Talamo G, Dovat S, Amin SG. Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways. Exp Hematol. 2014 Oct; 42(10):883-96. PMID: 25034231.
      View in: PubMed
    29. Iempridee T, Reusch JA, Riching A, Johannsen EC, Dovat S, Kenney SC, Mertz JE. Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. J Virol. 2014 May; 88(9):4811-27. PMID: 24522918; PMCID: PMC3993812.
    30. Wang H, Ouyang H, Lai L, Petrovic-Dovat L, Stankov K, Bogdanovic G, Dovat S. Pathogenesis and regulation of cellular proliferation in acute lymphoblastic leukemia - the role of Ikaros. J BUON. 2014 Jan-Mar; 19(1):22-8. PMID: 24659638.
      View in: PubMed
    31. Payne KJ, Dovat S. G0S2--a new player in leukemia. Leuk Res. 2014 Feb; 38(2):147-8. PMID: 24332429; PMCID: PMC4370841.
    32. Dovat S. Ikaros: the enhancer makes the difference. Blood. 2013 Oct 31; 122(18):3091-2. PMID: 24178958; PMCID: PMC3814726.
    33. Yang D, Song J, Wu L, Ma Y, Song C, Dovat S, Nishizaki T, Liu J. Induction of senescence by adenosine suppressing the growth of lung cancer cells. Biochem Biophys Res Commun. 2013 Oct 11; 440(1):62-7. PMID: 24051088.
      View in: PubMed
    34. Gowda C, Dovat S. Genetic targets in pediatric acute lymphoblastic leukemia. Adv Exp Med Biol. 2013; 779:327-40. PMID: 23288647.
      View in: PubMed
    35. Uckun FM, Ma H, Zhang J, Ozer Z, Dovat S, Mao C, Ishkhanian R, Goodman P, Qazi S. Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18072-7. PMID: 23071339; PMCID: PMC3497833.
    36. Savic A, Cemerikic-Martinovic V, Dovat S, Rajic N, Urosevic I, Sekulic B, Kvrgic V, Popovic S. Angiogenesis and survival in patients with myelodysplastic syndrome. Pathol Oncol Res. 2012 Jul; 18(3):681-90. PMID: 22270865.
      View in: PubMed
    37. Li Z, Song C, Ouyang H, Lai L, Payne KJ, Dovat S. Cell cycle-specific function of Ikaros in human leukemia. Pediatr Blood Cancer. 2012 Jul 15; 59(1):69-76. PMID: 22106042; PMCID: PMC3292658.
    38. Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011 Oct 13; 118(15):4174-8. PMID: 21856866; PMCID: PMC3204735.
    39. Dovat S, Song C, Payne KJ, Li Z. Ikaros, CK2 kinase, and the road to leukemia. Mol Cell Biochem. 2011 Oct; 356(1-2):201-7. PMID: 21750978; PMCID: PMC3665334.
    40. Song C, Li Z, Erbe AK, Savic A, Dovat S. Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1. World J Biol Chem. 2011 Jun 26; 2(6):126-31. PMID: 21765978; PMCID: PMC3135859.
    41. Li Z, Perez-Casellas LA, Savic A, Song C, Dovat S. Ikaros isoforms: The saga continues. World J Biol Chem. 2011 Jun 26; 2(6):140-5. PMID: 21765980; PMCID: PMC3135861.
    42. Dovat S. Ikaros in hematopoiesis and leukemia. World J Biol Chem. 2011 Jun 26; 2(6):105-7. PMID: 21765974; PMCID: PMC3135855.
    43. Goldman FD, Gurel Z, Al-Zubeidi D, Fried AJ, Icardi M, Song C, Dovat S. Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene. Pediatr Blood Cancer. 2012 Apr; 58(4):591-7. PMID: 21548011; PMCID: PMC3161153.
    44. Yang D, Yaguchi T, Nagata T, Gotoh A, Dovat S, Song C, Nishizaki T. AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell Physiol Biochem. 2011; 27(1):37-44. PMID: 21325820; PMCID: PMC3221265.
    45. Payne KJ, Dovat S. Ikaros and tumor suppression in acute lymphoblastic leukemia. Crit Rev Oncog. 2011; 16(1-2):3-12. PMID: 22150303; PMCID: PMC3243972.
    46. Dovat S, Payne KJ. Tumor suppression in T cell leukemia--the role of Ikaros. Leuk Res. 2010 Apr; 34(4):416-7. PMID: 19892402; PMCID: PMC2826580.
    47. Benton KD, Hermann RJ, Vomhof-DeKrey EE, Haring JS, Van der Steen T, Smith J, Dovat S, Dorsam GP. A transcriptionally permissive epigenetic landscape at the vasoactive intestinal peptide receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells. Regul Pept. 2009 Nov 27; 158(1-3):68-76. PMID: 19729043; PMCID: PMC2771554.
    48. Parrish YK, Baez I, Milford TA, Benitez A, Galloway N, Rogerio JW, Sahakian E, Kagoda M, Huang G, Hao QL, Sevilla Y, Barsky LW, Zielinska E, Price MA, Wall NR, Dovat S, Payne KJ. IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow. J Immunol. 2009 Apr 01; 182(7):4255-66. PMID: 19299724; PMCID: PMC2659466.
    49. Popescu M, Gurel Z, Ronni T, Song C, Hung KY, Payne KJ, Dovat S. Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem. 2009 May 15; 284(20):13869-80. PMID: 19282287; PMCID: PMC2679487.
    50. Kim JH, Ebersole T, Kouprina N, Noskov VN, Ohzeki J, Masumoto H, Mravinac B, Sullivan BA, Pavlicek A, Dovat S, Pack SD, Kwon YW, Flanagan PT, Loukinov D, Lobanenkov V, Larionov V. Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. Genome Res. 2009 Apr; 19(4):533-44. PMID: 19141594; PMCID: PMC2665773.
    51. Tcheng WY, Dovat S, Gurel Z, Donkin J, Wong WY. Severe congenital protein C deficiency: description of a new mutation and prophylactic protein C therapy and in vivo pharmacokinetics. J Pediatr Hematol Oncol. 2008 Feb; 30(2):166-71. PMID: 18376272.
      View in: PubMed
    52. Gurel Z, Ronni T, Ho S, Kuchar J, Payne KJ, Turk CW, Dovat S. Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation. J Biol Chem. 2008 Mar 28; 283(13):8291-300. PMID: 18223295; PMCID: PMC2276389.
    53. Ronni T, Payne KJ, Ho S, Bradley MN, Dorsam G, Dovat S. Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms. J Biol Chem. 2007 Jan 26; 282(4):2538-47. PMID: 17135265.
      View in: PubMed
    54. Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F. Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion. Mol Hum Reprod. 2005 Nov; 11(11):825-31. PMID: 16364975.
      View in: PubMed
    55. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. PMID: 16148093.
      View in: PubMed
    56. Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST. A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev. 2002 Dec 01; 16(23):2985-90. PMID: 12464629; PMCID: PMC187490.
    57. Ziegner UH, Ochs HD, Schanen C, Feig SA, Seyama K, Futatani T, Gross T, Wakim M, Roberts RL, Rawlings DJ, Dovat S, Fraser JK, Stiehm ER. Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies. J Pediatr. 2001 Apr; 138(4):570-3. PMID: 11295723.
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    58. Dovat S, Roberts RL, Wakim M, Stiehm ER, Feig SA. Immune thrombocytopenia after umbilical cord progenitor cell transplant: response to vincristine. Bone Marrow Transplant. 1999 Aug; 24(3):321-3. PMID: 10455373.
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    59. Dovat S, Gilbert KA, Petrovic-Dovat L, Rannels DE. Isolation, cloning, and characterization of a novel rat lung zinc finger gene, RLZF-Y. Biochim Biophys Acta. 1998 Nov 08; 1442(2-3):380-8. PMID: 9804994.
      View in: PubMed
    60. Dovat S, Gilbert KA, Petrovic-Dovat L, Rannels DE. Targeted identification of zinc finger genes expressed in rat lungs. Am J Physiol. 1998 Jul; 275(1 Pt 1):L30-7. PMID: 9688932.
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    61. Dovat S, Feig SA. The use of umbilical cord blood stem cells for hematopoietic reconstitution. West J Med. 1997 May; 166(5):342-3. PMID: 9217441; PMCID: PMC1304236.
    62. Dovat S, Nikolic-Dovat V, Stevanovic V, Malesevic S, Varga J, Protic S, Vukadinovic I. [Supplementary feeding--additional food in daily infant nutrition]. Med Pregl. 1992; 45(5-6):179-83. PMID: 1365053.
      View in: PubMed
    63. Stevanovic V, Dovat S, Nikolic-Dovat V, Stevanovic S. [Hematologic parameter of red blood cells in children up to 2 years of age]. Med Pregl. 1991; 44(11-12):478-81. PMID: 1821447.
      View in: PubMed
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