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Susan Hafenstein

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Mailbox: H036
Phone7175318881

 Overview 
 overview
WEBSITE:
www.hafensteinlab.com

PREFERRED TITLE/ROLE:

Assistant Professor of Medicine & Microbiology and Immunology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Infectious Diseases

EDUCATION:

B.S., Louisiana State University, Baton Rouge, LA - 1992
Ph.D. University of Arizona, Tucson, AZ - 2003
Post-doctoral Fellowship, Purdue University - 2003-2007
Associate Research Scientist, Purdue University - 2007-2009




 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee H, Cifuente JO, Ashley RE, Conway JF, Makhov AM, Tano Y, Shimizu H, Nishimura Y, Hafenstein S. A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody. J Virol. 2013 Nov; 87(21):11363-70.
    View in: PubMed
  2. Nishimura Y, Lee H, Hafenstein S, Kataoka C, Wakita T, Bergelson JM, Shimizu H. Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction. PLoS Pathog. 2013; 9(7):e1003511.
    View in: PubMed
  3. Gullberg M, Muszynski B, Organtini LJ, Ashley RE, Hafenstein SL, Belsham GJ, Polacek C. Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells. J Gen Virol. 2013 Aug; 94(Pt 8):1769-79.
    View in: PubMed
  4. Cifuente JO, Lee H, Yoder JD, Shingler KL, Carnegie MS, Yoder JL, Ashley RE, Makhov AM, Conway JF, Hafenstein S. Structures of the procapsid and mature virion of enterovirus 71 strain 1095. J Virol. 2013 Jul; 87(13):7637-45.
    View in: PubMed
  5. Shingler KL, Yoder JL, Carnegie MS, Ashley RE, Makhov AM, Conway JF, Hafenstein S. The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoEM study of picornavirus uncoating. PLoS Pathog. 2013 Mar; 9(3):e1003240.
    View in: PubMed
  6. Yoder JD, Cifuente JO, Pan J, Bergelson JM, Hafenstein S. The crystal structure of a coxsackievirus B3-RD variant and a refined 9-angstrom cryo-electron microscopy reconstruction of the virus complexed with decay-accelerating factor (DAF) provide a new footprint of DAF on the virus surface. J Virol. 2012 Dec; 86(23):12571-81.
    View in: PubMed
  7. Stucker KM, Pagan I, Cifuente JO, Kaelber JT, Lillie TD, Hafenstein S, Holmes EC, Parrish CR. The role of evolutionary intermediates in the host adaptation of canine parvovirus. J Virol. 2012 Feb; 86(3):1514-21.
    View in: PubMed
  8. Ning X, Nguyen D, Mentzer L, Adams C, Lee H, Ashley R, Hafenstein S, Hu J. Secretion of genome-free hepatitis B virus--single strand blocking model for virion morphogenesis of para-retrovirus. PLoS Pathog. 2011 Sep; 7(9):e1002255.
    View in: PubMed
  9. Cifuente JO, Ferrer MF, Jaquenod de Giusti C, Song WC, Romanowski V, Hafenstein SL, Gómez RM. Molecular determinants of disease in coxsackievirus B1 murine infection. J Med Virol. 2011 Sep; 83(9):1571-81.
    View in: PubMed
  10. Cherwa JE, Organtini LJ, Ashley RE, Hafenstein SL, Fane BA. In VITRO ASSEMBLY of the øX174 procapsid from external scaffolding protein oligomers and early pentameric assembly intermediates. J Mol Biol. 2011 Sep 23; 412(3):387-96.
    View in: PubMed
  11. Pan J, Narayanan B, Shah S, Yoder JD, Cifuente JO, Hafenstein S, Bergelson JM. Single amino acid changes in the virus capsid permit coxsackievirus B3 to bind decay-accelerating factor. J Virol. 2011 Jul; 85(14):7436-43.
    View in: PubMed
  12. Plevka P, Hafenstein S, Li L, D'Abrgamo A, Cotmore SF, Rossmann MG, Tattersall P. Structure of a packaging-defective mutant of minute virus of mice indicates that the genome is packaged via a pore at a 5-fold axis. J Virol. 2011 May; 85(10):4822-7.
    View in: PubMed
  13. Carson SD, Chapman NM, Hafenstein S, Tracy S. Variations of coxsackievirus B3 capsid primary structure, ligands, and stability are selected for in a coxsackievirus and adenovirus receptor-limited environment. J Virol. 2011 Apr; 85(7):3306-14.
    View in: PubMed
  14. Plevka P, Hafenstein S, Harris KG, Cifuente JO, Zhang Y, Bowman VD, Chipman PR, Bator CM, Lin F, Medof ME, Rossmann MG. Interaction of decay-accelerating factor with echovirus 7. J Virol. 2010 Dec; 84(24):12665-74.
    View in: PubMed
  15. Gullberg M, Tolf C, Jonsson N, Mulders MN, Savolainen-Kopra C, Hovi T, Van Ranst M, Lemey P, Hafenstein S, Lindberg AM. Characterization of a putative ancestor of coxsackievirus B5. J Virol. 2010 Oct; 84(19):9695-708.
    View in: PubMed
  16. Gullberg M, Tolf C, Jonsson N, Polacek C, Precechtelova J, Badurova M, Sojka M, Mohlin C, Israelsson S, Johansson K, Bopegamage S, Hafenstein S, Lindberg AM. A single coxsackievirus B2 capsid residue controls cytolysis and apoptosis in rhabdomyosarcoma cells. J Virol. 2010 Jun; 84(12):5868-79.
    View in: PubMed
  17. Goodman LB, Lyi SM, Johnson NC, Cifuente JO, Hafenstein SL, Parrish CR. Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection. J Virol. 2010 May; 84(10):4969-78.
    View in: PubMed
  18. Cotmore SF, Hafenstein S, Tattersall P. Depletion of virion-associated divalent cations induces parvovirus minute virus of mice to eject its genome in a 3'-to-5' direction from an otherwise intact viral particle. J Virol. 2010 Feb; 84(4):1945-56.
    View in: PubMed
  19. Xiao C, Kuznetsov YG, Sun S, Hafenstein SL, Kostyuchenko VA, Chipman PR, Suzan-Monti M, Raoult D, McPherson A, Rossmann MG. Structural studies of the giant mimivirus. PLoS Biol. 2009 Apr 28; 7(4):e92.
    View in: PubMed
  20. Hafenstein S, Bowman VD, Sun T, Nelson CD, Palermo LM, Chipman PR, Battisti AJ, Parrish CR, Rossmann MG. Structural comparison of different antibodies interacting with parvovirus capsids. J Virol. 2009 Jun; 83(11):5556-66.
    View in: PubMed
  21. Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18284-9.
    View in: PubMed
  22. Hafenstein S, Bowman VD, Chipman PR, Bator Kelly CM, Lin F, Medof ME, Rossmann MG. Interaction of decay-accelerating factor with coxsackievirus B3. J Virol. 2007 Dec; 81(23):12927-35.
    View in: PubMed
  23. Hafenstein S, Palermo LM, Kostyuchenko VA, Xiao C, Morais MC, Nelson CD, Bowman VD, Battisti AJ, Chipman PR, Parrish CR, Rossmann MG. Asymmetric binding of transferrin receptor to parvovirus capsids. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6585-9.
    View in: PubMed
  24. Nelson CD, Palermo LM, Hafenstein SL, Parrish CR. Different mechanisms of antibody-mediated neutralization of parvoviruses revealed using the Fab fragments of monoclonal antibodies. Virology. 2007 May 10; 361(2):283-93.
    View in: PubMed
  25. Rossmann MG, Arisaka F, Battisti AJ, Bowman VD, Chipman PR, Fokine A, Hafenstein S, Kanamaru S, Kostyuchenko VA, Mesyanzhinov VV, Shneider MM, Morais MC, Leiman PG, Palermo LM, Parrish CR, Xiao C. From structure of the complex to understanding of the biology. Acta Crystallogr D Biol Crystallogr. 2007 Jan; 63(Pt 1):9-16.
    View in: PubMed
  26. Palermo LM, Hafenstein SL, Parrish CR. Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges. J Virol. 2006 Sep; 80(17):8482-92.
    View in: PubMed
  27. Bernal RA, Hafenstein S, Esmeralda R, Fane BA, Rossmann MG. The phiX174 protein J mediates DNA packaging and viral attachment to host cells. J Mol Biol. 2004 Apr 9; 337(5):1109-22.
    View in: PubMed
  28. Hafenstein SL, Chen M, Fane BA. Genetic and functional analyses of the øX174 DNA binding protein: the effects of substitutions for amino acid residues that spatially organize the two DNA binding domains. Virology. 2004 Jan 5; 318(1):204-13.
    View in: PubMed
  29. Bernal RA, Hafenstein S, Olson NH, Bowman VD, Chipman PR, Baker TS, Fane BA, Rossmann MG. Structural studies of bacteriophage alpha3 assembly. J Mol Biol. 2003 Jan 3; 325(1):11-24.
    View in: PubMed
  30. Hafenstein S, Fane BA. phi X174 genome-capsid interactions influence the biophysical properties of the virion: evidence for a scaffolding-like function for the genome during the final stages of morphogenesis. J Virol. 2002 Jun; 76(11):5350-6.
    View in: PubMed
  31. Brentlinger KL, Hafenstein S, Novak CR, Fane BA, Borgon R, McKenna R, Agbandje-McKenna M. Microviridae, a family divided: isolation, characterization, and genome sequence of phiMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus. J Bacteriol. 2002 Feb; 184(4):1089-94.
    View in: PubMed
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