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Satvir Tevethia

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentMicrobiology and Immunology
Address500 University Drive Hershey PA 17033
Mailbox: H107
Phone7175318872
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Distinguished Professor Emeritus of Microbiology and Immunology

    GRADUATE PROGRAM AFFILIATIONS:

    Genetics, MD/PhD Degree Program, Integrative Biosciences, Microbiology and Immunology

    EDUCATION:

    Ph.D., Michigan State University, 1964
    Postdoctoral Training, Baylor College of Medicine, 1964-1966

    NARRATIVE:

    Cytotoxic T Lymphocyte Based Vaccines Against Viruses and Virus Induced Tumors

    The primary emphasis of my laboratory is directed toward elucidating the role of the immune response to pathogenic and oncogenic DNA tumor viruses. The model system utilizes simian virus 40 (SV40) tumor, or T antigen, a transforming protein, which also provides a target for the major histocompatibility complex (MHC) class I restricted cytotoxic T lymphocytes (CTL). CTL recognition epitopes on T antigen have been localized using site-specific CTL clones, truncated proteins expressed in mouse cells, and synthetic peptides corresponding to these epitopes. Current studies include determining the contribution of each epitope to generating an effective anti-tumor immune response and elucidating, at the molecular level, events in the processing, presentation by the MHC class I antigen, and recognition of SV40 T antigen epitopes by the T cell receptor of specifically sensitized CTL.

    A second area of interest deals with exploring the role of the immune response in resistance of the host to herpes simplex virus (HSV) infections. Emphasis is placed on determining the target protein(s) for CTL and the ability of CTL to suppress HSV pathogenesis.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wilson JJ, Pack CD, Lin E, Frost EL, Albrecht JA, Hadley A, Hofstetter AR, Tevethia SS, Schell TD, Lukacher AE. CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion. J Immunol. 2012 May 01; 188(9):4340-8. PMID: 22447978; PMCID: PMC3331907.
    2. Tatum AM, Mylin LM, Bender SJ, Fischer MA, Vigliotti BA, Tevethia MJ, Tevethia SS, Schell TD. CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors. J Immunol. 2008 Sep 15; 181(6):4406-17. PMID: 18768900; PMCID: PMC2631553.
    3. de Witte MA, Bendle GM, van den Boom MD, Coccoris M, Schell TD, Tevethia SS, van Tinteren H, Mesman EM, Song JY, Schumacher TN. TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation. J Immunol. 2008 Aug 15; 181(4):2563-71. PMID: 18684947; PMCID: PMC2587021.
    4. Tagaram HR, Watson AM, Lemonnier FA, Staveley-O'Carroll K, Tevethia SS, Schell TD. An SV40 VP1-derived epitope recognized by CD8+ T cells is naturally processed and presented by HLA-A*0201 and cross-reactive with human polyomavirus determinants. Virology. 2008 Jun 20; 376(1):183-90. PMID: 18402997; PMCID: PMC2464359.
    5. Yorty JL, Tevethia SS, Schell TD. Rapid accumulation of adoptively transferred CD8+ T cells at the tumor site is associated with long-term control of SV40 T antigen-induced tumors. Cancer Immunol Immunother. 2008 Jun; 57(6):883-95. PMID: 18004562; PMCID: PMC2958109.
    6. Otahal P, Knowles BB, Tevethia SS, Schell TD. Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors. J Immunol. 2007 Nov 15; 179(10):6686-95. PMID: 17982058.
      View in: PubMed
    7. Mylin LM, Schell TD, Epler M, Kusuma C, Assis D, Matsko C, Smith A, Allebach A, Tevethia SS. Diversity of escape variant mutations in Simian virus 40 large tumor antigen (SV40 Tag) epitopes selected by cytotoxic T lymphocyte (CTL) clones. Virology. 2007 Jul 20; 364(1):155-68. PMID: 17368499; PMCID: PMC3866617.
    8. Otahal P, Schell TD, Hutchinson SC, Knowles BB, Tevethia SS. Early immunization induces persistent tumor-infiltrating CD8+ T cells against an immunodominant epitope and promotes lifelong control of pancreatic tumor progression in SV40 tumor antigen transgenic mice. J Immunol. 2006 Sep 01; 177(5):3089-99. PMID: 16920946.
      View in: PubMed
    9. Sullivan CS, Grundhoff A, Tevethia S, Treisman R, Pipas JM, Ganem D. Expression and function of microRNAs in viruses great and small. Cold Spring Harb Symp Quant Biol. 2006; 71:351-6. PMID: 17381316.
      View in: PubMed
    10. Otahal P, Hutchinson SC, Mylin LM, Tevethia MJ, Tevethia SS, Schell TD. Inefficient cross-presentation limits the CD8+ T cell response to a subdominant tumor antigen epitope. J Immunol. 2005 Jul 15; 175(2):700-12. PMID: 16002665.
      View in: PubMed
    11. Sullivan CS, Grundhoff AT, Tevethia S, Pipas JM, Ganem D. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature. 2005 Jun 02; 435(7042):682-6. PMID: 15931223.
      View in: PubMed
    12. Barton LF, Runnels HA, Schell TD, Cho Y, Gibbons R, Tevethia SS, Deepe GS, Monaco JJ. Immune defects in 28-kDa proteasome activator gamma-deficient mice. J Immunol. 2004 Mar 15; 172(6):3948-54. PMID: 15004203.
      View in: PubMed
    13. Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. J Immunol. 2003 Nov 01; 171(9):4539-51. PMID: 14568927.
      View in: PubMed
    14. Staveley-O'Carroll K, Schell TD, Jimenez M, Mylin LM, Tevethia MJ, Schoenberger SP, Tevethia SS. In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice. J Immunol. 2003 Jul 15; 171(2):697-707. PMID: 12847236.
      View in: PubMed
    15. Wong M, Pagano JS, Schiller JT, Tevethia SS, Raab-Traub N, Gruber J. New associations of human papillomavirus, Simian virus 40, and Epstein-Barr virus with human cancer. J Natl Cancer Inst. 2002 Dec 18; 94(24):1832-6. PMID: 12488476.
      View in: PubMed
    16. Schell TD, Mylin LM, Tevethia SS, Joyce S. The assembly of functional beta(2)-microglobulin-free MHC class I molecules that interact with peptides and CD8(+) T lymphocytes. Int Immunol. 2002 Jul; 14(7):775-82. PMID: 12096037.
      View in: PubMed
    17. Schell TD, Tevethia SS. Control of advanced choroid plexus tumors in SV40 T antigen transgenic mice following priming of donor CD8(+) T lymphocytes by the endogenous tumor antigen. J Immunol. 2001 Dec 15; 167(12):6947-56. PMID: 11739514.
      View in: PubMed
    18. Schell TD, Lippolis JD, Tevethia SS. Cytotoxic T lymphocytes from HLA-A2.1 transgenic mice define a potential human epitope from simian virus 40 large T antigen. Cancer Res. 2001 Feb 01; 61(3):873-9. PMID: 11221873.
      View in: PubMed
    19. Kumaraguru U, Davis IA, Deshpande S, Tevethia SS, Rouse BT. Lymphotoxin alpha-/- mice develop functionally impaired CD8+ T cell responses and fail to contain virus infection of the central nervous system. J Immunol. 2001 Jan 15; 166(2):1066-74. PMID: 11145686.
      View in: PubMed
    20. Tevethia S, Beachy T, Schell T, Lippolis J, Newmaster R, Mylin L, Tevethia MJ. Role of CTL host responses and their implication for tumorigenicity testing and the use of tumour cells as vaccine substrate. Dev Biol (Basel). 2001; 106:109-21; discussion 143-60. PMID: 11761225.
      View in: PubMed
    21. Schell TD, Tevethia SS. Cytotoxic T lymphocytes in SV40 infections. Methods Mol Biol. 2001; 165:243-56. PMID: 11217391.
      View in: PubMed
    22. Mylin LM, Schell TD, Roberts D, Epler M, Boesteanu A, Collins EJ, Frelinger JA, Joyce S, Tevethia SS. Quantitation of CD8(+) T-lymphocyte responses to multiple epitopes from simian virus 40 (SV40) large T antigen in C57BL/6 mice immunized with SV40, SV40 T-antigen-transformed cells, or vaccinia virus recombinants expressing full-length T antigen or epitope minigenes. J Virol. 2000 Aug; 74(15):6922-34. PMID: 10888631; PMCID: PMC112209.
    23. Schell TD, Knowles BB, Tevethia SS. Sequential loss of cytotoxic T lymphocyte responses to simian virus 40 large T antigen epitopes in T antigen transgenic mice developing osteosarcomas. Cancer Res. 2000 Jun 01; 60(11):3002-12. PMID: 10850449.
      View in: PubMed
    24. Schell TD, Mylin LM, Georgoff I, Teresky AK, Levine AJ, Tevethia SS. Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice. J Virol. 1999 Jul; 73(7):5981-93. PMID: 10364350; PMCID: PMC112659.
    25. Brehm M, Samaniego LA, Bonneau RH, DeLuca NA, Tevethia SS. Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0. Virology. 1999 Apr 10; 256(2):258-69. PMID: 10191191.
      View in: PubMed
    26. Blaney JE, Nobusawa E, Brehm MA, Bonneau RH, Mylin LM, Fu TM, Kawaoka Y, Tevethia SS. Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity. J Virol. 1998 Dec; 72(12):9567-74. PMID: 9811690; PMCID: PMC110466.
    27. Boesteanu A, Brehm M, Mylin LM, Christianson GJ, Tevethia SS, Roopenian DC, Joyce S. A molecular basis for how a single TCR interfaces multiple ligands. J Immunol. 1998 Nov 01; 161(9):4719-27. PMID: 9794402.
      View in: PubMed
    28. Newmaster RS, Mylin LM, Fu TM, Tevethia SS. Role of a subdominant H-2Kd-restricted SV40 tumor antigen cytotoxic T lymphocyte epitope in tumor rejection. Virology. 1998 May 10; 244(2):427-41. PMID: 9601511.
      View in: PubMed
    29. Fu TM, Mylin LM, Schell TD, Bacik I, Russ G, Yewdell JW, Bennink JR, Tevethia SS. An endoplasmic reticulum-targeting signal sequence enhances the immunogenicity of an immunorecessive simian virus 40 large T antigen cytotoxic T-lymphocyte epitope. J Virol. 1998 Feb; 72(2):1469-81. PMID: 9445050; PMCID: PMC124628.
    30. Tevethia SS, Mylin L, Newmaster R, Epler M, Lednicky JA, Butel JS, Tevethia MJ. Cytotoxic T lymphocyte recognition sequences as markers for distinguishing among tumour antigens encoded by SV40, BKV and JCV. Dev Biol Stand. 1998; 94:329-39. PMID: 9776254.
      View in: PubMed
    31. Brehm MA, Bonneau RH, Knipe DM, Tevethia SS. Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1. J Virol. 1997 May; 71(5):3534-44. PMID: 9094625; PMCID: PMC191500.
    32. Fu TM, Bonneau RH, Epler M, Tevethia MJ, Alam S, Verner K, Tevethia SS. Induction and persistence of a cytotoxic T lymphocyte (CTL) response against a herpes simplex virus-specific CTL epitope expressed in a cellular protein. Virology. 1996 Aug 01; 222(1):269-74. PMID: 8806508.
      View in: PubMed
    33. Mylin LM, Bonneau RH, Lippolis JD, Tevethia SS. Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen. J Virol. 1995 Nov; 69(11):6665-77. PMID: 7474076; PMCID: PMC189576.
    34. Lippolis JD, Mylin LM, Simmons DT, Tevethia SS. Functional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen. J Virol. 1995 May; 69(5):3134-46. PMID: 7535867; PMCID: PMC189015.
    35. Salvucci LA, Bonneau RH, Tevethia SS. Polymorphism within the herpes simplex virus (HSV) ribonucleotide reductase large subunit (ICP6) confers type specificity for recognition by HSV type 1-specific cytotoxic T lymphocytes. J Virol. 1995 Feb; 69(2):1122-31. PMID: 7529328; PMCID: PMC188685.
    36. Bonneau RH, Fu TM, Tevethia SS. In vivo priming and activation of memory cytotoxic T-lymphocytes (CTL) by a chimeric simian virus 40 T antigen expressing an eight amino acid residue herpes simplex virus gB CTL epitope. Virology. 1993 Dec; 197(2):782-7. PMID: 7504370.
      View in: PubMed
    37. Fu TM, Bonneau RH, Tevethia MJ, Tevethia SS. Simian virus 40 T antigen as a carrier for the expression of cytotoxic T-lymphocyte recognition epitopes. J Virol. 1993 Nov; 67(11):6866-71. PMID: 7692088; PMCID: PMC238134.
    38. Bonneau RH, Salvucci LA, Johnson DC, Tevethia SS. Epitope specificity of H-2Kb-restricted, HSV-1-, and HSV-2-cross-reactive cytotoxic T lymphocyte clones. Virology. 1993 Jul; 195(1):62-70. PMID: 7686314.
      View in: PubMed
    39. Tevethia SS, Epler M, Georgoff I, Teresky A, Marlow M, Levine AJ. Antibody response to human papovavirus JC (JCV) and simian virus 40 (SV40) T antigens in SV40 T antigen-transgenic mice. Virology. 1992 Sep; 190(1):459-64. PMID: 1382342.
      View in: PubMed
    40. Lill NL, Tevethia MJ, Hendrickson WG, Tevethia SS. Cytotoxic T lymphocytes (CTL) against a transforming gene product select for transformed cells with point mutations within sequences encoding CTL recognition epitopes. J Exp Med. 1992 Aug 01; 176(2):449-57. PMID: 1380062; PMCID: PMC2119332.
    41. Deckhut AM, Tevethia SS. Effect of point mutations in the native simian virus 40 tumor antigen, and in synthetic peptides corresponding to the H-2Db-restricted epitopes, on antigen presentation and recognition by cytotoxic T lymphocyte clones. J Immunol. 1992 May 15; 148(10):3012-20. PMID: 1374447.
      View in: PubMed
    42. Deckhut AM, Lippolis JD, Tevethia SS. Comparative analysis of core amino acid residues of H-2D(b)-restricted cytotoxic T-lymphocyte recognition epitopes in simian virus 40 T antigen. J Virol. 1992 Jan; 66(1):440-7. PMID: 1370091; PMCID: PMC238304.
    43. Deckhut AM, Tevethia MJ, Haggerty S, Frisque RJ, Tevethia SS. Localization of common cytotoxic T lymphocyte recognition epitopes on simian papovavirus SV40 and human papovavirus JC virus T antigens. Virology. 1991 Jul; 183(1):122-32. PMID: 1711255.
      View in: PubMed
    44. Tevethia SS, Lewis M, Tanaka Y, Milici J, Knowles B, Maloy WL, Anderson R. Dissection of H-2Db-restricted cytotoxic T-lymphocyte epitopes on simian virus 40 T antigen by the use of synthetic peptides and H-2Dbm mutants. J Virol. 1990 Mar; 64(3):1192-200. PMID: 1689391; PMCID: PMC249233.
    45. Tevethia SS. Recognition of simian virus 40 T antigen by cytotoxic T lymphocytes. Mol Biol Med. 1990 Feb; 7(1):83-96. PMID: 2157938.
      View in: PubMed
    46. Tanaka Y, Tevethia SS. Loss of immunorecessive cytotoxic T lymphocyte determinant V on SV40 T antigen following cocultivation with site-specific cytotoxic T lymphocyte clone Y-5. Intervirology. 1990; 31(2-4):197-202. PMID: 1695620.
      View in: PubMed
    47. Tanaka Y, Anderson RW, Maloy WL, Tevethia SS. Localization of an immunorecessive epitope on SV40 T antigen by H-2Db-restricted cytotoxic T-lymphocyte clones and a synthetic peptide. Virology. 1989 Jul; 171(1):205-13. PMID: 2472702.
      View in: PubMed
    48. Jennings SR, Fresa KL, Lippe PA, Milici JE, Tevethia SS. Frequency analysis of simian virus 40-specific cytotoxic T lymphocyte precursors in the high responder C57BL/6 mouse strain. J Gen Virol. 1988 Oct; 69 ( Pt 10):2493-503. PMID: 2459302.
      View in: PubMed
    49. Tanaka Y, Tevethia SS. Differential effect of adenovirus 2 E3/19K glycoprotein on the expression of H-2Kb and H-2Db class I antigens and H-2Kb- and H-2Db-restricted SV40-specific CTL-mediated lysis. Virology. 1988 Aug; 165(2):357-66. PMID: 2970152.
      View in: PubMed
    50. Tanaka Y, Tevethia SS. In vitro selection of SV40 T antigen epitope loss variants by site-specific cytotoxic T lymphocyte clones. J Immunol. 1988 Jun 15; 140(12):4348-54. PMID: 2453578.
      View in: PubMed
    51. Tanaka Y, Tevethia MJ, Kalderon D, Smith AE, Tevethia SS. Clustering of antigenic sites recognized by cytotoxic T lymphocyte clones in the amino terminal half of SV40 T antigen. Virology. 1988 Feb; 162(2):427-36. PMID: 2448953.
      View in: PubMed
    52. Bates MP, Jennings SR, Tanaka Y, Tevethia MJ, Tevethia SS. Recognition of simian virus 40 T antigen synthesized during viral lytic cycle in monkey kidney cells expressing mouse H-2Kb- and H-2Db-transfected genes by SV40-specific cytotoxic T lymphocytes leads to the abrogation of virus lytic cycle. Virology. 1988 Jan; 162(1):197-205. PMID: 2827378.
      View in: PubMed
    53. Anderson RW, Tevethia MJ, Kalderon D, Smith AE, Tevethia SS. Fine mapping two distinct antigenic sites on simian virus 40 (SV40) T antigen reactive with SV40-specific cytotoxic T-cell clones by using SV40 deletion mutants. J Virol. 1988 Jan; 62(1):285-96. PMID: 2446015; PMCID: PMC250529.
    54. Fresa KL, Karjalainen HE, Tevethia SS. Sensitivity of simian virus 40-transformed C57BL/6 mouse embryo fibroblasts to lysis by murine natural killer cells. J Immunol. 1987 Feb 15; 138(4):1215-20. PMID: 3027174.
      View in: PubMed
    55. Jennings SR, Lippe PA, Pauza KJ, Spear PG, Pereira L, Tevethia SS. Kinetics of expression of herpes simplex virus type 1-specific glycoprotein species on the surfaces of infected murine, simian, and human cells: flow cytometric analysis. J Virol. 1987 Jan; 61(1):104-12. PMID: 3023688; PMCID: PMC255213.
    56. Tevethia MJ, Anderson RW, Tevethia SS, Simmons D, Feunteun J, Cole C. Influence of amino acids encoded in the 3' open reading frame of the SV40 early region on transformation and antigenicity of large T antigen. Virology. 1986 Apr 30; 150(2):361-72. PMID: 3008414.
      View in: PubMed
    57. Lum CT, Jennings SR, Wanner FJ, Tevethia SS. Inhibition of T cell cytotoxicity by cyclosporine (CSA), adenosine (Ado) and an inhibitor of adenosine deaminase (ADA). Adv Exp Med Biol. 1986; 195 Pt B:235-8. PMID: 3490123.
      View in: PubMed
    58. Jennings SR, Rice PL, Kloszewski ED, Anderson RW, Thompson DL, Tevethia SS. Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells. J Virol. 1985 Dec; 56(3):757-66. PMID: 2999432; PMCID: PMC252646.
    59. Karjalainen HE, Tevethia MJ, Tevethia SS. Abrogation of simian virus 40 DNA-mediated transformation of primary C57BL/6 mouse embryo fibroblasts by exposure to a simian virus 40-specific cytotoxic T-lymphocyte clone. J Virol. 1985 Nov; 56(2):373-7. PMID: 2414463; PMCID: PMC252589.
    60. Tevethia SS, Tevethia MJ. Cytotoxic T-lymphocyte recognition of simian virus 40 antigens. Cancer Surv. 1985; 4(1):101-14. PMID: 3022921.
      View in: PubMed
    61. Tevethia SS, Lewis AJ, Campbell AE, Tevethia MJ, Rigby PW. Simian virus 40 specific cytotoxic lymphocyte clones localize two distinct TSTA sites on cells synthesizing a 48 kD SV40 T antigen. Virology. 1984 Mar; 133(2):443-7. PMID: 6200989.
      View in: PubMed
    62. Carter VC, Jennings SR, Rice PL, Tevethia SS. Mapping of a herpes simplex virus type 2-encoded function that affects the susceptibility of herpes simplex virus-infected target cells to lysis by herpes simplex virus-specific cytotoxic T lymphocytes. J Virol. 1984 Mar; 49(3):766-71. PMID: 6321762; PMCID: PMC255536.
    63. Jennings SR, Rice PL, Pan S, Knowles BB, Tevethia SS. Recognition of herpes simplex virus antigens on the surface of mouse cells of the H-2b haplotype by virus-specific cytotoxic T lymphocytes. J Immunol. 1984 Jan; 132(1):475-81. PMID: 6197457.
      View in: PubMed
    64. Flyer DC, Pretell J, Campbell AE, Liao WS, Tevethia MJ, Taylor JM, Tevethia SS. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). X. Tumorigenic potential of mouse cells transformed by SV40 in high responder C57BL/6 mice and correlation with the persistence of SV40 TrAg, early proteins and sequences. Virology. 1983 Nov; 131(1):207-20. PMID: 6316651.
      View in: PubMed
    65. Tevethia SS, Tevethia MJ, Lewis AJ, Reddy VB, Weissman SM. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). IX. Analysis of TrAg in mouse cells synthesizing truncated SV40 large T antigen. Virology. 1983 Jul 30; 128(2):319-30. PMID: 6310860.
      View in: PubMed
    66. Tevethia SS. Cytolytic T lymphocyte response to SV40. Surv Immunol Res. 1983; 2(3):312-4. PMID: 6326233.
      View in: PubMed
    67. Choi KH, Tevethia SS, Shin S. Tumor formation by SV40-transformed human cells in nude mice: the role of SV40 T antigens. Cytogenet Cell Genet. 1983; 36(4):633-40. PMID: 6319085.
      View in: PubMed
    68. Campbell AE, Foley FL, Tevethia SS. Demonstration of multiple antigenic sites of the SV40 transplantation rejection antigen by using cytotoxic T lymphocyte clones. J Immunol. 1983 Jan; 130(1):490-2. PMID: 6183360.
      View in: PubMed
    69. Reddy VB, Tevethia MJ, Tevethia SS, Weissman SM, Biro PA, Pan J, Das H, Sood AK, Weissman SM, Barbosa J, Kamarck M, Ruddle F. Molecular dissection of mhc complex and of sv40-induced surface antigen. Ann N Y Acad Sci. 1982 Dec 10; 397:229-37. PMID: 6297351.
      View in: PubMed
    70. Flyer DC, Anderson RW, Tevethia SS. Lyt phenotype of H-2b CTL effectors and precursors specific for the SV40 transplantation rejection antigen. J Immunol. 1982 Dec; 129(6):2368-71. PMID: 6292288.
      View in: PubMed
    71. Carter VC, Rice PL, Tevethia SS. Intratypic and intertypic specificity of lymphocytes involved in the recognition of herpes simplex virus glycoproteins. Infect Immun. 1982 Jul; 37(1):116-26. PMID: 6286488; PMCID: PMC347498.
    72. Reddy VB, Tevethia SS, Tevethia MJ, Weissman SM. Nonselective expression of simian virus 40 large tumor antigen fragments in mouse cells. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):2064-7. PMID: 6281793; PMCID: PMC346123.
    73. Ransom JH, Thompson DL, Tevethia SS. Kinetics of the immune response of tumor-bearing hamsters to two simian virus 40 coded non-structural polypeptides present in simian virus 40 tumor cells. Int J Cancer. 1982 Feb 15; 29(2):217-22. PMID: 6277810.
      View in: PubMed
    74. Flyer DC, Tevethia SS. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). VIII. Retention of SV40 TrAg sites on purified SV40 large T antigen following denaturation with sodium dodecyl sulfate. Virology. 1982 Feb; 117(1):267-70. PMID: 6175086.
      View in: PubMed
    75. Carter VC, Schaffer PA, Tevethia SS. The involvement of herpes simplex virus type 1 glycoproteins in cell-mediated immunity. J Immunol. 1981 May; 126(5):1655-60. PMID: 6971309.
      View in: PubMed
    76. Tevethia SS, Flyer DC, Tevethia MJ, Topp WC. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). VII. Induction of SV40 TrAg in nonpermissive mouse cells by early viable SV40 deletion (o.54/0.59) mutants. Virology. 1980 Dec; 107(2):488-96. PMID: 6256944.
      View in: PubMed
    77. Tevethia SS, Flyer DC, Tjian R. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). VI. Mechanism of induction of SV40 transplantation immunity in mice by purified SV40 T antigen (D2 protein). Virology. 1980 Nov; 107(1):13-23. PMID: 6255675.
      View in: PubMed
    78. Greenfield RS, Flyer DC, Tevethia SS. Demonstration of unique and common antigenic sites located on the SV40 large T and small t antigens. Virology. 1980 Jul 30; 104(2):312-22. PMID: 6156542.
      View in: PubMed
    79. Machtiger NA, Pancake BA, Eberle R, Courtney RJ, Tevethia SS, Schaffer PA. Herpes simplex virus glycoproteins: isolation of mutants resistant to immune cytolysis. J Virol. 1980 May; 34(2):336-46. PMID: 6246268; PMCID: PMC288710.
    80. Tevethia SS, Greenfield RS, Flyer DC, Tevethia MJ. SV40 transplantation antigen: relationship to SV40-specific proteins. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:235-42. PMID: 6253137.
      View in: PubMed
    81. Pretell J, Greenfield RS, Tevethia SS. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). V In vitro demonstration of SV40 TrAg in SV40 infected nonpermissive mouse cells by the lymphocyte mediated cytotoxicity assay. Virology. 1979 Aug; 97(1):32-41. PMID: 224580.
      View in: PubMed
    82. Siebens H, Tevethia SS, Babior BM. Neutrophil-mediated antibody-dependent killing of herpes-simplex-virus-infected cells. Blood. 1979 Jul; 54(1):88-94. PMID: 221057.
      View in: PubMed
    83. Tevethia SS, Greenfield RS, Rieder V, Tevethia MJ. Biology of simian virus 40 (SV40) transplantation antigen (TrAg). IV. Inhibition by human interferon of expression of SV40 TrAg in SV40-infected monkey cells. Virology. 1979 Jun; 95(2):587-92. PMID: 223293.
      View in: PubMed
    84. Tevethia SS, Singh SB. Further studies on the activation of hamster lymphocytes by concanavalin A. Fed Proc. 1978 May 15; 37(7):2037-8. PMID: 205439.
      View in: PubMed
    85. Tevethia MJ, Tevethia SS. Biology of simian virus 40 (SV40) transplantation antigen (TrAg) III. Involvement of SV40 gene A in the expression of TrAg in permissive cells. Virology. 1977 Sep; 81(2):212-23. PMID: 197694.
      View in: PubMed
    86. Tevethia SS, Waneck G, Tevethia MJ. Immune response of athymic nude mice to papovavirus SV40 tumor-associated antigens. Int J Cancer. 1977 May 15; 19(5):700-6. PMID: 193802.
      View in: PubMed
    87. Tevethia SS, Rapp F. Comparative immunology of carcinogenesis by DNA viruses. Contemp Top Immunobiol. 1977; 6:1-69. PMID: 194745.
      View in: PubMed
    88. Tevethia SS, Lewis AM. Two adenovirus type 2-simian virus 40 hybrid populations that contain the entire SV40 genome differ in their ability to induce SV40 transplantation immunity in hamsters but not in mice. J Virol. 1976 Nov; 20(2):539-42. PMID: 185429; PMCID: PMC355023.
    89. Tevethia MJ, Tevethia SS. Biology of SV40 transplantation antigen (TrAg). I. Demonstration of SV40 TrAg on glutaraldehyde-fixed SV40-infected African green monkey kidney cells. Virology. 1976 Feb; 69(2):474-89. PMID: 176782.
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    90. Tevethia SS, Tevethia MJ. Significance of specific transplantation antigen expression at the surface of papovavirus SV40-infected permissive cells. Bibl Haematol. 1975 Oct; (43):74-7. PMID: 183734.
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    91. Blasecki JW, Tevethia SS. Restoration of specific immunity against SV40 tumor-specific transplantation antigen to lymphoid cells from tumor-bearing mice. Int J Cancer. 1975 Aug 15; 16(2):275-83. PMID: 51012.
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    92. Tevethia SS. Immunofluorescence staining of DNA tumor virus-induced antigens. Ann N Y Acad Sci. 1975 Jun 30; 254:541-50. PMID: 52323.
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    93. Tevethia SS, Tevethia MJ. Cell-mediated immunity to virus-induced tumors: generation of lymphocytes sensitized to specific transplantation antigen in mouse cells infected with papovavirus SV40. Prog Med Virol. 1975; 21:103-17. PMID: 174151.
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    94. Blasecki JW, Tevethia SS. In vitro studies on the cellular immune response of tumor-bearing mice to SV40-transformed cells. J Immunol. 1975 Jan; 114(1 Pt 1):244-9. PMID: 163278.
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    95. Tevethia SS, Blasecki JW, Waneck G, Goldstein AL. Requirement of thymus-derived theta-positive lymphocytes for rejection of DNA virus (SV 40) tumors in mice. J Immunol. 1974 Nov; 113(5):1417-23. PMID: 4371155.
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    96. Tevethia SS. Evidence for virus-specific transplantation antigen in cells of lymphoid neoplasms induced by papovavirus SV40. Int J Cancer. 1974 Apr 15; 13(4):494-9. PMID: 4135417.
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    97. Tevethia MJ, Ripper LW, Tevethia SS. A simple qualitative spot complementation test for temperature-sensitive mutants of SV40. Intervirology. 1974; 3(4):245-55. PMID: 4376805.
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    98. Tevethia SS, MacMillan VL. Acquisition of malignant properties by SV40-transformed mouse cells: relationship to type-C viral antigen expression. Intervirology. 1974; 3(4):269-76. PMID: 4376806.
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    99. Smith JW, Tevethia SS, Levy BM, Rawls WE. Comparative studies on host responses to Shope fibroma virus in adult and newborn rabbits. J Natl Cancer Inst. 1973 Jun; 50(6):1529-39. PMID: 4577768.
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    100. Singh SB, Tevethia SS. Demonstration of mixed lymphocyte interaction in hamsters. Proc Soc Exp Biol Med. 1973 Feb; 142(2):443-5. PMID: 4266021.
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    101. Blasecki JW, Tevethia SS. In vitro assay of cellular immunity to tumor-specific antigen(s) of virus-induced tumors by macrophage migration inhibition. J Immunol. 1973 Feb; 110(2):590-4. PMID: 4346097.
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    102. Melnick JL, Altenburg B, Arnstein P, Mirkovic R, Tevethia SS. Transformation of baboon cells with feline sarcoma virus. Intervirology. 1973; 1(5-6):386-98. PMID: 4361814.
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    103. Singh SB, Tevethia SS. Cytotoxicity of concanavalin A-activated hamster lymphocytes. Infect Immun. 1973 Jan; 7(1):46-52. PMID: 4689913; PMCID: PMC422637.
    104. Todaro GJ, Tevethia SS, Melnick JL. Isolation of an RD-114 related type-C virus from feline sarcoma virus-transformed baboon cells. Intervirology. 1973; 1(5):399-404. PMID: 4131819.
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    105. Zarling JM, Tevethia SS. Transplantation immunity to simian virus 40-transformed cells in tumor-bearing mice. II. Evidence for macrophage participation at the effector level of tumor cell rejection. J Natl Cancer Inst. 1973 Jan; 50(1):149-57. PMID: 4348219.
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    106. Tevethia SS, Butel JS. Induction of common transplantation antigen by various isolates of papovavirus SV40 and by virus rescued from transformed cells. Intervirology. 1973; 2(3):200-5. PMID: 4366480.
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    107. Zarling JM, Tevethia SS. Transplantation immunity to simian virus 40-transformed cells in tumor-bearing mice. I. Development of cellular immunity to simian virus 40 tumor-specific transplantation antigens during tumorigenesis by transplanted cells. J Natl Cancer Inst. 1973 Jan; 50(1):137-47. PMID: 4348218.
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    108. Mace ML, Tevethia SS, Brinkley BR. Differential immunofluorescent labeling of chromosomes with antisera specific for single strand DNA. Exp Cell Res. 1972 Dec; 75(2):521-3. PMID: 4566307.
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    109. Tevethia SS, Zarling JM. Participation of macrophages in tumor immunity. Natl Cancer Inst Monogr. 1972 Dec; 35:279-82. PMID: 4349149.
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    110. Prasad R, Prasad N, Tevethia SS. Expression of lactate and malate dehydrogenases in tumors induced by SV40 and 7,12-dimethylbenz(a)anthracene. Science. 1972 Oct 06; 178(4056):70-1. PMID: 4341820.
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    111. Tevethia SS, Lowry S, Rawls WE, Melnick JL, McMillan V. Detection of early cell surface changes in herpes simplex virus infected cells by agglutination with concanavalin A. J Gen Virol. 1972 Apr; 15(1):93-7. PMID: 4337222.
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    112. Singh SB, Tevethia SS. In vitro stimulation of hamster lymphocytes with concanavalin A. Infect Immun. 1972 Mar; 5(3):339-45. PMID: 4636291; PMCID: PMC422372.
    113. Singh SB, Smith JW, Rawls WE, Tevethia SS. Demonstration of cytotoxic antibodies in rabbits bearing tumors induced by Shope fibroma virus. Infect Immun. 1972 Mar; 5(3):352-8. PMID: 4344218; PMCID: PMC422374.
    114. Butel JS, Tevethia SS, Melnick JL. Oncogenicity and cell transformation by papovavirus SV40: the role of the viral genome. Adv Cancer Res. 1972; 15:1-55. PMID: 4333789.
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    115. Zarling JM, Tevethia SS. Expression of concanavalin A binding sites in rabbit kidney cells infected with vaccinia virus. Virology. 1971 Jul; 45(1):313-6. PMID: 5165252.
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    116. Tevethia SS, McMillan VL, Kaplan PM, Bushong SC. Variation in immunosensitivity of SV40-transformed hamster cells. J Immunol. 1971 May; 106(5):1295-300. PMID: 4326127.
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    117. Butel JS, Tevethia SS, Nachtigal M. Malignant transformation in vitro by "non-oncogenic" variants of defective SV40 (PARA). J Immunol. 1971 Apr; 106(4):969-74. PMID: 4324260.
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    118. Kaplan PM, Melnick JL, Tevethia SS. Development of nononcogenic SA7-adenovirus 2 populations that immunize against SA7-transformed cells. J Natl Cancer Inst. 1971 Mar; 46(3):565-76. PMID: 4323136.
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    119. Melnick JL, Butel JS, Tevethia SS, Biswal N, Benyesh-Melnick M. Cell transformation by viruses. I. Significance of virus-specific antigens induced by deoxyribonucleic acid-containing tumor viruses. II. Complementary ribonucleic acid in cells transformed by ribonucleic acid-containing tumor viruses. In Vitro. 1971 Mar-Apr; 6(5):335-48. PMID: 4360732.
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    120. Butel JS, Melnick JL, Tevethia SS. Effect of adenovirus type 12 on tumor induction by SV40 and para (defective SV40). Int J Cancer. 1971 Jan 15; 7(1):112-8. PMID: 4322932.
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    121. Tompkins WA, Crouch NA, Tevethia SS, Rawls WE. Characterization of surface antigen on cells infected by fibroma virus. J Immunol. 1970 Nov; 105(5):1181-9. PMID: 4321290.
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    122. Tevethia SS, Crouch NA, Melnick JL, Rapp F. Detection of specific surface antigens by colony inhibition in cells transformed by papovavirus SV40. Int J Cancer. 1970 Mar 15; 5(2):176-84. PMID: 4317726.
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    123. Lausch RN, Tevethia SS, Rapp F. Evidence for tolerance to SV40 tumor antigen in hamsters bearing para-adenovirus 12 tumor transplants. J Immunol. 1970 Feb; 104(2):305-11. PMID: 4312872.
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    124. Tevethia SS. Immune response of rabbits to purified papovavirus SV40. J Immunol. 1970 Jan; 104(1):72-8. PMID: 4312438.
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    125. Tevethia SS, Rapp F. The effect of phleomycin on the replication of papovavirus SV40 and other DNA viruses in simian cells. Cancer Res. 1969 Apr; 29(4):912-7. PMID: 4304732.
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    126. Tevethia SS, Diamandopoulos GT, Rapp F, Enders JF. Lack of relationship between virus-specific surface and transplantation antigens in hamster cells transformed by simian papovavirus SV40. J Immunol. 1968 Dec; 101(6):1192-8. PMID: 4881078.
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    127. Lausch RN, Tevethia SS, Rapp F. Evidence of SV40-specific transplantation and surface antigens in cells transformed by PARA-adenovirus 12. J Immunol. 1968 Oct; 101(4):645-9. PMID: 4878719.
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    128. Tevethia SS, Cunningham CH. Antigenic characterization of infectious bronchitis virus. J Immunol. 1968 Apr; 100(4):793-8. PMID: 4967045.
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    129. Tevethia SS. Development in hamsters of antibodies against surface antigens present in cells transformed by papovavirus SV40. J Immunol. 1968 Feb; 100(2):358-62. PMID: 4295750.
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    130. Diamandopoulos GT, Tevethia SS, Rapp F, Enders JF. Development of S and T antigens and oncogenicity in hamster embryonic cell lines exposed to SV40. Virology. 1968 Feb; 34(2):331-6. PMID: 4295917.
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    131. Rapp F, Butel JS, Tevethia SS, Melnick JL. Comparison of ability of defective foreign genomes (PARA and MAC) carried by human adenoviruses to induce SV40 transplantation immunity. J Immunol. 1967 Aug; 99(2):386-91. PMID: 4291652.
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    132. Rapp F, Tevethia SS, Rawls WE, Melnick JL. Production of antibodies to papovavirus SV40 tumor antigen in African green monkeys. Proc Soc Exp Biol Med. 1967 Jul; 125(3):794-8. PMID: 15938269.
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    133. Tevethia S. Characterization of hamster antibody reacting with papovavirus SV40 tumor antigen. J Immunol. 1967 Jun; 98(6):1257-64. PMID: 4290805.
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    134. Rapp F, Butel JS, Tevethia SS, Katz M, Melnick JL. Antigenic analysis of tumors and sera from aimals inoculated with para-adenovirus populations. J Immunol. 1966 Dec; 97(6):833-9. PMID: 4289076.
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    135. Tevethia SS, Rapp F. Prevention and interruption of SV40 induced transplantation immunity with tumor cell extracts. Proc Soc Exp Biol Med. 1966 Nov; 123(2):612-5. PMID: 4288641.
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    136. Rapp F, Tevethia SS, Melnick JL. Papovavirus SV40 transplantation immunity conferred by an adenovirus-SV40 hybrid. J Natl Cancer Inst. 1966 Apr; 36(4):703-8. PMID: 4286938.
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    137. Tevethia SS, Rapp F. Demonstration of new surface antigens in cells transformed by papovavirus SV40 by cytotoxic tests. Proc Soc Exp Biol Med. 1965 Nov; 120(2):455-8. PMID: 5323096.
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    138. TEVETHIA SS, KATZ M, RAPP F. NEW SURFACE ANTIGEN IN CELLS TRANSFORMED BY SIMIAN PAPOVAVIRUS SV40. Proc Soc Exp Biol Med. 1965 Jul; 119:896-901. PMID: 14330903.
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