PSU Profiles
Keywords
Last Name
Institution

Sarah Bronson

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey PA 17033
Mailbox: H166
Phone7175315194

 Overview 
 overview
TITLES/ROLES:

Director, Research Development and Interdisciplinary Research
Co-Director Junior Faculty Development Program
Director, Graduate Core Curriculum


GRADUATE PROGRAM AFFILIATIONS:

Biomedical Sciences

EDUCATION:

B.A. Saint Olaf College, 1986
Ph.D., Washington University, 1991
Postdoctoral Training, University of North Carolina at Chapel Hill, 1991-1996

NARRATIVE:

Dr. Bronson is known for the creation of targeted transgenic lines, where small recombinant transgenic sequences as well as bacterial artificial chromosome-based transgenic sequences are introduced in a single-copy at the X-linked hypoxanthine phosphoribosyl transferase (HPRT) locus by a directly selectable homologous recombination event in murine embryonic stem cells. She has had a long-standing interest in manipulating the mouse genome via genetic alteration of mouse embryonic stem cells to study diseases of hematologic, immunologic, developmental, and metabolic importance. Dr. Bronson is a Distinguished Educator of the Penn State College of Medicine. As Director of Research Development and Interdisciplinary Research she catalyzes the response to a large variety of funding opportunities available to an academic health center with strengths in basic, translational, clinical, educational, and health services research.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Masser DR, VanGuilder Starkey HD, Bixler GV, Dunton W, Bronson SK, Freeman WM. Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats. Exp Eye Res. 2014 Aug; 125:95-106.
    View in: PubMed
  2. Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS, Unrath KA, Pedersen MM, Dai P, Freeman WM, Bronson SK, Gardner TW, Kester M. Nanoliposomal minocycline for ocular drug delivery. Nanomedicine. 2013 Jan; 9(1):130-40.
    View in: PubMed
  3. Hirschler-Laszkiewicz I, Zhang W, Keefer K, Conrad K, Tong Q, Chen SJ, Bronson S, Cheung JY, Miller BA. Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis. Exp Hematol. 2012 Jan; 40(1):71-83.
    View in: PubMed
  4. Zhang Y, Paul EM, Sathyendra V, Davison A, Sharkey N, Bronson S, Srinivasan S, Gross TS, Donahue HJ. Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS One. 2011; 6(8):e23516.
    View in: PubMed
  5. Dennis MD, Schrufer TL, Bronson SK, Kimball SR, Jefferson LS. Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. J Biol Chem. 2011 Sep 30; 286(39):34286-97.
    View in: PubMed
  6. Bixler GV, Vanguilder HD, Brucklacher RM, Kimball SR, Bronson SK, Freeman WM. Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome. BMC Med Genomics. 2011; 4:40.
    View in: PubMed
  7. VanGuilder HD, Bixler GV, Kutzler L, Brucklacher RM, Bronson SK, Kimball SR, Freeman WM. Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. PLoS One. 2011; 6(1):e16271.
    View in: PubMed
  8. Fox TE, Bewley MC, Unrath KA, Pedersen MM, Anderson RE, Jung DY, Jefferson LS, Kim JK, Bronson SK, Flanagan JM, Kester M. Circulating sphingolipid biomarkers in models of type 1 diabetes. J Lipid Res. 2011 Mar; 52(3):509-17.
    View in: PubMed
  9. Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC. Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1283-94.
    View in: PubMed
  10. Li F, Bronson S, Niyibizi C. Derivation of murine induced pluripotent stem cells (iPS) and assessment of their differentiation toward osteogenic lineage. J Cell Biochem. 2010 Mar 1; 109(4):643-52.
    View in: PubMed
  11. Freeman WM, Bixler GV, Brucklacher RM, Lin CM, Patel KM, VanGuilder HD, LaNoue KF, Kimball SR, Barber AJ, Antonetti DA, Gardner TW, Bronson SK. A multistep validation process of biomarkers for preclinical drug development. Pharmacogenomics J. 2010 Oct; 10(5):385-95.
    View in: PubMed
  12. Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM. Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC Med Genomics. 2008; 1:26.
    View in: PubMed
  13. Gastinger MJ, Kunselman AR, Conboy EE, Bronson SK, Barber AJ. Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2635-42.
    View in: PubMed
  14. Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK. Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1687-96.
    View in: PubMed
  15. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep; 6(3):181-94.
    View in: PubMed
  16. Woll NL, Heaney JD, Bronson SK. Osteogenic nodule formation from single embryonic stem cell-derived progenitors. Stem Cells Dev. 2006 Dec; 15(6):865-79.
    View in: PubMed
  17. Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 2006 Sep; 55(9):2401-11.
    View in: PubMed
  18. Heaney JD, Bronson SK. Artificial chromosome-based transgenes in the study of genome function. Mamm Genome. 2006 Aug; 17(8):791-807.
    View in: PubMed
  19. Woll NL, Bronson SK. Analysis of embryonic stem cell-derived osteogenic cultures. Methods Mol Biol. 2006; 330:149-59.
    View in: PubMed
  20. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2210-8.
    View in: PubMed
  21. Schwindinger WF, Giger KE, Betz KS, Stauffer AM, Sunderlin EM, Sim-Selley LJ, Selley DE, Bronson SK, Robishaw JD. Mice with deficiency of G protein gamma3 are lean and have seizures. Mol Cell Biol. 2004 Sep; 24(17):7758-68.
    View in: PubMed
  22. Le TH, Oliverio MI, Kim HS, Salzler H, Dash RC, Howell DN, Smithies O, Bronson S, Coffman TM. A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics. 2004 Aug 11; 18(3):290-8.
    View in: PubMed
  23. Heaney JD, Rettew AN, Bronson SK. Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells. Genomics. 2004 Jun; 83(6):1072-82.
    View in: PubMed
  24. Snow JW, Abraham N, Ma MC, Bronson SK, Goldsmith MA. Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice. Exp Hematol. 2003 Dec; 31(12):1253-8.
    View in: PubMed
  25. Bronson SK, Reiter CE, Gardner TW. An eye on insulin. J Clin Invest. 2003 Jun; 111(12):1817-9.
    View in: PubMed
  26. Bronson SK. Bone nodule formation via in vitro differentiation of murine embryonic stem cells. Methods Enzymol. 2003; 365:241-51.
    View in: PubMed
  27. Erin N, Bronson SK, Billingsley ML. Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue. Neuroscience. 2003; 117(3):541-55.
    View in: PubMed
  28. Misra RP, Bronson SK, Xiao Q, Garrison W, Li J, Zhao R, Duncan SA. Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation. BMC Biotechnol. 2001; 1:12.
    View in: PubMed
  29. Bronson R, Bronson S, Oula L, Zhang W, Ghebrehiwet B. Detection of complement C1q receptors on human spermatozoa. J Reprod Immunol. 1998 Apr; 38(1):1-14.
    View in: PubMed
  30. Bronson SK, Plaehn EG, Kluckman KD, Hagaman JR, Maeda N, Smithies O. Single-copy transgenic mice with chosen-site integration. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9067-72.
    View in: PubMed
  31. Min J, Shukla H, Kozono H, Bronson SK, Weissman SM, Chaplin DD. A novel Creb family gene telomeric of HLA-DRA in the HLA complex. Genomics. 1995 Nov 20; 30(2):149-56.
    View in: PubMed
  32. Bronson SK, Smithies O. Altering mice by homologous recombination using embryonic stem cells. J Biol Chem. 1994 Nov 4; 269(44):27155-8.
    View in: PubMed
  33. Kozono H, Bronson SK, Taillon-Miller P, Moorti MK, Jamry I, Chaplin DD. Molecular linkage of the HLA-DR, HLA-DQ, and HLA-DO genes in yeast artificial chromosomes. Genomics. 1991 Nov; 11(3):577-86.
    View in: PubMed
Bronson's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_