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Sean Stocker

TitleProfessor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey PA 17033
Mailbox: H166
Phone7175318566

 Overview 
 overview
EDUCATION
1993-1997.......BS - Allegheny College, Meadville, PA
1997-2002.......PhD - Neuroscience, University of Pittsburgh
2002-2005.......Postdoctoral - Physiology, University of Texas Health Science Center at San Antonio


POSITIONS
2005-2009.......Assistant Professor, Department of Physiology, University of Kentucky
2009-2015.......Associate Professor of Physiology, Penn State COM
2015-Present...Professor of Physiology and Neural & Behavioral Sciences, Penn State COM

2009-Present...Director, American Heart Association SURF Program
2013-Present...Director, Rodent Telemetry Core
2013-Present...Chair, American Physiological Society Central Nervous System Section
2014-Present...Vice-Chair, American Heart Association Great Rivers Research Committee
2015-Present...Chair, American Heart Association Vascular Biology & Blood Pressure Peer Review
2015-Present...Board of Directors, American Heart Association Capital Region

HONORS
2012.....Established Investigator of the American Heart Association
2016.....American Physiological Society Henry Pickering Bowditch Award


RESEARCH.
Our laboratory investigates how the central nervous system contributes to cardiovascular disease including obesity-induced and salt-sensitive hypertension. We utilize a variety of approaches that include in vivo cardiovascular monitoring, in vivo and in vitro electrophysiology, functional neuroanatomy, and translational studies in humans (microneurography, blood flow). Our projects are currently funded by the National Institutes of Health and the American Heart Association.

PROJECT 1 (NIH R01 - Obesity-Induced Hypertension). Clinical studies suggest approximately 2/3 of hypertension cases is attributed to obesity and activation of the sympathetic nervous system. This project uses a number of approaches to identify the neural circuits and cellular mechanisms that support obesity-induced hypertension. Current studies focus on the ability of hormonal factors such as insulin and leptin to enter the brain, activate neuronal circuits, and increase sympathetic outflow and blood pressure.

PROJECT 2 (American Heart Association Established Investigator and NIH R01 - Salt-Sensitive Hypertension). Salt-sensitive hypertension is associated with changes in plasma sodium concentration and activation of the sympathetic nervous system. Our laboratory investigates how the central nervous system senses changes in dietary sodium to subsequently alter sympathetic outflow and arterial blood pressure. These projects use state-of-art approaches in both animal models and humans.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Stocker SD, Gordon KW. Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation. J Neurophysiol. 2015 Mar 1; 113(5):1302-9.
    View in: PubMed
  2. Steiner JL, Bardgett ME, Wolfgang L, Lang CH, Stocker SD. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol. 2014 Nov 15; 112(10):2597-604.
    View in: PubMed
  3. Kinsman B, Cowles J, Lay J, Simmonds SS, Browning KN, Stocker SD. Osmoregulatory thirst in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) and/or type 4 (TRPV4) receptor. Am J Physiol Regul Integr Comp Physiol. 2014 Nov 1; 307(9):R1092-100.
    View in: PubMed
  4. Simmonds SS, Lay J, Stocker SD. Dietary salt intake exaggerates sympathetic reflexes and increases blood pressure variability in normotensive rats. Hypertension. 2014 Sep; 64(3):583-9.
    View in: PubMed
  5. Stocker SD, Monahan KD, Browning KN. Neurogenic and sympathoexcitatory actions of NaCl in hypertension. Curr Hypertens Rep. 2013 Dec; 15(6):538-46.
    View in: PubMed
  6. Yamauchi K, Tsuchimochi H, Stone AJ, Stocker SD, Kaufman MP. Increased dietary salt intake enhances the exercise pressor reflex. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H450-4.
    View in: PubMed
  7. Stocker SD, Muntzel MS. Recording sympathetic nerve activity chronically in rats: surgery techniques, assessment of nerve activity, and quantification. Am J Physiol Heart Circ Physiol. 2013 Nov 15; 305(10):H1407-16.
    View in: PubMed
  8. Drew RC, Muller MD, Blaha CA, Mast JL, Herr MD, Stocker SD, Sinoway LI. Aspirin augments carotid-cardiac baroreflex sensitivity during muscle mechanoreflex and metaboreflex activation in humans. J Appl Physiol (1985). 2013 Oct 15; 115(8):1183-90.
    View in: PubMed
  9. Luckett BS, Frielle JL, Wolfgang L, Stocker SD. Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. Am J Physiol Heart Circ Physiol. 2013 Jun 1; 304(11):H1538-46.
    View in: PubMed
  10. Stocker SD, Monahan KD, Sinoway LI. The hypothalamic paraventricular nucleus may not be at the heart of sympathetic outflow. J Physiol. 2013 Jan 1; 591(Pt 1):1.
    View in: PubMed
  11. Yamauchi K, Stone AJ, Stocker SD, Kaufman MP. Blockade of ATP-sensitive potassium channels prevents the attenuation of the exercise pressor reflex by tempol in rats with ligated femoral arteries. Am J Physiol Heart Circ Physiol. 2012 Aug 1; 303(3):H332-40.
    View in: PubMed
  12. Ward KR, Bardgett JF, Wolfgang L, Stocker SD. Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus. Hypertension. 2011 Mar; 57(3):435-41.
    View in: PubMed
  13. Toney GM, Stocker SD. Hyperosmotic activation of CNS sympathetic drive: implications for cardiovascular disease. J Physiol. 2010 Sep 15; 588(Pt 18):3375-84.
    View in: PubMed
  14. Stocker SD, Madden CJ, Sved AF. Excess dietary salt intake alters the excitability of central sympathetic networks. Physiol Behav. 2010 Jul 14; 100(5):519-24.
    View in: PubMed
  15. Bardgett ME, McCarthy JJ, Stocker SD. Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. Hypertension. 2010 Feb; 55(2):284-90.
    View in: PubMed
  16. Adams JM, Bardgett ME, Stocker SD. Ventral lamina terminalis mediates enhanced cardiovascular responses of rostral ventrolateral medulla neurons during increased dietary salt. Hypertension. 2009 Aug; 54(2):308-14.
    View in: PubMed
  17. Adams JM, McCarthy JJ, Stocker SD. Excess dietary salt alters angiotensinergic regulation of neurons in the rostral ventrolateral medulla. Hypertension. 2008 Nov; 52(5):932-7.
    View in: PubMed
  18. Taylor AC, McCarthy JJ, Stocker SD. Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia. Am J Physiol Regul Integr Comp Physiol. 2008 Apr; 294(4):R1285-93.
    View in: PubMed
  19. Stocker SD, Osborn JL, Carmichael SP. Forebrain osmotic regulation of the sympathetic nervous system. Clin Exp Pharmacol Physiol. 2008 May; 35(5-6):695-700.
    View in: PubMed
  20. Shi P, Stocker SD, Toney GM. Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Physiol Regul Integr Comp Physiol. 2007 Dec; 293(6):R2279-89.
    View in: PubMed
  21. Adams JM, Madden CJ, Sved AF, Stocker SD. Increased dietary salt enhances sympathoexcitatory and sympathoinhibitory responses from the rostral ventrolateral medulla. Hypertension. 2007 Aug; 50(2):354-9.
    View in: PubMed
  22. Stocker SD, Meador R, Adams JM. Neurons of the rostral ventrolateral medulla contribute to obesity-induced hypertension in rats. Hypertension. 2007 Mar; 49(3):640-6.
    View in: PubMed
  23. Stocker SD, Toney GM. Vagal afferent input alters the discharge of osmotic and ANG II-responsive median preoptic neurons projecting to the hypothalamic paraventricular nucleus. Brain Res. 2007 Feb 2; 1131(1):118-28.
    View in: PubMed
  24. Stocker SD, Wilson ME, Madden CJ, Lone U, Sved AF. Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. Am J Physiol Regul Integr Comp Physiol. 2006 Jul; 291(1):R59-67.
    View in: PubMed
  25. Madden CJ, Stocker SD, Sved AF. Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla neurons. Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R751-9.
    View in: PubMed
  26. Stocker SD, Simmons JR, Stornetta RL, Toney GM, Guyenet PG. Water deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medulla. J Comp Neurol. 2006 Feb 1; 494(4):673-85.
    View in: PubMed
  27. Stocker SD, Toney GM. Median preoptic neurones projecting to the hypothalamic paraventricular nucleus respond to osmotic, circulating Ang II and baroreceptor input in the rat. J Physiol. 2005 Oct 15; 568(Pt 2):599-615.
    View in: PubMed
  28. Stocker SD, Hunwick KJ, Toney GM. Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived rats. J Physiol. 2005 Feb 15; 563(Pt 1):249-63.
    View in: PubMed
  29. Stocker SD, Cunningham JT, Toney GM. Water deprivation increases Fos immunoreactivity in PVN autonomic neurons with projections to the spinal cord and rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol. 2004 Nov; 287(5):R1172-83.
    View in: PubMed
  30. Stocker SD, Schiltz JC, Sved AF. Acute increases in arterial blood pressure do not reduce plasma vasopressin levels stimulated by angiotensin II or hyperosmolality in rats. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287(1):R127-37.
    View in: PubMed
  31. Stocker SD, Keith KJ, Toney GM. Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats. Am J Physiol Regul Integr Comp Physiol. 2004 Apr; 286(4):R719-25.
    View in: PubMed
  32. Stocker SD, Muldoon MF, Sved AF. Blunted fenfluramine-evoked prolactin secretion in hypertensive rats. Hypertension. 2003 Oct; 42(4):719-24.
    View in: PubMed
  33. Stocker SD, Smith CA, Kimbrough CM, Stricker EM, Sved AF. Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats. Am J Physiol Regul Integr Comp Physiol. 2003 Jun; 284(6):R1521-8.
    View in: PubMed
  34. Toney GM, Chen QH, Cato MJ, Stocker SD. Central osmotic regulation of sympathetic nerve activity. Acta Physiol Scand. 2003 Jan; 177(1):43-55.
    View in: PubMed
  35. Stocker SD, Stricker EM, Sved AF. Arterial baroreceptors mediate the inhibitory effect of acute increases in arterial blood pressure on thirst. Am J Physiol Regul Integr Comp Physiol. 2002 Jun; 282(6):R1718-29.
    View in: PubMed
  36. Sved AF, Ito S, Madden CJ, Stocker SD, Yajima Y. Excitatory inputs to the RVLM in the context of the baroreceptor reflex. Ann N Y Acad Sci. 2001 Jun; 940:247-58.
    View in: PubMed
  37. Stocker SD, Stricker EM, Sved AF. Acute hypertension inhibits thirst stimulated by ANG II, hyperosmolality, or hypovolemia in rats. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R214-24.
    View in: PubMed
  38. Stocker SD, Sved AF, Stricker EM. Role of renin-angiotensin system in hypotension-evoked thirst: studies with hydralazine. Am J Physiol Regul Integr Comp Physiol. 2000 Aug; 279(2):R576-85.
    View in: PubMed
  39. Yates BJ, Smail JA, Stocker SD, Card JP. Transneuronal tracing of neural pathways controlling activity of diaphragm motoneurons in the ferret. Neuroscience. 1999; 90(4):1501-13.
    View in: PubMed
  40. Yates BJ, Stocker SD. Integration of somatic and visceral inputs by the brainstem: functional considerations. Exp Brain Res. 1998 Apr; 119(3):269-75.
    View in: PubMed
  41. Stocker SD, Steinbacher BC, Balaban CD, Yates BJ. Connections of the caudal ventrolateral medullary reticular formation in the cat brainstem. Exp Brain Res. 1997 Sep; 116(2):270-82.
    View in: PubMed
  42. Rossiter CD, Hayden NL, Stocker SD, Yates BJ. Changes in outflow to respiratory pump muscles produced by natural vestibular stimulation. J Neurophysiol. 1996 Nov; 76(5):3274-84.
    View in: PubMed
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