|Institution||College of Medicine|
|Department||Cellular and Molecular Physiology|
|Address||500 University Drive Hershey PA 17033|
BS - Allegheny College, Meadville, PA
PhD - Neuroscience, University of Pittsburgh
Postdoctoral - Physiology, University of Texas Health Science Center at San Antonio
Associate Professor of Cellular and Molecular Physiology
Director, American Heart Association Summer Undergraduate Research Fellowship (SURF) Program
Our laboratory investigates how the central nervous system contributes to cardiovascular disease including obesity-induced and salt-sensitive hypertension. We utilize a variety of approaches that include in vivo cardiovascular monitoring, in vivo and in vitro electrophysiology, functional neuroanatomy, and translational studies in humans (microneurography, blood flow). Our projects are currently funded by the National Institutes of Health and the American Heart Association.
PROJECT 1 (NIH R01 - Obesity-Induced Hypertension). Clinical studies suggest approximately 2/3 of hypertension cases is attributed to obesity and activation of the sympathetic nervous system. This project uses a number of approaches to identify the neural circuits and cellular mechanisms that support obesity-induced hypertension. Current studies focus on the ability of hormonal factors such as insulin and leptin to enter the brain, activate neuronal circuits, and increase sympathetic outflow and blood pressure.
PROJECT 2 (American Heart Association Established Investigator and NIH R01 - Salt-Sensitive Hypertension). Salt-sensitive hypertension is associated with changes in plasma sodium concentration and activation of the sympathetic nervous system. Our laboratory investigates how the central nervous system senses changes in dietary sodium to subsequently alter sympathetic outflow and arterial blood pressure. These projects use state-of-art approaches in both animal models and humans.
Kirsteen Browning, PhD (Neural & Behavioral Sciences)
Marc Kaufman, PhD (Heart & Vascular Institute)
Kevin Monahan, PhD (Cardiology)
Lawrence Sinoway, MD (Director, Heart & Vascular Institute)
Alberto Travagli, PhD (Neural & Behavioral Sciences)
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