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Sergei Grigoryev

TitleProfessor
InstitutionCollege of Medicine
DepartmentBiochemistry and Molecular Biology
Address500 University Drive Hershey PA 17033
Mailbox: H171
Phone7175318588
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Professor of Biochemistry and Molecular Biology

    SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

    Penn State Hershey Cancer Institute, Experimental Thereuputics

    GRADUATE PROGRAM AFFILIATIONS:

    Biochemistry and Molecular Biology, Cell and Molecular Biology, Genetics, Biomedical Sciences

    EDUCATION:

    Ph.D., M.V.Lomonosov Moscow State University, 1985
    Postdoctoral Training, University of Massachusetts, 1991-1992
    Postdoctoral Training, California Institute of Technology, 1992-1995



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nikitina T, Norouzi D, Grigoryev SA, Zhurkin VB. DNA topology in chromatin is defined by nucleosome spacing. Sci Adv. 2017 Oct; 3(10):e1700957. PMID: 29098179.
      View in: PubMed
    2. Buckwalter JM, Norouzi D, Harutyunyan A, Zhurkin VB, Grigoryev SA. Regulation of chromatin folding by conformational variations of nucleosome linker DNA. Nucleic Acids Res. 2017 Sep 19; 45(16):9372-9387. PMID: 28934465.
      View in: PubMed
    3. Salzberg AC, Harris-Becker A, Popova EY, Keasey N, Loughran TP, Claxton DF, Grigoryev SA. Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability. PLoS One. 2017; 12(3):e0173723. PMID: 28301528.
      View in: PubMed
    4. Adkins NL, Swygert SG, Kaur P, Niu H, Grigoryev SA, Sung P, Wang H, Peterson CL. Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA Double Strand Break Repair. J Biol Chem. 2017 Mar 31; 292(13):5271-5281. PMID: 28202543.
      View in: PubMed
    5. Grigoryev SA, Bascom G, Buckwalter JM, Schubert MB, Woodcock CL, Schlick T. Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1238-43. PMID: 26787893; PMCID: PMC4747710.
    6. Maher K, Jeric Kokelj B, Butinar M, Mikhaylov G, Mancek-Keber M, Stoka V, Vasiljeva O, Turk B, Grigoryev SA, Kopitar-Jerala N. A role for stefin B (cystatin B) in inflammation and endotoxemia. J Biol Chem. 2014 Nov 14; 289(46):31736-50. PMID: 25288807; PMCID: PMC4231653.
    7. Chakraborty SA, Kazi AA, Khan TM, Grigoryev SA. Nucleosome-positioning sequence repeats impact chromatin silencing in yeast minichromosomes. Genetics. 2014 Nov; 198(3):1015-29. PMID: 25189873; PMCID: PMC4224149.
    8. Luque A, Collepardo-Guevara R, Grigoryev S, Schlick T. Dynamic condensation of linker histone C-terminal domain regulates chromatin structure. Nucleic Acids Res. 2014 Jul; 42(12):7553-60. PMID: 24906881; PMCID: PMC4081093.
    9. Walker SI, Callahan BJ, Arya G, Barry JD, Bhattacharya T, Grigoryev S, Pellegrini M, Rippe K, Rosenberg SM. Evolutionary dynamics and information hierarchies in biological systems. Ann N Y Acad Sci. 2013 Dec; 1305:1-17. PMID: 23691975.
      View in: PubMed
    10. Popova EY, Grigoryev SA, Fan Y, Skoultchi AI, Zhang SS, Barnstable CJ. Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina. J Biol Chem. 2013 Jun 14; 288(24):17895-907. PMID: 23645681; PMCID: PMC3682587.
    11. Nikitina T, Wang D, Gomberg M, Grigoryev SA, Zhurkin VB. Combined micrococcal nuclease and exonuclease III digestion reveals precise positions of the nucleosome core/linker junctions: implications for high-resolution nucleosome mapping. J Mol Biol. 2013 Jun 12; 425(11):1946-60. PMID: 23458408.
      View in: PubMed
    12. Lukášová E, Koristek Z, Klabusay M, Ondrej V, Grigoryev S, Bacíková A, Rezácová M, Falk M, Vávrová J, Kohútová V, Kozubek S. Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes. Biochim Biophys Acta. 2013 Mar; 1833(3):767-79. PMID: 23269287.
      View in: PubMed
    13. Grigoryev SA. Nucleosome spacing and chromatin higher-order folding. Nucleus. 2012 Nov-Dec; 3(6):493-9. PMID: 22990522; PMCID: PMC3515531.
    14. Correll SJ, Schubert MH, Grigoryev SA. Short nucleosome repeats impose rotational modulations on chromatin fibre folding. EMBO J. 2012 May 16; 31(10):2416-26. PMID: 22473209; PMCID: PMC3364735.
    15. Grigoryev SA, Woodcock CL. Chromatin organization - the 30 nm fiber. Exp Cell Res. 2012 Jul 15; 318(12):1448-55. PMID: 22394510.
      View in: PubMed
    16. Schlick T, Hayes J, Grigoryev S. Toward convergence of experimental studies and theoretical modeling of the chromatin fiber. J Biol Chem. 2012 Feb 17; 287(8):5183-91. PMID: 22157002; PMCID: PMC3285299.
    17. Chakraborty SA, Simpson RT, Grigoryev SA. A single heterochromatin boundary element imposes position-independent antisilencing activity in Saccharomyces cerevisiae minichromosomes. PLoS One. 2011; 6(9):e24835. PMID: 21949764; PMCID: PMC3174977.
    18. Grigoryev S, McGowan S. Isolation and characterization of the nuclear serpin MENT. Methods Enzymol. 2011; 501:29-47. PMID: 22078529.
      View in: PubMed
    19. Arya G, Maitra A, Grigoryev SA. A structural perspective on the where, how, why, and what of nucleosome positioning. J Biomol Struct Dyn. 2010 Jun; 27(6):803-20. PMID: 20232935.
      View in: PubMed
    20. Zhao Y, Wang S, Popova EY, Grigoryev SA, Zhu J. Rearrangement of upstream sequences of the hTERT gene during cellular immortalization. Genes Chromosomes Cancer. 2009 Nov; 48(11):963-74. PMID: 19672873; PMCID: PMC2889911.
    21. Rochman M, Postnikov Y, Correll S, Malicet C, Wincovitch S, Karpova TS, McNally JG, Wu X, Bubunenko NA, Grigoryev S, Bustin M. The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription. Mol Cell. 2009 Sep 11; 35(5):642-56. PMID: 19748358; PMCID: PMC2757144.
    22. Grigoryev SA, Arya G, Correll S, Woodcock CL, Schlick T. Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13317-22. PMID: 19651606; PMCID: PMC2726360.
    23. Ong PC, Golding SJ, Pearce MC, Irving JA, Grigoryev SA, Pike D, Langendorf CG, Bashtannyk-Puhalovich TA, Bottomley SP, Whisstock JC, Pike RN, McGowan S. Conformational change in the chromatin remodelling protein MENT. PLoS One. 2009; 4(3):e4727. PMID: 19266095; PMCID: PMC2648895.
    24. Popova EY, Krauss SW, Short SA, Lee G, Villalobos J, Etzell J, Koury MJ, Ney PA, Chasis JA, Grigoryev SA. Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation. Chromosome Res. 2009; 17(1):47-64. PMID: 19172406; PMCID: PMC2667965.
    25. Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev SA, Allis CD, Coonrod SA. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol. 2009 Jan 26; 184(2):205-13. PMID: 19153223; PMCID: PMC2654299.
    26. Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN. DNA accelerates the inhibition of human cathepsin V by serpins. J Biol Chem. 2007 Dec 21; 282(51):36980-6. PMID: 17923478.
      View in: PubMed
    27. Nikitina T, Ghosh RP, Horowitz-Scherer RA, Hansen JC, Grigoryev SA, Woodcock CL. MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome. J Biol Chem. 2007 Sep 21; 282(38):28237-45. PMID: 17660293.
      View in: PubMed
    28. McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC. X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation. EMBO J. 2006 Jul 12; 25(13):3144-55. PMID: 16810322; PMCID: PMC1500978.
    29. Bulynko YA, Hsing LC, Mason RW, Tremethick DJ, Grigoryev SA. Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin. Mol Cell Biol. 2006 Jun; 26(11):4172-84. PMID: 16705169; PMCID: PMC1489105.
    30. Popova EY, Claxton DF, Lukasova E, Bird PI, Grigoryev SA. Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood. Exp Hematol. 2006 Apr; 34(4):453-62. PMID: 16569592.
      View in: PubMed
    31. Grigoryev SA, Bulynko YA, Popova EY. The end adjusts the means: heterochromatin remodelling during terminal cell differentiation. Chromosome Res. 2006; 14(1):53-69. PMID: 16506096.
      View in: PubMed
    32. Grigoryev SA, Nikitina T, Pehrson JR, Singh PB, Woodcock CL. Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence. J Cell Sci. 2004 Dec 01; 117(Pt 25):6153-62. PMID: 15564378.
      View in: PubMed
    33. Lukásová E, Koristek Z, Falk M, Kozubek S, Grigoryev S, Kozubek M, Ondrej V, Kroupová I. Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities. J Leukoc Biol. 2005 Jan; 77(1):100-11. PMID: 15507473.
      View in: PubMed
    34. Grigoryev SA. Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays. FEBS Lett. 2004 Apr 23; 564(1-2):4-8. PMID: 15094034.
      View in: PubMed
    35. Istomina NE, Shushanov SS, Springhetti EM, Karpov VL, Krasheninnikov IA, Stevens K, Zaret KS, Singh PB, Grigoryev SA. Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT. Mol Cell Biol. 2003 Sep; 23(18):6455-68. PMID: 12944473; PMCID: PMC193700.
    36. Springhetti EM, Istomina NE, Whisstock JC, Nikitina T, Woodcock CL, Grigoryev SA. Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT. J Biol Chem. 2003 Oct 31; 278(44):43384-93. PMID: 12930828.
      View in: PubMed
    37. Irving JA, Shushanov SS, Pike RN, Popova EY, Brömme D, Coetzer TH, Bottomley SP, Boulynko IA, Grigoryev SA, Whisstock JC. Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem. 2002 Apr 12; 277(15):13192-201. PMID: 11821386.
      View in: PubMed
    38. Grigoryev SA. Higher-order folding of heterochromatin: protein bridges span the nucleosome arrays. Biochem Cell Biol. 2001; 79(3):227-41. PMID: 11467737.
      View in: PubMed
    39. Bednar J, Studitsky VM, Grigoryev SA, Felsenfeld G, Woodcock CL. The nature of the nucleosomal barrier to transcription: direct observation of paused intermediates by electron cryomicroscopy. Mol Cell. 1999 Sep; 4(3):377-86. PMID: 10518218.
      View in: PubMed
    40. Grigoryev SA, Bednar J, Woodcock CL. MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member. J Biol Chem. 1999 Feb 26; 274(9):5626-36. PMID: 10026180.
      View in: PubMed
    41. Bednar J, Horowitz RA, Grigoryev SA, Carruthers LM, Hansen JC, Koster AJ, Woodcock CL. Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14173-8. PMID: 9826673; PMCID: PMC24346.
    42. Grigoryev SA, Woodcock CL. Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT). J Biol Chem. 1998 Jan 30; 273(5):3082-9. PMID: 9446625.
      View in: PubMed
    43. Woodcock CL, Grigoryev SA, Horowitz RA, Whitaker N. A chromatin folding model that incorporates linker variability generates fibers resembling the native structures. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):9021-5. PMID: 8415647; PMCID: PMC47493.
    44. Grigoryev SA, Woodcock CL. Stage-specific expression and localization of MENT, a nuclear protein associated with chromatin condensation in terminally differentiating avian erythroid cells. Exp Cell Res. 1993 Jun; 206(2):335-43. PMID: 8500553.
      View in: PubMed
    45. Grigoryev SA, Solovieva VO, Spirin KS, Krasheninnikov IA. A novel nonhistone protein (MENT) promotes nuclear collapse at the terminal stage of avian erythropoiesis. Exp Cell Res. 1992 Feb; 198(2):268-75. PMID: 1729133.
      View in: PubMed
    46. Grigoryev SA, Spirin KS, Krasheninnikov IA. Loosened nucleosome linker folding in transcriptionally active chromatin of chicken embryo erythrocyte nuclei. Nucleic Acids Res. 1990 Dec 25; 18(24):7397-406. PMID: 2259630; PMCID: PMC332878.
    47. Grigoryev SA, Krasheninnikov IA. A topological model for chromatin transcription and a role for nucleosome linkers. FEBS Lett. 1983 Oct 03; 162(1):1-4. PMID: 6194015.
      View in: PubMed
    48. Grigoryev SA, Krasheninnikov IA. Transient unfolding of trypsin-digested chromatin core particles. Eur J Biochem. 1982 Dec; 129(1):119-25. PMID: 7160375.
      View in: PubMed
    49. Grigoryev SA, Ioffe LB. The dependence of the linking number of a circular minichromosome upon the shape and the orientation of its nucleosomes. FEBS Lett. 1981 Jul 20; 130(1):43-6. PMID: 7286225.
      View in: PubMed
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