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Robert Zelis

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Mailbox: H047
Phone7175311790

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor and Chair Emeritus of Medicine, Professor Cellular and Molecular Physiology, Physician

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Cellular and Molecular Physiology

EDUCATION:

M.D., University of Chicago, 1964
Postdoctoral Training, Harvard University, Boston, 1964-1966
Postdoctoral Training, National Heart Institute, 1966-1968

NARRATIVE:

The primary research interest in this laboratory is to define the abnormalities in the control of regional blood flow and the sympathetic nervous system that accompany congestive heart failure. Chronic heart failure in rats (myocardial infarction) and humans is currently being investigated. The role of the sympathetic nervous system in heart failure is being evaluated by 3H-norepinephrine kinetic studies using multicompartmental modeling in humans and isolated perfused rat hearts.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Vargas EJ, Zelis R. Integrating nutrition education into the cardiovascular curriculum changes eating habits of second-year medical students. J Clin Lipidol. 2014 Mar-Apr; 8(2):199-205.
    View in: PubMed
  2. Zelis R. Evaluation and treatment of lipid disorders in women. Curr Womens Health Rep. 2003 Apr; 3(2):97-103.
    View in: PubMed
  3. Zhang XQ, Musch TI, Zelis R, Cheung JY. Effects of impaired Ca2+ homeostasis on contraction in postinfarction myocytes. J Appl Physiol (1985). 1999 Mar; 86(3):943-50.
    View in: PubMed
  4. Zhang XQ, Ng YC, Musch TI, Moore RL, Zelis R, Cheung JY. Sprint training attenuates myocyte hypertrophy and improves Ca2+ homeostasis in postinfarction myocytes. J Appl Physiol (1985). 1998 Feb; 84(2):544-52.
    View in: PubMed
  5. Zhang XQ, Tillotson DL, Moore RL, Zelis R, Cheung JY. Na+/Ca2+ exchange currents and SR Ca2+ contents in postinfarction myocytes. Am J Physiol. 1996 Dec; 271(6 Pt 1):C1800-7.
    View in: PubMed
  6. Sinoway L, Shenberger J, Leaman G, Zelis R, Gray K, Baily R, Leuenberger U. Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. J Appl Physiol (1985). 1996 Oct; 81(4):1778-84.
    View in: PubMed
  7. Leuenberger U, Gaul L, Noack H, Gubin S, Zelis R. Angiotensin-converting enzyme inhibition and the norepinephrine spillover response to dynamic exercise. J Appl Physiol (1985). 1996 Sep; 81(3):1138-42.
    View in: PubMed
  8. Todd JS, Rafferty M, Zelis R. Effects of short-term brachial arterial vasodilator infusions on forearm blood flow response to acetylcholine. Am J Cardiol. 1995 Mar 1; 75(7):546-7.
    View in: PubMed
  9. Stylos L, Parilak L, Green MH, Leuenberger U, Zelis R. Compartmental analysis of norepinephrine kinetics in congestive heart failure. Am J Cardiol. 1995 Feb 1; 75(4):299-301.
    View in: PubMed
  10. Zelis R, Nussberger J, Clemson B, Waeber B, Grouzmann E, Brunner HR. Neuropeptide Y infusion decreases plasma renin activity in postmyocardial infarction rats. J Cardiovasc Pharmacol. 1994 Dec; 24(6):896-9.
    View in: PubMed
  11. Zelis R, Nussberger J, Niederberger M, Zelis GA, Genton C, Waeber B, Brunner HR. Reciprocal changes in vasoactive hormones in the rat myocardial infarction model of heart failure. J Card Fail. 1994 Oct; 1(1):63-9.
    View in: PubMed
  12. Baily RG, Davis D, Clemson B, Zelis R. Normalization of the norepinephrine kinetic response to orthostatic stress after cardiac transplantation. Am J Cardiol. 1994 Sep 15; 74(6):624-5.
    View in: PubMed
  13. Clemson B, Gaul L, Gubin SS, Campsey DM, McConville J, Nussberger J, Zelis R. Prejunctional angiotensin II receptors. Facilitation of norepinephrine release in the human forearm. J Clin Invest. 1994 Feb; 93(2):684-91.
    View in: PubMed
  14. Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol (1985). 1993 Aug; 75(2):668-74.
    View in: PubMed
  15. Zelis R, Clemson B, Baily R, Davis D. Regulation of tissue noradrenaline in the rat myocardial infarction model of chronic heart failure. Cardiovasc Res. 1992 Oct; 26(10):933-8.
    View in: PubMed
  16. Leuenberger U, Kenney G, Davis D, Clemson B, Zelis R. Comparison of norepinephrine and isoproterenol clearance in congestive heart failure. Am J Physiol. 1992 Jul; 263(1 Pt 2):H56-60.
    View in: PubMed
  17. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, Sinoway L. Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1659-64.
    View in: PubMed
  18. Zelis R, Sinoway LI, Leuenberger U, Clemson BS, Davis D. Time-constant adaptations in heart failure. Eur Heart J. 1991 Aug; 12 Suppl C:2-7.
    View in: PubMed
  19. Musch TI, Zelis R. Norepinephrine response to exercise of rats with a chronic myocardial infarction. Med Sci Sports Exerc. 1991 May; 23(5):569-77.
    View in: PubMed
  20. Musch TI, Ghaul MR, Tranchitella V, Zelis R. Skeletal muscle glycogen depletion during submaximal exercise in rats with chronic heart failure. Basic Res Cardiol. 1990 Nov-Dec; 85(6):606-18.
    View in: PubMed
  21. Clemson B, Baily RG, Davis D, Zelis R. Effects of desipramine on norepinephrine clearance in congestive heart failure. Am J Physiol. 1990 Aug; 259(2 Pt 1):E261-5.
    View in: PubMed
  22. Baily RG, Prophet SA, Shenberger JS, Zelis R, Sinoway LI. Direct neurohumoral evidence for isolated sympathetic nervous system activation to skeletal muscle in response to cardiopulmonary baroreceptor unloading. Circ Res. 1990 Jun; 66(6):1720-8.
    View in: PubMed
  23. Zelis R, Moore R. Recent insights into the calcium channels. Circulation. 1989 Dec; 80(6 Suppl):IV14-6.
    View in: PubMed
  24. Simons RJ, Baily RG, Zelis R, Zwillich CW. The physiologic and psychological effects of the bedside presentation. N Engl J Med. 1989 Nov 2; 321(18):1273-5.
    View in: PubMed
  25. McInerney JJ, Copenhaver GL, Herr MD, Morris DL, Zelis R. High precision Compton backscatter maps of myocardial wall dynamics. Theory and applications. Invest Radiol. 1989 Sep; 24(9):654-65.
    View in: PubMed
  26. Gascho JA, Fanelli C, Sumner A, Zelis R. Effects of posture on the venodilatory response to nitroglycerin. J Appl Physiol (1985). 1989 Jun; 66(6):2585-8.
    View in: PubMed
  27. Gascho JA, Fanelli C, Zelis R. Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects. Am J Cardiol. 1989 May 15; 63(17):1267-70.
    View in: PubMed
  28. Sumner A, Zelis R, Bennett M, Gascho JA. Effect of the venodilated state on sympathetic-induced venoconstriction in normal subjects. Am J Cardiol. 1989 Apr 15; 63(13):973-6.
    View in: PubMed
  29. Fanelli C, Zelis R, Gascho JA. Comparison of venodilatory effects of nitroglycerin spray and tablets in healthy volunteers. Am J Cardiol. 1989 Mar 1; 63(9):637-9.
    View in: PubMed
  30. Sinoway LI, Zelis R. The peripheral circulation. Cardiol Clin. 1989 Feb; 7(1):63-71.
    View in: PubMed
  31. Musch TI, Moore RL, Smaldone PG, Riedy M, Zelis R. Cardiac adaptations to endurance training in rats with a chronic myocardial infarction. J Appl Physiol (1985). 1989 Feb; 66(2):712-9.
    View in: PubMed
  32. Sinoway LI, Hendrickson C, Davidson WR, Prophet S, Zelis R. Characteristics of flow-mediated brachial artery vasodilation in human subjects. Circ Res. 1989 Jan; 64(1):32-42.
    View in: PubMed
  33. Sinoway L, Prophet S, Gorman I, Mosher T, Shenberger J, Dolecki M, Briggs R, Zelis R. Muscle acidosis during static exercise is associated with calf vasoconstriction. J Appl Physiol (1985). 1989 Jan; 66(1):429-36.
    View in: PubMed
  34. Sinoway LI, Wilson JS, Zelis R, Shenberger J, McLaughlin DP, Morris DL, Day FP. Sympathetic tone affects human limb vascular resistance during a maximal metabolic stimulus. Am J Physiol. 1988 Oct; 255(4 Pt 2):H937-46.
    View in: PubMed
  35. Zelis R, Brunner H, Zelis K, Wichmann T. Vascular sympathetic nerve function in congestive heart failure. Am J Cardiol. 1988 Sep 9; 62(8):63E-67E.
    View in: PubMed
  36. Zelis R, Sinoway LI, Musch TI, Davis D, Just H. Regional blood flow in congestive heart failure: concept of compensatory mechanisms with short and long time constants. Am J Cardiol. 1988 Sep 9; 62(8):2E-8E.
    View in: PubMed
  37. Davis D, Baily R, Zelis R. Abnormalities in systemic norepinephrine kinetics in human congestive heart failure. Am J Physiol. 1988 Jun; 254(6 Pt 1):E760-6.
    View in: PubMed
  38. Sinoway LI, Minotti JR, Davis D, Pennock JL, Burg JE, Musch TI, Zelis R. Delayed reversal of impaired vasodilation in congestive heart failure after heart transplantation. Am J Cardiol. 1988 May 1; 61(13):1076-9.
    View in: PubMed
  39. Musch TI, Moore RL, Riedy M, Burke P, Zelis R, Leo ME, Bruno A, Bradford GE. Glycogen concentrations and endurance capacity of rats with chronic heart failure. J Appl Physiol (1985). 1988 Mar; 64(3):1153-9.
    View in: PubMed
  40. Zelis R, Sinoway L, Musch T, Davis D. The peripheral distribution of cardiac output in heart failure. Z Kardiol. 1988; 77 Suppl 5:61-5.
    View in: PubMed
  41. Davis D, Sinoway LI, Robison J, Minotti JR, Day FP, Baily R, Zelis R. Norepinephrine kinetics during orthostatic stress in congestive heart failure. Circ Res. 1987 Oct; 61(4 Pt 2):I87-90.
    View in: PubMed
  42. McInerney JJ, Herr MD, Kenney ES, Copenhaver GL, Zelis RF. The measurement of multidimensional myocardial dynamics using scattered radiation fields. Invest Radiol. 1984 Sep-Oct; 19(5):385-93.
    View in: PubMed
  43. Leaman DM, Zelis RF. What is the appropriate "dress code" for the cardiac catheterization laboratory? Cathet Cardiovasc Diagn. 1983; 9(1):33-8.
    View in: PubMed
  44. Zelis RF, Kinney EL. The pharmacokinetics of diltiazem in healthy American men. Am J Cardiol. 1982 Feb 18; 49(3):529-32.
    View in: PubMed
  45. Zelis RF. Calcium entry blockers in cardiologic therapy. Hosp Pract (Off Ed). 1981 Aug; 16(8):49-56.
    View in: PubMed
  46. Leaman DM, Crawshaw SL, Zelis RF. Assessing the value of mass screening for coronary risks. Pa Med. 1981 Feb; 84(2):29-31.
    View in: PubMed
  47. Kinney EL, Liedtke AJ, Zelis RF. "Therapeutic" Holter monitoring. Chest. 1980 Oct; 78(4):674.
    View in: PubMed
  48. Flaim SF, Zelis RF. Regional distribution of cardiac output in conscious rats at rest and during exercise. Effects of diltiazem. Chest. 1980 Jul; 78(1 Suppl):187-92.
    View in: PubMed
  49. Moskowitz RM, Kinney EL, Zelis RF. Hemodynamic and metabolic responses to upright exercise in patients with congestive heart failure. Treatment with nitroglycerin ointment. Chest. 1979 Dec; 76(6):640-6.
    View in: PubMed
  50. Kinney EL, Allen RP, Weidner WA, Pierce WS, Leaman DM, Zelis RF. Recurrent pulmonary emboli secondary to right atrial thrombus around a permanent pacing catheter: a case report and review of the literature. Pacing Clin Electrophysiol. 1979 Mar; 2(2):196-202.
    View in: PubMed
  51. Kinney EL, Trautlein JJ, Harbaugh CV, Lambert D, Zelis RF. Ventricular tachycardia after terbutaline. JAMA. 1978 Nov 17; 240(21):2247.
    View in: PubMed
  52. D'Ambrosia RD, Zelis RF, Chuinard RG, Wilmore J. Interstitial pressure measurements in the anterior and posterior compartments in athletes with shin splints. Am J Sports Med. 1977 May-Jun; 5(3):127-31.
    View in: PubMed
  53. DeJoseph RL, Shiroff RA, Levenson LW, Martin CE, Zelis RF. Echocardiographic diagnosis of intraventricular clot. Chest. 1977 Mar; 71(3):417-9.
    View in: PubMed
  54. Tyers GF, Williams DR, Babb JD, Levenson L, Zelis RF, Waldhausen JA. The changing status of ejection fraction as a predictor of early mortality following surgery for acquired heart disease. Chest. 1977 Mar; 71(3):371-5.
    View in: PubMed
  55. Field J, Shiroff RA, Zelis RF, Babb JD. Limitations in the use of the pulmonary capillary wedge pressure. Cardiac tamponade. Chest. 1976 Oct; 70(4):451-3.
    View in: PubMed
  56. Zelis RF. Diagnosis and treatment of supraventricular arrhythmia. Pa Med. 1976 Jun; 79(6):26.
    View in: PubMed
  57. Zelis RF, DeJoseph RL. Diagnosis and treatment of superventricular arrhythmia. Pa Med. 1976 May; 79(5):28.
    View in: PubMed
  58. Eisele JH, Reitan JA, Massumi RA, Zelis RF, Miller RR. Myocardial performance and N2O analgesia in coronary-artery disease. Anesthesiology. 1976 Jan; 44(1):16-20.
    View in: PubMed
  59. Eisele JH, Cross CE, Rausch DC, Kurpershoek CJ, Zelis RF. Abnormal respiratory control in acquired dysautonomia. N Engl J Med. 1971 Aug 12; 285(7):366-8.
    View in: PubMed
  60. Spann JF, Mason DT, Zelis RF. Recent advances in the understanding of congestive heart failure. II. Mod Concepts Cardiovasc Dis. 1970 Feb; 39(2):79-84.
    View in: PubMed
  61. Spann JF, Mason DT, Zelis RF. Recent advances in the understanding of congestive heart failure. Mod Concepts Cardiovasc Dis. 1970 Jan; 39(1):73-8.
    View in: PubMed
  62. Spann JF, Mason DT, Zelis RF. The altered performance of the hypertrophied and failing heart. Am J Med Sci. 1969 Nov; 258(5):291-303.
    View in: PubMed
  63. Barth WF, Glenner GG, Waldmann TA, Zelis RF. Primary amyloidosis. Ann Intern Med. 1968 Oct; 69(4):787-805.
    View in: PubMed
  64. HANCOCK RL, ZELIS RF, SHAW M, WILLIAMS-ASHMAN HG. Incorporation of ribonucleoside triphosphates into ribonucleic acid by nuclei of the prostate gland. Biochim Biophys Acta. 1962 Jan 22; 55:257-60.
    View in: PubMed
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