PSU Profiles
Last Name

Rongling Wu

TitleDistinguished Professor of Public Health Sciences and Statistics
InstitutionCollege of Medicine
DepartmentPublic Health Sciences
Address500 University Drive Hershey PA 17033
Mailbox: A210
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    Collapse Biography 
    Collapse awards and honors
    2016Fellow, American Association for the Advancement of Science

    Collapse Overview 
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    Distinguished Professor, Division of Biostatistics and Bioinformatics


    Distinguished Professor, Department of Statistics


    Public Health Sciences


    Ph.D., University of Washington, 1995


    With a rigorous training in genetics, Dr. Wu is fascinated by the mystery of how genes can generate such a vast amount of variation in nature and what mechanistic and developmental regulation guides gene to respond to environmental signals. Dr. Wu's current research interest focuses on the development of statistical and computational methods necessary to unravel the genetic machinery of complex traits, diseases, and life processes. He is particularly interested in integrating the idea and principle of systems biology into statistical genetic research, ultimately elucidating a comprehensive atlas of the genetic control network of complex biology. He is alert and sensitive to concrete genetic or developmental problems fundamentally meaningful to agriculture, forestry, biology, and biomedicine and exceptionally good at the design of statistical models and algorithms to solve these problems. His pioneering statistical work on functional mapping was highlighted in Nature Reviews Genetics in 2004 and 2006. Dr. Wu serves Associate Editors for a number of statistical and genetic journals.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lin Z, Hao H, Hegarty JP, Lin TR, Wang Y, Harris LR, Xu HN, Wu R, Thomas NJ, Floros J. Association of the haem oxygenase-1 gene with inflammatory bowel disease. Swiss Med Wkly. 2017 08 03; 147:w14456. PMID: 28770550.
      View in: PubMed
    2. Lin Z, Wang Z, Hegarty JP, Lin TR, Wang Y, Deiling S, Wu R, Thomas NJ, Floros J. Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease. World J Gastroenterol. 2017 Jul 21; 23(27):4897-4909. PMID: 28785144.
      View in: PubMed
    3. Gosik K, Kong L, Chinchilli VM, Wu R. iFORM/eQTL: an ultrahigh-dimensional platform for inferring the global genetic architecture of gene transcripts. Brief Bioinform. 2017 03 01; 18(2):250-259. PMID: 26944084.
      View in: PubMed
    4. Hao H, Haas MJ, Wu R, Gragnoli C. T2D and Depression Risk Gene Proteasome Modulator 9 is Linked to Insomnia. Sci Rep. 2015 Jul 13; 5:12032. PMID: 26166263; PMCID: PMC4648424.
    5. Sun L, Wu R. Toward the practical utility of systems mapping: Reply to comments on "Mapping complex traits as a dynamic system". Phys Life Rev. 2015 Jun; 13:198-201. PMID: 26009264.
      View in: PubMed
    6. Sun L, Wu R. Mapping complex traits as a dynamic system. Phys Life Rev. 2015 Jun; 13:155-85. PMID: 25772476.
      View in: PubMed
    7. Wang N, Wang Y, Han H, Huber KJ, Yang JM, Li R, Wu R. Modeling Expression Plasticity of Genes that Differentiate Drug-sensitive from Drug-resistant Cells to Chemotherapeutic Treatment. Curr Genomics. 2014 Oct; 15(5):349-56. PMID: 25435798; PMCID: PMC4245695.
    8. Wang Y, Wang N, Hao H, Guo Y, Zhen Y, Shi J, Wu R. A computational algorithm for functional clustering of proteome dynamics during development. Curr Genomics. 2014 Jun; 15(3):237-43. PMID: 24955031.
      View in: PubMed
    9. Wu R, Wang Z. Mathematical modeling of systems pharmacogenomics towards personalized drug delivery. Preface. Adv Drug Deliv Rev. 2013 Jun 30; 65(7):903-4. PMID: 23722051.
      View in: PubMed
    10. Liu G, Kong L, Wang Z, Wang C, Wu R. Systems mapping of metabolic genes through control theory. Adv Drug Deliv Rev. 2013 Jun 30; 65(7):918-28. PMID: 23603209; PMCID: PMC4233129.
    11. Wang Y, Wang N, Wang J, Wang Z, Wu R. Delivering systems pharmacogenomics towards precision medicine through mathematics. Adv Drug Deliv Rev. 2013 Jun 30; 65(7):905-11. PMID: 23523629; PMCID: PMC3988791.
    12. Sui Y, Wu W, Wang Z, Wang J, Wang Z, Wu R. A case-control design for testing and estimating epigenetic effects on complex diseases. Brief Bioinform. 2014 Mar; 15(2):319-26. PMID: 23334587; PMCID: PMC3956067.
    13. Zeng Y, Hou W, Song S, Feng S, Shen L, Xia G, Wu R. A statistical design for testing apomictic diversification through linkage analysis. Brief Bioinform. 2014 Mar; 15(2):306-18. PMID: 23271157.
      View in: PubMed
    14. Zhu S, Wang Z, Wang J, Wang Y, Wang N, Wang Z, Xu M, Su X, Wang M, Zhang S, Huang M, Wu R. A quantitative model of transcriptional differentiation driving host-pathogen interactions. Brief Bioinform. 2013 Nov; 14(6):713-23. PMID: 22962337.
      View in: PubMed
    15. Wang Z, Wang Y, Wang N, Wang J, Wang Z, Vallejos CE, Wu R. Towards a comprehensive picture of the genetic landscape of complex traits. Brief Bioinform. 2014 Jan; 15(1):30-42. PMID: 22930650; PMCID: PMC3896925.
    16. Das K, Li J, Fu G, Wang Z, Li R, Wu R. Dynamic semiparametric Bayesian models for genetic mapping of complex trait with irregular longitudinal data. Stat Med. 2013 Feb 10; 32(3):509-23. PMID: 22903809; PMCID: PMC3770845.
    17. Huber-Keener KJ, Liu X, Wang Z, Wang Y, Freeman W, Wu S, Planas-Silva MD, Ren X, Cheng Y, Zhang Y, Vrana K, Liu CG, Yang JM, Wu R. Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-Seq data. PLoS One. 2012; 7(7):e41333. PMID: 22844461; PMCID: PMC3402532.
    18. Liu J, Wang Z, Wang Y, Li R, Wu R. Model and algorithm for linkage disequilibrium analysis in a non-equilibrium population. Front Genet. 2012; 3:78. PMID: 22754562; PMCID: PMC3386617.
    19. Wang Z, Liu J, Wang J, Wang Y, Wang N, Li Y, Li R, Wu R. Dynamic modeling of genes controlling cancer stem cell proliferation. Front Genet. 2012; 3:84. PMID: 22661984; PMCID: PMC3357477.
    20. Das K, Huang Z, Liu J, Fu G, Li J, Li Y, Tong C, Gai J, Wu R. Functional mapping of developmental processes: theory, applications, and prospects. Methods Mol Biol. 2012; 871:227-43. PMID: 22565840.
      View in: PubMed
    21. Li J, Das K, Liu J, Fu G, Li Y, Tobias C, Wu R. Statistical models for genetic mapping in polyploids: challenges and opportunities. Methods Mol Biol. 2012; 871:245-61. PMID: 22565841.
      View in: PubMed
    22. Lin Z, Hegarty JP, Berb A, Wang Z, Kelly AA, Wang Y, Poritz LS, Wu R, Koltun WA. DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility. Swiss Med Wkly. 2011 Nov 08; 141:w13290. PMID: 22065243.
      View in: PubMed
    23. Tong C, Zhang B, Wang Z, Xu M, Pang X, Si J, Huang M, Wu R. Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci. BMC Plant Biol. 2011 Oct 31; 11:148. PMID: 22039993; PMCID: PMC3377927.
    24. Wu R, Tong C, Wang Z, Mauger D, Tantisira K, Szefler SJ, Chinchilli VM, Israel E. A conceptual framework for pharmacodynamic genome-wide association studies in pharmacogenomics. Drug Discov Today. 2011 Oct; 16(19-20):884-90. PMID: 21920452; PMCID: PMC4029408.
    25. Fu G, Wang Z, Li J, Wu R. A mathematical framework for functional mapping of complex phenotypes using delay differential equations. J Theor Biol. 2011 Nov 21; 289:206-16. PMID: 21871898.
      View in: PubMed
    26. Wang Y, Xu M, Wang Z, Tao M, Zhu J, Wang L, Li R, Berceli SA, Wu R. How to cluster gene expression dynamics in response to environmental signals. Brief Bioinform. 2012 Mar; 13(2):162-74. PMID: 21746694; PMCID: PMC3294239.
    27. Das K, Li J, Wang Z, Tong C, Fu G, Li Y, Xu M, Ahn K, Mauger D, Li R, Wu R. A dynamic model for genome-wide association studies. Hum Genet. 2011 Jun; 129(6):629-39. PMID: 21293879; PMCID: PMC3103104.
    28. Yap JS, Li Y, Das K, Li J, Wu R. Functional mapping of reaction norms to multiple environmental signals through nonparametric covariance estimation. BMC Plant Biol. 2011 Jan 26; 11:23. PMID: 21269481; PMCID: PMC3039563.
    29. Li J, Das K, Fu G, Tong C, Li Y, Tobias C, Wu R. Em algorithm for mapping quantitative trait Loci in multivalent tetraploids. Int J Plant Genomics. 2010; 2010:216547. PMID: 21317976; PMCID: PMC3022269.
    30. Berg A, Li N, Tong C, Wang Z, Berceli SA, Wu R. Functional mapping of expression quantitative trait loci that regulate oscillatory gene expression. Methods Mol Biol. 2011; 734:241-55. PMID: 21468993.
      View in: PubMed
    31. Fu G, Luo J, Berg A, Wang Z, Li J, Das K, Li R, Wu R. A dynamic model for functional mapping of biological rhythms. J Biol Dyn. 2011 Jan; 5(1):84-101. PMID: 21278847; PMCID: PMC3027063.
    32. Liao D, Shaffer ML, He F, Rodriguez-Colon S, Wu R, Whitsel EA, Bixler EO, Cascio WE. Fine particulate air pollution is associated with higher vulnerability to atrial fibrillation--the APACR study. J Toxicol Environ Health A. 2011; 74(11):693-705. PMID: 21480044; PMCID: PMC3082849.
    33. Li J, Das K, Fu G, Li R, Wu R. The Bayesian lasso for genome-wide association studies. Bioinformatics. 2011 Feb 15; 27(4):516-23. PMID: 21156729; PMCID: PMC3105480.
    34. He F, Shaffer ML, Rodriguez-Colon S, Bixler EO, Vgontzas AN, Williams RW, Wu R, Cascio WE, Liao D. Acute effects of fine particulate air pollution on ST segment height: a longitudinal study. Environ Health. 2010 Nov 08; 9:68. PMID: 21059260; PMCID: PMC2989950.
    35. Wang Z, Liu T, Lin Z, Hegarty J, Koltun WA, Wu R. A general model for multilocus epistatic interactions in case-control studies. PLoS One. 2010 Aug 18; 5(8):e11384. PMID: 20814428; PMCID: PMC2909900.
    36. Fu G, Berg A, Das K, Li J, Li R, Wu R. A statistical model for mapping morphological shape. Theor Biol Med Model. 2010 Jul 01; 7:28. PMID: 20594352; PMCID: PMC2915964.
    37. Ahn K, Luo J, Berg A, Keefe D, Wu R. Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles. Trends Pharmacol Sci. 2010 Jul; 31(7):306-11. PMID: 20488563.
      View in: PubMed
    38. Li Y, Ma C, Wang Z, Chen G, Ahn K, Lazarus P, Wu R. A disequilibrium model for detecting genetic mutations for cancer. J Theor Biol. 2010 Aug 07; 265(3):218-24. PMID: 20450921.
      View in: PubMed
    39. Berg A, He Q, Shen Y, Chen Y, Huang M, Wu R. Trilocus disequilibrium analysis of multiallelic markers in outcrossing populations. Stat Appl Genet Mol Biol. 2010; 9:Article 16. PMID: 20196751.
      View in: PubMed
    40. Lin Z, Nelson L, Franke A, Poritz L, Li TY, Wu R, Wang Y, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease. J Crohns Colitis. 2010 Jun; 4(2):132-8. PMID: 21122496.
      View in: PubMed
    41. Liu JH, Ho SC, Lai TH, Liu TH, Chi PY, Wu RY. Protective effects of Chinese herbs on D-galactose-induced oxidative damage. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug; 25(6):447-52. PMID: 12949630.
      View in: PubMed
    42. Wang YM, Zheng JJ, Ren GR, Gong ZL, Huang FZ, Xue LS, Jiang JH, Zhu XS, Wu RY, Ling K, et al. [Carcinoembryonic antigen and immunoglobin in gastric juice in the diagnosis of gastric cancer]. Zhonghua Zhong Liu Za Zhi. 1986 Jul; 8(4):270-2. PMID: 3757741.
      View in: PubMed
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