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Richard Tenser

TitleProfessor
InstitutionCollege of Medicine
DepartmentNeurology
Address500 University Drive Hershey PA 17033
Phone7175311801

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Professor of Neurology, and Microbiology and Immunology

GRADUATE PROGRAM AFFILIATIONS:

Microbiology and Immunology, Neuroscience

EDUCATION:

Fellowship, Neurology, Yale-New Haven Hospital (1976)
Residency, Neurology, Yale-New Haven Hospital (1972)
Internship, Internal Medicine, Albany Medical Center (1969)
M.D., SUNY Upstate University, Syracuse College of Medicine (1968)

NARRATIVE:

Latent and Slow Virus Infection of the Nervous System, Multiple Sclerosis

Herpes simplex virus (HSV) latent infection of sensory ganglion neurons is the substrate of recurrent mucocutaneous HSV infection. In this context HSV latency is a prototypic latent viral infection of the nervous system, which undergoes periodic reactivation. During latency infectious virus and viral antigens are not detectable, and only a single species of viral RNA is present, the latency associated transcript (LAT). The goals in our laboratory have centered on understanding the pathogenesis of HSV latency in terms of biochemical factors important for the establishment-reactivation of latency, and also neuronal functions important in this process. Emphasis has been on the role of viral specified thymidine kinase expression, including the role of exogenous nucleosides, and secondly on latency after neuronal injury (e.g., neurectomy).

In pathogenesis studies we have utilized virological and immunological methods to demonstrate the criteria of HSV latency and in situ hybridization methods to demonstrate LAT. In other studies viral DNA after neurectomy was investigated by PCR methods. Investigations have largely been in vivo studies in mice, in which experimental surgery was used in conjunction with cell biology and molecular biology procedures. The emphasis in future studies will continue on the study of the pathogenesis of latent virus infection and reactivation, and disease of the nervous system. Toward this end, sensory ganglion transplantation is being utilized to investigate methods of this establishment of latency, and also mechanisms which control reactivation.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tenser RB, Nath A. Re: Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised. Neurology. 2013 Jul 30; 81(5):514.
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  2. Tenser RB, French JA, England JD. Comparative effectiveness research, evidence-based medicine, and the AAN. Neurology. 2011 Mar 8; 76(10):934; author reply 934-5.
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  3. Tenser RB. MRI as an outcome in multiple sclerosis clinical trials. Neurology. 2009 Dec 1; 73(22):1933-4; author reply 1934.
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  4. Tenser RB, Polman CH. Ethics of placebo-controlled clinical trials in multiple sclerosis: a reassessment. Neurology. 2009 Mar 31; 72(13):1191-2; author reply 1192.
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  5. Tenser RB. Natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006 Jun 1; 354(22):2387-9; author reply 2387-9.
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  6. Tenser RB, Dworkin RH. Herpes zoster and the prevention of postherpetic neuralgia: beyond antiviral therapy. Neurology. 2005 Aug 9; 65(3):349-50.
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  7. Tenser RB. Methylprednisolone, valacyclovir, or both for vestibular neuritis. N Engl J Med. 2004 Nov 25; 351(22):2344-5; author reply 2344-5.
    View in: PubMed
  8. Szwejbka PE, Conter R, Tenser R, Kothari MJ. Bilateral anterior interosseous neuropathy following surgery: a case report. Electromyogr Clin Neurophysiol. 2004 Apr-May; 44(3):183-6.
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  9. Tenser RB. Epstein-barr virus and risk of multiple sclerosis. JAMA. 2003 Jul 9; 290(2):192-3; author reply 193.
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  10. Tenser RB, Gaydos A, Hay KA. Inhibition of herpes simplex virus reactivation by dipyridamole. Antimicrob Agents Chemother. 2001 Dec; 45(12):3657-9.
    View in: PubMed
  11. Tenser RB. Herpes zoster infection and postherpetic neuralgia. Curr Neurol Neurosci Rep. 2001 Nov; 1(6):526-32.
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  12. Hay KA, Tenser RB. Leukotropic herpesviruses in multiple sclerosis. Mult Scler. 2000 Apr; 6(2):66-8.
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  13. Tenser RB. Quantitative MRI in patients with clinically isolated syndromes suggestive of demyelination. Neurology. 1999 Nov 10; 53(8):1893.
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  14. Hay KA, Edris WA, Gaydos A, Tenser RB. Herpes simplex virus latency after direct ganglion virus inoculation. J Neurovirol. 1998 Oct; 4(5):531-8.
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  15. McCabe PH, Blakeslee MA, Tenser RB. Guillain-Barré syndrome after thalamotomy for tremor in MS. Neurology. 1998 Oct; 51(4):1229-30.
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  16. Tenser RB. Imaging and multiple sclerosis. Ann Neurol. 1998 Sep; 44(3):424-5.
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  17. Tenser RB. Trigeminal neuralgia: mechanisms of treatment. Neurology. 1998 Jul; 51(1):17-9.
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  18. Hay KA, Gaydos A, Tenser RB. Inhibition of herpes simplex virus reactivation by dipyridamole in a mouse model. J Med Virol. 1996 Oct; 50(2):198-203.
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  19. Tenser RB. The role of antibody in the treatment of acute herpes simplex virus disease and in the pathogenesis of latency in newborn guinea pigs. J Infect Dis. 1996 Sep; 174(3):667-8.
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  20. Tenser RB, Gaydos A, Hay KA. Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside. J Virol. 1996 Feb; 70(2):1271-6.
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  21. Hay KA, Gaydos A, Tenser RB. The role of herpes simplex thymidine kinase expression in neurovirulence and latency in newborn vs. adult mice. J Neuroimmunol. 1995 Aug; 61(1):41-52.
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  22. Tenser RB, Edris WA, Gaydos A, Hay KA. Secondary herpes simplex virus latent infection in transplanted ganglia. J Virol. 1994 Nov; 68(11):7212-20.
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  23. Tenser RB, Edris WA, Hay KA. Neuronal control of herpes simplex virus latency. Virology. 1993 Aug; 195(2):337-47.
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  24. Tenser RB, Hay KA, Aberg JA. Immunoglobulin G immunosuppression of multiple sclerosis. Suppression of all three major lymphocyte subsets. Arch Neurol. 1993 Apr; 50(4):417-20.
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  25. Tenser RB, Viselli AL, Savage DH. Reversible decrease of fluoride resistant acid phosphatase-positive neurons after herpes simplex virus infection. Neurosci Lett. 1991 Sep 2; 130(1):85-8.
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  26. Tenser RB, Edris WA, Hay KA, de Galan BE. Expression of herpes simplex virus type 2 latency-associated transcript in neurons and nonneurons. J Virol. 1991 May; 65(5):2745-50.
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  27. Tenser RB. Role of herpes simplex virus thymidine kinase expression in viral pathogenesis and latency. Intervirology. 1991; 32(2):76-92.
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  28. Aberg JA, Demers LM, Romano PJ, Tenser RB. Prostaglandin production in chronic progressive multiple sclerosis. J Clin Lab Anal. 1990; 4(4):246-50.
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  29. Tenser RB, Hay KA, Edris WA. Latency-associated transcript but not reactivatable virus is present in sensory ganglion neurons after inoculation of thymidine kinase-negative mutants of herpes simplex virus type 1. J Virol. 1989 Jun; 63(6):2861-5.
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  30. Tenser RB, Edris WA, Hay KA. Herpes simplex latent infection: quantitation of latency-associated transcript-positive neurons and reactivable neurons. Yale J Biol Med. 1989 Mar-Apr; 62(2):197-204.
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  31. Tenser RB, Edris WA, Hay KA. Herpes simplex virus latent infection: reactivation and elimination of latency after neurectomy. Virology. 1988 Nov; 167(1):302-5.
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  32. Pearlman RL, Towfighi J, Pezeshkpour GH, Tenser RB, Turel AP. Clinical significance of types of cerebellar amyloid plaques in human spongiform encephalopathies. Neurology. 1988 Aug; 38(8):1249-54.
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  33. Westheim AI, Tenser RB, Marks JG. Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection. J Am Acad Dermatol. 1987 Nov; 17(5 Pt 2):875-80.
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  34. Fang ZY, Tenser RB, Rapp F, Yu XP. [Herpes simplex virus infection in the regenerating mouse liver]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1987 Aug; 9(4):302-5.
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  35. Tenser RB, Edris WA. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus after in vivo complementation. J Virol. 1987 Jul; 61(7):2171-4.
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  36. Tenser RB, Hyman RW. Latent herpesvirus infections of neurons in guinea pigs and humans. Yale J Biol Med. 1987 Mar-Apr; 60(2):159-67.
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  37. Tenser RB, Edris WA. Thymidine kinase (TK) activity in herpes simplex virus type 1 recombinants that carry insertions affecting regulation of the TK gene. Virology. 1986 Nov; 155(1):257-61.
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  38. Tenser RB. How does vascular decompression surgery improve trigeminal neuralgia? Ann Neurol. 1986 May; 19(5):514.
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  39. Tenser RB, Sommerville KW, Mummaw JG, Frisque RJ. Isolation of JC virus capsomer-like structures from progressive multifocal leukoencephalopathy brain. J Neurol Sci. 1986 Feb; 72(2-3):243-54.
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  40. Tenser RB. Infectious origin and Epstein-Barr virus. Arch Neurol. 1985 Jul; 42(7):626.
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  41. Tenser RB. Sequential changes of sensory neuron (fluoride-resistant) acid phosphatase in dorsal root ganglion neurons following neurectomy and rhizotomy. Brain Res. 1985 Apr 22; 332(2):386-9.
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  42. Tenser RB, Jones JC, Ressel SJ. Acute and latent infection by thymidine kinase mutants of herpes simplex virus type 2. J Infect Dis. 1985 Mar; 151(3):548-50.
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  43. Tenser RB. Herpes simplex and herpes zoster. Nervous system involvement. Neurol Clin. 1984 May; 2(2):215-40.
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  44. Hyman RW, Ecker JR, Tenser RB. Varicella-zoster virus RNA in human trigeminal ganglia. Lancet. 1983 Oct 8; 2(8354):814-6.
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  45. Fang ZY, Tenser RB, Rapp F. Hepatic infection by thymidine kinase-positive and thymidine kinase-negative herpes simplex virus after partial hepatectomy. Infect Immun. 1983 Oct; 42(1):402-8.
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  46. Tenser RB, Ressel SJ, Fralish FA, Jones JC. The role of pseudorabies virus thymidine kinase expression in trigeminal ganglion infection. J Gen Virol. 1983 Jun; 64 (Pt 6):1369-73.
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  47. Tenser RB. Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1. J Infect Dis. 1983 May; 147(5):956.
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  48. Tenser RB, Jones JC, Ressel SJ, Fralish FA. Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses. J Clin Microbiol. 1983 Jan; 17(1):122-7.
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  49. Abb J, Deinhardt F, Zander H, Tenser RB, Rapp F, Goust JM, Fudenberg HH, Vilcek J, Ho M, Merigan TC, Oldstone MB, Jackson GG. Infectious Diseases Society of America. Trials of interferon therapy for multiple sclerosis. J Infect Dis. 1982 Jul; 146(1):109-15.
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  50. Murphy MJ, Tenser RB. Nevoid basal cell carcinoma syndrome and epilepsy. Ann Neurol. 1982 Apr; 11(4):372-6.
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  51. Tenser RB, Dawson M, Ressel SJ, Dunstan ME. Detection of herpes simplex virus mRNA in latently infected trigeminal ganglion neurons by in situ hybridization. Ann Neurol. 1982 Mar; 11(3):285-91.
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  52. Giordano GF, Masland W, Ketchel SJ, Holland K, Tilmann K, Wallace BA, DeGreen HP, Tenser R, Kasprisin D, Hamburger M, Rosen A, Pitts W. Lymphocytapheresis in multiple sclerosis: a preliminary report. Prog Clin Biol Res. 1982; 106:255-62.
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  53. Tenser RB, Ressel S, Dunstan ME. Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation. Virology. 1981 Jul 15; 112(1):328-41.
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  54. Robbins SJ, Wrzos H, Kline AL, Tenser RB, Rapp F. Rescue of a cytopathic paramyxovirus from peripheral blood leukocytes in subacute sclerosing panencephalitis. J Infect Dis. 1981 Mar; 143(3):396-403.
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  55. Tenser RB, Dunstan ME. Mechanisms of herpes simplex virus infectivity enhanced by ultracentrifugal inoculation. Infect Immun. 1980 Oct; 30(1):193-7.
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  56. Strauss M, Krieger R, Lord SG, Tenser RB, Abt AB, Maisels MJ. Clinicopathologic study of cytomegalovirus and congenital hearing loss: a progress report. Trans Pa Acad Ophthalmol Otolaryngol. 1980; 33(2):175-82.
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  57. Tenser RB, Dunstan ME. Herpes simplex virus thymidine kinase expression in infection of the trigeminal ganglion. Virology. 1979 Dec; 99(2):417-22.
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  58. Tenser RB, Miller RL, Rapp F. Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus. Science. 1979 Aug 31; 205(4409):915-7.
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  59. Tenser RB, Hsiung GD. Oncornavirus particles in neurons of guinea pig trigeminal ganglion. J Neuropathol Exp Neurol. 1978 Sep; 37(5):508-17.
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  60. Tenser RB. Ultracentrifugal inoculation of herpes simplex virus. Infect Immun. 1978 Jul; 21(1):281-5.
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  61. Nordlund JJ, Anderson C, Hsiung GD, Tenser RB. The use of temperature sensitivity and selective cell culture systems for differentiation of herpes simplex virus types 1 and 2 in a clinical laboratory. Proc Soc Exp Biol Med. 1977 May; 155(1):118-23.
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  62. Tenser RB, Hsiung GD. Pathogenesis of latent herpes simplex virus infection of the trigeminal ganglion in guinea pigs: effects of age, passive immunization, and hydrocortisone. Infect Immun. 1977 Apr; 16(1):69-74.
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  63. Tenser RB, Hsiung GD. Distribution of guinea pig herpeslike virus in brain and other tissues of naturally and experimentally infected animals. Proc Soc Exp Biol Med. 1976 Jul; 152(3):428-31.
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  64. Tenser RB, Hsiung GD. Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: pathogenesis and persistence in experimentally infected animals. Infect Immun. 1976 Mar; 13(3):934-40.
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  65. Tenser RB. Letter: Enveloped virions in PML. Neurology. 1976 Mar; 26(3):294.
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  66. Hsiung GD, Tenser RB, Fong CK. Comparison of guinea pig cytomegalovirus and guinea pig herpes-like virus: growth characteristics and antigentic relationship. Infect Immun. 1976 Mar; 13(3):926-33.
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  67. Tenser RB. Myokymia and facial contraction in multiple sclerosis. Arch Intern Med. 1976 Jan; 136(1):81-3.
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  68. Tenser RB, Hsiung GD. Distribution of herpes simplex virus in guinea pig brain following corneal inoculation. Trans Am Neurol Assoc. 1975; 100:246-8.
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  69. Cate JC IV, Tenser R. Acute primidone overdosage with massive crystalluria. Clin Toxicol. 1975; 8(4):385-9.
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  70. Tenser RB, Corbett JJ. Myokymia and facial contraction in brain stem glioma. An electromyographic study. Arch Neurol. 1974 Jun; 30(6):425-7.
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  71. Tenser RB. Trigeminal neuralgia and herpesvirus. N Engl J Med. 1973 Jun 7; 288(23):1243-4.
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  72. Fong CK, Tenser RB, Hsiung GD, Gross PA. Ultrastructural studies of the envelopment and release of guinea pig herpes-like virus in cultured cells. Virology. 1973 Apr; 52(2):468-77.
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  73. Tenser RB, Hsiung GD. Infection of thymus cells in vivo and in vitro with a guinea pig herpes-like virus and the effect of antibody on virus replication in organ culture. J Immunol. 1973 Feb; 110(2):552-60.
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