PSU Profiles
Last Name

Rebecca Bascom

InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033
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    Physician, Professor of Medicine


    Fellowship, Pulmonary/Critical Care, Johns Hopkins University Hospital (1985) Residency, Internal Medicine, Johns Hopkins University Hospital (1982) Internship, Internal Medicine, Johns Hopkins University Hospital (1980) M.D., University of Oregon Health Science Center (1979)


    Dr. Bascom engages in interdisciplinary research with a wide range of collaborators. Her primary areas of focus are:

    1) Clinical research in idiopathic pulmonary fibrosis, as a co-founder of the Pennsylvania IPF Registry and member of the PCORI-funded PaTH Clinical Data Research Network's rare disease/IPF group. She leads the Penn State Hershey Medical Center Pulmonary Fibrosis (PFF) Care Center and the bi-weekly Multidisciplinary Diffuse Parenchymal Lung Disease conference. Consented patients contribute to bio-repositories nationally (PFF) and locally (IPM). IPF research focuses on patient-reported outcomes and interventions to improve functional status. Researchers in her group are developing a cough challenge model. She is a site investigator for multiple pharmaceutical trials for IPF therapies.

    2) Inhalation toxicology, with a focus on markers and mechanisms of upper respiratory injury. She and Dr. Ali Borhan (Chemical Engineering, University Park) are collaborating to establish dosimetric models of toxicant induced lung injury using chest CT scans from consented patients with healthy and diseased lungs. She is currently on the internal scientific advisory committee for the Penn State Tobacco Center of Regulatory Science (TCORS) and data safety monitor for their clinical trials of modified risk tobacco products.

    3) Ehlers-Danlos Syndromes/Heritable Disorders of Connective Tissue (EDS/HDCT). She is collaborating with Dr.Clair Francomano (head, Ehlers-Danlos National Center for Clinical Care and Research) to analyze a rich phenotypic dataset of EDS patients. She and Dr. Jane Schubart (Department of Surgery) have a CTSI Bridges to Translation award to establish a research program at Penn State focused on heritable disorders of connective tissue. The focus will be on nighttime sleep and daytime fatigue and sleepiness (in collaboration with Dr. Fernandez-Mendoza), dysautonomia (with Dr. Amanda Ross Miller) and pain.

    4) Development of multimodal guidance systems for diagnostic bronchoscopy, as clinical partner with the NIH-funded Multidimensional Image Processing Laboratory (MIPL) at Penn State, led by William Higgins, PhD, Professor of Electrical Engineering.

    5) Pulmonary Trials Cooperative Network Management Core (NEMO, Environmental and Occupational consultation) site investigator for 2 PTC clinical trials: INSIGHT (exercise interventions for COPD); CLEAN UP IPF (antibiotics to prevent IPF exacerbation),

    Previously, she led the analysis team to evaluate the cardiorespiratory health effects of the 9/11 terrorist attack on New York City police officers in collaboration with the Living Heart Foundation (LHF), and directed the University of Maryland’s Environmental Research Facility, which was a controlled human exposure facility focusing on exposure to environmental pollutants such as sidestream tobacco smoke, ozone, and other pollutants.

    Dr. Bascom has served on several Institute of Medicine committees, including the Indoor Allergens: Assessing and Controlling Adverse Health Effects, Occupational Health and Safety in the Care and Use of Research Animals, Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants, Scientific Standards for Modified Risk Tobacco Products, and most recently, Standards for Controlled Human Exposure Studies.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Krebs NM, Allen SI, Veldheer S, Martinez DJ, Horn K, Livelsberger C, Modesto J, Kuprewicz R, Wilhelm A, Hrabovsky S, Kazi A, Fazzi A, Liao J, Zhu J, Wasserman E, Reilly SM, Reinhart L, Trushin N, Moyer RE, Bascom R, Foulds J, Richie JP, Muscat JE. Correction to Reduced nicotine content cigarettes in smokers of low socioeconomic status: study protocol for a randomized control trial. Trials. 2017 Dec 15; 18(1):598. PMID: 29246173.
      View in: PubMed
    2. Krebs NM, Allen SI, Veldheer S, Martinez DJ, Horn K, Livelsberger C, Modesto J, Kuprewicz R, Wilhelm A, Hrabovsky S, Kazi A, Fazzi A, Liao J, Zhu J, Wasserman E, Reilly SM, Reinhart L, Trushin N, Moyer RE, Bascom R, Foulds J, Richie JP, Muscat JE. Reduced nicotine content cigarettes in smokers of low socioeconomic status: study protocol for a randomized control trial. Trials. 2017 Jul 03; 18(1):300. PMID: 28673312.
      View in: PubMed
    3. Hawley B, Cummings KJ, Mohammed M, Dimmock AE, Bascom R. Allergic sinusitis and severe asthma caused by occupational exposure to locust bean gum: Case report. Am J Ind Med. 2017 Jul; 60(7):658-663. PMID: 28497854.
      View in: PubMed
    4. Van Scoy LJ, Green MJ, Dimmock AE, Bascom R, Boehmer JP, Hensel JK, Hozella JB, Lehman EB, Schubart JR, Farace E, Stewart RR, Levi BH. High satisfaction and low decisional conflict with advance care planning among chronically ill patients with advanced chronic obstructive pulmonary disease or heart failure using an online decision aid: A pilot study. Chronic Illn. 2016 09; 12(3):227-35. PMID: 27055468.
      View in: PubMed
    5. Zang X, Bascom R, Gilbert C, Toth J, Higgins W. Methods for 2-D and 3-D Endobronchial Ultrasound Image Segmentation. IEEE Trans Biomed Eng. 2016 07; 63(7):1426-39. PMID: 26529748; PMCID: PMC4989849 [Available on 07/01/17].
    6. Cheirsilp R, Bascom R, Allen TW, Higgins WE. Thoracic cavity definition for 3D PET/CT analysis and visualization. Comput Biol Med. 2015 Jul; 62:222-38. PMID: 25957746; PMCID: PMC4429311.
    7. Khare R, Bascom R, Higgins WE. Hands-Free System for Bronchoscopy Planning and Guidance. IEEE Trans Biomed Eng. 2015 Dec; 62(12):2794-811. PMID: 25675452.
      View in: PubMed
    8. Bates ML, Brenza TM, Ben-Jebria A, Bascom R, Eldridge MW, Ultman JS. Pulmonary function responses to ozone in smokers with a limited smoking history. Toxicol Appl Pharmacol. 2014 Jul 01; 278(1):85-90. PMID: 24747805.
      View in: PubMed
    9. Gibbs JD, Graham MW, Bascom R, Cornish DC, Khare R, Higgins WE. Optimal procedure planning and guidance system for peripheral bronchoscopy. IEEE Trans Biomed Eng. 2014 Mar; 61(3):638-57. PMID: 24235246.
      View in: PubMed
    10. Pinkerton M, Chinchilli V, Banta E, Craig T, August A, Bascom R, Cantorna M, Harvill E, Ishmael FT. Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults. J Allergy Clin Immunol. 2013 Jul; 132(1):217-9. PMID: 23628339.
      View in: PubMed
    11. Merritt SA, Khare R, Bascom R, Higgins WE. Interactive CT-video registration for the continuous guidance of bronchoscopy. IEEE Trans Med Imaging. 2013 Aug; 32(8):1376-96. PMID: 23508260; PMCID: PMC3911781.
    12. Carter RM, Symons Downs D, Bascom R, Dyer AM, Weisman CS. The moderating influence of asthma diagnosis on biobehavioral health characteristics of women of reproductive age. Matern Child Health J. 2012 Feb; 16(2):448-55. PMID: 21400202.
      View in: PubMed
    13. Brody AL, Mandelkern MA, London ED, Khan A, Kozman D, Costello MR, Vellios EE, Archie MM, Bascom R, Mukhin AG. Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. Arch Gen Psychiatry. 2011 Sep; 68(9):953-60. PMID: 21536968; PMCID: PMC3380615.
    14. Lu K, Taeprasartsit P, Bascom R, Mahraj RP, Higgins WE. Automatic definition of the central-chest lymph-node stations. Int J Comput Assist Radiol Surg. 2011 Jul; 6(4):539-55. PMID: 21359877; PMCID: PMC3111859.
    15. Bates ML, Brenza TM, Ben-Jebria A, Bascom R, Ultman JS. Longitudinal distribution of ozone absorption in the lung: comparison of cigarette smokers and nonsmokers. Toxicol Appl Pharmacol. 2009 May 01; 236(3):270-5. PMID: 19233220.
      View in: PubMed
    16. Qian Z, Lin HM, Chinchilli VM, Lehman EB, Duan Y, Craig TJ, Wilson WE, Liao D, Lazarus SC, Bascom R. Interaction of ambient air pollution with asthma medication on exhaled nitric oxide among asthmatics. Arch Environ Occup Health. 2009; 64(3):168-76. PMID: 19864219; PMCID: PMC3713465.
    17. Qian Z, Lin HM, Chinchilli VM, Lehman EB, Stewart WF, Shah N, Duan Y, Craig TJ, Wilson WE, Liao D, Lazarus SC, Bascom R. Associations between air pollution and peak expiratory flow among patients with persistent asthma. J Toxicol Environ Health A. 2009; 72(1):39-46. PMID: 18979353; PMCID: PMC2848818.
    18. Benninghoff MG, Todd WU, Bascom R. Incidental pleural-based pulmonary lymphangioma. J Am Osteopath Assoc. 2008 Sep; 108(9):525-8. PMID: 18806082.
      View in: PubMed
    19. Merritt SA, Gibbs JD, Yu KC, Patel V, Rai L, Cornish DC, Bascom R, Higgins WE. Image-guided bronchoscopy for peripheral lung lesions: a phantom study. Chest. 2008 Nov; 134(5):1017-1026. PMID: 18583513.
      View in: PubMed
    20. Dolina MY, Cornish DC, Merritt SA, Rai L, Mahraj R, Higgins WE, Bascom R. Interbronchoscopist variability in endobronchial path selection: a simulation study. Chest. 2008 Apr; 133(4):897-905. PMID: 18263679.
      View in: PubMed
    21. Qian Z, He Q, Kong L, Xu F, Wei F, Chapman RS, Chen W, Edwards RD, Bascom R. Respiratory responses to diverse indoor combustion air pollution sources. Indoor Air. 2007 Apr; 17(2):135-42. PMID: 17391236.
      View in: PubMed
    22. Buyantseva LV, Tulchinsky M, Kapalka GM, Chinchilli VM, Qian Z, Gillio R, Roberts A, Bascom R. Evolution of lower respiratory symptoms in New York police officers after 9/11: a prospective longitudinal study. J Occup Environ Med. 2007 Mar; 49(3):310-7. PMID: 17351517.
      View in: PubMed
    23. Buyantseva LV, Chinchilli VM, Tulchinsky M, Bascom R, Martin RJ. Alternatives for measuring endogenous adrenocortical activity in asthmatics treated with inhaled corticosteroids. Endocr Res. 2005; 31(4):245-58. PMID: 16433245.
      View in: PubMed
    24. Bollinger ME, Mudd K, Keible LA, Hess BL, Bascom R, Hamilton RG. A hospital-based screening program for natural rubber latex allergy. Ann Allergy Asthma Immunol. 2002 Jun; 88(6):560-7. PMID: 12086362.
      View in: PubMed
    25. Hopper KD, Lucas TA, Gleeson K, Stauffer JL, Bascom R, Mauger DT, Mahraj R. Transbronchial biopsy with virtual CT bronchoscopy and nodal highlighting. Radiology. 2001 Nov; 221(2):531-6. PMID: 11687700.
      View in: PubMed
    26. Tucakovic M, Bascom R, Bascom PB. Pulmonary medicine and palliative care. Best Pract Res Clin Obstet Gynaecol. 2001 Apr; 15(2):291-304. PMID: 11358403.
      View in: PubMed
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