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Robert Bonneau

TitleProfessor
InstitutionCollege of Medicine
DepartmentMicrobiology and Immunology
Address500 University Drive Hershey PA 17033
Mailbox: H107
Phone7175314078

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor and Distinguished Educator of Microbiology and Immunology

GRADUATE PROGRAM AFFILIATIONS:

Integrative Biosciences, Microbiology and Immunology, Cell and Molecular Biology, Neuroscience

EDUCATION:

Ph.D., Pennsylvania State University College of Medicine, 1988
Postdoctoral Training, Ohio State University College of Medicine, 1988-1990

NARRATIVE:

There is substantial experimental evidence indicating that the immune system is functionally integrated with both the central nervous system and endocrine system. Recent studies in both humans and in animals suggest that this neuroendocrine-immune axis operates bi-directionally in that the immune system receives and responds to signals originating from the nervous and endocrine systems as well as delivering signals to which these systems can each respond. This intercellular communication is mediated through receptor-specific binding of lymphokines, hormones, and neuropeptides as well as by direct contact between nerve fibers and cells of the immune system within the architecture of immune tissues such as the thymus, lymph nodes, and spleen. As a result, immune responses are potentially subject to direct neuroendocrine regulation. In addition, a number of studies have demonstrated that psychologically stressful events play a significant role in modulation of both humoral and cellular immunity through such neuroendocrine-immune interactions. However, few studies have focused on elucidating the mechanisms that underlie stress-induced modulation of the immune response that is necessary for resolution of a specific virus infection. The overall aim of our research is to use an established murine model system of herpes simplex virus (HSV) infection to investigate the mechanisms underlying stress-associated neuroendocrine interactions with the immune system and how these interactions may contribute to the pathogenesis of HSV infection. These studies focus on the stress-associated activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system and their role in modulating the activation and function of both primary and memory HSV-specific cytotoxic T lymphocytes (CTL). Overall, these studies will provide insight into the role of and mechanisms by which stress-related neuroendocrine activation modulate anti-viral immune responses and should contribute significantly to the overall understanding of the relationship among neuroendocrine-associated alterations in immune function and viral pathogenesis.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hunzeker JT, Elftman MD, Mellinger JC, Princiotta MF, Bonneau RH, Truckenmiller ME, Norbury CC. A marked reduction in priming of cytotoxic CD8+ T cells mediated by stress-induced glucocorticoids involves multiple deficiencies in cross-presentation by dendritic cells. J Immunol. 2011 Jan 1; 186(1):183-94.
    View in: PubMed
  2. Zagon IS, Donahue RN, Bonneau RH, McLaughlin PJ. T lymphocyte proliferation is suppressed by the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis: implication for the treatment of autoimmune diseases. Immunobiology. 2011 May; 216(5):579-90.
    View in: PubMed
  3. Zagon IS, Donahue RN, Bonneau RH, McLaughlin PJ. B lymphocyte proliferation is suppressed by the opioid growth factor-opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases. Immunobiology. 2011 Jan-Feb; 216(1-2):173-83.
    View in: PubMed
  4. Lee AJ, Zhou X, Chang M, Hunzeker J, Bonneau RH, Zhou D, Sun SC. Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J. 2010 May 5; 29(9):1600-12.
    View in: PubMed
  5. Elftman MD, Hunzeker JT, Mellinger JC, Bonneau RH, Norbury CC, Truckenmiller ME. Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol. 2010 Feb 15; 184(4):1867-75.
    View in: PubMed
  6. Gulani J, Norbury CC, Bonneau RH, Beckwith CS. The effect of Helicobacter hepaticus infection on immune responses specific to herpes simplex virus type 1 and characteristics of dendritic cells. Comp Med. 2009 Dec; 59(6):534-44.
    View in: PubMed
  7. Zagon IS, Rahn KA, Bonneau RH, Turel AP, McLaughlin PJ. Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis. Brain Res. 2010 Jan 15; 1310:154-61.
    View in: PubMed
  8. Ashcraft KA, Hunzeker J, Bonneau RH. Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism. Psychoneuroendocrinology. 2008 Aug; 33(7):951-63.
    View in: PubMed
  9. Ashcraft KA, Bonneau RH. Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses. Brain Behav Immun. 2008 Nov; 22(8):1231-40.
    View in: PubMed
  10. Zahwa H, Yorty JL, Bonneau RH. Elevated maternal corticosterone during lactation hinders the neonatal adaptive immune response to herpes simplex virus (HSV) infection. Brain Behav Immun. 2008 Mar; 22(3):339-53.
    View in: PubMed
  11. Elftman MD, Norbury CC, Bonneau RH, Truckenmiller ME. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct; 122(2):279-90.
    View in: PubMed
  12. Bonneau RH. Controlling immunopathology at the expense of critical immune functions--a tipping of the balance by neuroendocrine-immune interactions. Brain Behav Immun. 2007 Oct; 21(7):888-9.
    View in: PubMed
  13. Freeman ML, Sheridan BS, Bonneau RH, Hendricks RL. Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. J Immunol. 2007 Jul 1; 179(1):322-8.
    View in: PubMed
  14. Nair A, Hunzeker J, Bonneau RH. Modulation of microglia and CD8(+) T cell activation during the development of stress-induced herpes simplex virus type-1 encephalitis. Brain Behav Immun. 2007 Aug; 21(6):791-806.
    View in: PubMed
  15. Bonneau RH, Padgett DA, Sheridan JF. Twenty years of psychoneuroimmunology and viral infections in Brain, Behavior, and Immunity. Brain Behav Immun. 2007 Mar; 21(3):273-80.
    View in: PubMed
  16. Truckenmiller ME, Bonneau RH, Norbury CC. Stress presents a problem for dendritic cells: corticosterone and the fate of MHC class I antigen processing and presentation. Brain Behav Immun. 2006 May; 20(3):210-8.
    View in: PubMed
  17. Bowman G, Bonneau RH, Chinchilli VM, Tracey KJ, Cockroft KM. A novel inhibitor of inflammatory cytokine production (CNI-1493) reduces rodent post-hemorrhagic vasospasm. Neurocrit Care. 2006; 5(3):222-9.
    View in: PubMed
  18. Nair A, Bonneau RH. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroimmunol. 2006 Feb; 171(1-2):72-85.
    View in: PubMed
  19. Truckenmiller ME, Princiotta MF, Norbury CC, Bonneau RH. Corticosterone impairs MHC class I antigen presentation by dendritic cells via reduction of peptide generation. J Neuroimmunol. 2005 Mar; 160(1-2):48-60.
    View in: PubMed
  20. Yorty JL, Bonneau RH. Impact of maternal stress on the transmammary transfer and protective capacity of herpes simplex virus-specific immunity. Am J Physiol Regul Integr Comp Physiol. 2004 Dec; 287(6):R1316-24.
    View in: PubMed
  21. Yorty JL, Schultz SA, Bonneau RH. Postpartum maternal corticosterone decreases maternal and neonatal antibody levels and increases the susceptibility of newborn mice to herpes simplex virus-associated mortality. J Neuroimmunol. 2004 May; 150(1-2):48-58.
    View in: PubMed
  22. Bowman G, Dixit S, Bonneau RH, Chinchilli VM, Cockroft KM. Neutralizing antibody against interleukin-6 attenuates posthemorrhagic vasospasm in the rat femoral artery model. Neurosurgery. 2004 Mar; 54(3):719-25; discussion 725-6.
    View in: PubMed
  23. Erin N, Boyer PJ, Bonneau RH, Clawson GA, Welch DR. Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res. 2004 Mar-Apr; 24(2B):1003-9.
    View in: PubMed
  24. Zhang L, Nair A, Krady K, Corpe C, Bonneau RH, Simpson IA, Vannucci SJ. Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice. J Clin Invest. 2004 Jan; 113(1):85-95.
    View in: PubMed
  25. Yorty JL, Bonneau RH. Prenatal transfer of low amounts of herpes simplex virus (HSV)-specific antibody protects newborn mice against HSV infection during acute maternal stress. Brain Behav Immun. 2004 Jan; 18(1):15-23.
    View in: PubMed
  26. Cronin AJ, Aucutt-Walter NM, Budinetz T, Bonafide CP, DiVittore NA, Gordin V, Schuler HG, Bonneau RH. Low-dose remifentanil infusion does not impair natural killer cell function in healthy volunteers. Br J Anaesth. 2003 Dec; 91(6):805-9.
    View in: PubMed
  27. Anglen CS, Truckenmiller ME, Schell TD, Bonneau RH. The dual role of CD8+ T lymphocytes in the development of stress-induced herpes simplex encephalitis. J Neuroimmunol. 2003 Jul; 140(1-2):13-27.
    View in: PubMed
  28. Yorty JL, Bonneau RH. Transplacental transfer and subsequent neonate utilization of herpes simplex virus-specific immunity are resilient to acute maternal stress. J Virol. 2003 Jun; 77(12):6613-9.
    View in: PubMed
  29. Khanna KM, Bonneau RH, Kinchington PR, Hendricks RL. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity. 2003 May; 18(5):593-603.
    View in: PubMed
  30. Wonnacott KM, Bonneau RH. The effects of stress on memory cytotoxic T lymphocyte-mediated protection against herpes simplex virus infection at mucosal sites. Brain Behav Immun. 2002 Apr; 16(2):104-17.
    View in: PubMed
  31. Leo NA, Bonneau RH. Mechanisms underlying chemical sympathectomy-induced suppression of herpes simplex virus-specific cytotoxic T lymphocyte activation and function. J Neuroimmunol. 2000 Oct 2; 110(1-2):45-56.
    View in: PubMed
  32. Zalys R, Zagon IS, Bonneau RH, Lang CM, McLaughlin PJ. In vivo effects of chronic treatment with [MET5]-enkephalin on hematological values and natural killer cell activity in athymic mice. Life Sci. 2000 Jan 21; 66(9):829-34.
    View in: PubMed
  33. Leo NA, Bonneau RH. Chemical sympathectomy alters cytotoxic T lymphocyte responses to herpes simplex virus infection. Ann N Y Acad Sci. 2000; 917:923-34.
    View in: PubMed
  34. Brehm M, Samaniego LA, Bonneau RH, DeLuca NA, Tevethia SS. Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0. Virology. 1999 Apr 10; 256(2):258-69.
    View in: PubMed
  35. Blaney JE, Nobusawa E, Brehm MA, Bonneau RH, Mylin LM, Fu TM, Kawaoka Y, Tevethia SS. Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity. J Virol. 1998 Dec; 72(12):9567-74.
    View in: PubMed
  36. Bonneau RH, Morm├Ęde P, Vogler GP, McClearn GE, Jones BC. A genetic basis for neuroendocrine-immune interactions. Brain Behav Immun. 1998 Jun; 12(2):83-9.
    View in: PubMed
  37. Bonneau RH, Zimmerman KM, Ikeda SC, Jones BC. Differential effects of stress-induced adrenal function on components of the herpes simplex virus-specific memory cytotoxic T-lymphocyte response. J Neuroimmunol. 1998 Mar 1; 82(2):191-9.
    View in: PubMed
  38. Leo NA, Callahan TA, Bonneau RH. Peripheral sympathetic denervation alters both the primary and memory cellular immune responses to herpes simplex virus infection. Neuroimmunomodulation. 1998 Jan-Apr; 5(1-2):22-35.
    View in: PubMed
  39. Tevethia MJ, Bonneau RH, Griffith JW, Mylin L. A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. J Virol. 1997 Nov; 71(11):8157-66.
    View in: PubMed
  40. Bonneau RH, Brehm MA, Kern AM. The impact of psychological stress on the efficacy of anti-viral adoptive immunotherapy in an immunocompromised host. J Neuroimmunol. 1997 Sep; 78(1-2):19-33.
    View in: PubMed
  41. Brehm MA, Bonneau RH, Knipe DM, Tevethia SS. Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1. J Virol. 1997 May; 71(5):3534-44.
    View in: PubMed
  42. Sharma P, Johnson CA, Bonneau RH, Lang CM, Chorney MJ. Transgenic mice expressing the thymus leukemia antigen fail to control cutaneous herpes simplex virus infection. Cell Immunol. 1996 Nov 25; 174(1):84-9.
    View in: PubMed
  43. Fu TM, Bonneau RH, Epler M, Tevethia MJ, Alam S, Verner K, Tevethia SS. Induction and persistence of a cytotoxic T lymphocyte (CTL) response against a herpes simplex virus-specific CTL epitope expressed in a cellular protein. Virology. 1996 Aug 1; 222(1):269-74.
    View in: PubMed
  44. Bonneau RH. Stress-induced effects on integral immune components involved in herpes simplex virus (HSV)-specific memory cytotoxic T lymphocyte activation. Brain Behav Immun. 1996 Jun; 10(2):139-63.
    View in: PubMed
  45. Sharma P, Joyce S, Chorney KA, Griffith JW, Bonneau RH, Wilson FD, Johnson CA, Flavell RA, Chorney MJ. Thymus-leukemia antigen interacts with T cells and self-peptides. J Immunol. 1996 Feb 1; 156(3):987-96.
    View in: PubMed
  46. Mylin LM, Bonneau RH, Lippolis JD, Tevethia SS. Hierarchy among multiple H-2b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen. J Virol. 1995 Nov; 69(11):6665-77.
    View in: PubMed
  47. Mylin LM, Deckhut AM, Bonneau RH, Kierstead TD, Tevethia MJ, Simmons DT, Tevethi SS. Cytotoxic T lymphocyte escape variants, induced mutations, and synthetic peptides define a dominant H-2Kb-restricted determinant in simian virus 40 tumor antigen. Virology. 1995 Apr 1; 208(1):159-72.
    View in: PubMed
  48. Salvucci LA, Bonneau RH, Tevethia SS. Polymorphism within the herpes simplex virus (HSV) ribonucleotide reductase large subunit (ICP6) confers type specificity for recognition by HSV type 1-specific cytotoxic T lymphocytes. J Virol. 1995 Feb; 69(2):1122-31.
    View in: PubMed
  49. Bonneau RH, Fu TM, Tevethia SS. In vivo priming and activation of memory cytotoxic T-lymphocytes (CTL) by a chimeric simian virus 40 T antigen expressing an eight amino acid residue herpes simplex virus gB CTL epitope. Virology. 1993 Dec; 197(2):782-7.
    View in: PubMed
  50. Fu TM, Bonneau RH, Tevethia MJ, Tevethia SS. Simian virus 40 T antigen as a carrier for the expression of cytotoxic T-lymphocyte recognition epitopes. J Virol. 1993 Nov; 67(11):6866-71.
    View in: PubMed
  51. Glaser R, Pearson GR, Bonneau RH, Esterling BA, Atkinson C, Kiecolt-Glaser JK. Stress and the memory T-cell response to the Epstein-Barr virus in healthy medical students. Health Psychol. 1993 Nov; 12(6):435-42.
    View in: PubMed
  52. Glaser R, Theil KS, Bonneau RH, Sheridan JF, Vasquez M, Allen CM. Spontaneous development of a chromosomal translocation 5;14 in an Epstein-Barr-virus-associated B-cell lymphoma in a SCID mouse. Int J Cancer. 1993 Sep 9; 55(2):281-7.
    View in: PubMed
  53. Bonneau RH, Salvucci LA, Johnson DC, Tevethia SS. Epitope specificity of H-2Kb-restricted, HSV-1-, and HSV-2-cross-reactive cytotoxic T lymphocyte clones. Virology. 1993 Jul; 195(1):62-70.
    View in: PubMed
  54. Glaser R, Lafuse WP, Bonneau RH, Atkinson C, Kiecolt-Glaser JK. Stress-associated modulation of proto-oncogene expression in human peripheral blood leukocytes. Behav Neurosci. 1993 Jun; 107(3):525-9.
    View in: PubMed
  55. Bonneau RH, Sheridan JF, Feng N, Glaser R. Stress-induced modulation of the primary cellular immune response to herpes simplex virus infection is mediated by both adrenal-dependent and independent mechanisms. J Neuroimmunol. 1993 Feb; 42(2):167-76.
    View in: PubMed
  56. Kusnecov AV, Grota LJ, Schmidt SG, Bonneau RH, Sheridan JF, Glaser R, Moynihan JA. Decreased herpes simplex viral immunity and enhanced pathogenesis following stressor administration in mice. J Neuroimmunol. 1992 May; 38(1-2):129-37.
    View in: PubMed
  57. Glaser R, Kiecolt-Glaser JK, Bonneau RH, Malarkey W, Kennedy S, Hughes J. Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom Med. 1992 Jan-Feb; 54(1):22-9.
    View in: PubMed
  58. Feng N, Pagniano R, Tovar CA, Bonneau RH, Glaser R, Sheridan JF. The effect of restraint stress on the kinetics, magnitude, and isotype of the humoral immune response to influenza virus infection. Brain Behav Immun. 1991 Dec; 5(4):370-82.
    View in: PubMed
  59. Bonneau RH, Sheridan JF, Feng NG, Glaser R. Stress-induced effects on cell-mediated innate and adaptive memory components of the murine immune response to herpes simplex virus infection. Brain Behav Immun. 1991 Sep; 5(3):274-95.
    View in: PubMed
  60. Bonneau RH, Sheridan JF, Feng NG, Glaser R. Stress-induced suppression of herpes simplex virus (HSV)-specific cytotoxic T lymphocyte and natural killer cell activity and enhancement of acute pathogenesis following local HSV infection. Brain Behav Immun. 1991 Jun; 5(2):170-92.
    View in: PubMed
  61. Jennings SR, Bonneau RH, Smith PM, Wolcott RM, Chervenak R. CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice. Cell Immunol. 1991 Mar; 133(1):234-52.
    View in: PubMed
  62. Sheridan JF, Feng NG, Bonneau RH, Allen CM, Huneycutt BS, Glaser R. Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice. J Neuroimmunol. 1991 Mar; 31(3):245-55.
    View in: PubMed
  63. Glaser R, Kennedy S, Lafuse WP, Bonneau RH, Speicher C, Hillhouse J, Kiecolt-Glaser JK. Psychological stress-induced modulation of interleukin 2 receptor gene expression and interleukin 2 production in peripheral blood leukocytes. Arch Gen Psychiatry. 1990 Aug; 47(8):707-12.
    View in: PubMed
  64. Bonneau RH, Jennings SR. Herpes simplex virus-specific cytolytic T lymphocytes restricted to a normally low responder H-2 allele are protective in vivo. Virology. 1990 Feb; 174(2):599-604.
    View in: PubMed
  65. Bonneau RH, Kiecolt-Glaser JK, Glaser R. Stress-induced modulation of the immune response. Ann N Y Acad Sci. 1990; 594:253-69.
    View in: PubMed
  66. Bonneau RH, Jennings SR. Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity. J Virol. 1989 Mar; 63(3):1480-4.
    View in: PubMed
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