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Robert Levenson

TitleProfessor
InstitutionCollege of Medicine
DepartmentPharmacology
Address500 University Drive Hershey PA 17033
Mailbox: R130
Phone7175314545

 Overview 
 overview
PREFERRED TITLE/ROLE:

Distinguished Professor of Pharmacology and Neural and Behavioral Sciences, Co-Director; MD/PhD Program

GRADUATE PROGRAM AFFILIATIONS:

MD/PhD Program, Biomedical Sciences Graduate Program, Neuroscience, Molecular Medicine, Molecular Toxicology

EDUCATION:

Ph.D., SUNY at Stony Brook, 1976
Postdoctoral Training, Massachusetts Institute of Technology, 1976-1980

PROFESSIONAL EXPERIENCE:

Assistant Professor, Department of Cell Biology, Yale University School of Medicine, 1983-1990
Associate Professor, Department of Cell Biology, Yale University School of Medicine, 1990-1994
Professor, Department of Pharmacology, Penn State College of Medicine, 1994-present

AWARDS:

Established Investigator, American Heart Association, 1986-1991
NARSAD Distinguished Investigator Award, 2003-2004
John and Samuel Bard Award in Medicine and Science, Bard College, 2003
Dean's Award for Excellence in Teaching, Penn State College of Medicine, 2011
University Distinguished Professor, 2012-present


NARRATIVE:

Dr. Levenson received an A.B. from Bard College in 1967, an M.S. from New York University in 1971, and a Ph.D. from SUNY Stony Brook in 1976. He also attended Medical School at the University of Florence in Florence Italy from 1968-1971. Dr. Levenson did postdoctoral work in cancer cell biology at MIT with Dr. David Housman. In 1984 he was appointed Assistant Professor of Cell Biology at Yale University School of Medicine. He was promoted to Associate Professor in 1990 and received a joint appointment in the Section of Neurobiology. Dr. Levenson joined the faculty of Penn State College of Medicine in 1994 as Professor of Pharmacology. From 2000-2002 he served as director of the Cell and Molecular Biology Graduate Program. In 2003 he was the recipient of the John and Samuel Bard Award in Medicine and Science from Bard College, and a Distinguished Investigator Award from NARSAD (National Alliance for Research on Schizophrenia and Depression). He has served on numerous NIH study sections and has been Co-Director of the MD/PhD Program since 2004. Dr. Levenson’s research has focused on the molecular regulation of GPCR signaling and the etiology of schizophrenia and substance abuse. Dr. Levenson is currently a senior member of the University of Pennsylvania Center for Translational Research on the Clinical Neurobiology of Drug Addiction.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ebersole B, Petko J, Levenson R. Bioorthogonal click chemistry to assay mu-opioid receptor palmitoylation using 15-hexadecynoic acid and immunoprecipitation. Anal Biochem. 2014 Apr 15; 451:25-7.
    View in: PubMed
  2. Jaremko KM, Thompson NL, Reyes BA, Jin J, Ebersole B, Jenney CB, Grigson PS, Levenson R, Berrettini WH, Van Bockstaele EJ. Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3; 50:53-65.
    View in: PubMed
  3. Petko J, Justice-Bitner S, Jin J, Wong V, Kittanakom S, Ferraro TN, Stagljar I, Levenson R. MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. PLoS One. 2013; 8(6):e67608.
    View in: PubMed
  4. Morse M, Sun H, Tran E, Levenson R, Fang Y. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol. 2013; 14:17.
    View in: PubMed
  5. Boehmler W, Petko J, Canfield VA, Levenson R. Genomic strategies for the identification of dopamine receptor genes in zebrafish. Methods Mol Biol. 2013; 964:201-14.
    View in: PubMed
  6. Kabbani N, Woll MP, Nordman JC, Levenson R. Dopamine receptor interacting proteins: targeting neuronal calcium sensor-1/D2 dopamine receptor interaction for antipsychotic drug development. Curr Drug Targets. 2012 Jan; 13(1):72-9.
    View in: PubMed
  7. Morse M, Tran E, Sun H, Levenson R, Fang Y. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS One. 2011; 6(10):e25643.
    View in: PubMed
  8. Reyes BA, Vakharia K, Ferraro TN, Levenson R, Berrettini WH, Van Bockstaele EJ. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Exp Neurol. 2012 Jan; 233(1):205-13.
    View in: PubMed
  9. Woll MP, De Cotiis DA, Bewley MC, Tacelosky DM, Levenson R, Flanagan JM. Interaction between the D2 dopamine receptor and neuronal calcium sensor-1 analyzed by fluorescence anisotropy. Biochemistry. 2011 Oct 18; 50(41):8780-91.
    View in: PubMed
  10. Heakal Y, Woll MP, Fox T, Seaton K, Levenson R, Kester M. Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Cancer Biol Ther. 2011 Sep 1; 12(5):427-35.
    View in: PubMed
  11. Reyes AR, Levenson R, Berrettini W, Van Bockstaele EJ. Ultrastructural relationship between the mu opioid receptor and its interacting protein, GPR177, in striatal neurons. Brain Res. 2010 Oct 28; 1358:71-80.
    View in: PubMed
  12. Jin J, Morse M, Frey C, Petko J, Levenson R. Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. Dev Dyn. 2010 Sep; 239(9):2426-34.
    View in: PubMed
  13. Jin J, Kittanakom S, Wong V, Reyes BA, Van Bockstaele EJ, Stagljar I, Berrettini W, Levenson R. Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci. 2010; 11:33.
    View in: PubMed
  14. Petko JA, Kabbani N, Frey C, Woll M, Hickey K, Craig M, Canfield VA, Levenson R. Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neurosci. 2009; 10:27.
    View in: PubMed
  15. Boehmler W, Petko J, Woll M, Frey C, Thisse B, Thisse C, Canfield VA, Levenson R. Identification of zebrafish A2 adenosine receptors and expression in developing embryos. Gene Expr Patterns. 2009 Mar; 9(3):144-51.
    View in: PubMed
  16. De Cotiis DA, Woll MP, Fox TE, Hill RB, Levenson R, Flanagan JM. Optimized expression and purification of myristoylated human neuronal calcium sensor 1 in E. coli. Protein Expr Purif. 2008 Oct; 61(2):103-12.
    View in: PubMed
  17. Petko JA, Millimaki BB, Canfield VA, Riley BB, Levenson R. Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish. Dev Neurobiol. 2008 Feb 1; 68(2):209-22.
    View in: PubMed
  18. Hannan MA, Kabbani N, Paspalas CD, Levenson R. Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface. Biochim Biophys Acta. 2008 Apr; 1778(4):974-82.
    View in: PubMed
  19. Kabbani N, Woll MP, Levenson R, Lindstrom JM, Changeux JP. Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20570-5.
    View in: PubMed
  20. Kabbani N, Levenson R. A proteomic approach to receptor signaling: molecular mechanisms and therapeutic implications derived from discovery of the dopamine D2 receptor signalplex. Eur J Pharmacol. 2007 Oct 31; 572(2-3):83-93.
    View in: PubMed
  21. Boehmler W, Carr T, Thisse C, Thisse B, Canfield VA, Levenson R. D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes Brain Behav. 2007 Mar; 6(2):155-66.
    View in: PubMed
  22. Dahl JP, Jepson C, Levenson R, Wileyto EP, Patterson F, Berrettini WH, Lerman C. Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence. Pharmacogenomics J. 2006 May-Jun; 6(3):194-9.
    View in: PubMed
  23. Blasiole B, Canfield VA, Vollrath MA, Huss D, Mohideen MA, Dickman JD, Cheng KC, Fekete DM, Levenson R. Separate Na,K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish. Dev Biol. 2006 Jun 1; 294(1):148-60.
    View in: PubMed
  24. Kabbani N, Levenson R. Antipsychotic-induced alterations in D2 dopamine receptor interacting proteins within the cortex. Neuroreport. 2006 Feb 27; 17(3):299-301.
    View in: PubMed
  25. Hui H, McHugh D, Hannan M, Zeng F, Xu SZ, Khan SU, Levenson R, Beech DJ, Weiss JL. Calcium-sensing mechanism in TRPC5 channels contributing to retardation of neurite outgrowth. J Physiol. 2006 Apr 1; 572(Pt 1):165-72.
    View in: PubMed
  26. Croushore JA, Blasiole B, Riddle RC, Thisse C, Thisse B, Canfield VA, Robertson GP, Cheng KC, Levenson R. Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Dev Dyn. 2005 Dec; 234(4):911-21.
    View in: PubMed
  27. Blasiole B, Kabbani N, Boehmler W, Thisse B, Thisse C, Canfield V, Levenson R. Neuronal calcium sensor-1 gene ncs-1a is essential for semicircular canal formation in zebrafish inner ear. J Neurobiol. 2005 Sep 5; 64(3):285-97.
    View in: PubMed
  28. Binda AV, Kabbani N, Levenson R. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). Biochem Pharmacol. 2005 May 15; 69(10):1451-61.
    View in: PubMed
  29. Hughes I, Blasiole B, Huss D, Warchol ME, Rath NP, Hurle B, Ignatova E, Dickman JD, Thalmann R, Levenson R, Ornitz DM. Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Dev Biol. 2004 Dec 15; 276(2):391-402.
    View in: PubMed
  30. Boehmler W, Obrecht-Pflumio S, Canfield V, Thisse C, Thisse B, Levenson R. Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Dev Dyn. 2004 Jul; 230(3):481-93.
    View in: PubMed
  31. Kabbani N, Jeromin A, Levenson R. Dynamin-2 associates with the dopamine receptor signalplex and regulates internalization of activated D2 receptors. Cell Signal. 2004 Apr; 16(4):497-503.
    View in: PubMed
  32. Blasiole B, Degrave A, Canfield V, Boehmler W, Thisse C, Thisse B, Mohideen MA, Levenson R. Differential expression of Na,K-ATPase alpha and beta subunit genes in the developing zebrafish inner ear. Dev Dyn. 2003 Nov; 228(3):386-92.
    View in: PubMed
  33. Cheng KC, Levenson R, Robishaw JD. Functional genomic dissection of multimeric protein families in zebrafish. Dev Dyn. 2003 Nov; 228(3):555-67.
    View in: PubMed
  34. Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS. Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling. Trends Pharmacol Sci. 2003 Sep; 24(9):486-92.
    View in: PubMed
  35. Koh PO, Undie AS, Kabbani N, Levenson R, Goldman-Rakic PS, Lidow MS. Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients. Proc Natl Acad Sci U S A. 2003 Jan 7; 100(1):313-7.
    View in: PubMed
  36. Blasiole B, Canfield V, Degrave A, Thisse C, Thisse B, Rajarao J, Levenson R. Cloning, mapping, and developmental expression of a sixth zebrafish Na,K-ATPase alpha1 subunit gene (atp1a1a.5). Mech Dev. 2002 Dec; 119 Suppl 1:S211-4.
    View in: PubMed
  37. Blasiole B, Canfield V, Degrave A, Thisse C, Thisse B, Rajarao J, Levenson R. Cloning, mapping, and developmental expression of a sixth zebrafish Na,K-ATPase alpha1 subunit gene (atp1a1a.5). Gene Expr Patterns. 2002 Dec; 2(3-4):243-6.
    View in: PubMed
  38. Lin R, Canfield V, Levenson R. Dominant negative mutants of filamin A block cell surface expression of the D2 dopamine receptor. Pharmacology. 2002 Dec; 66(4):173-81.
    View in: PubMed
  39. Kabbani N, Negyessy L, Lin R, Goldman-Rakic P, Levenson R. Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor. J Neurosci. 2002 Oct 1; 22(19):8476-86.
    View in: PubMed
  40. Binda AV, Kabbani N, Lin R, Levenson R. D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Mol Pharmacol. 2002 Sep; 62(3):507-13.
    View in: PubMed
  41. Canfield VA, Loppin B, Thisse B, Thisse C, Postlethwait JH, Mohideen MA, Rajarao SJ, Levenson R. Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis. Mech Dev. 2002 Aug; 116(1-2):51-9.
    View in: PubMed
  42. Rajarao JR, Canfield VA, Loppin B, Thisse B, Thisse C, Yan YL, Postlethwait JH, Levenson R. Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis. Dev Dyn. 2002 Mar; 223(2):254-61.
    View in: PubMed
  43. Albrecht PJ, Dahl JP, Stoltzfus OK, Levenson R, Levison SW. Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival. Exp Neurol. 2002 Jan; 173(1):46-62.
    View in: PubMed
  44. Sweeney G, Niu W, Canfield VA, Levenson R, Klip A. Insulin increases plasma membrane content and reduces phosphorylation of Na(+)-K(+) pump alpha(1)-subunit in HEK-293 cells. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1797-803.
    View in: PubMed
  45. Rajarao SJ, Canfield VA, Mohideen MA, Yan YL, Postlethwait JH, Cheng KC, Levenson R. The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Genome Res. 2001 Jul; 11(7):1211-20.
    View in: PubMed
  46. Scarselli M, Novi F, Schallmach E, Lin R, Baragli A, Colzi A, Griffon N, Corsini GU, Sokoloff P, Levenson R, Vogel Z, Maggio R. D2/D3 dopamine receptor heterodimers exhibit unique functional properties. J Biol Chem. 2001 Aug 10; 276(32):30308-14.
    View in: PubMed
  47. Lin R, Karpa K, Kabbani N, Goldman-Rakic P, Levenson R. Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5258-63.
    View in: PubMed
  48. Dahl JP, Binda A, Canfield VA, Levenson R. Participation of Na,K-ATPase in FGF-2 secretion: rescue of ouabain-inhibitable FGF-2 secretion by ouabain-resistant Na,K-ATPase alpha subunits. Biochemistry. 2000 Dec 5; 39(48):14877-83.
    View in: PubMed
  49. Karpa KD, Lin R, Kabbani N, Levenson R. The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors. Mol Pharmacol. 2000 Oct; 58(4):677-83.
    View in: PubMed
  50. Lezcano N, Mrzljak L, Eubanks S, Levenson R, Goldman-Rakic P, Bergson C. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. Science. 2000 Mar 3; 287(5458):1660-4.
    View in: PubMed
  51. Underhill DA, Canfield VA, Dahl JP, Gros P, Levenson R. The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Biochemistry. 1999 Nov 9; 38(45):14746-51.
    View in: PubMed
  52. Karpa KD, Lidow MS, Pickering MT, Levenson R, Bergson C. N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells. Mol Pharmacol. 1999 Nov; 56(5):1071-8.
    View in: PubMed
  53. Canfield VA, Levenson R. Domain swapping between Na,K- and H,K-ATPase identifies regions that specify Na,K-ATPase activity. Biochemistry. 1998 May 19; 37(20):7509-16.
    View in: PubMed
  54. Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R. Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. Mamm Genome. 1998 Feb; 9(2):136-43.
    View in: PubMed
  55. Cheng XJ, Fisone G, Aizman O, Aizman R, Levenson R, Greengard P, Aperia A. PKA-mediated phosphorylation and inhibition of Na(+)-K(+)-ATPase in response to beta-adrenergic hormone. Am J Physiol. 1997 Sep; 273(3 Pt 1):C893-901.
    View in: PubMed
  56. Billecocq A, Horne WC, Chakraborty M, Takeyasu K, Levenson R, Baron R. 1,25-Dihydroxyvitamin D3 selectively induces increased expression of the Na,K-ATPase beta 1 subunit in avian myelomonocytic cells without a concomitant change in Na,K-ATPase activity. J Cell Physiol. 1997 Aug; 172(2):221-9.
    View in: PubMed
  57. Lavoie L, Levenson R, Martin-Vasallo P, Klip A. The molar ratios of alpha and beta subunits of the Na+-K+-ATPase differ in distinct subcellular membranes from rat skeletal muscle. Biochemistry. 1997 Jun 24; 36(25):7726-32.
    View in: PubMed
  58. Wang SG, Eakle KA, Levenson R, Farley RA. Na+-K+-ATPase alpha-subunit containing Q905-V930 of gastric H+-K+-ATPase alpha preferentially assembles with H+-K+-ATPase beta. Am J Physiol. 1997 Mar; 272(3 Pt 1):C923-30.
    View in: PubMed
  59. Canfield VA, Norbeck L, Levenson R. Localization of cytoplasmic and extracellular domains of Na,K-ATPase by epitope tag insertion. Biochemistry. 1996 Nov 12; 35(45):14165-72.
    View in: PubMed
  60. Malik N, Canfield VA, Beckers MC, Gros P, Levenson R. Identification of the mammalian Na,K-ATPase 3 subunit. J Biol Chem. 1996 Sep 13; 271(37):22754-8.
    View in: PubMed
  61. Beckers MC, Ernst E, Belcher S, Howe J, Levenson R, Gros P. A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. Genomics. 1996 Aug 15; 36(1):202-5.
    View in: PubMed
  62. Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature. 1996 May 16; 381(6579):245-8.
    View in: PubMed
  63. Kast C, Canfield V, Levenson R, Gros P. Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence. J Biol Chem. 1996 Apr 19; 271(16):9240-8.
    View in: PubMed
  64. Canfield V, West AB, Goldenring JR, Levenson R. Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2431-5.
    View in: PubMed
  65. Bergson C, Mrzljak L, Smiley JF, Pappy M, Levenson R, Goldman-Rakic PS. Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain. J Neurosci. 1995 Dec; 15(12):7821-36.
    View in: PubMed
  66. Belcher SM, Zerillo CA, Levenson R, Ritchie JM, Howe JR. Cloning of a sodium channel alpha subunit from rabbit Schwann cells. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11034-8.
    View in: PubMed
  67. Bergson C, Mrzljak L, Lidow MS, Goldman-Rakic PS, Levenson R. Characterization of subtype-specific antibodies to the human D5 dopamine receptor: studies in primate brain and transfected mammalian cells. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3468-72.
    View in: PubMed
  68. Kast C, Canfield V, Levenson R, Gros P. Membrane topology of P-glycoprotein as determined by epitope insertion: transmembrane organization of the N-terminal domain of mdr3. Biochemistry. 1995 Apr 4; 34(13):4402-11.
    View in: PubMed
  69. Liu K, Bergson C, Levenson R, Schmauss C. On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain. J Biol Chem. 1994 Nov 18; 269(46):29220-6.
    View in: PubMed
  70. Cameron R, Klein L, Shyjan AW, Rakic P, Levenson R. Neurons and astroglia express distinct subsets of Na,K-ATPase alpha and beta subunits. Brain Res Mol Brain Res. 1994 Feb; 21(3-4):333-43.
    View in: PubMed
  71. Levenson R. Isoforms of the Na,K-ATPase: family members in search of function. Rev Physiol Biochem Pharmacol. 1994; 123:1-45.
    View in: PubMed
  72. Canfield VA, Levenson R. Transmembrane organization of the Na,K-ATPase determined by epitope addition. Biochemistry. 1993 Dec 21; 32(50):13782-6.
    View in: PubMed
  73. Malo D, Gros P, Bergmann A, Trask B, Mohrenweiser HW, Canfield VA, Levenson R. Genes encoding the H,K-ATPase alpha and Na,K-ATPase alpha 3 subunits are linked on mouse chromosome 7 and human chromosome 19. Mamm Genome. 1993 Nov; 4(11):644-9.
    View in: PubMed
  74. Zhou XM, Cunha MJ, Epstein J, Levenson R, Cantley LC, Cantley LG. A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. J Biol Chem. 1993 Feb 25; 268(6):4126-33.
    View in: PubMed
  75. Canfield VA, Xu KY, D'Aquila T, Shyjan AW, Levenson R. Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme evolution and ouabain sensitivity. New Biol. 1992 Apr; 4(4):339-48.
    View in: PubMed
  76. Shyjan AW, Canfield VA, Levenson R. Evolution of the Na,K- and H,K-ATPase beta subunit gene family: structure of the murine Na,K-ATPase beta 2 subunit gene. Genomics. 1991 Oct; 11(2):435-42.
    View in: PubMed
  77. Canfield VA, Levenson R. Structural organization and transcription of the mouse gastric H+, K(+)-ATPase beta subunit gene. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8247-51.
    View in: PubMed
  78. Watts AG, Sanchez-Watts G, Emanuel JR, Levenson R. Cell-specific expression of mRNAs encoding Na+,K(+)-ATPase alpha- and beta-subunit isoforms within the rat central nervous system. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7425-9.
    View in: PubMed
  79. Malo D, Schurr E, Dorfman J, Canfield V, Levenson R, Gros P. Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Genomics. 1991 Jul; 10(3):666-72.
    View in: PubMed
  80. Schneider BG, Shyjan AW, Levenson R. Co-localization and polarized distribution of Na,K-ATPase alpha 3 and beta 2 subunits in photoreceptor cells. J Histochem Cytochem. 1991 Apr; 39(4):507-17.
    View in: PubMed
  81. Canfield VA, Okamato CT, Chow D, Dorfman J, Gros P, Forte JG, Levenson R. Identification and characterization of a gene for the H,K-ATPase beta-subunit. Soc Gen Physiol Ser. 1991; 46:89-98.
    View in: PubMed
  82. Canfield VA, Okamoto CT, Chow D, Dorfman J, Gros P, Forte JG, Levenson R. Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. J Biol Chem. 1990 Nov 15; 265(32):19878-84.
    View in: PubMed
  83. Billecocq A, Emanuel JR, Levenson R, Baron R. 1 alpha,25-dihydroxyvitamin D3 regulates the expression of carbonic anhydrase II in nonerythroid avian bone marrow cells. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6470-4.
    View in: PubMed
  84. Malo D, Schurr E, Levenson R, Gros P. Assignment of Na,K-ATPase beta 2-subunit gene (Atpb-2) to mouse chromosome 11. Genomics. 1990 Apr; 6(4):697-9.
    View in: PubMed
  85. Canfield V, Emanuel JR, Spickofsky N, Levenson R, Margolskee RF. Ouabain-resistant mutants of the rat Na,K-ATPase alpha 2 isoform identified by using an episomal expression vector. Mol Cell Biol. 1990 Apr; 10(4):1367-72.
    View in: PubMed
  86. Shyjan AW, Gottardi C, Levenson R. The Na,K-ATPase beta 2 subunit is expressed in rat brain and copurifies with Na,K-ATPase activity. J Biol Chem. 1990 Mar 25; 265(9):5166-9.
    View in: PubMed
  87. Shyjan AW, Ceña V, Klein DC, Levenson R. Differential expression and enzymatic properties of the Na+,K(+)-ATPase alpha 3 isoenzyme in rat pineal glands. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):1178-82.
    View in: PubMed
  88. Watson AJ, Pape C, Emanuel JR, Levenson R, Kidder GM. Expression of Na,K-ATPase alpha and beta subunit genes during preimplantation development of the mouse. Dev Genet. 1990; 11(1):41-8.
    View in: PubMed
  89. Emanuel JR, Graw S, Housman D, Levenson R. Identification of a region within the Na,K-ATPase alpha subunit that contributes to differential ouabain sensitivity. Mol Cell Biol. 1989 Sep; 9(9):3744-9.
    View in: PubMed
  90. Shyjan AW, Levenson R. Antisera specific for the alpha 1, alpha 2, alpha 3, and beta subunits of the Na,K-ATPase: differential expression of alpha and beta subunits in rat tissue membranes. Biochemistry. 1989 May 30; 28(11):4531-5.
    View in: PubMed
  91. Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R. Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. J Biol Chem. 1989 Mar 15; 264(8):4613-8.
    View in: PubMed
  92. Harley HG, Brook JD, Jackson CL, Glaser T, Walsh KV, Sarfarazi M, Kent R, Lager M, Koch M, Harper PS, et al. Localization of a human Na+,K+-ATPase alpha subunit gene to chromosome 19q12----q13.2 and linkage to the myotonic dystrophy locus. Genomics. 1988 Nov; 3(4):380-4.
    View in: PubMed
  93. Emanuel JR, Schulz J, Zhou XM, Kent RB, Housman D, Cantley L, Levenson R. Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit. J Biol Chem. 1988 Jun 5; 263(16):7726-33.
    View in: PubMed
  94. Kent RB, Fallows DA, Emanuel JR, Lalley PA, Levenson R, Housman DE. Application of gene transfer and gene mapping techniques to functional analysis of the Na,K-ATPase. Prog Clin Biol Res. 1988; 268B:97-104.
    View in: PubMed
  95. Schneider JW, Mercer RW, Benz EJ, Levenson R. Molecular cloning of Na+,K+-ATPase alpha subunit gene using antibody probes. Methods Enzymol. 1988; 156:379-92.
    View in: PubMed
  96. Emanuel JR, Garetz S, Stone L, Levenson R. Differential expression of Na+,K+-ATPase alpha- and beta-subunit mRNAs in rat tissues and cell lines. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9030-4.
    View in: PubMed
  97. Herrera VL, Emanuel JR, Ruiz-Opazo N, Levenson R, Nadal-Ginard B. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. J Cell Biol. 1987 Oct; 105(4):1855-65.
    View in: PubMed
  98. Kent RB, Emanuel JR, Ben Neriah Y, Levenson R, Housman DE. Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. Science. 1987 Aug 21; 237(4817):901-3.
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  99. Kent RB, Fallows DA, Geissler E, Glaser T, Emanuel JR, Lalley PA, Levenson R, Housman DE. Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5369-73.
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  100. Fallows D, Kent RB, Nelson DL, Emanuel JR, Levenson R, Housman DE. Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. Mol Cell Biol. 1987 Aug; 7(8):2985-7.
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  101. Schneider JW, Mercer RW, Emanuel J, Levenson RM, Benz EJ. Expression of genes for the alpha and beta subunits of the Na,K-ATPase in normal and drug resistant cells. Blood Cells. 1987; 13(1-2):299-307.
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  102. Chaudhury S, Ismail-Beigi F, Gick GG, Levenson R, Edelman IS. Effect of thyroid hormone on the abundance of Na,K-adenosine triphosphatase alpha-subunit messenger ribonucleic acid. Mol Endocrinol. 1987 Jan; 1(1):83-9.
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  103. Mercer RW, Schneider JW, Savitz A, Emanuel J, Benz EJ, Levenson R. Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mol Cell Biol. 1986 Nov; 6(11):3884-90.
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  104. Emanuel JR, Garetz S, Schneider J, Ash JF, Benz EJ, Levenson R. Amplification of DNA sequences coding for the Na,K-ATPase alpha-subunit in ouabain-resistant C+ cells. Mol Cell Biol. 1986 Jul; 6(7):2476-81.
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  105. Schneider JW, Mercer RW, Caplan M, Emanuel JR, Sweadner KJ, Benz EJ, Levenson R. Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA. Proc Natl Acad Sci U S A. 1985 Sep; 82(18):6357-61.
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  106. English LH, Epstein J, Cantley L, Housman D, Levenson R. Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. J Biol Chem. 1985 Jan 25; 260(2):1114-9.
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  107. Levenson R, Racaniello V, Albritton L, Housman D. Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1489-93.
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  108. Levenson R, Macara I, Cantley L, Housman D. Ionic regulation of MEL cell commitment. J Cell Biochem. 1983; 21(1):1-8.
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  109. Levenson R, Macara IG, Smith RL, Cantley L, Housman D. Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation. Cell. 1982 Apr; 28(4):855-63.
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  110. Smith RL, Macara IG, Levenson R, Housman D, Cantley L. Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. J Biol Chem. 1982 Jan 25; 257(2):773-80.
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  111. Levenson R, Housman D. Erasure of the memory response in MEL cells. Dev Biol. 1981 Aug; 86(1):81-6.
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  112. Bridges K, Levenson R, Housman D, Cantley L. Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation. J Cell Biol. 1981 Aug; 90(2):542-4.
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  113. Levenson R, Housman D. Commitment: how do cells make the decision to differentiate? Cell. 1981 Jul; 25(1):5-6.
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  114. Levenson R, Housman D, Cantley L. Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5948-52.
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  115. Housman D, Levenson R, Volloch V, Tsiftsoglou A, Gusella J, Parker D, Kernen J, Mitrani A, Weeks V, Witte O, Besmer P. Control of proliferation and differentiation in cells transformed by Friend virus. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 2,:1177-85.
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  116. Levenson R, Kernen J, Mitrani A, Housman D. DNA synthesis is not required for the commitment of murine erythroleukemia cells. Dev Biol. 1980 Jan; 74(1):224-30.
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  117. Levenson R, Kernen J, Housman D. Synchronization of MEL cell commitment with cordycepin. Cell. 1979 Dec; 18(4):1073-8.
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  118. Levenson R, Housman D. Developmental program of murine erythroleukemia cells. Effect of the inhibition of protein synthesis. J Cell Biol. 1979 Sep; 82(3):715-25.
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  119. Levenson R, Housman D. Memory of MEL cells to a previous exposure to inducer. Cell. 1979 Jul; 17(3):485-90.
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  120. Geller R, Levenson R, Housman D. Significance of the cell cycle in commitment of murine erythroleukemia cells to erythroid differentiation. J Cell Physiol. 1978 May; 95(2):213-22.
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  121. Kane DJ, Levenson RG, Jones RF. A rapid and sensitive method for the detection of histone peptides. Anal Biochem. 1978 May; 86(1):214-9.
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  122. Levenson RG, Marcu KB. On the existence of polyadenylated histone mRNA in Xenopus laevis oocytes. Cell. 1976 Oct; 9(2):311-22.
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