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Qing Yang

TitleProfessor
InstitutionCollege of Medicine
DepartmentRadiology
Address500 University Drive Hershey PA 17033
Mailbox: H066
Phone7175315858

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Radiology, Bioengineering, Engineering Sciences and Neurosurgery

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Center for NMR Research and MRI Core Facility

GRADUATE PROGRAM AFFILIATIONS:

Bioengineering and Neural and Behavioral Sciences

EDUCATION:

Ph.D., Georgia Institute of Technology

NARRATIVE:

My research focuses on two fundamental problems that become increasingly important in high field MRI. The problems include magnetic susceptibility effects on the static magnetic and the dielectric effects on the radio-frequency (RF) field. The current is focused on three areas. These three areas of research are closely related to one another and all relate to high field MRI technology.

T2* contrast imaging and its applications.
T2* contrast techniques have become increasingly useful for their unique tissue contrast. T2* image contrast is sensitive to variation in tissue bulk magnetic susceptibility. The T2* contrast provide a useful tool for brain research. One important application is the assessment of relative brain iron concentration. Brain iron dysregulation and resultant deposition have been implicated in many common degenerative diseases such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and multiple sclerosis (MS). Unfortunately, T2* contrast for research and clinical investigations is limited by two major problems in existing techniques:
i. Severe artifact and loss of signal due to magnetic field inhomogeneity,
ii. Low contrast to noise ratio (CNR).

The research objective is to exploit the full potential of T2* contrast by developing reliable T2* contrast-enhanced imaging methods for brain research and clinical examinations.

Olfactory deficit in AD and olfactory functional MRI The behavioral and neuropathological findings of preferential involvement of the central olfactory pathways in the early stages of AD makes olfaction an important system for investigation of AD with fMRI. The purpose of this project is to develop a reliable olfactory fMRI technique for clinical research on olfactory deficits occurring in early AD patients. This study can be correlated with the iron deposition using T2* contrast as mentioned above. This project involves rapid MRI methodology development as well as medical application of fMRI.

Radio frequency field and dielectric materials in high field MRI It is desirable to increase the static magnetic field strength because MR image quality and sensitivity are expected to improve at higher field strength. The RF field becomes significantly inhomogeneous at high fields due to the strong wave behavior of the RF field. The understanding and eventual utilization of the wave behavior are fundamentally important for the development of high field NMR. Computer modeling is used to study the interaction between RF field and dielectric materials including tissues. Dielectric materials can be used in various ways to manipulate the RF field and their potential applications are enormous.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Meadowcroft MD, Connor JR, Yang QX. Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1?E9 mice: a histological perspective. Front Neurosci. 2015; 9:255.
    View in: PubMed
  2. Dewal RP, Yang QX. Volume of interest-based fourier transform method for calculation of static magnetic field maps from susceptibility distributions. Magn Reson Med. 2015 Jul 3.
    View in: PubMed
  3. Wang Z, Wang J, Zhang H, Mchugh R, Sun X, Li K, Yang QX. Interhemispheric Functional and Structural Disconnection in Alzheimer's Disease: A Combined Resting-State fMRI and DTI Study. PLoS One. 2015; 10(5):e0126310.
    View in: PubMed
  4. Wang J, Yang QX, Sun X, Vesek J, Mosher Z, Vasavada M, Chu J, Kanekar S, Shivkumar V, Venkiteswaran K, Subramanian T. MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinson's disease. Parkinsonism Relat Disord. 2015 Jun; 21(6):590-6.
    View in: PubMed
  5. Vasavada MM, Wang J, Eslinger PJ, Gill DJ, Sun X, Karunanayaka P, Yang QX. Olfactory cortex degeneration in Alzheimer's disease and mild cognitive impairment. J Alzheimers Dis. 2015 Jan 1; 45(3):947-58.
    View in: PubMed
  6. Zhang B, Zhang X, Zhang F, Li M, Schwarz CG, Zhang J, Yin Z, Qian L, Zhao H, Wang K, Tian C, Yu H, Chen W, Lu F, Wu W, Yang QX, Xu Y, Zhu B. Characterizing topological patterns in amnestic mild cognitive impairment by quantitative water diffusivity. J Alzheimers Dis. 2015 Jan 1; 43(2):687-97.
    View in: PubMed
  7. Meadowcroft MD, Peters DG, Dewal RP, Connor JR, Yang QX. The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease. NMR Biomed. 2015 Mar; 28(3):297-305.
    View in: PubMed
  8. Meadowcroft MD, Mutic NJ, Bigler DC, Wang JL, Simmons Z, Connor JR, Yang QX. Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis. J Magn Reson Imaging. 2015 Mar; 41(3):665-75.
    View in: PubMed
  9. Wang J, Sun X, Yang QX. Methods for olfactory fMRI studies: Implication of respiration. Hum Brain Mapp. 2014 Aug; 35(8):3616-24.
    View in: PubMed
  10. Fang W, Lv F, Luo T, Cheng O, Liao W, Sheng K, Wang X, Wu F, Hu Y, Luo J, Yang QX, Zhang H. Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI. PLoS One. 2013; 8(7):e69199.
    View in: PubMed
  11. Karunanayaka P, Eslinger PJ, Wang JL, Weitekamp CW, Molitoris S, Gates KM, Molenaar PC, Yang QX. Networks involved in olfaction and their dynamics using independent component analysis and unified structural equation modeling. Hum Brain Mapp. 2014 May; 35(5):2055-72.
    View in: PubMed
  12. Yang QX, Rupprecht S, Luo W, Sica C, Herse Z, Wang J, Cao Z, Vesek J, Lanagan MT, Carluccio G, Ryu YC, Collins CM. Radiofrequency field enhancement with high dielectric constant (HDC) pads in a receive array coil at 3.0T. J Magn Reson Imaging. 2013 Aug; 38(2):435-40.
    View in: PubMed
  13. Du G, Lewis MM, Sen S, Wang J, Shaffer ML, Styner M, Yang QX, Huang X. Imaging nigral pathology and clinical progression in Parkinson's disease. Mov Disord. 2012 Nov; 27(13):1636-43.
    View in: PubMed
  14. Luo W, Lanagan MT, Sica CT, Ryu Y, Oh S, Ketterman M, Yang QX, Collins CM. Permittivity and performance of dielectric pads with sintered ceramic beads in MRI: early experiments and simulations at 3 T. Magn Reson Med. 2013 Jul; 70(1):269-75.
    View in: PubMed
  15. Du G, Lewis MM, Shaffer ML, Chen H, Yang QX, Mailman RB, Huang X. Serum cholesterol and nigrostriatal R2* values in Parkinson's disease. PLoS One. 2012; 7(4):e35397.
    View in: PubMed
  16. Liu W, Kao CP, Collins CM, Smith MB, Yang QX. On consideration of radiated power in RF field simulations for MRI. Magn Reson Med. 2013 Jan; 69(1):290-4.
    View in: PubMed
  17. Wang J, Shaffer ML, Eslinger PJ, Sun X, Weitekamp CW, Patel MM, Dossick D, Gill DJ, Connor JR, Yang QX. Maturational and aging effects on human brain apparent transverse relaxation. PLoS One. 2012; 7(2):e31907.
    View in: PubMed
  18. Roopnariane CA, Ryu YC, Tofighi MR, Miller PA, Oh S, Wang J, Park BS, Ansel L, Lieu CA, Subramanian T, Yang QX, Collins CM. Quadrature RF Coil for In Vivo Brain MRI of a Macaque Monkey in a Stereotaxic Head Frame. Concepts Magn Reson Part B Magn Reson Eng. 2012 Feb; 41B(1):22-27.
    View in: PubMed
  19. Aksu Y, Miller DJ, Kesidis G, Bigler DC, Yang QX. An MRI-derived definition of MCI-to-AD conversion for long-term, automatic prognosis of MCI patients. PLoS One. 2011; 6(10):e25074.
    View in: PubMed
  20. Du G, Lewis MM, Styner M, Shaffer ML, Sen S, Yang QX, Huang X. Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease. Mov Disord. 2011 Aug 1; 26(9):1627-32.
    View in: PubMed
  21. Connor JR, Ponnuru P, Lee BY, Podskalny GD, Alam S, Allen RP, Earley CJ, Yang QX. Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome. Sleep Med. 2011 Jun; 12(6):614-9.
    View in: PubMed
  22. Yang QX, Wang J, Wang J, Collins CM, Wang C, Smith MB. Reducing SAR and enhancing cerebral signal-to-noise ratio with high permittivity padding at 3 T. Magn Reson Med. 2011 Feb; 65(2):358-62.
    View in: PubMed
  23. Wang J, Eslinger PJ, Doty RL, Zimmerman EK, Grunfeld R, Sun X, Meadowcroft MD, Connor JR, Price JL, Smith MB, Yang QX. Olfactory deficit detected by fMRI in early Alzheimer's disease. Brain Res. 2010 Oct 21; 1357:184-94.
    View in: PubMed
  24. Aksu Y, Miller DJ, Kesidis G, Yang QX. Margin-maximizing feature elimination methods for linear and nonlinear kernel-based discriminant functions. IEEE Trans Neural Netw. 2010 May; 21(5):701-17.
    View in: PubMed
  25. Robinson-Long M, Eslinger PJ, Wang J, Meadowcroft M, Yang QX. Functional MRI evidence for distinctive binding and consolidation pathways for face-name associations: analysis of activation maps and BOLD response amplitudes. Top Magn Reson Imaging. 2009 Oct; 20(5):271-8.
    View in: PubMed
  26. Meadowcroft MD, Connor JR, Smith MB, Yang QX. MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. J Magn Reson Imaging. 2009 May; 29(5):997-1007.
    View in: PubMed
  27. Bigler DC, Aksu Y, Miller DJ, Yang QX. STAMPS: Software Tool for Automated MRI Post-processing on a supercomputer. Comput Methods Programs Biomed. 2009 Aug; 95(2):146-57.
    View in: PubMed
  28. Madhankumar AB, Slagle-Webb B, Wang X, Yang QX, Antonetti DA, Miller PA, Sheehan JM, Connor JR. Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model. Mol Cancer Ther. 2009 Mar; 8(3):648-54.
    View in: PubMed
  29. Thompson K, Biddle KR, Robinson-Long M, Poger J, Wang J, Yang QX, Eslinger PJ. Cerebral plasticity and recovery of function after childhood prefrontal cortex damage. Dev Neurorehabil. 2009; 12(5):298-312.
    View in: PubMed
  30. Eslinger PJ, Robinson-Long M, Realmuto J, Moll J, deOliveira-Souza R, Tovar-Moll F, Wang J, Yang QX. Developmental frontal lobe imaging in moral judgment: Arthur Benton's enduring influence 60 years later. J Clin Exp Neuropsychol. 2009 Feb; 31(2):158-69.
    View in: PubMed
  31. Eslinger PJ, Blair C, Wang J, Lipovsky B, Realmuto J, Baker D, Thorne S, Gamson D, Zimmerman E, Rohrer L, Yang QX. Developmental shifts in fMRI activations during visuospatial relational reasoning. Brain Cogn. 2009 Feb; 69(1):1-10.
    View in: PubMed
  32. Meadowcroft MD, Zhang S, Liu W, Park BS, Connor JR, Collins CM, Smith MB, Yang QX. Direct magnetic resonance imaging of histological tissue samples at 3.0T. Magn Reson Med. 2007 May; 57(5):835-41.
    View in: PubMed
  33. Lindquist MA, Zhang CH, Glover G, Shepp L, Yang QX. A generalization of the two-dimensional prolate spheroidal wave function method for nonrectilinear MRI data acquisition methods. IEEE Trans Image Process. 2006 Sep; 15(9):2792-804.
    View in: PubMed
  34. Yang QX, Mao W, Wang J, Smith MB, Lei H, Zhang X, Ugurbil K, Chen W. Manipulation of image intensity distribution at 7.0 T: passive RF shimming and focusing with dielectric materials. J Magn Reson Imaging. 2006 Jul; 24(1):197-202.
    View in: PubMed
  35. Lazovic J, Wrzos HF, Yang QX, Collins CM, Smith MB, Norgren R, Matyas K, Ouyang A. Regional activation in the rat brain during visceral stimulation detected by c-fos expression and fMRI. Neurogastroenterol Motil. 2005 Aug; 17(4):548-56.
    View in: PubMed
  36. Yang QX, Shao CK, Feng ZY, Huang BQ, Han AJ, Xiong M, Zhao WL, Wu TT. [Detection of cytokeratin 19 and thyroperoxidase expressions in the diagnosis of thyroid diseases]. Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun; 25(6):678-81.
    View in: PubMed
  37. Lazovic J, Stojkovic DS, Collins CM, Yang QX, Vaughan JT, Smith MB. Hexagonal zero mode TEM coil: a single-channel coil design for imaging multiple small animals. Magn Reson Med. 2005 May; 53(5):1150-7.
    View in: PubMed
  38. Wang J, Eslinger PJ, Smith MB, Yang QX. Functional magnetic resonance imaging study of human olfaction and normal aging. J Gerontol A Biol Sci Med Sci. 2005 Apr; 60(4):510-4.
    View in: PubMed
  39. Collins CM, Liu W, Schreiber W, Yang QX, Smith MB. Central brightening due to constructive interference with, without, and despite dielectric resonance. J Magn Reson Imaging. 2005 Feb; 21(2):192-6.
    View in: PubMed
  40. Wang J, Qiu M, Yang QX, Smith MB, Constable RT. Measurement and correction of transmitter and receiver induced nonuniformities in vivo. Magn Reson Med. 2005 Feb; 53(2):408-17.
    View in: PubMed
  41. Yang QX, Wang J, Smith MB, Meadowcroft M, Sun X, Eslinger PJ, Golay X. Reduction of magnetic field inhomogeneity artifacts in echo planar imaging with SENSE and GESEPI at high field. Magn Reson Med. 2004 Dec; 52(6):1418-23.
    View in: PubMed
  42. Yang QX, Wang J, Collins CM, Smith MB, Zhang X, Ugurbil K, Chen W. Phantom design method for high-field MRI human systems. Magn Reson Med. 2004 Nov; 52(5):1016-20.
    View in: PubMed
  43. Mosher TJ, Liu Y, Yang QX, Yao J, Smith R, Dardzinski BJ, Smith MB. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum. 2004 Sep; 50(9):2820-8.
    View in: PubMed
  44. Lazovic-Stojkovic J, Mosher TJ, Smith HE, Yang QX, Dardzinski BJ, Smith MB. Interphalangeal joint cartilage: high-spatial-resolution in vivo MR T2 mapping--a feasibility study. Radiology. 2004 Oct; 233(1):292-6.
    View in: PubMed
  45. Yang QX, Lindquist MA, Shepp L, Zhang CH, Wang J, Smith MB. Two dimensional prolate spheroidal wave functions for MRI. J Magn Reson. 2002 Sep-Oct; 158(1-2):43-51.
    View in: PubMed
  46. Bus SA, Yang QX, Wang JH, Smith MB, Wunderlich R, Cavanagh PR. Intrinsic muscle atrophy and toe deformity in the diabetic neuropathic foot: a magnetic resonance imaging study. Diabetes Care. 2002 Aug; 25(8):1444-50.
    View in: PubMed
  47. Wang J, Yang QX, Zhang X, Collins CM, Smith MB, Zhu XH, Adriany G, Ugurbil K, Chen W. Polarization of the RF field in a human head at high field: a study with a quadrature surface coil at 7.0 T. Magn Reson Med. 2002 Aug; 48(2):362-9.
    View in: PubMed
  48. Collins CM, Yang B, Yang QX, Smith MB. Numerical calculations of the static magnetic field in three-dimensional multi-tissue models of the human head. Magn Reson Imaging. 2002 Jun; 20(5):413-24.
    View in: PubMed
  49. Demeure RJ, Jordan BF, Yang QX, Beghein N, Smith MB, Grégoire V, Gallez B. Removal of local field gradient artefacts in BOLD contrast imaging of head and neck tumours. Phys Med Biol. 2002 May 21; 47(10):1819-25.
    View in: PubMed
  50. Collins CM, Yang QX, Wang JH, Zhang X, Liu H, Michaeli S, Zhu XH, Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K, Smith MB, Chen W. Different excitation and reception distributions with a single-loop transmit-receive surface coil near a head-sized spherical phantom at 300 MHz. Magn Reson Med. 2002 May; 47(5):1026-8.
    View in: PubMed
  51. Yang QX, Wang J, Zhang X, Collins CM, Smith MB, Liu H, Zhu XH, Vaughan JT, Ugurbil K, Chen W. Analysis of wave behavior in lossy dielectric samples at high field. Magn Reson Med. 2002 May; 47(5):982-9.
    View in: PubMed
  52. Yang QX, Smith MB, Briggs RW, Rycyna RE. Microimaging at 14 tesla using GESEPI for removal of magnetic susceptibility artifacts in T(2)(*)-weighted image contrast. J Magn Reson. 1999 Nov; 141(1):1-6.
    View in: PubMed
  53. Yang QX, Williams GD, Demeure RJ, Mosher TJ, Smith MB. Removal of local field gradient artifacts in T2*-weighted images at high fields by gradient-echo slice excitation profile imaging. Magn Reson Med. 1998 Mar; 39(3):402-9.
    View in: PubMed
  54. Yang QX, Huang FY, Lin TH, Gelbaum L, Howell EE, Huang TH. Dynamics of trimethoprim bound to dihydrofolate reductase--a deuterium NMR study. Solid State Nucl Magn Reson. 1996 Dec; 7(3):193-201.
    View in: PubMed
  55. Li S, Dardzinski BJ, Collins CM, Yang QX, Smith MB. Three-dimensional mapping of the static magnetic field inside the human head. Magn Reson Med. 1996 Nov; 36(5):705-14.
    View in: PubMed
  56. Li S, Yang QX, Smith MB. RF coil optimization: evaluation of B1 field homogeneity using field histograms and finite element calculations. Magn Reson Imaging. 1994; 12(7):1079-87.
    View in: PubMed
  57. Yang QX, Huang FY, Huang TH, Gelbaum L. The effect of hydration on the dynamics of trimethoprim bound to dihydrofolate reductase. A deuterium NMR study. Biophys J. 1993 Apr; 64(4):1361-5.
    View in: PubMed
  58. Huang FY, Yang QX, Huang TH. 15N NMR studies of the conformation of E. coli dihydrofolate reductase in complex with folate or methotrexate. FEBS Lett. 1991 Sep 9; 289(2):231-4.
    View in: PubMed
  59. Huang FY, Yang QX, Huang TH, Gelbaum L, Kuyper LF. The conformations of trimethoprim/E. coli dihydrofolate reductase complexes. A 15N and 31P NMR study. FEBS Lett. 1991 May 20; 283(1):44-6.
    View in: PubMed
  60. Huang TH, DeSiervo AJ, Yang QX. Effect of cholesterol and lanosterol on the structure and dynamics of the cell membrane of Mycoplasma capricolum. Deuterium nuclear magnetic resonance study. Biophys J. 1991 Mar; 59(3):691-702.
    View in: PubMed
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