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Patricia Grigson-Kennedy

TitleProfessor
InstitutionCollege of Medicine
DepartmentNeural and Behavioral Sciences
Address500 University Drive Hershey PA 17033
Mailbox: H181
Phone7175315772

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Neural and Behavioral Sciences

GRADUATE PROGRAM AFFILIATIONS:

MD/PhD Degree Program, integrative Sciences, Neuroscience

EDUCATION:

Ph.D., Rutgers University, 1990
Postdoctoral Training, Pennsylvania State University College of Medicine, 1990-1993

NARRATIVE:

A great deal is known about the neural pathways involved in responding to the rewarding properties of food, water, or drugs of abuse, for example. However, these rewards are not typically experienced in a vacuum. At any given time, an animal can engage in a number of different activities, each of which may lead to a different rewarding outcome. The choice to select one behavior over another serves as evidence that very different rewards must be compared by some common neural substrate. However, there currently is little known about the neural pathways involved in such reward comparison processes. It is the focus of this laboratory to identify the substrate.

Rewards are compared in three ways over time. First, a reward can be compared with a different reward that is available closely in time. This form of reward comparison requires short-term memory processes. We have found that a brainstem relay, in particular the nucleus of the solitary tract, is involved in making this type of short-term memory dependent comparison process and that the effect is reflected in the activity of single taste cells in this nucleus (see figures). Second, a reward can be compared with the "memory" of another reward received 24h earlier. This form of reward comparison relies upon long-term memory and necessitates the involvement of the second gustatory relay, the parabrachial nucleus of the pons. Finally, a reward can be compared with another that is expected in the future. The anticipated reward may be a preferred gustatory stimulus or a drug of abuse, such as morphine or cocaine. This phenomenon seems to rely upon more complex associative processes occurring in the forebrain.

Given that drug addiction often is accompanied by an apparent devaluation of that which is naturally rewarding (e.g., relationships, employment, food...), we hope that these efforts will begin to illuminate the neural substrates by which natural rewards and drugs of abuse are compared.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Grigson PS, Colechio EM, Power ML, Schulkin J, Norgren R. Parabrachial lesions in rats disrupt sodium appetite induced by furosemide but not by calcium deprivation. Physiol Behav. 2015 Mar 1; 140:172-9.
    View in: PubMed
  2. Puhl MD, Blum JS, Acosta-Torres S, Grigson PS. Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue. Behav Pharmacol. 2012 Feb; 23(1):43-53.
    View in: PubMed
  3. Puhl MD, Cason AM, Wojnicki FH, Corwin RL, Grigson PS. A history of bingeing on fat enhances cocaine seeking and taking. Behav Neurosci. 2011 Dec; 125(6):930-42.
    View in: PubMed
  4. Liang NC, Grigson PS, Norgren R. Pontine and thalamic influences on fluid rewards: II. Sucrose and corn oil conditioned aversions. Physiol Behav. 2012 Jan 18; 105(2):589-94.
    View in: PubMed
  5. Liang NC, Norgren R, Grigson PS. Pontine and thalamic influences on fluid rewards: III. Anticipatory contrast for sucrose and corn oil. Physiol Behav. 2012 Jan 18; 105(2):595-606.
    View in: PubMed
  6. Liang NC, Freet CS, Grigson PS, Norgren R. Pontine and thalamic influences on fluid rewards: I. Operant responding for sucrose and corn oil. Physiol Behav. 2012 Jan 18; 105(2):576-88.
    View in: PubMed
  7. Puhl MD, Fang J, Grigson PS. Acute sleep deprivation increases the rate and efficiency of cocaine self-administration, but not the perceived value of cocaine reward in rats. Pharmacol Biochem Behav. 2009 Dec; 94(2):262-70.
    View in: PubMed
  8. Twining RC, Bolan M, Grigson PS. Yoked delivery of cocaine is aversive and protects against the motivation for drug in rats. Behav Neurosci. 2009 Aug; 123(4):913-25.
    View in: PubMed
  9. Freet CS, Steffen C, Nestler EJ, Grigson PS. Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice. Behav Neurosci. 2009 Apr; 123(2):397-407.
    View in: PubMed
  10. Geddes RI, Han L, Baldwin AE, Norgren R, Grigson PS. Gustatory insular cortex lesions disrupt drug-induced, but not lithium chloride-induced, suppression of conditioned stimulus intake. Behav Neurosci. 2008 Oct; 122(5):1038-50.
    View in: PubMed
  11. Kuntz KL, Twining RC, Baldwin AE, Vrana KE, Grigson PS. Heroin self-administration: I. Incubation of goal-directed behavior in rats. Pharmacol Biochem Behav. 2008 Sep; 90(3):344-8.
    View in: PubMed
  12. Kuntz KL, Patel KM, Grigson PS, Freeman WM, Vrana KE. Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior. Pharmacol Biochem Behav. 2008 Sep; 90(3):349-56.
    View in: PubMed
  13. Wheeler RA, Twining RC, Jones JL, Slater JM, Grigson PS, Carelli RM. Behavioral and electrophysiological indices of negative affect predict cocaine self-administration. Neuron. 2008 Mar 13; 57(5):774-85.
    View in: PubMed
  14. Grigson PS. Reward Comparison: The Achilles' heel and hope for addiction. Drug Discov Today Dis Models. 2008; 5(4):227-233.
    View in: PubMed
  15. Grigson PS, Hajnal A. Once is too much: conditioned changes in accumbens dopamine following a single saccharin-morphine pairing. Behav Neurosci. 2007 Dec; 121(6):1234-42.
    View in: PubMed
  16. Liu C, Grigson PS. Brief access to sweets protect against relapse to cocaine-seeking. Brain Res. 2005 Jul 5; 1049(1):128-31.
    View in: PubMed
  17. Schroy PL, Wheeler RA, Davidson C, Scalera G, Twining RC, Grigson PS. Role of gustatory thalamus in anticipation and comparison of rewards over time in rats. Am J Physiol Regul Integr Comp Physiol. 2005 Apr; 288(4):R966-80.
    View in: PubMed
  18. Jones BC, Wheeler DS, Beard JL, Grigson PS. Iron deficiency in rats decreases acquisition of and suppresses responding for cocaine. Pharmacol Biochem Behav. 2002 Nov; 73(4):813-9.
    View in: PubMed
  19. Grigson PS. Like drugs for chocolate: separate rewards modulated by common mechanisms? Physiol Behav. 2002 Jul; 76(3):389-95.
    View in: PubMed
  20. Grigson PS, Twining RC. Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards. Behav Neurosci. 2002 Apr; 116(2):321-33.
    View in: PubMed
  21. Grigson PS, Cornelius K, Wheeler DS. The suppressive effects of intraperitoneal cocaine are augmented when evaluated in nondeprived rats. Pharmacol Biochem Behav. 2001 May-Jun; 69(1-2):117-23.
    View in: PubMed
  22. Grigson PS, Wheeler RA, Wheeler DS, Ballard SM. Chronic morphine treatment exaggerates the suppressive effects of sucrose and cocaine, but not lithium chloride, on saccharin intake in Sprague-Dawley rats. Behav Neurosci. 2001 Apr; 115(2):403-16.
    View in: PubMed
  23. Grigson PS, Twining RC, Carelli RM. Heroin-induced suppression of saccharin intake in water-deprived and water-replete rats. Pharmacol Biochem Behav. 2000 Jul; 66(3):603-8.
    View in: PubMed
  24. Gomez F, Leo NA, Grigson PS. Morphine-induced suppression of saccharin intake is correlated with elevated corticosterone levels. Brain Res. 2000 Apr 28; 863(1-2):52-8.
    View in: PubMed
  25. Grigson PS, Freet CS. The suppressive effects of sucrose and cocaine, but not lithium chloride, are greater in Lewis than in Fischer rats: evidence for the reward comparison hypothesis. Behav Neurosci. 2000 Apr; 114(2):353-63.
    View in: PubMed
  26. Grigson PS, Lyuboslavsky P, Tanase D. Bilateral lesions of the gustatory thalamus disrupt morphine- but not LiCl-induced intake suppression in rats: evidence against the conditioned taste aversion hypothesis. Brain Res. 2000 Mar 10; 858(2):327-37.
    View in: PubMed
  27. Grigson PS, Lyuboslavsky PN, Tanase D, Wheeler RA. Water-deprivation prevents morphine-, but not LiCl-induced, suppression of sucrose intake. Physiol Behav. 1999 Aug; 67(2):277-86.
    View in: PubMed
  28. Grigson PS, Reilly S, Scalera G, Norgren R. The parabrachial nucleus is essential for acquisition of a conditioned odor aversion in rats. Behav Neurosci. 1998 Oct; 112(5):1104-13.
    View in: PubMed
  29. Grigson PS, Reilly S, Shimura T, Norgren R. Ibotenic acid lesions of the parabrachial nucleus and conditioned taste aversion: further evidence for an associative deficit in rats. Behav Neurosci. 1998 Feb; 112(1):160-71.
    View in: PubMed
  30. Grigson PS, Shimura T, Norgren R. Brainstem lesions and gustatory function: II. The role of the nucleus of the solitary tract in Na+ appetite, conditioned taste aversion, and conditioned odor aversion in rats. Behav Neurosci. 1997 Feb; 111(1):169-79.
    View in: PubMed
  31. Grigson PS. Conditioned taste aversions and drugs of abuse: a reinterpretation. Behav Neurosci. 1997 Feb; 111(1):129-36.
    View in: PubMed
  32. Grigson PS, Shimura T, Norgren R. Brainstem lesions and gustatory function: III. The role of the nucleus of the solitary tract and the parabrachial nucleus in retention of a conditioned taste aversion in rats. Behav Neurosci. 1997 Feb; 111(1):180-7.
    View in: PubMed
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