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Paul Eslinger

TitleProfessor
InstitutionCollege of Medicine
DepartmentNeurology
Address500 University Drive Hershey PA 17033
Phone7175318692

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Neurology, Physician

GRADUATE PROGRAM AFFILIATIONS:

Neuroscience

EDUCATION:

Ph.D., Texas Christian University, 1980
Postdoctoral Training, University of Iowa, 1979-1983
Fellowship, Neurology, University of Iowa Hospitals and Clinics (1986)

NARRATIVE:

Cognitive neuroscience has emerged from the interdisciplinary need to understand the complex relations between neural systems and behavior. In the Cognitive Neuroscience Laboratory, Dr. Eslinger systematically studies both normal subjects and patients who have acquired brain lesions to limbic and cortical structures. Visual and auditory organization in the normal brain is examined with specialized techniques such as tachistoscopic analysis and dichotic listening. The cerebral lesions of neurologic patients are localized from CT and MRI scans according to standarized neuroimaging procedures for the purpose of comparing the effects of different locations of damage on diverse cognitive experimental tasks. Major research programs include: 1) the neural substrate of memory, focusing particularly on the role of the amygdala, hippocampal formation and frontal lobe; 2) the organization of pattern recognition (reading and facial recognition) and spatial perception in upper and lower visual association of cortices; 3) the fractionation of the frontal lobes into regions specialized for response initiation and the executive abilities of decision-making and social judgement; and 4) cognitive architectures of right and left cerebral hemispheres as revealed by the Wada (intracarotid sodium amytal) procedure and effects of temporal lobectomy for intractable epilepsy.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee EY, Sen S, Eslinger PJ, Wagner D, Shaffer ML, Kong L, Lewis MM, Du G, Huang X. Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients. Parkinsonism Relat Disord. 2013 Dec; 19(12):1088-93.
    View in: PubMed
  2. Sterling NW, Du G, Lewis MM, Dimaio C, Kong L, Eslinger PJ, Styner M, Huang X. Striatal shape in Parkinson's disease. Neurobiol Aging. 2013 Nov; 34(11):2510-6.
    View in: PubMed
  3. Reginold W, Duff-Canning S, Meaney C, Armstrong MJ, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger P, Marshall F, Mapstone M, Chou KL, Persad C, Litvan I, Mast B, Tang-Wai D, Lang AE, Marras C. Impact of mild cognitive impairment on health-related quality of life in Parkinson's disease. Dement Geriatr Cogn Disord. 2013; 36(1-2):67-75.
    View in: PubMed
  4. Marras C, Armstrong MJ, Meaney CA, Fox S, Rothberg B, Reginold W, Tang-Wai DF, Gill D, Eslinger PJ, Zadikoff C, Kennedy N, Marshall FJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Gerstenecker AT, Weintraub S, Duff-Canning S. Measuring mild cognitive impairment in patients with Parkinson's disease. Mov Disord. 2013 May; 28(5):626-33.
    View in: PubMed
  5. Eslinger PJ, Flaherty-Craig CV, Chakara FM. Rehabilitation and management of executive function disorders. Handb Clin Neurol. 2013; 110:365-76.
    View in: PubMed
  6. Armstrong MJ, Duff-Canning S, Tang-Wai DF, Fox S, Zadikoff C, Kennedy N, Gill D, Eslinger PJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Marras C. The meaning of a "hippo" response on the Montreal Cognitive Assessment in Parkinson's disease. Parkinsonism Relat Disord. 2013 Apr; 19(4):463-5.
    View in: PubMed
  7. Armstrong MJ, Naglie G, Duff-Canning S, Meaney C, Gill D, Eslinger PJ, Zadikoff C, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Fox S, Tang-Wai DF, Marras C. Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):343-52.
    View in: PubMed
  8. Reginold W, Armstrong MJ, Duff-Canning S, Lang A, Tang-Wai D, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger P, Mapstone M, Chou K, Persad C, Litvan I, Mast B, Marras C. The pill questionnaire in a nondemented Parkinson's disease population. Mov Disord. 2012 Sep 1; 27(10):1308-11.
    View in: PubMed
  9. Galletta EE, Lequerica AH, Pekrul SR, Eslinger PJ, Barrett AM. Visual distraction: an altered aiming spatial response in dementia. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):229-37.
    View in: PubMed
  10. Wang J, Shaffer ML, Eslinger PJ, Sun X, Weitekamp CW, Patel MM, Dossick D, Gill DJ, Connor JR, Yang QX. Maturational and aging effects on human brain apparent transverse relaxation. PLoS One. 2012; 7(2):e31907.
    View in: PubMed
  11. Eslinger PJ, Moore P, Antani S, Anderson C, Grossman M. Apathy in frontotemporal dementia: behavioral and neuroimaging correlates. Behav Neurol. 2012; 25(2):127-36.
    View in: PubMed
  12. Baker DP, Salinas D, Eslinger PJ. An envisioned bridge: schooling as a neurocognitive developmental institution. Dev Cogn Neurosci. 2012 Feb 15; 2 Suppl 1:S6-17.
    View in: PubMed
  13. Zappalà G, Thiebaut de Schotten M, Eslinger PJ. Traumatic brain injury and the frontal lobes: what can we gain with diffusion tensor imaging? Cortex. 2012 Feb; 48(2):156-65.
    View in: PubMed
  14. Royer M, Ballentine NH, Eslinger PJ, Houser K, Mistrick R, Behr R, Rakos K. Light therapy for seniors in long term care. J Am Med Dir Assoc. 2012 Feb; 13(2):100-2.
    View in: PubMed
  15. Eslinger PJ, Moore P, Anderson C, Grossman M. Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2011; 23(1):74-82.
    View in: PubMed
  16. Wang J, Eslinger PJ, Doty RL, Zimmerman EK, Grunfeld R, Sun X, Meadowcroft MD, Connor JR, Price JL, Smith MB, Yang QX. Olfactory deficit detected by fMRI in early Alzheimer's disease. Brain Res. 2010 Oct 21; 1357:184-94.
    View in: PubMed
  17. Grossman M, Eslinger PJ, Troiani V, Anderson C, Avants B, Gee JC, McMillan C, Massimo L, Khan A, Antani S. The role of ventral medial prefrontal cortex in social decisions: converging evidence from fMRI and frontotemporal lobar degeneration. Neuropsychologia. 2010 Oct; 48(12):3505-12.
    View in: PubMed
  18. Robinson-Long M, Eslinger PJ, Wang J, Meadowcroft M, Yang QX. Functional MRI evidence for distinctive binding and consolidation pathways for face-name associations: analysis of activation maps and BOLD response amplitudes. Top Magn Reson Imaging. 2009 Oct; 20(5):271-8.
    View in: PubMed
  19. Flaherty-Craig C, Brothers A, Dearman B, Eslinger P, Simmons Z. Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: application to ALS. Amyotroph Lateral Scler. 2009 Apr; 10(2):107-12.
    View in: PubMed
  20. Thompson K, Biddle KR, Robinson-Long M, Poger J, Wang J, Yang QX, Eslinger PJ. Cerebral plasticity and recovery of function after childhood prefrontal cortex damage. Dev Neurorehabil. 2009; 12(5):298-312.
    View in: PubMed
  21. Eslinger PJ, Robinson-Long M, Realmuto J, Moll J, deOliveira-Souza R, Tovar-Moll F, Wang J, Yang QX. Developmental frontal lobe imaging in moral judgment: Arthur Benton's enduring influence 60 years later. J Clin Exp Neuropsychol. 2009 Feb; 31(2):158-69.
    View in: PubMed
  22. Eslinger PJ, Blair C, Wang J, Lipovsky B, Realmuto J, Baker D, Thorne S, Gamson D, Zimmerman E, Rohrer L, Yang QX. Developmental shifts in fMRI activations during visuospatial relational reasoning. Brain Cogn. 2009 Feb; 69(1):1-10.
    View in: PubMed
  23. Garza JP, Eslinger PJ, Barrett AM. Perceptual-attentional and motor-intentional bias in near and far space. Brain Cogn. 2008 Oct; 68(1):9-14.
    View in: PubMed
  24. Satish U, Streufert S, Eslinger PJ. Simulation-based executive cognitive assessment and rehabilitation after traumatic frontal lobe injury: a case report. Disabil Rehabil. 2008; 30(6):468-78.
    View in: PubMed
  25. Barrett AM, Eslinger PJ. Amantadine for adynamic speech: possible benefit for aphasia? Am J Phys Med Rehabil. 2007 Aug; 86(8):605-12.
    View in: PubMed
  26. Zimmerman EK, Eslinger PJ, Simmons Z, Barrett AM. Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol. 2007 Jun; 20(2):79-82.
    View in: PubMed
  27. Flaherty-Craig C, Eslinger P, Stephens B, Simmons Z. A rapid screening battery to identify frontal dysfunction in patients with ALS. Neurology. 2006 Dec 12; 67(11):2070-2.
    View in: PubMed
  28. Eslinger PJ, Moore P, Troiani V, Antani S, Cross K, Kwok S, Grossman M. Oops! Resolving social dilemmas in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2007 May; 78(5):457-60.
    View in: PubMed
  29. Eslinger PJ, Dennis K, Moore P, Antani S, Hauck R, Grossman M. Metacognitive deficits in frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2005 Dec; 76(12):1630-5.
    View in: PubMed
  30. Wang J, Eslinger PJ, Smith MB, Yang QX. Functional magnetic resonance imaging study of human olfaction and normal aging. J Gerontol A Biol Sci Med Sci. 2005 Apr; 60(4):510-4.
    View in: PubMed
  31. Eslinger PJ, Tranel D. Integrative study of cognitive, social, and emotional processes in clinical neuroscience. Cogn Behav Neurol. 2005 Mar; 18(1):1-4.
    View in: PubMed
  32. Moll J, de Oliveira-Souza R, Moll FT, Ignácio FA, Bramati IE, Caparelli-Dáquer EM, Eslinger PJ. The moral affiliations of disgust: a functional MRI study. Cogn Behav Neurol. 2005 Mar; 18(1):68-78.
    View in: PubMed
  33. Barrett AM, Eslinger PJ, Ballentine NH, Heilman KM. Unawareness of cognitive deficit (cognitive anosognosia) in probable AD and control subjects. Neurology. 2005 Feb 22; 64(4):693-9.
    View in: PubMed
  34. Yang QX, Wang J, Smith MB, Meadowcroft M, Sun X, Eslinger PJ, Golay X. Reduction of magnetic field inhomogeneity artifacts in echo planar imaging with SENSE and GESEPI at high field. Magn Reson Med. 2004 Dec; 52(6):1418-23.
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  35. Eslinger PJ, Flaherty-Craig CV, Benton AL. Developmental outcomes after early prefrontal cortex damage. Brain Cogn. 2004 Jun; 55(1):84-103.
    View in: PubMed
  36. Moll J, de Oliveira-Souza R, Eslinger PJ. Morals and the human brain: a working model. Neuroreport. 2003 Mar 3; 14(3):299-305.
    View in: PubMed
  37. Eslinger PJ, Swan GE, Carmelli D. Changes in Mini-Mental State Exam in community-dwelling older persons over 6 years: relationship to health and neuropsychological measures. Neuroepidemiology. 2003 Jan-Feb; 22(1):23-30.
    View in: PubMed
  38. Eslinger PJ. The anatomic basis of utilisation behaviour: a shift from frontal-parietal to intra-frontal mechanisms. Cortex. 2002 Jun; 38(3):273-6.
    View in: PubMed
  39. Moll J, de Oliveira-Souza R, Eslinger PJ, Bramati IE, Mourão-Miranda J, Andreiuolo PA, Pessoa L. The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral emotions. J Neurosci. 2002 Apr 1; 22(7):2730-6.
    View in: PubMed
  40. Eslinger PJ, Parkinson K, Shamay SG. Empathy and social-emotional factors in recovery from stroke. Curr Opin Neurol. 2002 Feb; 15(1):91-7.
    View in: PubMed
  41. Moll J, Eslinger PJ, Oliveira-Souza R. Frontopolar and anterior temporal cortex activation in a moral judgment task: preliminary functional MRI results in normal subjects. Arq Neuropsiquiatr. 2001 Sep; 59(3-B):657-64.
    View in: PubMed
  42. McCabe PH, Eslinger PJ. Abnormal Wada and neuropsychological testing results due to topiramate therapy. Epilepsia. 2000 Jul; 41(7):906-8.
    View in: PubMed
  43. Ng VW, Eslinger PJ, Williams SC, Brammer MJ, Bullmore ET, Andrew CM, Suckling J, Morris RG, Benton AL. Hemispheric preference in visuospatial processing: a complementary approach with fMRI and lesion studies. Hum Brain Mapp. 2000 Jun; 10(2):80-6.
    View in: PubMed
  44. Tranel D, Eslinger PJ. Effects of early onset brain injury on the development of cognition and behavior: introduction to the special issue. Dev Neuropsychol. 2000; 18(3):273-80.
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  45. Eslinger PJ, Biddle KR. Adolescent neuropsychological development after early right prefrontal cortex damage. Dev Neuropsychol. 2000; 18(3):297-329.
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  46. Malecki EA, Devenyi AG, Barron TF, Mosher TJ, Eslinger P, Flaherty-Craig CV, Rossaro L. Iron and manganese homeostasis in chronic liver disease: relationship to pallidal T1-weighted magnetic resonance signal hyperintensity. Neurotoxicology. 1999 Aug; 20(4):647-52.
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  47. Pritchard TC, Macaluso DA, Eslinger PJ. Taste perception in patients with insular cortex lesions. Behav Neurosci. 1999 Aug; 113(4):663-71.
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  48. Eslinger PJ. Neurological and neuropsychological bases of empathy. Eur Neurol. 1998; 39(4):193-9.
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  49. Yang QX, Dardzinski BJ, Li S, Eslinger PJ, Smith MB. Multi-gradient echo with susceptibility inhomogeneity compensation (MGESIC): demonstration of fMRI in the olfactory cortex at 3.0 T. Magn Reson Med. 1997 Mar; 37(3):331-5.
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  50. Carmelli D, Swan GE, LaRue A, Eslinger PJ. Correlates of change in cognitive function in survivors from the Western Collaborative Group Study. Neuroepidemiology. 1997; 16(6):285-95.
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  51. Eslinger PJ, Easton A, Grattan LM, Van Hoesen GW. Distinctive forms of partial retrograde amnesia after asymmetric temporal lobe lesions: possible role of the occipitotemporal gyri in memory. Cereb Cortex. 1996 May-Jun; 6(3):530-9.
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  52. Eslinger PJ, Grattan LM. Altered serial position learning after frontal lobe lesion. Neuropsychologia. 1994 Jun; 32(6):729-39.
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  53. Eslinger PJ, Damasio H, Damasio AR, Butters N. Nonverbal amnesia and asymmetric cerebral lesions following encephalitis. Brain Cogn. 1993 Mar; 21(2):140-52.
    View in: PubMed
  54. Eslinger PJ, Grattan LM. Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility. Neuropsychologia. 1993 Jan; 31(1):17-28.
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  55. Grattan LM, Eslinger PJ. Long-term psychological consequences of childhood frontal lobe lesion in patient DT. Brain Cogn. 1992 Sep; 20(1):185-95.
    View in: PubMed
  56. Eslinger PJ, Grattan LM, Damasio H, Damasio AR. Developmental consequences of childhood frontal lobe damage. Arch Neurol. 1992 Jul; 49(7):764-9.
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  57. O'Connor M, Butters N, Miliotis P, Eslinger P, Cermak LS. The dissociation of anterograde and retrograde amnesia in a patient with herpes encephalitis. J Clin Exp Neuropsychol. 1992 Mar; 14(2):159-78.
    View in: PubMed
  58. Eslinger PJ, Warner GC, Grattan LM, Easton JD. "Frontal lobe" utilization behavior associated with paramedian thalamic infarction. Neurology. 1991 Mar; 41(3):450-2.
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  59. Swan GE, Carmelli D, Reed T, Harshfield GA, Fabsitz RR, Eslinger PJ. Heritability of cognitive performance in aging twins. The National Heart, Lung, and Blood Institute Twin Study. Arch Neurol. 1990 Mar; 47(3):259-62.
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  60. Teng EL, Wimer C, Roberts E, Damasio AR, Eslinger PJ, Folstein MF, Tune LE, Whitehouse PJ, Bardolph EL, Chui HC, et al. Alzheimer's dementia: performance on parallel forms of the dementia assessment battery. J Clin Exp Neuropsychol. 1989 Dec; 11(6):899-912.
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  61. Grattan LM, Eslinger PJ. Empirical study of empathy. Am J Psychiatry. 1989 Nov; 146(11):1521-2.
    View in: PubMed
  62. Pepin EP, Eslinger PJ. Verbal memory decline in Alzheimer's disease: a multiple-processes deficit. Neurology. 1989 Nov; 39(11):1477-82.
    View in: PubMed
  63. Rizzo M, Eslinger PJ. Colored hearing synesthesia: an investigation of neural factors. Neurology. 1989 Jun; 39(6):781-4.
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  64. Henderson VW, Roberts E, Wimer C, Bardolph EL, Chui HC, Damasio AR, Eslinger PJ, Folstein MF, Schneider LS, Teng EL, et al. Multicenter trial of naloxone in Alzheimer's disease. Ann Neurol. 1989 Apr; 25(4):404-6.
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  65. Graff-Radford NR, Rezai K, Godersky JC, Eslinger P, Damasio H, Kirchner PT. Regional cerebral blood flow in normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 1987 Dec; 50(12):1589-96.
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  66. Eslinger PJ, Damasio AR. Preserved motor learning in Alzheimer's disease: implications for anatomy and behavior. J Neurosci. 1986 Oct; 6(10):3006-9.
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  67. Eslinger PJ, Damasio AR. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology. 1985 Dec; 35(12):1731-41.
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  68. Hyman BT, Eslinger PJ, Damasio AR. Effect of naltrexone on senile dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry. 1985 Nov; 48(11):1169-71.
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  69. Corbett JJ, Phelps CD, Eslinger P, Montague PR. The neurologic evaluation of patients with low-tension glaucoma. Invest Ophthalmol Vis Sci. 1985 Aug; 26(8):1101-4.
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  70. Graff-Radford NR, Damasio H, Yamada T, Eslinger PJ, Damasio AR. Nonhaemorrhagic thalamic infarction. Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography. Brain. 1985 Jun; 108 ( Pt 2):485-516.
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  71. Damasio AR, Graff-Radford NR, Eslinger PJ, Damasio H, Kassell N. Amnesia following basal forebrain lesions. Arch Neurol. 1985 Mar; 42(3):263-71.
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  72. Damasio AR, Eslinger PJ, Damasio H, Van Hoesen GW, Cornell S. Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage. Arch Neurol. 1985 Mar; 42(3):252-9.
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  73. Eslinger PJ, Damasio AR, Benton AL, Van Allen M. Neuropsychologic detection of abnormal mental decline in older persons. JAMA. 1985 Feb 1; 253(5):670-4.
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  74. Eslinger PJ, Damasio H, Graff-Radford N, Damasio AR. Examining the relationship between computed tomography and neuropsychological measures in normal and demented elderly. J Neurol Neurosurg Psychiatry. 1984 Dec; 47(12):1319-25.
    View in: PubMed
  75. Graff-Radford NR, Eslinger PJ, Damasio AR, Yamada T. Nonhemorrhagic infarction of the thalamus: behavioral, anatomic, and physiologic correlates. Neurology. 1984 Jan; 34(1):14-23.
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  76. Damasio H, Eslinger P, Damasio AR, Rizzo M, Huang HK, Demeter S. Quantitative computed tomographic analysis in the diagnosis of dementia. Arch Neurol. 1983 Nov; 40(12):715-9.
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  77. Eslinger PJ, Benton AL. Visuoperceptual performances in aging and dementia: clinical and theoretical implications. J Clin Neuropsychol. 1983 Sep; 5(3):213-20.
    View in: PubMed
  78. Eslinger PJ, Damasio AR, Van Hoesen GW. Olfactory dysfunction in man: anatomical and behavioral aspects. Brain Cogn. 1982 Jul; 1(3):259-85.
    View in: PubMed
  79. Benton AL, Eslinger PJ, Damasio AR. Normative observations on neuropsychological test performances in old age. J Clin Neuropsychol. 1981 May; 3(1):33-42.
    View in: PubMed
  80. Eslinger PJ, Damasio AR. Age and type of aphasia in patients with stroke. J Neurol Neurosurg Psychiatry. 1981 May; 44(5):377-81.
    View in: PubMed
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