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Nancy Olsen

TitleProfessor Of Medicine, Chief Of Rheumatology
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Phone7175315384

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Professor of Medicine, Chief of Rheumatology

EDUCATION:

Fellowship, Rheumatology, University of Texas Southwestern Medical Center (Dallas) (1983)
Residency, Internal Medicine, Medical College of Virginia/Virginia Commonwealth University (Richmond) (1980)
M.D., University of Chicago-Pritzker School of Medicine (Illinois) (1977)


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM. Methotrexate Inhibits NF-?B Activity Via Long Intergenic (Noncoding) RNA-p21 Induction. Arthritis Rheumatol. 2014 Nov; 66(11):2947-57.
    View in: PubMed
  2. Gu J, Lu L, Chen M, Xu L, Lan Q, Li Q, Liu Z, Chen G, Wang P, Wang X, Brand D, Olsen N, Zheng SG. TGF-ß-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells. J Immunol. 2014 Oct 1; 193(7):3388-97.
    View in: PubMed
  3. Spurlock CF, Gass HM, Bryant CJ, Wells BC, Olsen NJ, Aune TM. Methotrexate-mediated inhibition of nuclear factor ?B activation by distinct pathways in T cells and fibroblast-like synoviocytes. Rheumatology (Oxford). 2015 Jan; 54(1):178-87.
    View in: PubMed
  4. Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, Wang J, Chen M, Liu Y, Shen Y, Brand DD, Ryffel B, Horwitz DA, Quismorio FP, Liu Z, Li B, Olsen NJ, Zheng SG. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3432-40.
    View in: PubMed
  5. Olsen NJ, Elmagboul N. Neutropenia after the third cycle of etanercept: could it be due to immunogenicity? J Clin Rheumatol. 2014 Jun; 20(4):237-8.
    View in: PubMed
  6. Olsen NJ, Benko AL, Kovacs WJ. Variation in the androgen receptor gene exon 1 CAG repeat correlates with manifestations of autoimmunity in women with lupus. Endocr Connect. 2014; 3(2):99-109.
    View in: PubMed
  7. Olsen NJ, Spurlock CF, Aune TM. Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014; 16(1):R17.
    View in: PubMed
  8. Olsen NJ, Karp DR. Autoantibodies and SLE: the threshold for disease. Nat Rev Rheumatol. 2014 Mar; 10(3):181-6.
    View in: PubMed
  9. Quan J, Lakhanpal A, Reddy MM, Zaman S, Li QZ, German DC, Olsen NJ, Kodadek T, Karp DR. Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates. J Immunol Methods. 2014 Jan 15; 402(1-2):23-34.
    View in: PubMed
  10. Benko AL, Olsen NJ, Kovacs WJ. Glucocorticoid inhibition of activation-induced cytidine deaminase expression in human B lymphocytes. Mol Cell Endocrinol. 2014 Feb 15; 382(2):881-7.
    View in: PubMed
  11. Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sánchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M. Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Hum Mol Genet. 2014 Mar 15; 23(6):1656-68.
    View in: PubMed
  12. Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Vosslamber S, Verweij CL, Olsen NJ, Aune TM. Using biomarkers to predict progression from clinically isolated syndrome to multiple sclerosis. J Clin Bioinforma. 2013; 3(1):18.
    View in: PubMed
  13. Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS. SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One. 2013; 8(6):e67003.
    View in: PubMed
  14. Olsen NJ, Yousif M, Mutwally A, Cory M, Elmagboul N, Karp DR. Organ damage in high-risk patients with systemic and incomplete lupus syndromes. Rheumatol Int. 2013 Oct; 33(10):2585-90.
    View in: PubMed
  15. Olsen NJ, Schleich MA, Karp DR. Multifaceted effects of hydroxychloroquine in human disease. Semin Arthritis Rheum. 2013 Oct; 43(2):264-72.
    View in: PubMed
  16. Sakiani S, Olsen NJ, Kovacs WJ. Gonadal steroids and humoral immunity. Nat Rev Endocrinol. 2013 Jan; 9(1):56-62.
    View in: PubMed
  17. Crooke PS, Tossberg JT, Horst SN, Tauscher JL, Henderson MA, Beaulieu DB, Schwartz DA, Olsen NJ, Aune TM. Using gene expression data to identify certain gastro-intestinal diseases. J Clin Bioinforma. 2012; 2(1):20.
    View in: PubMed
  18. Benko AL, Olsen NJ, Kovacs WJ. Estrogen and telomerase in human peripheral blood mononuclear cells. Mol Cell Endocrinol. 2012 Nov 25; 364(1-2):83-8.
    View in: PubMed
  19. Olsen NJ, Li QZ, Quan J, Wang L, Mutwally A, Karp DR. Autoantibody profiling to follow evolution of lupus syndromes. Arthritis Res Ther. 2012; 14(4):R174.
    View in: PubMed
  20. Chong BF, Tseng LC, Lee T, Vasquez R, Li QZ, Zhang S, Karp DR, Olsen NJ, Mohan C. IgG and IgM autoantibody differences in discoid and systemic lupus patients. J Invest Dermatol. 2012 Dec; 132(12):2770-9.
    View in: PubMed
  21. Bellatin MF, Han M, Fallena M, Fan L, Xia D, Olsen N, Branch V, Karp D, Stastny P. Production of autoantibodies against citrullinated antigens/peptides by human B cells. J Immunol. 2012 Apr 1; 188(7):3542-50.
    View in: PubMed
  22. Graeber KE, Olsen NJ. Th17 cell cytokine secretion profile in host defense and autoimmunity. Inflamm Res. 2012 Feb; 61(2):87-96.
    View in: PubMed
  23. Spurlock CF, Tossberg JT, Fuchs HA, Olsen NJ, Aune TM. Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun; 64(6):1780-9.
    View in: PubMed
  24. Chong BF, Song J, Olsen NJ. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. Br J Dermatol. 2012 Jan; 166(1):29-35.
    View in: PubMed
  25. Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Chitnis S, Polman C, Vosslamber S, Verweij CL, Olsen NJ, Aune TM. Gene-expression signatures: biomarkers toward diagnosing multiple sclerosis. Genes Immun. 2012 Feb; 13(2):146-54.
    View in: PubMed
  26. Spurlock CF, Aune ZT, Tossberg JT, Collins PL, Aune JP, Huston JW, Crooke PS, Olsen NJ, Aune TM. Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK. Arthritis Rheum. 2011 Sep; 63(9):2606-16.
    View in: PubMed
  27. Stoll ML, Li QZ, Zhou J, Punaro M, Olsen NJ. Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. Clin Exp Rheumatol. 2011 Jul-Aug; 29(4):736-42.
    View in: PubMed
  28. Merrill JT, Wallace DJ, Petri M, Kirou KA, Yao Y, White WI, Robbie G, Levin R, Berney SM, Chindalore V, Olsen N, Richman L, Le C, Jallal B, White B. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon a monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov; 70(11):1905-13.
    View in: PubMed
  29. Tessnow AH, Olsen NJ, Kovacs WJ. Expression of humoral autoimmunity is related to androgen receptor CAG repeat length in men with systemic lupus erythematosus. J Clin Immunol. 2011 Aug; 31(4):567-73.
    View in: PubMed
  30. Li QZ, Karp DR, Quan J, Branch VK, Zhou J, Lian Y, Chong BF, Wakeland EK, Olsen NJ. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther. 2011; 13(2):R38.
    View in: PubMed
  31. Olsen NJ. Nutraceuticals for the treatment of osteoarthritis. Minerva Med. 2011 Feb; 102(1):33-40.
    View in: PubMed
  32. Kovacs WJ, Olsen NJ. Sexual dimorphism of RA manifestations: genes, hormones and behavior. Nat Rev Rheumatol. 2011 May; 7(5):307-10.
    View in: PubMed
  33. Olsen NJ, Kovacs WJ. Evidence that androgens modulate human thymic T cell output. J Investig Med. 2011 Jan; 59(1):32-5.
    View in: PubMed
  34. Olsen NJ, Branch VK, Jonnala G, Seskar M, Cooper M. Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord. 2010; 11:156.
    View in: PubMed
  35. McMahan ZH, Sailors JL, Toto R, Olsen NJ. Systemic amyloidosis presenting as chronic diarrhea in a patient with ankylosing spondylitis. J Clin Rheumatol. 2010 Jan; 16(1):22-5.
    View in: PubMed
  36. Li QZ, Zhou J, Lian Y, Zhang B, Branch VK, Carr-Johnson F, Karp DR, Mohan C, Wakeland EK, Olsen NJ. Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes. Clin Exp Immunol. 2010 Mar; 159(3):281-91.
    View in: PubMed
  37. Goldbach-Mansky R, Wilson M, Fleischmann R, Olsen N, Silverfield J, Kempf P, Kivitz A, Sherrer Y, Pucino F, Csako G, Costello R, Pham TH, Snyder C, van der Heijde D, Tao X, Wesley R, Lipsky PE. Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Ann Intern Med. 2009 Aug 18; 151(4):229-40, W49-51.
    View in: PubMed
  38. Liu Z, Sokka T, Maas K, Olsen NJ, Aune TM. Prediction of disease severity in patients with early rheumatoid arthritis by gene expression profiling. Hum Genomics Proteomics. 2009; 2009.
    View in: PubMed
  39. Thudi A, Yin S, Wandstrat AE, Li QZ, Olsen NJ. Vitamin D levels and disease status in Texas patients with systemic lupus erythematosus. Am J Med Sci. 2008 Feb; 335(2):99-104.
    View in: PubMed
  40. Fossey SC, Vnencak-Jones CL, Olsen NJ, Sriram S, Garrison G, Deng X, Crooke PS, Aune TM. Identification of molecular biomarkers for multiple sclerosis. J Mol Diagn. 2007 Apr; 9(2):197-204.
    View in: PubMed
  41. Li QZ, Zhou J, Wandstrat AE, Carr-Johnson F, Branch V, Karp DR, Mohan C, Wakeland EK, Olsen NJ. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 2007 Jan; 147(1):60-70.
    View in: PubMed
  42. Wandstrat AE, Carr-Johnson F, Branch V, Gray H, Fairhurst AM, Reimold A, Karp D, Wakeland EK, Olsen NJ. Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus. J Autoimmun. 2006 Nov; 27(3):153-60.
    View in: PubMed
  43. Liu Z, Yelverton RW, Kraft B, Tanner SB, Olsen NJ, Aune TM. Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. Clin Exp Allergy. 2005 Dec; 35(12):1581-90.
    View in: PubMed
  44. Maas K, Chen H, Shyr Y, Olsen NJ, Aune T. Shared gene expression profiles in individuals with autoimmune disease and unaffected first-degree relatives of individuals with autoimmune disease. Hum Mol Genet. 2005 May 15; 14(10):1305-14.
    View in: PubMed
  45. Maas K, Westfall M, Pietenpol J, Olsen NJ, Aune T. Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis. Arthritis Rheum. 2005 Apr; 52(4):1047-57.
    View in: PubMed
  46. Olsen N, Sokka T, Seehorn CL, Kraft B, Maas K, Moore J, Aune TM. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis. 2004 Nov; 63(11):1387-92.
    View in: PubMed
  47. Olsen NJ. Drug-induced autoimmunity. Best Pract Res Clin Rheumatol. 2004 Oct; 18(5):677-88.
    View in: PubMed
  48. Aune TM, Parker JS, Maas K, Liu Z, Olsen NJ, Moore JH. Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity. Genet Epidemiol. 2004 Sep; 27(2):162-72.
    View in: PubMed
  49. Olsen NJ, Moore JH, Aune TM. Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells. Arthritis Res Ther. 2004; 6(3):120-8.
    View in: PubMed
  50. Aune TM, Maas K, Parker J, Moore JH, Olsen NJ. Profiles of gene expression in human autoimmune disease. Cell Biochem Biophys. 2004; 40(2):81-96.
    View in: PubMed
  51. Drake WP, Byrd VM, Olsen NJ. Reactivation of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for acquired immunodeficiency syndrome. J Clin Rheumatol. 2003 Jun; 9(3):176-80.
    View in: PubMed
  52. Aune TM, Maas K, Moore JH, Olsen NJ. Gene expression profiles in human autoimmune disease. Curr Pharm Des. 2003; 9(23):1905-17.
    View in: PubMed
  53. Maas K, Chan S, Parker J, Slater A, Moore J, Olsen N, Aune TM. Cutting edge: molecular portrait of human autoimmune disease. J Immunol. 2002 Jul 1; 169(1):5-9.
    View in: PubMed
  54. Olsen NJ, Kovacs WJ. Hormones, pregnancy, and rheumatoid arthritis. J Gend Specif Med. 2002 Jul-Aug; 5(4):28-37.
    View in: PubMed
  55. Moore JH, Parker JS, Olsen NJ, Aune TM. Symbolic discriminant analysis of microarray data in autoimmune disease. Genet Epidemiol. 2002 Jun; 23(1):57-69.
    View in: PubMed
  56. Olsen NJ, Gu X, Kovacs WJ. Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development. J Clin Invest. 2001 Dec; 108(11):1697-704.
    View in: PubMed
  57. Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5211-6.
    View in: PubMed
  58. Olsen NJ, Olson G, Viselli SM, Gu X, Kovacs WJ. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology. 2001 Mar; 142(3):1278-83.
    View in: PubMed
  59. Olsen NJ, Kovacs WJ. Effects of androgens on T and B lymphocyte development. Immunol Res. 2001; 23(2-3):281-8.
    View in: PubMed
  60. Olsen NJ, Viselli SM, Fan J, Kovacs WJ. Androgens accelerate thymocyte apoptosis. Endocrinology. 1998 Feb; 139(2):748-52.
    View in: PubMed
  61. Viselli SM, Reese KR, Fan J, Kovacs WJ, Olsen NJ. Androgens alter B cell development in normal male mice. Cell Immunol. 1997 Dec 15; 182(2):99-104.
    View in: PubMed
  62. Nakazawa M, Fantappie MR, Freeman GL, Eloi-Santos S, Olsen NJ, Kovacs WJ, Secor WE, Colley DG. Schistosoma mansoni: susceptibility differences between male and female mice can be mediated by testosterone during early infection. Exp Parasitol. 1997 Mar; 85(3):233-40.
    View in: PubMed
  63. Olsen NJ, Kovacs WJ. Gonadal steroids and immunity. Endocr Rev. 1996 Aug; 17(4):369-84.
    View in: PubMed
  64. Olsen NJ, Kovacs WJ. Case report: testosterone treatment of systemic lupus erythematosus in a patient with Klinefelter's syndrome. Am J Med Sci. 1995 Oct; 310(4):158-60.
    View in: PubMed
  65. Viselli SM, Olsen NJ, Shults K, Steizer G, Kovacs WJ. Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes. Mol Cell Endocrinol. 1995 Mar; 109(1):19-26.
    View in: PubMed
  66. Viselli SM, Stanziale S, Shults K, Kovacs WJ, Olsen NJ. Castration alters peripheral immune function in normal male mice. Immunology. 1995 Feb; 84(2):337-42.
    View in: PubMed
  67. Olsen NJ, Viselli SM, Shults K, Stelzer G, Kovacs WJ. Induction of immature thymocyte proliferation after castration of normal male mice. Endocrinology. 1994 Jan; 134(1):107-13.
    View in: PubMed
  68. Olsen NJ, Zhou P, Ong H, Kovacs WJ. Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus. J Steroid Biochem Mol Biol. 1993 May; 45(5):327-32.
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  69. Olsen NJ, Watson MB, Henderson GS, Kovacs WJ. Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology. 1991 Nov; 129(5):2471-6.
    View in: PubMed
  70. Olsen NJ, Watson MB, Kovacs WJ. Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alterations due to other genetic factors. Immunology. 1991 May; 73(1):52-7.
    View in: PubMed
  71. Olsen NJ, Kovacs WJ. Increased thymic size and thymocyte interleukin 2 production in androgen-resistant mice. Scand J Immunol. 1989 Jun; 29(6):733-8.
    View in: PubMed
  72. Olsen NJ, Murray LM. Antiproliferative effects of methotrexate on peripheral blood mononuclear cells. Arthritis Rheum. 1989 Apr; 32(4):378-85.
    View in: PubMed
  73. Kovacs WJ, Olsen NJ. Androgen receptors in human thymocytes. J Immunol. 1987 Jul 15; 139(2):490-3.
    View in: PubMed
  74. Olsen NJ, Jasin HE. Synthesis of rheumatoid factor in vitro: implications for the pathogenesis of rheumatoid arthritis. Semin Arthritis Rheum. 1985 Nov; 15(2):146-56.
    View in: PubMed
  75. Olsen N, Ziff M, Jasin HE. In vitro synthesis of immunoglobulins and IgM-rheumatoid factor by blood mononuclear cells of patients with rheumatoid arthritis. Rheumatol Int. 1982; 2(2):59-66.
    View in: PubMed
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