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Nancy Olsen

TitleProfessor Of Medicine, Chief Of Rheumatology
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Phone7175315384
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Physician, Professor of Medicine, Chief of Rheumatology

    EDUCATION:

    Fellowship, Rheumatology, University of Texas Southwestern Medical Center (Dallas) (1983)
    Residency, Internal Medicine, Medical College of Virginia/Virginia Commonwealth University (Richmond) (1980)
    M.D., University of Chicago-Pritzker School of Medicine (Illinois) (1977)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Benko AL, McAloose CA, Becker PM, Wright D, Sunyer T, Kawasawa YI, Olsen NJ, Kovacs WJ. Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids. Clin Exp Immunol. 2018 Apr; 192(1):68-81. PMID: 29205315.
      View in: PubMed
    2. Xiao ZX, Zheng X, Hu L, Wang J, Olsen N, Zheng SG. Immunosuppressive Effect of B7-H4 Pathway in a Murine Systemic Lupus Erythematosus Model. Front Immunol. 2017; 8:1765. PMID: 29321778.
      View in: PubMed
    3. Aberle T, Bourn RL, Munroe ME, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, Liles M, Merrill JT, Harley JB, Olsen NJ, Karp DR, James JA. Clinical and Serologic Features in Patients With Incomplete Lupus Classification Versus Systemic Lupus Erythematosus Patients and Controls. Arthritis Care Res (Hoboken). 2017 Dec; 69(12):1780-1788. PMID: 28118528.
      View in: PubMed
    4. Zhang W, Zhou L, Dang J, Zhang X, Wang J, Chen Y, Liang J, Li D, Ma J, Yuan J, Chen W, Zadeh HH, Olsen N, Zheng SG. Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets. Sci Rep. 2017 Nov 10; 7(1):15249. PMID: 29127315.
      View in: PubMed
    5. Chen W, Xu Z, Zheng Y, Wang J, Qian W, Olsen N, Brand D, Lin J, Zheng SG. A protocol to develop T helper and Treg cells in vivo. Cell Mol Immunol. 2017 Dec; 14(12):1013-1016. PMID: 29082917.
      View in: PubMed
    6. Chen X, Su W, Wan T, Yu J, Zhu W, Tang F, Liu G, Olsen N, Liang D, Zheng SG. Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. Biochem Pharmacol. 2017 10 15; 142:111-119. PMID: 28684304.
      View in: PubMed
    7. Guan SY, Leng RX, Tao JH, Li XP, Ye DQ, Olsen N, Zheng SG, Pan HF. Hypoxia-inducible factor-1a: a promising therapeutic target for autoimmune diseases. Expert Opin Ther Targets. 2017 07; 21(7):715-723. PMID: 28553732.
      View in: PubMed
    8. Wang H, Chen W, Li D, Yin X, Zhang X, Olsen N, Zheng SG. Vitamin D and Chronic Diseases. Aging Dis. 2017 May; 8(3):346-353. PMID: 28580189.
      View in: PubMed
    9. Aune TM, Crooke PS, Patrick AE, Tossberg JT, Olsen NJ, Spurlock CF. Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants. J Autoimmun. 2017 Jul; 81:99-109. PMID: 28420548.
      View in: PubMed
    10. Thong B, Olsen NJ. Systemic lupus erythematosus diagnosis and management. Rheumatology (Oxford). 2017 Apr 01; 56(suppl_1):i3-i13. PMID: 28013206.
      View in: PubMed
    11. Aberle T, Bourn RL, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, Liles M, Merrill JT, Harley JB, Olsen NJ, Karp DR, James JA. Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus. Lupus Sci Med. 2017; 4(1):e000176. PMID: 28409015.
      View in: PubMed
    12. Huang F, Chen M, Chen W, Gu J, Yuan J, Xue Y, Dang J, Su W, Wang J, Zadeh HH, He X, Rong L, Olsen N, Zheng SG. Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39-CD73-Adenosine and IDO Signals. Front Immunol. 2017; 8:68. PMID: 28210258.
      View in: PubMed
    13. Liu Y, Pan YF, Xue YQ, Fang LK, Guo XH, Guo X, Liu M, Mo BY, Yang MR, Liu F, Wu YT, Olsen N, Zheng SG. uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis. Cell Mol Immunol. 2017 Jan 16. PMID: 28090093.
      View in: PubMed
    14. Olsen NJ, McAloose C, Carter J, Han BK, Raman I, Li QZ, Liao D. Clinical and Immunologic Profiles in Incomplete Lupus Erythematosus and Improvement with Hydroxychloroquine Treatment. Autoimmune Dis. 2016; 2016:8791629. PMID: 28116147.
      View in: PubMed
    15. June RR, Olsen NJ. Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis. Expert Opin Biol Ther. 2016 Oct; 16(10):1303-9. PMID: 27464017.
      View in: PubMed
    16. Han BK, Kuzin I, Gaughan JP, Olsen NJ, Bottaro A. Baseline CXCL10 and CXCL13 levels are predictive biomarkers for tumor necrosis factor inhibitor therapy in patients with moderate to severe rheumatoid arthritis: a pilot, prospective study. Arthritis Res Ther. 2016 Apr 22; 18:93. PMID: 27102921; PMCID: PMC4840903.
    17. Xu A, Liu Y, Chen W, Wang J, Xue Y, Huang F, Rong L, Lin J, Liu D, Yan M, Li QZ, Li B, Song J, Olsen N, Zheng SG. TGF-ß-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol. 2016 05 01; 196(9):3631-41. PMID: 27001954; PMCID: PMC4868785 [Available on 05/01/17].
    18. Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK. Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. Elife. 2016 Feb 15; 5. PMID: 26880555; PMCID: PMC4811771.
    19. Chong BF, Tseng LC, Hosler GA, Teske NM, Zhang S, Karp DR, Olsen NJ, Mohan C. A subset of CD163+ macrophages displays mixed polarizations in discoid lupus skin. Arthritis Res Ther. 2015 Nov 13; 17:324. PMID: 26568320; PMCID: PMC4644297.
    20. Olsen NJ, Decker DA, Higgins P, Becker PM, McAloose CA, Benko AL, Kovacs WJ. Direct effects of HP Acthar Gel on human B lymphocyte activation in vitro. Arthritis Res Ther. 2015 Oct 27; 17:300. PMID: 26507974; PMCID: PMC4624189.
    21. Chen W, Cao H, Lin J, Olsen N, Zheng SG. Biomarkers for Primary Sjögren's Syndrome. Genomics Proteomics Bioinformatics. 2015 Aug; 13(4):219-23. PMID: 26362815; PMCID: PMC4610966.
    22. Han BK, Olsen NJ, Bottaro A. The CD27-CD70 pathway and pathogenesis of autoimmune disease. Semin Arthritis Rheum. 2016 Feb; 45(4):496-501. PMID: 26359318.
      View in: PubMed
    23. Zhu SL, Huang JL, Peng WX, Wu DC, Luo MQ, Li QX, Li ZX, Feng XX, Liu F, Wang MX, Chen WQ, Olsen N, Zheng SG. Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis. Cell Mol Immunol. 2017 Feb; 14(2):214-222. PMID: 26189371.
      View in: PubMed
    24. Spurlock CF, Tossberg JT, Olsen NJ, Aune TM. Cutting Edge: Chronic NF-?B Activation in CD4+ T Cells in Rheumatoid Arthritis Is Genetically Determined by HLA Risk Alleles. J Immunol. 2015 Aug 01; 195(3):791-5. PMID: 26091715; PMCID: PMC4506868.
    25. Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):E3246-54. PMID: 26060310; PMCID: PMC4485127.
    26. Su W, Wan Q, Huang J, Han L, Chen X, Chen G, Olsen N, Zheng SG, Liang D. Culture medium from TNF-a-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms. J Allergy Clin Immunol. 2015 Aug; 136(2):423-32.e8. PMID: 25652765.
      View in: PubMed
    27. Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM. Methotrexate inhibits NF-?B activity via long intergenic (noncoding) RNA-p21 induction. Arthritis Rheumatol. 2014 Nov; 66(11):2947-57. PMID: 25077978; PMCID: PMC4211976.
    28. Gu J, Lu L, Chen M, Xu L, Lan Q, Li Q, Liu Z, Chen G, Wang P, Wang X, Brand D, Olsen N, Zheng SG. TGF-ß-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells. J Immunol. 2014 Oct 01; 193(7):3388-97. PMID: 25156367; PMCID: PMC4247987.
    29. Spurlock CF, Gass HM, Bryant CJ, Wells BC, Olsen NJ, Aune TM. Methotrexate-mediated inhibition of nuclear factor ?B activation by distinct pathways in T cells and fibroblast-like synoviocytes. Rheumatology (Oxford). 2015 Jan; 54(1):178-87. PMID: 25118313; PMCID: PMC4269792.
    30. Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, Wang J, Chen M, Liu Y, Shen Y, Brand DD, Ryffel B, Horwitz DA, Quismorio FP, Liu Z, Li B, Olsen NJ, Zheng SG. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3432-40. PMID: 25099355; PMCID: PMC4143025.
    31. Olsen NJ, Elmagboul N. Neutropenia after the third cycle of etanercept: could it be due to immunogenicity? J Clin Rheumatol. 2014 Jun; 20(4):237-8. PMID: 24847756.
      View in: PubMed
    32. Olsen NJ, Benko AL, Kovacs WJ. Variation in the androgen receptor gene exon 1 CAG repeat correlates with manifestations of autoimmunity in women with lupus. Endocr Connect. 2014; 3(2):99-109. PMID: 24711544; PMCID: PMC4012646.
    33. Olsen NJ, Spurlock CF, Aune TM. Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20; 16(1):R17. PMID: 24444433; PMCID: PMC3978848.
    34. Olsen NJ, Karp DR. Autoantibodies and SLE: the threshold for disease. Nat Rev Rheumatol. 2014 03; 10(3):181-6. PMID: 24296678.
      View in: PubMed
    35. Quan J, Lakhanpal A, Reddy MM, Zaman S, Li QZ, German DC, Olsen NJ, Kodadek T, Karp DR. Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates. J Immunol Methods. 2014 Jan 15; 402(1-2):23-34. PMID: 24269750; PMCID: PMC3946867.
    36. Benko AL, Olsen NJ, Kovacs WJ. Glucocorticoid inhibition of activation-induced cytidine deaminase expression in human B lymphocytes. Mol Cell Endocrinol. 2014 Feb 15; 382(2):881-7. PMID: 24239615.
      View in: PubMed
    37. Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sánchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M. Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Hum Mol Genet. 2014 Mar 15; 23(6):1656-68. PMID: 24163247; PMCID: PMC3929085.
    38. Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Vosslamber S, Verweij CL, Olsen NJ, Aune TM. Using biomarkers to predict progression from clinically isolated syndrome to multiple sclerosis. J Clin Bioinforma. 2013 Oct 03; 3(1):18. PMID: 24088512; PMCID: PMC3850501.
    39. Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS. SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One. 2013; 8(6):e67003. PMID: 23826184; PMCID: PMC3691135.
    40. Olsen NJ, Yousif M, Mutwally A, Cory M, Elmagboul N, Karp DR. Organ damage in high-risk patients with systemic and incomplete lupus syndromes. Rheumatol Int. 2013 Oct; 33(10):2585-90. PMID: 23715694; PMCID: PMC4429789.
    41. Olsen NJ, Schleich MA, Karp DR. Multifaceted effects of hydroxychloroquine in human disease. Semin Arthritis Rheum. 2013 Oct; 43(2):264-72. PMID: 23481418.
      View in: PubMed
    42. Sakiani S, Olsen NJ, Kovacs WJ. Gonadal steroids and humoral immunity. Nat Rev Endocrinol. 2013 Jan; 9(1):56-62. PMID: 23183675.
      View in: PubMed
    43. Crooke PS, Tossberg JT, Horst SN, Tauscher JL, Henderson MA, Beaulieu DB, Schwartz DA, Olsen NJ, Aune TM. Using gene expression data to identify certain gastro-intestinal diseases. J Clin Bioinforma. 2012 Nov 21; 2(1):20. PMID: 23171526; PMCID: PMC3599448.
    44. Benko AL, Olsen NJ, Kovacs WJ. Estrogen and telomerase in human peripheral blood mononuclear cells. Mol Cell Endocrinol. 2012 Nov 25; 364(1-2):83-8. PMID: 22954679; PMCID: PMC3473148.
    45. Olsen NJ, Li QZ, Quan J, Wang L, Mutwally A, Karp DR. Autoantibody profiling to follow evolution of lupus syndromes. Arthritis Res Ther. 2012 Jul 27; 14(4):R174. PMID: 22838636; PMCID: PMC3580568.
    46. Chong BF, Tseng LC, Lee T, Vasquez R, Li QZ, Zhang S, Karp DR, Olsen NJ, Mohan C. IgG and IgM autoantibody differences in discoid and systemic lupus patients. J Invest Dermatol. 2012 Dec; 132(12):2770-9. PMID: 22763789; PMCID: PMC3465644.
    47. Wu T, Xie C, Han J, Ye Y, Weiel J, Li Q, Blanco I, Ahn C, Olsen N, Putterman C, Saxena R, Mohan C. Metabolic disturbances associated with systemic lupus erythematosus. PLoS One. 2012; 7(6):e37210. PMID: 22723834; PMCID: PMC3378560.
    48. Bellatin MF, Han M, Fallena M, Fan L, Xia D, Olsen N, Branch V, Karp D, Stastny P. Production of autoantibodies against citrullinated antigens/peptides by human B cells. J Immunol. 2012 Apr 01; 188(7):3542-50. PMID: 22345652.
      View in: PubMed
    49. Stoll ML, Patel AS, Christadoss ML, Punaro M, Olsen NJ. IgA transglutaminase levels in children with Juvenile Idiopathic Arthritis. Ann Paediatr Rheumatol. 2012; 1(1):31-35. PMID: 23750324.
      View in: PubMed
    50. Graeber KE, Olsen NJ. Th17 cell cytokine secretion profile in host defense and autoimmunity. Inflamm Res. 2012 Feb; 61(2):87-96. PMID: 22197935.
      View in: PubMed
    51. Spurlock CF, Tossberg JT, Fuchs HA, Olsen NJ, Aune TM. Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun; 64(6):1780-9. PMID: 22183962; PMCID: PMC3310965.
    52. Chong BF, Song J, Olsen NJ. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. Br J Dermatol. 2012 Jan; 166(1):29-35. PMID: 21910708.
      View in: PubMed
    53. Olsen NJ. Scleroderma: the need for extreme remedies. Am J Med Sci. 2011 Nov; 342(5):416-21. PMID: 21233696.
      View in: PubMed
    54. Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Chitnis S, Polman C, Vosslamber S, Verweij CL, Olsen NJ, Aune TM. Gene-expression signatures: biomarkers toward diagnosing multiple sclerosis. Genes Immun. 2012 Feb; 13(2):146-54. PMID: 21938015; PMCID: PMC3291793.
    55. Spurlock CF, Aune ZT, Tossberg JT, Collins PL, Aune JP, Huston JW, Crooke PS, Olsen NJ, Aune TM. Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK. Arthritis Rheum. 2011 Sep; 63(9):2606-16. PMID: 21618198; PMCID: PMC3165146.
    56. Stoll ML, Li QZ, Zhou J, Punaro M, Olsen NJ. Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. Clin Exp Rheumatol. 2011 Jul-Aug; 29(4):736-42. PMID: 21813070; PMCID: PMC3171611.
    57. Merrill JT, Wallace DJ, Petri M, Kirou KA, Yao Y, White WI, Robbie G, Levin R, Berney SM, Chindalore V, Olsen N, Richman L, Le C, Jallal B, White B. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon a monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis. 2011 Nov; 70(11):1905-13. PMID: 21798883.
      View in: PubMed
    58. Tessnow AH, Olsen NJ, Kovacs WJ. Expression of humoral autoimmunity is related to androgen receptor CAG repeat length in men with systemic lupus erythematosus. J Clin Immunol. 2011 Aug; 31(4):567-73. PMID: 21445561; PMCID: PMC3156391.
    59. Li QZ, Karp DR, Quan J, Branch VK, Zhou J, Lian Y, Chong BF, Wakeland EK, Olsen NJ. Risk factors for ANA positivity in healthy persons. Arthritis Res Ther. 2011 Mar 02; 13(2):R38. PMID: 21366908; PMCID: PMC3132017.
    60. Olsen NJ. Nutraceuticals for the treatment of osteoarthritis. Minerva Med. 2011 Feb; 102(1):33-40. PMID: 21317847.
      View in: PubMed
    61. Kovacs WJ, Olsen NJ. Sexual dimorphism of RA manifestations: genes, hormones and behavior. Nat Rev Rheumatol. 2011 05; 7(5):307-10. PMID: 21283144.
      View in: PubMed
    62. Olsen NJ, Kovacs WJ. Evidence that androgens modulate human thymic T cell output. J Investig Med. 2011 Jan; 59(1):32-5. PMID: 21218609; PMCID: PMC3077079.
    63. Olsen NJ, Branch VK, Jonnala G, Seskar M, Cooper M. Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee. BMC Musculoskelet Disord. 2010 Jul 09; 11:156. PMID: 20618964; PMCID: PMC2912794.
    64. Olsen NJ, Prather H, Li QZ, Burns DK. Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity. Neuromuscul Disord. 2010 Mar; 20(3):188-91. PMID: 20110170; PMCID: PMC2841214.
    65. McMahan ZH, Sailors JL, Toto R, Olsen NJ. Systemic amyloidosis presenting as chronic diarrhea in a patient with ankylosing spondylitis. J Clin Rheumatol. 2010 Jan; 16(1):22-5. PMID: 20051751.
      View in: PubMed
    66. Li QZ, Zhou J, Lian Y, Zhang B, Branch VK, Carr-Johnson F, Karp DR, Mohan C, Wakeland EK, Olsen NJ. Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes. Clin Exp Immunol. 2010 Mar; 159(3):281-91. PMID: 19968664; PMCID: PMC2819494.
    67. Goldbach-Mansky R, Wilson M, Fleischmann R, Olsen N, Silverfield J, Kempf P, Kivitz A, Sherrer Y, Pucino F, Csako G, Costello R, Pham TH, Snyder C, van der Heijde D, Tao X, Wesley R, Lipsky PE. Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Ann Intern Med. 2009 Aug 18; 151(4):229-40, W49-51. PMID: 19687490; PMCID: PMC2938780.
    68. Liu Z, Sokka T, Maas K, Olsen NJ, Aune TM. Prediction of disease severity in patients with early rheumatoid arthritis by gene expression profiling. Hum Genomics Proteomics. 2009 Apr 27; 2009. PMID: 20948566; PMCID: PMC2950309.
    69. Thudi A, Yin S, Wandstrat AE, Li QZ, Olsen NJ. Vitamin D levels and disease status in Texas patients with systemic lupus erythematosus. Am J Med Sci. 2008 Feb; 335(2):99-104. PMID: 18277116.
      View in: PubMed
    70. Qi J, Olsen NJ, Price RR, Winston JA, Park JH. Diffusion-weighted imaging of inflammatory myopathies: polymyositis and dermatomyositis. J Magn Reson Imaging. 2008 Jan; 27(1):212-7. PMID: 18022843.
      View in: PubMed
    71. Fossey SC, Vnencak-Jones CL, Olsen NJ, Sriram S, Garrison G, Deng X, Crooke PS, Aune TM. Identification of molecular biomarkers for multiple sclerosis. J Mol Diagn. 2007 Apr; 9(2):197-204. PMID: 17384211; PMCID: PMC1867435.
    72. Li QZ, Zhou J, Wandstrat AE, Carr-Johnson F, Branch V, Karp DR, Mohan C, Wakeland EK, Olsen NJ. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 2007 Jan; 147(1):60-70. PMID: 17177964; PMCID: PMC1810453.
    73. Wandstrat AE, Carr-Johnson F, Branch V, Gray H, Fairhurst AM, Reimold A, Karp D, Wakeland EK, Olsen NJ. Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus. J Autoimmun. 2006 Nov; 27(3):153-60. PMID: 17052888.
      View in: PubMed
    74. Stanic AK, Stein CM, Morgan AC, Fazio S, Linton MF, Wakeland EK, Olsen NJ, Major AS. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):7018-23. PMID: 16636270; PMCID: PMC1459011.
    75. Liu Z, Yelverton RW, Kraft B, Tanner SB, Olsen NJ, Aune TM. Highly conserved gene expression profiles in humans with allergic rhinitis altered by immunotherapy. Clin Exp Allergy. 2005 Dec; 35(12):1581-90. PMID: 16393324.
      View in: PubMed
    76. Maas K, Chen H, Shyr Y, Olsen NJ, Aune T. Shared gene expression profiles in individuals with autoimmune disease and unaffected first-degree relatives of individuals with autoimmune disease. Hum Mol Genet. 2005 May 15; 14(10):1305-14. PMID: 15814587.
      View in: PubMed
    77. Maas K, Westfall M, Pietenpol J, Olsen NJ, Aune T. Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis. Arthritis Rheum. 2005 Apr; 52(4):1047-57. PMID: 15818671.
      View in: PubMed
    78. Olsen N, Sokka T, Seehorn CL, Kraft B, Maas K, Moore J, Aune TM. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis. 2004 Nov; 63(11):1387-92. PMID: 15479887; PMCID: PMC1754808.
    79. Olsen NJ. Drug-induced autoimmunity. Best Pract Res Clin Rheumatol. 2004 Oct; 18(5):677-88. PMID: 15454126.
      View in: PubMed
    80. Aune TM, Parker JS, Maas K, Liu Z, Olsen NJ, Moore JH. Co-localization of differentially expressed genes and shared susceptibility loci in human autoimmunity. Genet Epidemiol. 2004 Sep; 27(2):162-72. PMID: 15305332.
      View in: PubMed
    81. Olsen NJ, Stein CM. New drugs for rheumatoid arthritis. N Engl J Med. 2004 May 20; 350(21):2167-79. PMID: 15152062.
      View in: PubMed
    82. Olsen NJ, Moore JH, Aune TM. Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells. Arthritis Res Ther. 2004; 6(3):120-8. PMID: 15142262; PMCID: PMC416456.
    83. Aune TM, Maas K, Parker J, Moore JH, Olsen NJ. Profiles of gene expression in human autoimmune disease. Cell Biochem Biophys. 2004; 40(2):81-96. PMID: 15054216.
      View in: PubMed
    84. Asanuma Y, Oeser A, Shintani AK, Turner E, Olsen N, Fazio S, Linton MF, Raggi P, Stein CM. Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med. 2003 Dec 18; 349(25):2407-15. PMID: 14681506.
      View in: PubMed
    85. Drake WP, Byrd VM, Olsen NJ. Reactivation of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for acquired immunodeficiency syndrome. J Clin Rheumatol. 2003 Jun; 9(3):176-80. PMID: 17041454.
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    86. Kavanaugh A, Genovese M, Baughman J, Kivitz A, Bulpitt K, Olsen N, Weisman M, Matteson E, Furst D, van Vollenhoven R, Anderson J, Cohen S, Wei N, Meijerink J, Jacobs C, Mocci S. Allele and antigen-specific treatment of rheumatoid arthritis: a double blind, placebo controlled phase 1 trial. J Rheumatol. 2003 Mar; 30(3):449-54. PMID: 12610799.
      View in: PubMed
    87. Aune TM, Maas K, Moore JH, Olsen NJ. Gene expression profiles in human autoimmune disease. Curr Pharm Des. 2003; 9(23):1905-17. PMID: 12871194.
      View in: PubMed
    88. Brogan BL, Olsen NJ. Drug-induced rheumatic syndromes. Curr Opin Rheumatol. 2003 Jan; 15(1):76-80. PMID: 12496514.
      View in: PubMed
    89. Maas K, Chan S, Parker J, Slater A, Moore J, Olsen N, Aune TM. Cutting edge: molecular portrait of human autoimmune disease. J Immunol. 2002 Jul 01; 169(1):5-9. PMID: 12077221.
      View in: PubMed
    90. Olsen NJ, Kovacs WJ. Hormones, pregnancy, and rheumatoid arthritis. J Gend Specif Med. 2002 Jul-Aug; 5(4):28-37. PMID: 12192884.
      View in: PubMed
    91. Moore JH, Parker JS, Olsen NJ, Aune TM. Symbolic discriminant analysis of microarray data in autoimmune disease. Genet Epidemiol. 2002 Jun; 23(1):57-69. PMID: 12112248.
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    92. Olsen NJ, Gu X, Kovacs WJ. Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development. J Clin Invest. 2001 Dec; 108(11):1697-704. PMID: 11733565; PMCID: PMC200984.
    93. Cohen S, Cannon GW, Schiff M, Weaver A, Fox R, Olsen N, Furst D, Sharp J, Moreland L, Caldwell J, Kaine J, Strand V. Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Utilization of Leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. Arthritis Rheum. 2001 Sep; 44(9):1984-92. PMID: 11592358.
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    94. Park JH, Olsen NJ. Utility of magnetic resonance imaging in the evaluation of patients with inflammatory myopathies. Curr Rheumatol Rep. 2001 Aug; 3(4):334-45. PMID: 11470053.
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    95. Olsen NJ, Park JH, King LE. Amyopathic dermatomyositis. Curr Rheumatol Rep. 2001 Aug; 3(4):346-51. PMID: 11470054.
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    96. Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5211-6. PMID: 11320253; PMCID: PMC33189.
    97. Olsen NJ, Olson G, Viselli SM, Gu X, Kovacs WJ. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology. 2001 Mar; 142(3):1278-83. PMID: 11181545.
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    98. Olsen NJ, Kovacs WJ. Effects of androgens on T and B lymphocyte development. Immunol Res. 2001; 23(2-3):281-8. PMID: 11444393.
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    99. St Clair EW, Cohen SB, Lee ML, Fleischmann RM, Lee SH, Moreland LW, Olsen NJ, Pratt PW, Yocum DE, Heck L, Winkelhake J, Holcenberg JS, Shulman MJ. Treatment of rheumatoid arthritis with a DR4/1 peptide. J Rheumatol. 2000 Aug; 27(8):1855-63. PMID: 10955324.
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    100. Park JH, Niermann KJ, Olsen N. Evidence for metabolic abnormalities in the muscles of patients with fibromyalgia. Curr Rheumatol Rep. 2000 Apr; 2(2):131-40. PMID: 11123050.
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    101. Strand V, Cohen S, Schiff M, Weaver A, Fleischmann R, Cannon G, Fox R, Moreland L, Olsen N, Furst D, Caldwell J, Kaine J, Sharp J, Hurley F, Loew-Friedrich I. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med. 1999 Nov 22; 159(21):2542-50. PMID: 10573044.
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    102. Olsen NJ, Strand V, Kremer JM. Leflunomide for the treatment of rheumatoid arthritis. Bull Rheum Dis. 1999; 48(8):1-4. PMID: 10628065.
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    103. Park JH, Kari S, King LE, Olsen NJ. Analysis of 31P MR spectroscopy data using artificial neural networks for longitudinal evaluation of muscle diseases: dermatomyositis. NMR Biomed. 1998 Jun-Aug; 11(4-5):245-56. PMID: 9719579.
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    104. Olsen NJ, Park JH. Skeletal muscle abnormalities in patients with fibromyalgia. Am J Med Sci. 1998 Jun; 315(6):351-8. PMID: 9638891.
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    105. Park JH, Phothimat P, Oates CT, Hernanz-Schulman M, Olsen NJ. Use of P-31 magnetic resonance spectroscopy to detect metabolic abnormalities in muscles of patients with fibromyalgia. Arthritis Rheum. 1998 Mar; 41(3):406-13. PMID: 9506567.
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    106. Olsen NJ, Viselli SM, Fan J, Kovacs WJ. Androgens accelerate thymocyte apoptosis. Endocrinology. 1998 Feb; 139(2):748-52. PMID: 9449649.
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    107. Park J, Bank W, Lech G, Long H, Olsen N, Chance B. Correlative magnetic resonance and near-infrared technologies for the evaluation of mitochondrial disease. Biofactors. 1998; 7(3):253-4. PMID: 9568261.
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    108. Viselli SM, Reese KR, Fan J, Kovacs WJ, Olsen NJ. Androgens alter B cell development in normal male mice. Cell Immunol. 1997 Dec 15; 182(2):99-104. PMID: 9514700.
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    109. Olsen NJ, Park JH. Inflammatory myopathies: issues in diagnosis and management. Arthritis Care Res. 1997 Jun; 10(3):200-7. PMID: 9335632.
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    110. Nakazawa M, Fantappie MR, Freeman GL, Eloi-Santos S, Olsen NJ, Kovacs WJ, Secor WE, Colley DG. Schistosoma mansoni: susceptibility differences between male and female mice can be mediated by testosterone during early infection. Exp Parasitol. 1997 Mar; 85(3):233-40. PMID: 9085920.
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    111. Olsen NJ, King LE, Park JH. Muscle abnormalities in scleroderma. Rheum Dis Clin North Am. 1996 Nov; 22(4):783-96. PMID: 8923596.
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    112. Olsen NJ, Kovacs WJ. Gonadal steroids and immunity. Endocr Rev. 1996 Aug; 17(4):369-84. PMID: 8854050.
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    113. Kari S, Olsen NJ, Park JH. Evaluation of muscle diseases using artificial neural network analysis of 31P MR spectroscopy data. Magn Reson Med. 1995 Nov; 34(5):664-72. PMID: 8544686.
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    114. Olsen NJ, Kovacs WJ. Case report: testosterone treatment of systemic lupus erythematosus in a patient with Klinefelter's syndrome. Am J Med Sci. 1995 Oct; 310(4):158-60. PMID: 7573120.
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    115. Adams LB, Park JH, Olsen NJ, Gardner ES, Hernanz-Schulman M, King LE. Quantitative evaluation of improvement in muscle weakness in a patient receiving extracorporeal photopheresis for scleroderma: magnetic resonance imaging and magnetic resonance spectroscopy. J Am Acad Dermatol. 1995 Sep; 33(3):519-22. PMID: 7657879.
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    116. Olsen NJ, Park JH. MRS and NIRS for muscle disease evaluation. Bull Rheum Dis. 1995 Aug; 44(5):4-7. PMID: 7550789.
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    117. Viselli SM, Olsen NJ, Shults K, Steizer G, Kovacs WJ. Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes. Mol Cell Endocrinol. 1995 Mar; 109(1):19-26. PMID: 7789613.
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    118. Viselli SM, Stanziale S, Shults K, Kovacs WJ, Olsen NJ. Castration alters peripheral immune function in normal male mice. Immunology. 1995 Feb; 84(2):337-42. PMID: 7751013; PMCID: PMC1415104.
    119. Park JH, Olsen NJ, King L, Vital T, Buse R, Kari S, Hernanz-Schulman M, Price RR. Use of magnetic resonance imaging and P-31 magnetic resonance spectroscopy to detect and quantify muscle dysfunction in the amyopathic and myopathic variants of dermatomyositis. Arthritis Rheum. 1995 Jan; 38(1):68-77. PMID: 7818575.
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    120. Moore S, Ruska K, Peters L, Olsen NJ. Associations of IgA and IgA-rheumatoid factor with disease features in patients with rheumatoid arthritis. Immunol Invest. 1994 Nov; 23(6-7):355-65. PMID: 7851956.
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    121. Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF. Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med. 1994 Jul 01; 180(1):341-6. PMID: 8006592; PMCID: PMC2191547.
    122. King LE, Park JH, Adams L, Vital T, Olsen NJ. Evaluation of muscles in a patient with suspected amyopathic dermatomyositis by magnetic resonance imaging and phosphorus-31-spectroscopy. J Am Acad Dermatol. 1994 Jan; 30(1):137-8. PMID: 8277018.
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    123. Olsen NJ, Viselli SM, Shults K, Stelzer G, Kovacs WJ. Induction of immature thymocyte proliferation after castration of normal male mice. Endocrinology. 1994 Jan; 134(1):107-13. PMID: 8275924.
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    124. Olsen NJ, Brooks RH, Furst D. Variability of immunologic and clinical features in patients with rheumatoid arthritis studied over 24 hours. J Rheumatol. 1993 Jun; 20(6):940-3. PMID: 8350328.
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    125. Strand V, Lipsky PE, Cannon GW, Calabrese LH, Wiesenhutter C, Cohen SB, Olsen NJ, Lee ML, Lorenz TJ, Nelson B. Effects of administration of an anti-CD5 plus immunoconjugate in rheumatoid arthritis. Results of two phase II studies. The CD5 Plus Rheumatoid Arthritis Investigators Group. Arthritis Rheum. 1993 May; 36(5):620-30. PMID: 7683881.
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    126. Olsen NJ, Zhou P, Ong H, Kovacs WJ. Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus. J Steroid Biochem Mol Biol. 1993 May; 45(5):327-32. PMID: 8499342.
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    127. Olsen NJ, Nicholson WE, DeBold CR, Orth DN. Lymphocyte-derived adrenocorticotropin is insufficient to stimulate adrenal steroidogenesis in hypophysectomized rats. Endocrinology. 1992 Apr; 130(4):2113-9. PMID: 1312443.
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    128. Olsen NJ, Watson MB, Henderson GS, Kovacs WJ. Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology. 1991 Nov; 129(5):2471-6. PMID: 1834454.
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    129. Peters LJ, Olsen NJ. Mechanisms of action of methotrexate. Bull Rheum Dis. 1991 Oct; 41(6):5-8. PMID: 1670292.
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    130. Olsen NJ, Teal GP, Brooks RH. IgM-rheumatoid factor and responses to second-line drugs in rheumatoid arthritis. Agents Actions. 1991 Sep; 34(1-2):169-71. PMID: 1793024.
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    131. Olsen NJ, Watson MB, Kovacs WJ. Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alterations due to other genetic factors. Immunology. 1991 May; 73(1):52-7. PMID: 2045127; PMCID: PMC1384517.
    132. May DG, Black CM, Olsen NJ, Csuka ME, Tanner SB, Bellino L, Porter JA, Wilkinson GR, Branch RA. Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin. Clin Pharmacol Ther. 1990 Sep; 48(3):286-95. PMID: 2401127.
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    133. Olsen NJ, Kovacs WJ. Increased thymic size and thymocyte interleukin 2 production in androgen-resistant mice. Scand J Immunol. 1989 Jun; 29(6):733-8. PMID: 2500705.
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    134. Olsen NJ, Murray LM. Antiproliferative effects of methotrexate on peripheral blood mononuclear cells. Arthritis Rheum. 1989 Apr; 32(4):378-85. PMID: 2784965.
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    135. Kovacs WJ, Olsen NJ. Androgen receptors in human thymocytes. J Immunol. 1987 Jul 15; 139(2):490-3. PMID: 3496383.
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    136. Olsen NJ, Jasin HE. Synthesis of rheumatoid factor in vitro: implications for the pathogenesis of rheumatoid arthritis. Semin Arthritis Rheum. 1985 Nov; 15(2):146-56. PMID: 2999987.
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    137. Olsen N, Ziff M, Jasin HE. In vitro synthesis of immunoglobulins and IgM-rheumatoid factor by blood mononuclear cells of patients with rheumatoid arthritis. Rheumatol Int. 1982; 2(2):59-66. PMID: 6983711.
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