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Keywords
Last Name
Institution

Neil Christensen

TitleProfessor
InstitutionCollege of Medicine
DepartmentPathology
Address500 University Drive Hershey PA 17033
Mailbox: H059
Phone7175316185

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Pathology, and Microbiology and Immunology
Associate Chief of Experimental Pathology
Medical Director, Jake Gittlen Cancer Research Foundation


GRADUATE PROGRAM AFFILIATIONS:

Integrative Biosciences, MD/PhD Degree Program, Microbiology and Immunology, Cell and Molecular Biology

EDUCATION:

Ph.D., Auckland University, Auckland, New Zealand, 1984
Postdoctoral Training, Pennsylvania State University College of Medicine, 1984-1990


NARRATIVE:

The overall research theme in Dr. Neil Christensen’s laboratory is studies on immunity and pathogenesis of papillomavirus infections. Human papillomavirus (HPV) infection causes hyperproliferative lesions in cutaneous and mucosal epithelium. A proportion of these HPV infections have been shown to progress to malignancies of the uterine cervix. The major subprojects include: 1) characterization of viral capsid neutralizing epitopes; 2) vaccine development; 3) analysis of T-cell recognition of viral epitopes on virus-infected papilloma cells; 4) papillomavirus animal model systems; 5) model systems to test for anti-viral compounds, and 6) methods to propagate human papillomaviruses. Current goals are to test both protective and prophylactic vaccines using animal models of papillomavirus infections. Our more recent studies include identification of host receptor molecules involved in papillomavirus uptake and internalization, and the development of a transgenic animal model to study the role of HLA Class I in papillomavirus immunity.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Hu J, Christensen ND. A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections. PLoS One. 2015; 10(3):e0120128.
    View in: PubMed
  2. Brendle SA, Christensen ND. HPV Binding Assay to Laminin-332/Integrin a6ß4 on Human Keratinocytes. Methods Mol Biol. 2015; 1249:53-66.
    View in: PubMed
  3. Aasi J, Abbott BP, Abbott R, Abbott T, Abernathy MR, Accadia T, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Affeldt C, Agathos M, Aggarwal N, Aguiar OD, Ain A, Ajith P, Alemic A, Allen B, Allocca A, Amariutei D, Andersen M, Anderson R, Anderson SB, Anderson WG, Arai K, Araya MC, Arceneaux C, Areeda J, Aston SM, Astone P, Aufmuth P, Aulbert C, Austin L, Aylott BE, Babak S, Baker PT, Ballardin G, Ballmer SW, Barayoga JC, Barbet M, Barish BC, Barker D, Barone F, Barr B, Barsotti L, Barsuglia M, Barton MA, Bartos I, Bassiri R, Basti A, Batch JC, Bauchrowitz J, Bauer TS, Behnke B, Bejger M, Beker MG, Belczynski C, Bell AS, Bell C, Bergmann G, Bersanetti D, Bertolini A, Betzwieser J, Beyersdorf PT, Bilenko IA, Billingsley G, Birch J, Biscans S, Bitossi M, Bizouard MA, Black E, Blackburn JK, Blackburn L, Blair D, Bloemen S, Blom M, Bock O, Bodiya TP, Boer M, Bogaert G, Bogan C, Bond C, Bondu F, Bonelli L, Bonnand R, Bork R, Born M, Boschi V, Bose S, Bosi L, Bradaschia C, Brady PR, Braginsky VB, Branchesi M, Brau JE, Briant T, Bridges DO, Brillet A, Brinkmann M, Brisson V, Brooks AF, Brown DA, Brown DD, Brückner F, Buchman S, Bulik T, Bulten HJ, Buonanno A, Burman R, Buskulic D, Buy C, Cadonati L, Cagnoli G, Bustillo JC, Calloni E, Camp JB, Campsie P, Cannon KC, Canuel B, Cao J, Capano CD, Carbognani F, Carbone L, Caride S, Castiglia A, Caudill S, Cavaglià M, Cavalier F, Cavalieri R, Celerier C, Cella G, Cepeda C, Cesarini E, Chakraborty R, Chalermsongsak T, Chamberlin SJ, Chao S, Charlton P, Chassande-Mottin E, Chen X, Chen Y, Chincarini A, Chiummo A, Cho HS, Chow J, Christensen N, Chu Q, Chua SS, Chung S, Ciani G, Clara F, Clark JA, Cleva F, Coccia E, Cohadon PF, Colla A, Collette C, Colombini M, Cominsky L, Constancio M, Conte A, Cook D, Corbitt TR, Cordier M, Cornish N, Corpuz A, Corsi A, Costa CA, Coughlin MW, Coughlin S, Coulon JP, Countryman S, Couvares P, Coward DM, Cowart M, Coyne DC, Coyne R, Craig K, Creighton JD, Crowder SG, Cumming A, Cunningham L, Cuoco E, Dahl K, Canton TD, Damjanic M, Danilishin SL, D'Antonio S, Danzmann K, Dattilo V, Daveloza H, Davier M, Davies GS, Daw EJ, Day R, Dayanga T, Debreczeni G, Degallaix J, Deléglise S, Del Pozzo W, Denker T, Dent T, Dereli H, Dergachev V, De Rosa R, DeRosa RT, DeSalvo R, Dhurandhar S, Díaz M, Di Fiore L, Di Lieto A, Di Palma I, Di Virgilio A, Donath A, Donovan F, Dooley KL, Doravari S, Dossa S, Douglas R, Downes TP, Drago M, Drever RW, Driggers JC, Du Z, Dwyer S, Eberle T, Edo T, Edwards M, Effler A, Eggenstein H, Ehrens P, Eichholz J, Eikenberry SS, Endroczi G, Essick R, Etzel T, Evans M, Evans T, Factourovich M, Fafone V, Fairhurst S, Fang Q, Farinon S, Farr B, Farr WM, Favata M, Fehrmann H, Fejer MM, Feldbaum D, Feroz F, Ferrante I, Ferrini F, Fidecaro F, Finn LS, Fiori I, Fisher RP, Flaminio R, Fournier JD, Franco S, Frasca S, Frasconi F, Frede M, Frei Z, Freise A, Frey R, Fricke TT, Fritschel P, Frolov VV, Fulda P, Fyffe M, Gair J, Gammaitoni L, Gaonkar S, Garufi F, Gehrels N, Gemme G, Genin E, Gennai A, Ghosh S, Giaime JA, Giardina KD, Giazotto A, Gill C, Gleason J, Goetz E, Goetz R, Gondan L, González G, Gordon N, Gorodetsky ML, Gossan S, Goßler S, Gouaty R, Gräf C, Graff PB, Granata M, Grant A, Gras S, Gray C, Greenhalgh RJ, Gretarsson AM, Groot P, Grote H, Grover K, Grunewald S, Guidi GM, Guido C, Gushwa K, Gustafson EK, Gustafson R, Hammer D, Hammond G, Hanke M, Hanks J, Hanna C, Hanson J, Harms J, Harry GM, Harry IW, Harstad ED, Hart M, Hartman MT, Haster CJ, Haughian K, Heidmann A, Heintze M, Heitmann H, Hello P, Hemming G, Hendry M, Heng IS, Heptonstall AW, Heurs M, Hewitson M, Hild S, Hoak D, Hodge KA, Holt K, Hooper S, Hopkins P, Hosken DJ, Hough J, Howell EJ, Hu Y, Huerta E, Hughey B, Husa S, Huttner SH, Huynh M, Huynh-Dinh T, Ingram DR, Inta R, Isogai T, Ivanov A, Iyer BR, Izumi K, Jacobson M, James E, Jang H, Jaranowski P, Ji Y, Jiménez-Forteza F, Johnson WW, Jones DI, Jones R, Jonker RJ, Ju L, K H, Kalmus P, Kalogera V, et al. Improved Upper Limits on the Stochastic Gravitational-Wave Background from 2009-2010 LIGO and Virgo Data. Phys Rev Lett. 2014 Dec 5; 113(23):231101.
    View in: PubMed
  4. Cozza EM, Cooper TK, Budgeon LR, Christensen ND, Schell TD. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. Cancer Immunol Immunother. 2015 Mar; 64(3):325-36.
    View in: PubMed
  5. Lee H, Brendle SA, Bywaters SM, Guan J, Ashley RE, Yoder JD, Makhov AM, Conway JF, Christensen ND, Hafenstein S. A cryo-electron microscopy study identifies the complete h16.v5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment. J Virol. 2015 Jan 15; 89(2):1428-38.
    View in: PubMed
  6. Temple RM, Zhu J, Budgeon L, Christensen ND, Meyers C, Sample CE. Efficient replication of Epstein-Barr virus in stratified epithelium in vitro. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16544-9.
    View in: PubMed
  7. Aasi J, Abbott BP, Abbott R, Abbott T, Abernathy MR, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Affeldt C, Agathos M, Aggarwal N, Aguiar OD, Ajith P, Alemic A, Allen B, Allocca A, Amariutei D, Andersen M, Anderson RA, Anderson SB, Anderson WG, Arai K, Araya MC, Arceneaux C, Areeda JS, Ast S, Aston SM, Astone P, Aufmuth P, Augustus H, Aulbert C, Aylott BE, Babak S, Baker PT, Ballardin G, Ballmer SW, Barayoga JC, Barbet M, Barish BC, Barker D, Barone F, Barr B, Barsotti L, Barsuglia M, Barton MA, Bartos I, Bassiri R, Basti A, Batch JC, Bauchrowitz J, Bauer TS, Baune C, Bavigadda V, Behnke B, Bejger M, Beker MG, Belczynski C, Bell AS, Bell C, Bergmann G, Bersanetti D, Bertolini A, Betzwieser J, Bilenko IA, Billingsley G, Birch J, Biscans S, Bitossi M, Biwer C, Bizouard MA, Black E, Blackburn JK, Blackburn L, Blair D, Bloemen S, Bock O, Bodiya TP, Boer M, Bogaert G, Bogan C, Bond C, Bondu F, Bonelli L, Bonnand R, Bork R, Born M, Boschi V, Bose S, Bosi L, Bradaschia C, Brady PR, Braginsky VB, Branchesi M, Brau JE, Briant T, Bridges DO, Brillet A, Brinkmann M, Brisson V, Brooks AF, Brown DA, Brown DD, Brückner F, Buchman S, Buikema A, Bulik T, Bulten HJ, Buonanno A, Burman R, Buskulic D, Buy C, Cadonati L, Cagnoli G, Calderón Bustillo J, Calloni E, Camp JB, Campsie P, Cannon KC, Canuel B, Cao J, Capano CD, Carbognani F, Carbone L, Caride S, Castaldi G, Caudill S, Cavaglià M, Cavalier F, Cavalieri R, Celerier C, Cella G, Cepeda C, Cesarini E, Chakraborty R, Chalermsongsak T, Chamberlin SJ, Chao S, Charlton P, Chassande-Mottin E, Chen X, Chen Y, Chincarini A, Chiummo A, Cho HS, Cho M, Chow JH, Christensen N, Chu Q, Chua SS, Chung S, Ciani G, Clara F, Clark DE, Clark JA, Clayton JH, Cleva F, Coccia E, Cohadon PF, Colla A, Collette C, Colombini M, Cominsky L, Constancio M, Conte A, Cook D, Corbitt TR, Cornish N, Corsi A, Costa CA, Coughlin MW, Coulon JP, Countryman S, Couvares P, Coward DM, Cowart MJ, Coyne DC, Coyne R, Craig K, Creighton JD, Croce RP, Crowder SG, Cumming A, Cunningham L, Cuoco E, Cutler C, Dahl K, Dal Canton T, Damjanic M, Danilishin SL, D'Antonio S, Danzmann K, Dattilo V, Daveloza H, Davier M, Davies GS, Daw EJ, Day R, Dayanga T, DeBra D, Debreczeni G, Degallaix J, Deléglise S, Del Pozzo W, Denker T, Dent T, Dereli H, Dergachev V, De Rosa R, DeRosa RT, DeSalvo R, Dhurandhar S, Díaz M, Dickson J, Di Fiore L, Di Lieto A, Di Palma I, Di Virgilio A, Dolique V, Dominguez E, Donovan F, Dooley KL, Doravari S, Douglas R, Downes TP, Drago M, Drever RW, Driggers JC, Du Z, Ducrot M, Dwyer S, Eberle T, Edo T, Edwards M, Effler A, Eggenstein HB, Ehrens P, Eichholz J, Eikenberry SS, Endroczi G, Essick R, Etzel T, Evans M, Evans T, Factourovich M, Fafone V, Fairhurst S, Fan X, Fang Q, Farinon S, Farr B, Farr WM, Favata M, Fazi D, Fehrmann H, Fejer MM, Feldbaum D, Feroz F, Ferrante I, Ferreira EC, Ferrini F, Fidecaro F, Finn LS, Fiori I, Fisher RP, Flaminio R, Fournier JD, Franco S, Frasca S, Frasconi F, Frede M, Frei Z, Freise A, Frey R, Fricke TT, Fritschel P, Frolov VV, Fulda P, Fyffe M, Gair JR, Gammaitoni L, Gaonkar S, Garufi F, Gehrels N, Gemme G, Gendre B, Genin E, Gennai A, Ghosh S, Giaime JA, Giardina KD, Giazotto A, Gleason J, Goetz E, Goetz R, Gondan L, González G, Gordon N, Gorodetsky ML, Gossan S, Goßler S, Gouaty R, Gräf C, Graff PB, Granata M, Grant A, Gras S, Gray C, Greenhalgh RJ, Gretarsson AM, Groot P, Grote H, Grover K, Grunewald S, Guidi GM, Guido CJ, Gushwa K, Gustafson EK, Gustafson R, Ha J, Hall ED, Hamilton W, Hammer D, Hammond G, Hanke M, Hanks J, Hanna C, Hannam MD, Hanson J, Harms J, Harry GM, Harry IW, Harstad ED, Hart M, Hartman MT, Haster CJ, Haughian K, Heidmann A, Heintze M, Heitmann H, Hello P, Hemming G, Hendry M, Heng IS, Heptonstall AW, Heurs M, Hewitson M, Hild S, Hoak D, Hodge KA, Hofman D, Holt K, Hopkins P, Horrom T, Hoske D, Hosken DJ, Hough J, Howell EJ, Hu Y, Huerta E, Hughey B, Husa S, Huttner SH, Huynh M, Huynh-Dinh T, Idrisy A, Ingram DR, Inta R, Islas G, et al. Search for gravitational waves associated with ?-ray bursts detected by the interplanetary network. Phys Rev Lett. 2014 Jul 4; 113(1):011102.
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  8. Christensen ND, Cladel NM, Hu J, Balogh KK. Formulation of cidofovir improves the anti-papillomaviral activity of topical treatments in the CRPV/rabbit model. Antiviral Res. 2014 Aug; 108:148-55.
    View in: PubMed
  9. Ryndock EJ, Conway MJ, Alam S, Gul S, Murad S, Christensen ND, Meyers C. Roles for human papillomavirus type 16 l1 cysteine residues 161, 229, and 379 in genome encapsidation and capsid stability. PLoS One. 2014; 9(6):e99488.
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  10. Hu J, Brendle S, Balogh K, Bywaters S, Christensen N. Antibody detection in tear samples as a surrogate to monitor host immunity against papillomavirus infections in vaccinated and naturally infected hosts. J Gen Virol. 2014 Sep; 95(Pt 9):2030-7.
    View in: PubMed
  11. Berry GJ, Budgeon LR, Cooper TK, Christensen ND, Waldner H. The type 1 diabetes resistance locus B10 Idd9.3 mediates impaired B-cell lymphopoiesis and implicates microRNA-34a in diabetes protection. Eur J Immunol. 2014 Jun; 44(6):1716-27.
    View in: PubMed
  12. Kalnin K, Tibbitts T, Yan Y, Stegalkina S, Shen L, Costa V, Sabharwal R, Anderson SF, Day PM, Christensen N, Schiller JT, Jagu S, Roden RB, Almond J, Kleanthous H. Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes. Vaccine. 2014 Jun 12; 32(28):3540-7.
    View in: PubMed
  13. Aasi J, Abadie J, Abbott BP, Abbott R, Abbott T, Abernathy MR, Accadia T, Acernese F, Adams C, Adams T, Adhikari RX, Affeldt C, Agathos M, Aggarwal N, Aguiar OD, Ajith P, Allen B, Allocca A, Amador Ceron E, Amariutei D, Anderson RA, Anderson SB, Anderson WG, Arai K, Araya MC, Arceneaux C, Areeda J, Ast S, Aston SM, Astone P, Aufmuth P, Aulbert C, Austin L, Aylott BE, Babak S, Baker PT, Ballardin G, Ballmer SW, Barayoga JC, Barker D, Barnum SH, Barone F, Barr B, Barsotti L, Barsuglia M, Barton MA, Bartos I, Bassiri R, Basti A, Batch J, Bauchrowitz J, Bauer TS, Bebronne M, Behnke B, Bejger M, Beker MG, Bell AS, Bell C, Belopolski I, Bergmann G, Berliner JM, Bersanetti D, Bertolini A, Bessis D, Betzwieser J, Beyersdorf PT, Bhadbhade T, Bilenko IA, Billingsley G, Birch J, Bitossi M, Bizouard MA, Black E, Blackburn JK, Blackburn L, Blair D, Blom M, Bock O, Bodiya TP, Boer M, Bogan C, Bond C, Bondu F, Bonelli L, Bonnand R, Bork R, Born M, Boschi V, Bose S, Bosi L, Bowers J, Bradaschia C, Brady PR, Braginsky VB, Branchesi M, Brannen CA, Brau JE, Breyer J, Briant T, Bridges DO, Brillet A, Brinkmann M, Brisson V, Britzger M, Brooks AF, Brown DA, Brown DD, Brückner F, Bulik T, Bulten HJ, Buonanno A, Buskulic D, Buy C, Byer RL, Cadonati L, Cagnoli G, Calderón Bustillo J, Calloni E, Camp JB, Campsie P, Cannon KC, Canuel B, Cao J, Capano CD, Carbognani F, Carbone L, Caride S, Castiglia A, Caudill S, Cavaglià M, Cavalier F, Cavalieri R, Cella G, Cepeda C, Cesarini E, Chakraborty R, Chalermsongsak T, Chao S, Charlton P, Chassande-Mottin E, Chen X, Chen Y, Chincarini A, Chiummo A, Cho HS, Chow J, Christensen N, Chu Q, Chua SS, Chung S, Ciani G, Clara F, Clark DE, Clark JA, Cleva F, Coccia E, Cohadon PF, Colla A, Colombini M, Constancio M, Conte A, Conte R, Cook D, Corbitt TR, Cordier M, Cornish N, Corsi A, Costa CA, Coughlin MW, Coulon JP, Countryman S, Couvares P, Coward DM, Cowart M, Coyne DC, Craig K, Creighton JD, Creighton TD, Crowder SG, Cumming A, Cunningham L, Cuoco E, Dahl K, Dal Canton T, Damjanic M, Danilishin SL, D'Antonio S, Danzmann K, Dattilo V, Daudert B, Daveloza H, Davier M, Davies GS, Daw EJ, Day R, Dayanga T, De Rosa R, Debreczeni G, Degallaix J, Del Pozzo W, Deleeuw E, Deléglise S, Denker T, Dent T, Dereli H, Dergachev V, DeRosa R, DeSalvo R, Dhurandhar S, Di Fiore L, Di Lieto A, Di Palma I, Di Virgilio A, Díaz M, Dietz A, Dmitry K, Donovan F, Dooley KL, Doravari S, Drago M, Drever RW, Driggers JC, Du Z, Dumas JC, Dwyer S, Eberle T, Edwards M, Effler A, Ehrens P, Eichholz J, Eikenberry SS, Endroczi G, Essick R, Etzel T, Evans K, Evans M, Evans T, Factourovich M, Fafone V, Fairhurst S, Fang Q, Farinon S, Farr B, Farr W, Favata M, Fazi D, Fehrmann H, Feldbaum D, Ferrante I, Ferrini F, Fidecaro F, Finn LS, Fiori I, Fisher R, Flaminio R, Foley E, Foley S, Forsi E, Fotopoulos N, Fournier JD, Franco S, Frasca S, Frasconi F, Frede M, Frei M, Frei Z, Freise A, Frey R, Fricke TT, Fritschel P, Frolov VV, Fujimoto MK, Fulda P, Fyffe M, Gair J, Gammaitoni L, Garcia J, Garufi F, Gehrels N, Gemme G, Genin E, Gennai A, Gergely L, Ghosh S, Giaime JA, Giampanis S, Giardina KD, Giazotto A, Gil-Casanova S, Gill C, Gleason J, Goetz E, Goetz R, Gondan L, González G, Gordon N, Gorodetsky ML, Gossan S, Goßler S, Gouaty R, Graef C, Graff PB, Granata M, Grant A, Gras S, Gray C, Greenhalgh RJ, Gretarsson AM, Griffo C, Groot P, Grote H, Grover K, Grunewald S, Guidi GM, Guido C, Gushwa KE, Gustafson EK, Gustafson R, Hall B, Hall E, Hammer D, Hammond G, Hanke M, Hanks J, Hanna C, Hanson J, Harms J, Harry GM, Harry IW, Harstad ED, Hartman MT, Haughian K, Hayama K, Heefner J, Heidmann A, Heintze M, Heitmann H, Hello P, Hemming G, Hendry M, Heng IS, Heptonstall AW, Heurs M, Hild S, Hoak D, Hodge KA, Holt K, Holtrop M, Hong T, Hooper S, Horrom T, Hosken DJ, Hough J, Howell EJ, Hu Y, Hua Z, Huang V, Huerta EA, Hughey B, Husa S, Huttner SH, Huynh M, Huynh-Dinh T, Iafrate J, Ingram DR, Inta R, Isogai T, Ivanov A, Iyer BR, Izumi K, Jacobson M, et al. Constraints on cosmic strings from the LIGO-Virgo gravitational-wave detectors. Phys Rev Lett. 2014 Apr 4; 112(13):131101.
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  14. Brendle SA, Bywaters SM, Christensen ND. Pathogenesis of infection by human papillomavirus. Curr Probl Dermatol. 2014; 45:47-57.
    View in: PubMed
  15. Christensen ND, Budgeon LR. Vaccines and immunization against human papillomavirus. Curr Probl Dermatol. 2014; 45:252-64.
    View in: PubMed
  16. Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Hu J, Christensen ND. Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus. J Virol. 2013 Aug; 87(16):9391-5.
    View in: PubMed
  17. Kwak K, Jiang R, Jagu S, Wang JW, Wang C, Christensen ND, Roden RB. Multivalent human papillomavirus l1 DNA vaccination utilizing electroporation. PLoS One. 2013; 8(3):e60507.
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  18. Cladel NM, Budgeon LR, Hu J, Balogh KK, Christensen ND. Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus. Virology. 2013 Apr 10; 438(2):70-83.
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  19. Wexler AG, Frielle C, Berry G, Budgeon LR, Baccon J, Christensen ND, Waldner H. The innate immune adaptor MyD88 is dispensable for spontaneous autoimmune demyelination in a mouse model of multiple sclerosis. J Neuroimmunol. 2013 Feb 15; 255(1-2):60-9.
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  91. Mintz A, Gibo DM, Slagle-Webb B, Christensen ND, Debinski W. IL-13Ralpha2 is a glioma-restricted receptor for interleukin-13. Neoplasia. 2002 Sep-Oct; 4(5):388-99.
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  102. Höpfl R, Heim K, Christensen N, Zumbach K, Wieland U, Volgger B, Widschwendter A, Haimbuchner S, Müller-Holzner E, Pawlita M, Pfister H, Fritsch P. Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7. Lancet. 2000 Dec 9; 356(9246):1985-6.
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  103. Christensen ND, Pickel MD, Budgeon LR, Kreider JW. In vivo anti-papillomavirus activity of nucleoside analogues including cidofovir on CRPV-induced rabbit papillomas. Antiviral Res. 2000 Nov; 48(2):131-42.
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  104. Han R, Cladel NM, Reed CA, Peng X, Budgeon LR, Pickel M, Christensen ND. DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. J Virol. 2000 Oct; 74(20):9712-6.
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  105. Han R, Reed CA, Cladel NM, Christensen ND. Immunization of rabbits with cottontail rabbit papillomavirus E1 and E2 genes: protective immunity induced by gene gun-mediated intracutaneous delivery but not by intramuscular injection. Vaccine. 2000 Jul 1; 18(26):2937-44.
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  106. Christensen ND, Cladel NM, Reed CA, Han R. Rabbit oral papillomavirus complete genome sequence and immunity following genital infection. Virology. 2000 Apr 10; 269(2):451-61.
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  107. Petter A, Heim K, Guger M, Ciresa-Kö Nig A, Christensen N, Sarcletti M, Wieland U, Pfister H, Zangerle R, Höpfl R. Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women. J Gen Virol. 2000 Mar; 81(Pt 3):701-8.
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  108. Ludmerer SW, McClements WL, Wang XM, Ling JC, Jansen KU, Christensen ND. HPV11 mutant virus-like particles elicit immune responses that neutralize virus and delineate a novel neutralizing domain. Virology. 2000 Jan 20; 266(2):237-45.
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  109. Samant RS, Seraj MJ, Saunders MM, Sakamaki TS, Shevde LA, Harms JF, Leonard TO, Goldberg SF, Budgeon L, Meehan WJ, Winter CR, Christensen ND, Verderame MF, Donahue HJ, Welch DR. Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clin Exp Metastasis. 2000; 18(8):683-93.
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  110. Peng S, Qi Y, Christensen N, Hengst K, Kennedy L, Frazer IH, Tindle RW. Capture ElISA and in vitro cell binding assay for the detection of antibodies to human papillomavirus type 6b virus-like particles in patients with anogenital warts. Pathology. 1999 Nov; 31(4):418-22.
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  111. Han R, Cladel NM, Reed CA, Peng X, Christensen ND. Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. J Virol. 1999 Aug; 73(8):7039-43.
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  112. Han R, Reed CA, Cladel NM, Christensen ND. Intramuscular injection of plasmid DNA encoding cottontail rabbit papillomavirus E1, E2, E6 and E7 induces T cell-mediated but not humoral immune responses in rabbits. Vaccine. 1999 Mar 17; 17(11-12):1558-66.
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  113. Howett MK, Neely EB, Christensen ND, Wigdahl B, Krebs FC, Malamud D, Patrick SD, Pickel MD, Welsh PA, Reed CA, Ward MG, Budgeon LR, Kreider JW. A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses. Antimicrob Agents Chemother. 1999 Feb; 43(2):314-21.
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  114. Han R, Cladel NM, Reed CA, Christensen ND. Characterization of transformation function of cottontail rabbit papillomavirus E5 and E8 genes. Virology. 1998 Nov 25; 251(2):253-63.
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  115. Harvey SB, Cladel NM, Budgeon LR, Welsh PA, Griffith JW, Lang CM, Christensen ND. Rabbit genital tissue is susceptible to infection by rabbit oral papillomavirus: an animal model for a genital tissue-targeting papillomavirus. J Virol. 1998 Jun; 72(6):5239-44.
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  116. Christensen ND, Koltun WA, Cladel NM, Budgeon LR, Reed CA, Kreider JW, Welsh PA, Patrick SD, Yang H. Coinfection of human foreskin fragments with multiple human papillomavirus types (HPV-11, -40, and -LVX82/MM7) produces regionally separate HPV infections within the same athymic mouse xenograft. J Virol. 1997 Oct; 71(10):7337-44.
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  117. Wang Z, Christensen N, Schiller JT, Dillner J. A monoclonal antibody against intact human papillomavirus type 16 capsids blocks the serological reactivity of most human sera. J Gen Virol. 1997 Sep; 78 ( Pt 9):2209-15.
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  118. Roden RB, Armstrong A, Haderer P, Christensen ND, Hubbert NL, Lowy DR, Schiller JT, Kirnbauer R. Characterization of a human papillomavirus type 16 variant-dependent neutralizing epitope. J Virol. 1997 Aug; 71(8):6247-52.
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  119. Leiserowitz GS, Hall KS, Foster CA, Hitchcock ME, Christensen ND, Heim K, Smith LH. Detection of serologic neutralizing antibodies against HPV-11 in patients with condyloma acuminata and cervical dysplasia using an in vitro assay. Gynecol Oncol. 1997 Aug; 66(2):295-9.
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  120. Ludmerer SW, Benincasa D, Mark GE, Christensen ND. A neutralizing epitope of human papillomavirus type 11 is principally described by a continuous set of residues which overlap a distinct linear, surface-exposed epitope. J Virol. 1997 May; 71(5):3834-9.
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  121. Howett MK, Christensen ND, Kreider JW. Tissue xenografts as a model system for study of the pathogenesis of papillomaviruses. Clin Dermatol. 1997 Mar-Apr; 15(2):229-36.
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  122. Carter JJ, Koutsky LA, Wipf GC, Christensen ND, Lee SK, Kuypers J, Kiviat N, Galloway DA. The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women. J Infect Dis. 1996 Nov; 174(5):927-36.
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  123. Christensen ND, Reed CA, Cladel NM, Hall K, Leiserowitz GS. Monoclonal antibodies to HPV-6 L1 virus-like particles identify conformational and linear neutralizing epitopes on HPV-11 in addition to type-specific epitopes on HPV-6. Virology. 1996 Oct 15; 224(2):477-86.
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  124. Christensen ND, Dillner J, Eklund C, Carter JJ, Wipf GC, Reed CA, Cladel NM, Galloway DA. Surface conformational and linear epitopes on HPV-16 and HPV-18 L1 virus-like particles as defined by monoclonal antibodies. Virology. 1996 Sep 1; 223(1):174-84.
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  125. Christensen ND, Cladel NM, Reed CA, Budgeon LR, Welsh PA, Patrick SD, Kreider JW. Laboratory production of infectious stocks of rabbit oral papillomavirus. J Gen Virol. 1996 Aug; 77 ( Pt 8):1793-8.
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  126. Belnap DM, Olson NH, Cladel NM, Newcomb WW, Brown JC, Kreider JW, Christensen ND, Baker TS. Conserved features in papillomavirus and polyomavirus capsids. J Mol Biol. 1996 Jun 7; 259(2):249-63.
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  127. Roden RB, Hubbert NL, Kirnbauer R, Christensen ND, Lowy DR, Schiller JT. Assessment of the serological relatedness of genital human papillomaviruses by hemagglutination inhibition. J Virol. 1996 May; 70(5):3298-301.
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  128. Christensen ND, Reed CA, Cladel NM, Han R, Kreider JW. Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus. J Virol. 1996 Feb; 70(2):960-5.
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  129. Kreider JW, Cladel NM, Patrick SD, Welsh PA, DiAngelo SL, Bower JM, Christensen ND. High efficiency induction of papillomas in vivo using recombinant cottontail rabbit papillomavirus DNA. J Virol Methods. 1995 Oct; 55(2):233-44.
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  130. Smith LH, Foster C, Hitchcock ME, Leiserowitz GS, Hall K, Isseroff R, Christensen ND, Kreider JW. Titration of HPV-11 infectivity and antibody neutralization can be measured in vitro. J Invest Dermatol. 1995 Sep; 105(3):438-44.
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  131. Heim K, Christensen ND, Hoepfl R, Wartusch B, Pinzger G, Zeimet A, Baumgartner P, Kreider JW, Dapunt O. Serum IgG, IgM, and IgA reactivity to human papillomavirus types 11 and 6 virus-like particles in different gynecologic patient groups. J Infect Dis. 1995 Aug; 172(2):395-402.
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  132. Christensen ND, Reed CA, Cladel NM. Induction of neutralizing antibodies to papillomaviruses by anti-idiotypic antibodies. Virology. 1995 Jul 10; 210(2):292-301.
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  133. Christensen ND, Cladel NM, Reed CA. Postattachment neutralization of papillomaviruses by monoclonal and polyclonal antibodies. Virology. 1995 Feb 20; 207(1):136-42.
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  134. Heim K, Christensen ND, Höpfl R, Wartusch B, Zeimet A, Larcher C, Ruth N, Bergant A, Pirschner G, Dierich MP, et al. [Specific serologic studies with a novel authentic HPV antigen (virus-like particles) for HPV-6 antibodies in gynecologic patient samples]. Gynakol Geburtshilfliche Rundsch. 1995; 35 Suppl 1:25-31.
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  135. Christensen ND, Kirnbauer R, Schiller JT, Ghim SJ, Schlegel R, Jenson AB, Kreider JW. Human papillomavirus types 6 and 11 have antigenically distinct strongly immunogenic conformationally dependent neutralizing epitopes. Virology. 1994 Nov 15; 205(1):329-35.
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  136. Hines JF, Ghim SJ, Christensen ND, Kreider JW, Barnes WA, Schlegel R, Jenson AB. Role of conformational epitopes expressed by human papillomavirus major capsid proteins in the serologic detection of infection and prophylactic vaccination. Gynecol Oncol. 1994 Oct; 55(1):13-20.
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  137. Christensen ND, Höpfl R, DiAngelo SL, Cladel NM, Patrick SD, Welsh PA, Budgeon LR, Reed CA, Kreider JW. Assembled baculovirus-expressed human papillomavirus type 11 L1 capsid protein virus-like particles are recognized by neutralizing monoclonal antibodies and induce high titres of neutralizing antibodies. J Gen Virol. 1994 Sep; 75 ( Pt 9):2271-6.
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  138. Hines JF, Ghim SJ, Christensen ND, Kreider JW, Barnes WA, Schlegel R, Jenson AB. The expressed L1 proteins of HPV-1, HPV-6, and HPV-11 display type-specific epitopes with native conformation and reactivity with neutralizing and nonneutralizing antibodies. Pathobiology. 1994; 62(4):165-71.
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  139. Höpfl RM, Christensen ND, Angell MG, Kreider JW. Skin test to assess immunity against cottontail rabbit papillomavirus antigens in rabbits with progressing papillomas or after papilloma regression. J Invest Dermatol. 1993 Aug; 101(2):227-31.
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  140. Christensen ND, Kreider JW. Monoclonal antibody neutralization of BPV-1. Virus Res. 1993 May; 28(2):195-202.
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  141. Kreider JW, Christensen ND, Christian CB, Pickel MD. Preclinical system for evaluating topical podofilox treatment of papillomas: dose-response and duration of growth prior to treatment. J Invest Dermatol. 1992 Dec; 99(6):813-8.
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  142. Angell MG, Christensen ND, Kreider JW. An in vitro system for studying the initial stages of cottontail rabbit papillomavirus infection. J Virol Methods. 1992 Sep; 39(1-2):207-16.
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  143. Christensen ND, Kreider JW, Shah KV, Rando RF. Detection of human serum antibodies that neutralize infectious human papillomavirus type 11 virions. J Gen Virol. 1992 May; 73 ( Pt 5):1261-7.
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  144. Okabayashi M, Angell MG, Christensen ND, Kreider JW. Morphometric analysis and identification of infiltrating leucocytes in regressing and progressing Shope rabbit papillomas. Int J Cancer. 1991 Dec 2; 49(6):919-23.
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  145. Christensen ND, Kreider JW. Neutralization of CRPV infectivity by monoclonal antibodies that identify conformational epitopes on intact virions. Virus Res. 1991 Nov; 21(3):169-79.
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  146. Ghim S, Christensen ND, Kreider JW, Jenson AB. Comparison of neutralization of BPV-1 infection of C127 cells and bovine fetal skin xenografts. Int J Cancer. 1991 Sep 9; 49(2):285-9.
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  147. Christensen ND, Kreider JW, Kan NC, DiAngelo SL. The open reading frame L2 of cottontail rabbit papillomavirus contains antibody-inducing neutralizing epitopes. Virology. 1991 Apr; 181(2):572-9.
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  148. Christensen ND, Kreider JW, Cladel NM, Patrick SD, Welsh PA. Monoclonal antibody-mediated neutralization of infectious human papillomavirus type 11. J Virol. 1990 Nov; 64(11):5678-81.
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  149. Christensen ND, Kreider JW. Antibody-mediated neutralization in vivo of infectious papillomaviruses. J Virol. 1990 Jul; 64(7):3151-6.
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  150. Christensen ND, Kreider JW, Cladel NM, Galloway DA. Immunological cross-reactivity to laboratory-produced HPV-11 virions of polysera raised against bacterially derived fusion proteins and synthetic peptides of HPV-6b and HPV-16 capsid proteins. Virology. 1990 Mar; 175(1):1-9.
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  151. Christensen ND, Kreider JW. Helper and suppressor functions of panned populations of immune peritoneal T cells with reactivity to the rat mammary adenocarcinoma 13762A. Cell Immunol. 1988 Mar; 112(1):200-13.
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  152. Christensen ND, Kreider JW, Horetsky RL. Suppressor lymphokine produced by rat T-cells in response to syngeneic mammary adenocarcinoma 13762A. Cancer Res. 1988 Feb 15; 48(4):943-9.
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  153. Christensen ND, Kreider JW, Bartlett GL, Horetsky RL. Distinct T-cell proliferative responses to 13762A rat mammary adenocarcinoma and derived clones. Cell Immunol. 1986 Feb; 97(2):433-45.
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  154. Kreider JW, Bartlett GL, Christensen ND, Welsh P. Systemic adoptive transfer of immunity and low-dose irradiation eradicate metastases of 13762A rat mammary adenocarcinoma. Int J Cancer. 1985 Aug 15; 36(2):217-24.
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  155. Christensen N, Skinner M, Marbrook J. The analysis of an anti-fluorescein cytotoxic response. Eur J Immunol. 1983 Sep; 13(9):701-7.
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