PSU Profiles
Keywords
Last Name
Institution

Barbara Miller

TitleProfessor
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive Hershey PA 17033
Phone7175316012

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Professor of Pediatrics

EDUCATION:

Fellowship, Pediatric Hematology/Oncology, Children's Hospital Boston (Boston) (1983)
Fellowship, Hematology, Duke University Medical Center (1980)
Residency, Pediatrics, Duke University Medical Center (1979)
M.D., Penn State Hershey College of Medicine (1976)


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA. A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2a. J Biol Chem. 2014 Dec 26; 289(52):36284-302.
    View in: PubMed
  2. Gao G, Wang W, Tadagavadi RK, Briley NE, Love MI, Miller BA, Reeves WB. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. J Clin Invest. 2014 Nov 3; 124(11):4989-5001.
    View in: PubMed
  3. Miller BA, Hoffman NE, Merali S, Zhang XQ, Wang J, Rajan S, Shanmughapriya S, Gao E, Barrero CA, Mallilankaraman K, Song J, Gu T, Hirschler-Laszkiewicz I, Koch WJ, Feldman AM, Madesh M, Cheung JY. TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury: ROLE OF MITOCHONDRIA. J Biol Chem. 2014 Mar 14; 289(11):7615-29.
    View in: PubMed
  4. Miller BA. Trpc2. Handb Exp Pharmacol. 2014; 222:53-65.
    View in: PubMed
  5. Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY. The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2013 Apr 1; 304(7):H1010-22.
    View in: PubMed
  6. Chen SJ, Zhang W, Tong Q, Conrad K, Hirschler-Laszkiewicz I, Bayerl M, Kim JK, Cheung JY, Miller BA. Role of TRPM2 in cell proliferation and susceptibility to oxidative stress. Am J Physiol Cell Physiol. 2013 Mar; 304(6):C548-60.
    View in: PubMed
  7. Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline RH, Lee E, Jun J, Ma Z, Kim F, Tsitsilianos N, Chapman K, Morrison A, Cooper MP, Miller BA, Kim JK. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Apr 1; 302(7):E807-16.
    View in: PubMed
  8. Hirschler-Laszkiewicz I, Zhang W, Keefer K, Conrad K, Tong Q, Chen SJ, Bronson S, Cheung JY, Miller BA. Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis. Exp Hematol. 2012 Jan; 40(1):71-83.
    View in: PubMed
  9. Hirschler-Laszkiewicz I, Tong Q, Waybill K, Conrad K, Keefer K, Zhang W, Chen SJ, Cheung JY, Miller BA. The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem. 2011 Sep 2; 286(35):30636-46.
    View in: PubMed
  10. Miller BA, Zhang W. TRP channels as mediators of oxidative stress. Adv Exp Med Biol. 2011; 704:531-44.
    View in: PubMed
  11. Miller BA. The Encyclopedia of Biological Chemistry, Lennarz WJ, Lane, MD (Eds). Hematopoietin Receptors. 2011.
  12. Hirschler-Laszkiewicz I, Tong Q, Conrad K, Zhang W, Flint WW, Barber AJ, Barber DL, Cheung JY, Miller BA. TRPC3 activation by erythropoietin is modulated by TRPC6. J Biol Chem. 2009 Feb 13; 284(7):4567-81.
    View in: PubMed
  13. Tong Q, Hirschler-Laszkiewicz I, Zhang W, Conrad K, Neagley DW, Barber DL, Cheung JY, Miller BA. TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells. J Biol Chem. 2008 Apr 18; 283(16):10385-95.
    View in: PubMed
  14. Zhang W, Tong Q, Conrad K, Wozney J, Cheung JY, Miller BA. Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1. Am J Physiol Cell Physiol. 2007 May; 292(5):C1746-58.
    View in: PubMed
  15. Tong Q, Zhang W, Conrad K, Mostoller K, Cheung JY, Peterson BZ, Miller BA. Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin. J Biol Chem. 2006 Apr 7; 281(14):9076-85.
    View in: PubMed
  16. Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1146-59.
    View in: PubMed
  17. Fonfria E, Marshall IC, Boyfield I, Skaper SD, Hughes JP, Owen DE, Zhang W, Miller BA, Benham CD, McNulty S. Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem. 2005 Nov; 95(3):715-23.
    View in: PubMed
  18. Chu X, Tong Q, Wozney J, Zhang W, Cheung JY, Conrad K, Mazack V, Stahl R, Barber DL, Miller BA. Identification of an N-terminal TRPC2 splice variant which inhibits calcium influx. Cell Calcium. 2005 Feb; 37(2):173-82.
    View in: PubMed
  19. Miller BA. Inhibition of TRPM2 function by PARP inhibitors protects cells from oxidative stress-induced death. Br J Pharmacol. 2004 Nov; 143(5):515-6.
    View in: PubMed
  20. Tong Q, Chu X, Cheung JY, Conrad K, Stahl R, Barber DL, Mignery G, Miller BA. Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R. Am J Physiol Cell Physiol. 2004 Dec; 287(6):C1667-78.
    View in: PubMed
  21. Miller BA, Cheung JY. The Encyclopedia of Biological Chemistry Lennarz W, Lane, MD (Eds); in Signaling, Exton, J (Ed). Hematopoietin Receptors. 2004; Vol II:348-353.
  22. Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V, Zhang W, Stahl R, Barber DL, Miller BA. Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. J Biol Chem. 2004 Mar 12; 279(11):10514-22.
    View in: PubMed
  23. Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J Biol Chem. 2003 May 2; 278(18):16222-9.
    View in: PubMed
  24. Chu X, Cheung JY, Barber DL, Birnbaumer L, Rothblum LI, Conrad K, Abrasonis V, Chan YM, Stahl R, Carey DJ, Miller BA. Erythropoietin modulates calcium influx through TRPC2. J Biol Chem. 2002 Sep 13; 277(37):34375-82.
    View in: PubMed
  25. Zhang MY, Huang NN, Clawson GA, Osmani SA, Pan W, Xin P, Razzaque MS, Miller BA. Involvement of the fungal nuclear migration gene nudC human homolog in cell proliferation and mitotic spindle formation. Exp Cell Res. 2002 Feb 1; 273(1):73-84.
    View in: PubMed
  26. Sutherland LC, Lerman M, Williams GT, Miller BA. LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cells. Oncogene. 2001 May 10; 20(21):2713-9.
    View in: PubMed
  27. Gocke CD, Osmani SA, Miller BA. The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia. Histochem Cell Biol. 2000 Oct; 114(4):293-301.
    View in: PubMed
  28. Sutherland LC, Edwards SE, Cable HC, Poirier GG, Miller BA, Cooper CS, Williams GT. LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis. Oncogene. 2000 Aug 3; 19(33):3774-81.
    View in: PubMed
  29. Miller BA, Zhang MY, Gocke CD, De Souza C, Osmani AH, Lynch C, Davies J, Bell L, Osmani SA. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Exp Hematol. 1999 Apr; 27(4):742-50.
    View in: PubMed
  30. Mathews-Roth MM, Wise RJ, Miller BA. Burst-forming units-erythroid from erythropoietic protoporphyria patients fluoresce under 405 nm light. Blood. 1996 May 15; 87(10):4480-1.
    View in: PubMed
  31. Whitfield CF, Follweiler JB, Lopresti-Morrow L, Miller BA. Deficiency of alpha-spectrin synthesis in burst-forming units-erythroid in lethal hereditary spherocytosis. Blood. 1991 Dec 1; 78(11):3043-51.
    View in: PubMed
  32. Oppenheim A, Yaari A, Rund D, Rachmilewitz EA, Nathan D, Wong C, Kazazian HH, Miller B. Intrinsic potential for high fetal hemoglobin production in a Druz family with beta-thalassemia is due to an unlinked genetic determinant. Hum Genet. 1990 Dec; 86(2):175-80.
    View in: PubMed
  33. Perrine SP, Faller DV, Swerdlow P, Miller BA, Bank A, Sytkowski AJ, Reczek J, Rudolph AM, Kan YW. Stopping the biologic clock for globin gene switching. Ann N Y Acad Sci. 1990; 612:134-40.
    View in: PubMed
  34. Gabbianelli M, Pelosi E, Bassano E, Labbaye C, Petti S, Rocca E, Tritarelli E, Miller BA, Valtieri M, Testa U, et al. Granulocyte-macrophage colony-stimulating factor reactivates fetal hemoglobin synthesis in erythroblast clones from normal adults. Blood. 1989 Dec; 74(8):2657-67.
    View in: PubMed
  35. Perrine SP, Miller BA, Morgan DA. MB-02 cells undergo fetal to adult globin gene switching in response to erythropoietin. Biochem Biophys Res Commun. 1989 Oct 31; 164(2):857-62.
    View in: PubMed
  36. Perrine SP, Miller BA, Faller DV, Cohen RA, Vichinsky EP, Hurst D, Lubin BH, Papayannopoulou T. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. Blood. 1989 Jul; 74(1):454-9.
    View in: PubMed
  37. Perrine SP, Miller BA, Papayannopoulou T, Faller DV, Rudolph AM, Vichinsky E, Hurst D, Kan YW. Butyrate analogues modulate globin gene expression in human and ovine erythroid cells. Prog Clin Biol Res. 1989; 316B:341-50.
    View in: PubMed
  38. Miller BA, Scaduto RC, Tillotson DL, Botti JJ, Cheung JY. Erythropoietin stimulates a rise in intracellular free calcium concentration in single early human erythroid precursors. J Clin Invest. 1988 Jul; 82(1):309-15.
    View in: PubMed
  39. Miller BA, Platt O, Hope S, Dover G, Nathan DG. Influence of hydroxyurea on fetal hemoglobin production in vitro. Blood. 1987 Dec; 70(6):1824-9.
    View in: PubMed
  40. Perrine SP, Miller BA, Greene MF, Cohen RA, Cook N, Shackleton C, Faller DV. Butryic acid analogues augment gamma globin gene expression in neonatal erythroid progenitors. Biochem Biophys Res Commun. 1987 Oct 29; 148(2):694-700.
    View in: PubMed
  41. Miller BA, Salameh M, Ahmed M, Olivieri N, Antognetti G, Orkin SH, Huisman TH, Nathan DG. Analysis of hemoglobin F production in Saudi Arabian families with sickle cell anemia. Blood. 1987 Sep; 70(3):716-20.
    View in: PubMed
  42. Miller BA, Perrine SP, Antognetti G, Perlmutter DH, Emerson SG, Sieff C, Faller DV. Gamma-interferon alters globin gene expression in neonatal and adult erythroid cells. Blood. 1987 Jun; 69(6):1674-81.
    View in: PubMed
  43. Miller BA, Olivieri N, Salameh M, Ahmed M, Antognetti G, Huisman TH, Nathan DG, Orkin SH. Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. N Engl J Med. 1987 Jan 29; 316(5):244-50.
    View in: PubMed
  44. Miller BA, Salameh M, Ahmed M, Olivieri N, Huisman TH, Orkin SH, Nathan DG. Analysis of high fetal hemoglobin production in sickle cell anemia patients from the Eastern Province of Saudi Arabia. Prog Clin Biol Res. 1987; 251:415-26.
    View in: PubMed
  45. Beard CJ, Key L, Newburger PE, Ezekowitz RA, Arceci R, Miller B, Proto P, Ryan T, Anast C, Simons ER. Neutrophil defect associated with malignant infantile osteopetrosis. J Lab Clin Med. 1986 Nov; 108(5):498-505.
    View in: PubMed
  46. Miller BA, Salameh M, Ahmed M, Wainscoat J, Antognetti G, Orkin S, Weatherall D, Nathan DG. High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood. 1986 May; 67(5):1404-10.
    View in: PubMed
  47. Letvin NL, Linch DC, Beardsley GP, McIntyre KW, Miller BA, Nathan DG. Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. J Clin Invest. 1985 Jun; 75(6):1999-2005.
    View in: PubMed
  48. Miller BA, Antognetti G, Springer TA. Identification of cell surface antigens present on murine hematopoietic stem cells. J Immunol. 1985 May; 134(5):3286-90.
    View in: PubMed
  49. Friedman AD, Linch DC, Miller B, Lipton JM, Javid J, Nathan DG. Determination of the hemoglobin F program in human progenitor-derived erythroid cells. J Clin Invest. 1985 Apr; 75(4):1359-68.
    View in: PubMed
  50. Miller BA, Lipton JM, Linch DC, Burakoff SJ, Nathan DG. Thy-1 is a differentiation antigen that characterizes immature murine erythroid and myeloid hematopoietic progenitors. J Cell Physiol. 1985 Apr; 123(1):25-32.
    View in: PubMed
  51. Miller BA, Weinstein HJ, Nell M, Henkle CT, Dillon PL, Tantravahi R. Sequential development of distinct clonal chromosome abnormalities in a patient with preleukaemia. Br J Haematol. 1985 Mar; 59(3):411-8.
    View in: PubMed
  52. Holmberg LA, Miller BA, Ault KA. The effect of natural killer cells on the development of syngeneic hematopoietic progenitors. J Immunol. 1984 Dec; 133(6):2933-9.
    View in: PubMed
  53. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984 Aug; 74(2):652-6.
    View in: PubMed
  54. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea increases fetal hemoglobin production in sickle cell anemia. Trans Assoc Am Physicians. 1984; 97:268-74.
    View in: PubMed
  55. Miller BA, Reid MM, Nell M, Lipton JM, Sallan SE, Nathan DG, Tantravahi R. T-cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome. Br J Haematol. 1984 Jan; 56(1):139-46.
    View in: PubMed
  56. Miller BA, Schultz Beardsley D. Autoimmune pancytopenia of childhood associated with multisystem disease manifestations. J Pediatr. 1983 Dec; 103(6):877-81.
    View in: PubMed
  57. Reid MM, Tantravahi R, Grier HE, O'Toole S, Miller BA, Lipton JM, Weinstein HJ, Nathan DG. Detection of leukemia-related karyotypes in granulocyte/macrophage colonies from a patient with acute myelomonocytic leukemia. N Engl J Med. 1983 Jun 2; 308(22):1324-8.
    View in: PubMed
  58. Miller BA, Lipton JM. Thy-1 antigen in murine hematopoietic progenitor differentiation. Prog Clin Biol Res. 1983; 134:389-97.
    View in: PubMed
  59. Sayed AK, Miller BA, Lack EE, Sallan SE, Levey RH. Heterochromia iridis and Horner's syndrome due to paravertebral neurilemmoma. J Surg Oncol. 1983 Jan; 22(1):15-6.
    View in: PubMed
  60. Miller B, Siedler D, Dunn CDR, Huang A. Blood. Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin. 1980; (60):99-107.
Miller's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_