PSU Profiles
Keywords
Last Name
Institution

Andrea Mastro

TitleProfessor of Microbiology and Cell Biology
InstitutionEberly College of Science
DepartmentBiochemistry and Molecular Biology
Address431 Frear South Lab
University Park, PA 16802
Phone8148630152
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Microbiology and Cell Biology

NARRATIVE:

Dr. Mastro's research focuses on the relationships between breast cancer and the immune system, and exercise, diet and the immune system. She studies the interaction of bone metastatic breast cancer cells with osteoblasts. Research models include cell culture, a bioreactor tissue model and animal model of disease.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Krishnan V, Vogler EA, Mastro AM. Three-Dimensional in Vitro Model to Study Osteobiology and Osteopathology. J Cell Biochem. 2015 Dec; 116(12):2715-23.
    View in: PubMed
  2. Sosnoski DM, Norgard RJ, Grove CD, Foster SJ, Mastro AM. Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment. Clin Exp Metastasis. 2015 Apr; 32(4):335-44.
    View in: PubMed
  3. Krishnan V, Vogler EA, Sosnoski DM, Mastro AM. In vitro mimics of bone remodeling and the vicious cycle of cancer in bone. J Cell Physiol. 2014 Apr; 229(4):453-62.
    View in: PubMed
  4. Chen YC, Prabhu KS, Das A, Mastro AM. Dietary selenium supplementation modifies breast tumor growth and metastasis. Int J Cancer. 2013 Nov; 133(9):2054-64.
    View in: PubMed
  5. Chen YC, Prabhu KS, Mastro AM. Is selenium a potential treatment for cancer metastasis? Nutrients. 2013 Apr; 5(4):1149-68.
    View in: PubMed
  6. Kraemer WJ, Fragala MS, van Henegouwen WR, Gordon SE, Bush JA, Volek JS, Triplett NT, Dunn-Lewis C, Comstock BA, Szivak TK, Flanagan SD, Hooper DR, Luk HY, Mastro AM. Responses of proenkephalin Peptide F to aerobic exercise stress in the plasma and white blood cell biocompartments. Peptides. 2013 Apr; 42:118-24.
    View in: PubMed
  7. Bezinover D, Kadry Z, Uemura T, Sharghi M, Mastro AM, Sosnoski DM, Dalal P, Janicki PK. Association between plasma cyclic guanosine monophosphate levels and hemodynamic instability during liver transplantation. Liver Transpl. 2013 Feb; 19(2):191-8.
    View in: PubMed
  8. Sosnoski DM, Krishnan V, Kraemer WJ, Dunn-Lewis C, Mastro AM. Changes in Cytokines of the Bone Microenvironment during Breast Cancer Metastasis. Int J Breast Cancer. 2012; 2012:160265.
    View in: PubMed
  9. Fragala MS, Kraemer WJ, Denegar CR, Maresh CM, Mastro AM, Volek JS. Neuroendocrine-immune interactions and responses to exercise. Sports Med. 2011 Aug 1; 41(8):621-39.
    View in: PubMed
  10. Krishnan V, Shuman LA, Sosnoski DM, Dhurjati R, Vogler EA, Mastro AM. Dynamic interaction between breast cancer cells and osteoblastic tissue: comparison of two- and three-dimensional cultures. J Cell Physiol. 2011 Aug; 226(8):2150-8.
    View in: PubMed
  11. Fragala MS, Kraemer WJ, Mastro AM, Denegar CR, Volek JS, Häkkinen K, Anderson JM, Lee EC, Maresh CM. Leukocyte ß2-adrenergic receptor expression in response to resistance exercise. Med Sci Sports Exerc. 2011 Aug; 43(8):1422-32.
    View in: PubMed
  12. Bodenstine TM, Beck BH, Cao X, Cook LM, Ismail A, Powers SJ, Powers JK, Mastro AM, Welch DR. Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model. Chin J Cancer. 2011 Mar; 30(3):189-96.
    View in: PubMed
  13. Bezinover D, Kadry Z, McCullough P, McQuillan PM, Uemura T, Welker K, Mastro AM, Janicki PK. Release of cytokines and hemodynamic instability during the reperfusion of a liver graft. Liver Transpl. 2011 Mar; 17(3):324-30.
    View in: PubMed
  14. Fragala MS, Kraemer WJ, Mastro AM, Denegar CR, Volek JS, Kupchak BR, Häkkinen K, Anderson JM, Maresh CM. Glucocorticoid receptor expression on human B cells in response to acute heavy resistance exercise. Neuroimmunomodulation. 2011; 18(3):156-64.
    View in: PubMed
  15. Chen YC, Sosnoski DM, Mastro AM. Breast cancer metastasis to the bone: mechanisms of bone loss. Breast Cancer Res. 2010; 12(6):215.
    View in: PubMed
  16. Bussard KM, Venzon DJ, Mastro AM. Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer. J Cell Biochem. 2010 Dec 1; 111(5):1138-48.
    View in: PubMed
  17. Bussard KM, Okita N, Sharkey N, Neuberger T, Webb A, Mastro AM. Localization of osteoblast inflammatory cytokines MCP-1 and VEGF to the matrix of the trabecula of the femur, a target area for metastatic breast cancer cell colonization. Clin Exp Metastasis. 2010 May; 27(5):331-40.
    View in: PubMed
  18. Bussard KM, Mastro AM. Ex-vivo analysis of the bone microenvironment in bone metastatic breast cancer. J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4):387-95.
    View in: PubMed
  19. Krishnan V, Dhurjati R, Vogler EA, Mastro AM. Osteogenesis in vitro: from pre-osteoblasts to osteocytes: a contribution from the Osteobiology Research Group, The Pennsylvania State University. In Vitro Cell Dev Biol Anim. 2010 Jan; 46(1):28-35.
    View in: PubMed
  20. Chen YC, Sosnoski DM, Gandhi UH, Novinger LJ, Prabhu KS, Mastro AM. Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. Carcinogenesis. 2009 Nov; 30(11):1941-8.
    View in: PubMed
  21. Mastro AM, Vogler EA. A three-dimensional osteogenic tissue model for the study of metastatic tumor cell interactions with bone. Cancer Res. 2009 May 15; 69(10):4097-100.
    View in: PubMed
  22. Welch DR, Cooper CR, Hurst DR, Lynch CC, Martin MD, Vaidya KS, VanSaun MN, Mastro AM. Metastasis Research Society-American Association For Cancer Research Joint Conference on Metastasis. Cancer Res. 2008 Dec 1; 68(23):9578-82.
    View in: PubMed
  23. Dhurjati R, Krishnan V, Shuman LA, Mastro AM, Vogler EA. Metastatic breast cancer cells colonize and degrade three-dimensional osteoblastic tissue in vitro. Clin Exp Metastasis. 2008; 25(7):741-52.
    View in: PubMed
  24. Bussard KM, Gay CV, Mastro AM. The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev. 2008 Mar; 27(1):41-55.
    View in: PubMed
  25. Kraemer WJ, Nindl BC, Volek JS, Marx JO, Gotshalk LA, Bush JA, Welsch JR, Vingren JL, Spiering BA, Fragala MS, Hatfield DL, Ho JY, Maresh CM, Mastro AM, Hymer WC. Influence of oral contraceptive use on growth hormone in vivo bioactivity following resistance exercise: responses of molecular mass variants. Growth Horm IGF Res. 2008 Jun; 18(3):238-44.
    View in: PubMed
  26. Kinder M, Chislock E, Bussard KM, Shuman L, Mastro AM. Metastatic breast cancer induces an osteoblast inflammatory response. Exp Cell Res. 2008 Jan 1; 314(1):173-83.
    View in: PubMed
  27. Tittmann BR, Miyasaka C, Mastro AM, Mercer RR. Study of cellular adhesion with scanning acoustic microscopy. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Aug; 54(8):1502-13.
    View in: PubMed
  28. Liu X, Lim JY, Donahue HJ, Dhurjati R, Mastro AM, Vogler EA. Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials. 2007 Nov; 28(31):4535-50.
    View in: PubMed
  29. Dhurjati R, Liu X, Gay CV, Mastro AM, Vogler EA. Extended-term culture of bone cells in a compartmentalized bioreactor. Tissue Eng. 2006 Nov; 12(11):3045-54.
    View in: PubMed
  30. Kraemer WJ, Nindl BC, Marx JO, Gotshalk LA, Bush JA, Welsch JR, Volek JS, Spiering BA, Maresh CM, Mastro AM, Hymer WC. Chronic resistance training in women potentiates growth hormone in vivo bioactivity: characterization of molecular mass variants. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1177-87.
    View in: PubMed
  31. Phadke PA, Mercer RR, Harms JF, Jia Y, Frost AR, Jewell JL, Bussard KM, Nelson S, Moore C, Kappes JC, Gay CV, Mastro AM, Welch DR. Kinetics of metastatic breast cancer cell trafficking in bone. Clin Cancer Res. 2006 Mar 1; 12(5):1431-40.
    View in: PubMed
  32. Bush JA, Mastro AM, Kraemer WJ. Proenkephalin peptide F immunoreactivity in different circulatory biocompartments after exercise. Peptides. 2006 Jun; 27(6):1498-506.
    View in: PubMed
  33. Molls RR, Ahluwalia N, Mastro AM, Smiciklas-Wright H, Handte GC. Nutritional status predicts primary subclasses of T cells and the lymphocyte proliferation response in healthy older women. J Nutr. 2005 Nov; 135(11):2644-50.
    View in: PubMed
  34. Hutnick NA, Williams NI, Kraemer WJ, Orsega-Smith E, Dixon RH, Bleznak AD, Mastro AM. Exercise and lymphocyte activation following chemotherapy for breast cancer. Med Sci Sports Exerc. 2005 Nov; 37(11):1827-35.
    View in: PubMed
  35. Mercer RR, Mastro AM. Cytokines secreted by bone-metastatic breast cancer cells alter the expression pattern of f-actin and reduce focal adhesion plaques in osteoblasts through PI3K. Exp Cell Res. 2005 Nov 1; 310(2):270-81.
    View in: PubMed
  36. Ahluwalia N, Sun J, Krause D, Mastro A, Handte G. Immune function is impaired in iron-deficient, homebound, older women. Am J Clin Nutr. 2004 Mar; 79(3):516-21.
    View in: PubMed
  37. Kraemer WJ, Mastro AM, Gordon SE, Koziris LP, Bush JA, Volek JS, Staron RS, French DN, Sharman MJ, Jemiolo B, Deschenes MR, Hymer WC. Responses of plasma proenkephalin peptide F in rats following 14 days of spaceflight. Aviat Space Environ Med. 2004 Feb; 75(2):114-7.
    View in: PubMed
  38. Mastro AM, Gay CV, Welch DR, Donahue HJ, Jewell J, Mercer R, DiGirolamo D, Chislock EM, Guttridge K. Breast cancer cells induce osteoblast apoptosis: a possible contributor to bone degradation. J Cell Biochem. 2004 Feb 1; 91(2):265-76.
    View in: PubMed
  39. Mercer RR, Miyasaka C, Mastro AM. Metastatic breast cancer cells suppress osteoblast adhesion and differentiation. Clin Exp Metastasis. 2004; 21(5):427-35.
    View in: PubMed
  40. Harms JF, Welch DR, Samant RS, Shevde LA, Miele ME, Babu GR, Goldberg SF, Gilman VR, Sosnowski DM, Campo DA, Gay CV, Budgeon LR, Mercer R, Jewell J, Mastro AM, Donahue HJ, Erin N, Debies MT, Meehan WJ, Jones AL, Mbalaviele G, Nickols A, Christensen ND, Melly R, Beck LN, Kent J, Rader RK, Kotyk JJ, Pagel MD, Westlin WF, Griggs DW. A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis. Clin Exp Metastasis. 2004; 21(2):119-28.
    View in: PubMed
  41. Molls RR, Ahluwalia N, Fick T, Mastro AM, Wagstaff D, Handte G, Ball R. Inter- and intra-individual variation in tests of cell-mediated immunity in young and old women. Mech Ageing Dev. 2003 May; 124(5):619-27.
    View in: PubMed
  42. Mastro AM, Gay CV, Welch DR. The skeleton as a unique environment for breast cancer cells. Clin Exp Metastasis. 2003; 20(3):275-84.
    View in: PubMed
  43. Dohi K, Kraemer WJ, Mastro AM. Exercise increases prolactin-receptor expression on human lymphocytes. J Appl Physiol (1985). 2003 Feb; 94(2):518-24.
    View in: PubMed
  44. Miles MP, Kraemer WJ, Grove DS, Leach SK, Dohi K, Bush JA, Marx JO, Nindl BC, Volek JS, Mastro AM. Effects of resistance training on resting immune parameters in women. Eur J Appl Physiol. 2002 Oct; 87(6):506-8.
    View in: PubMed
  45. Dylewski ML, Mastro AM, Picciano MF. Maternal selenium nutrition and neonatal immune system development. Biol Neonate. 2002 Aug; 82(2):122-7.
    View in: PubMed
  46. Shiels MJ, Mastro AM, Gay CV. The effect of donor age on the sensitivity of osteoblasts to the proliferative effects of TGF(beta) and 1,25(OH(2)) vitamin D(3). Life Sci. 2002 May 10; 70(25):2967-75.
    View in: PubMed
Mastro's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_