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Lisa Poritz
Title Assistant Professor
Institution College of Medicine
Department Surgery
Division Colorectal Surgery
Address 500 University Drive Hershey PA 17033
Telephone 7175315164
Email
Background
PREFERRED TITLE/ROLE:

Physician, Assistant Professor of Surgery

EDUCATION:

M.D., Northwestern University Medical School (1992)
Internship, Penn State Milton S. Hershey Medical Center
Residency, Surgery, General, Penn State Milton S. Hershey Medical Center (1999)
Fellowship, Surgery, Colon/Rectal, University of Toronto - Post Graduate Training (2000)
Publications
1. Connelly TM, Sehgal R, Berg AS, Hegarty JP, Deiling S, Stewart DB, Poritz LS, Koltun WA. Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease. Dis Colon Rectum. 2012 Nov; 55(11):1145-52.
  View in: PubMed
 
2. Rotramel A, Poritz LS, Messaris E, Berg A, Stewart DB. PPI Therapy and Albumin are Better Predictors of Recurrent Clostridium difficile Colitis than Choice of Antibiotics. J Gastrointest Surg. 2012 Dec; 16(12):2267-73.
  View in: PubMed
 
3. Lin Z, Hegarty JP, Yu W, Cappel JA, Chen X, Faber PW, Wang Y, Poritz LS, Fan JB, Koltun WA. Identification of disease-associated DNA methylation in B cells from Crohn's disease and ulcerative colitis patients. Dig Dis Sci. 2012 Dec; 57(12):3145-53.
  View in: PubMed
 
4. Yu W, Lin Z, Hegarty JP, Chen X, Kelly AA, Wang Y, Poritz LS, Koltun WA. Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1. Inflammation. 2012 Jun; 35(3):889-99.
  View in: PubMed
 
5. Sehgal R, Berg A, Polinski JI, Hegarty JP, Lin Z, McKenna KJ, Stewart DB, Poritz LS, Koltun WA. Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease. Dis Colon Rectum. 2012 Feb; 55(2):115-21.
  View in: PubMed
 
6. Messaris E, Sehgal R, Deiling S, Koltun WA, Stewart D, McKenna K, Poritz LS. Dehydration is the most common indication for readmission after diverting ileostomy creation. Dis Colon Rectum. 2012 Feb; 55(2):175-80.
  View in: PubMed
 
7. Yu W, Hegarty JP, Berg A, Kelly AA, Wang Y, Poritz LS, Franke A, Schreiber S, Koltun WA, Lin Z. PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3. Dis Markers. 2012; 32(2):83-91.
  View in: PubMed
 
8. Lin Z, Hegarty JP, Berb A, Wang Z, Kelly AA, Wang Y, Poritz LS, Wu R, Koltun WA. DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility. Swiss Med Wkly. 2011; 141:w13290.
  View in: PubMed
 
9. Poritz LS, Sehgal R, Hartnett K, Berg A, Koltun WA. Tumor volume and percent positive lymph nodes as a predictor of 5-year survival in colorectal cancer. Surgery. 2011 Oct; 150(4):649-55.
  View in: PubMed
 
10. Lin Z, John G, Hegarty JP, Berg A, Yu W, Wang Y, Kelly AA, Peterson BZ, Poritz LS, Floros J, Koltun WA. Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel disease. Ann Hum Genet. 2011 Sep; 75(5):559-68.
  View in: PubMed
 
11. Poritz LS, Harris LR, Kelly AA, Koltun WA. Increase in the tight junction protein claudin-1 in intestinal inflammation. Dig Dis Sci. 2011 Oct; 56(10):2802-9.
  View in: PubMed
 
12. John G, Hegarty JP, Yu W, Berg A, Pastor DM, Kelly AA, Wang Y, Poritz LS, Schreiber S, Koltun WA, Lin Z. NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT. Mol Genet Metab. 2011 Sep-Oct; 104(1-2):174-9.
  View in: PubMed
 
13. Yu W, Hegarty JP, Berg A, Chen X, West G, Kelly AA, Wang Y, Poritz LS, Koltun WA, Lin Z. NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PLoS One. 2011; 6(5):e20454.
  View in: PubMed
 
14. Lin Z, Hegarty JP, Lin T, Ostrov B, Wang Y, Yu W, Kelly AA, Poritz LS, Koltun WA. Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene. Inflamm Bowel Dis. 2011 Jun; 17(6):E41-2.
  View in: PubMed
 
15. Haveran LA, Sehgal R, Poritz LS, McKenna KJ, Stewart DB, Koltun WA. Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAA. Dis Colon Rectum. 2011 Jan; 54(1):15-20.
  View in: PubMed
 
16. Sehgal R, Berg A, Figueroa R, Poritz LS, McKenna KJ, Stewart DB, Koltun WA. Risk factors for surgical site infections after colorectal resection in diabetic patients. J Am Coll Surg. 2011 Jan; 212(1):29-34.
  View in: PubMed
 
17. Mukherjee A, McGarrity TJ, Ruggiero F, Koltun W, McKenna K, Poritz L, Baker MJ. The revised Bethesda guidelines: extent of utilization in a university hospital medical center with a cancer genetics program. Hered Cancer Clin Pract. 2010; 8:9.
  View in: PubMed
 
18. Sehgal R, Berg A, Hegarty JP, Kelly AA, Lin Z, Poritz LS, Koltun WA. NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis. Dis Colon Rectum. 2010 Nov; 53(11):1487-94.
  View in: PubMed
 
19. Lin Z, Hegarty JP, Cappel JA, Yu W, Chen X, Faber P, Wang Y, Kelly AA, Poritz LS, Peterson BZ, Schreiber S, Fan JB, Koltun WA. Identification of disease-associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease. Clin Genet. 2011 Jul; 80(1):59-67.
  View in: PubMed
 
20. Brown C, Poritz L, Stephen W. Canadian Association of General Surgeons, the American College of Surgeons, the Canadian Society of Colorectal Surgeons, and the American Society of Colon and Rectal Surgeons: evidence based reviews in surgery - colorectal surgery. Dis Colon Rectum. 2010 Apr; 53(4):483-5.
  View in: PubMed
 
21. Pastor DM, Irby RB, Poritz LS. Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. Dis Colon Rectum. 2010 Mar; 53(3):257-63.
  View in: PubMed
 
22. Pastor DM, Poritz LS, Olson TL, Kline CL, Harris LR, Koltun WA, Chinchilli VM, Irby RB. Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines. Int J Clin Exp Med. 2010; 3(1):69-83.
  View in: PubMed
 
23. Yu W, Lin Z, Pastor DM, Hegarty JP, Chen X, Kelly AA, Wang Y, Poritz LS, Koltun WA. Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell lines. Dig Dis Sci. 2010 Nov; 55(11):3171-80.
  View in: PubMed
 
24. Yu W, Lin Z, Hegarty JP, John G, Chen X, Faber PW, Kelly AA, Wang Y, Poritz LS, Schreiber S, Koltun WA. Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease. Mol Genet Metab. 2010 May; 100(1):88-95.
  View in: PubMed
 
25. Lin Z, Nelson L, Franke A, Poritz L, Li TY, Wu R, Wang Y, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease. J Crohns Colitis. 2010 Jun; 4(2):132-8.
  View in: PubMed
 
26. Yu W, Lin Z, Kelly AA, Hegarty JP, Poritz LS, Wang Y, Li T, Schreiber S, Koltun WA. Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease. J Crohns Colitis. 2009 Sep; 3(3):189-95.
  View in: PubMed
 
27. Pastor DM, Pauli EM, Koltun WA, Haluck RS, Shope TR, Poritz LS. Parastomal hernia repair: a single center experience. JSLS. 2009 Apr-Jun; 13(2):170-5.
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28. Lin Z, Poritz L, Franke A, Li TY, Ruether A, Byrnes KA, Wang Y, Gebhard AW, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women. Dig Dis Sci. 2010 Mar; 55(3):739-46.
  View in: PubMed
 
29. Poritz LS, Zhang WJ, Thompson J, Boyer M, Clark C, Koltun WA. Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells. J Surg Res. 2010 Aug; 162(2):290-8.
  View in: PubMed
 
30. Lin Z, Poritz L, Franke A, Li TY, Ruether A, Byrnes KA, Wang Y, Gebhard AW, MacNeill C, Thomas NJ, Wu R, Schreiber S, Koltun WA. Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men. Dis Markers. 2009; 27(5):193-201.
  View in: PubMed
 
31. Poritz LS, Lebo MA, Bobb AD, Ardell CM, Koltun WA. Management of peristomal pyoderma gangrenosum. J Am Coll Surg. 2008 Feb; 206(2):311-5.
  View in: PubMed
 
32. Wisner DM, Harris LR, Green CL, Poritz LS. Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4. J Surg Res. 2008 Jan; 144(1):1-7.
  View in: PubMed
 
33. Poritz LS, Garver KI, Green C, Fitzpatrick L, Ruggiero F, Koltun WA. Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis. J Surg Res. 2007 Jun 1; 140(1):12-9.
  View in: PubMed
 
34. Fitzpatrick LR, Small JS, Poritz LS, McKenna KJ, Koltun WA. Enhanced intestinal expression of the proteasome subunit low molecular mass polypeptide 2 in patients with inflammatory bowel disease. Dis Colon Rectum. 2007 Mar; 50(3):337-48; discussion 348-50.
  View in: PubMed
 
35. Poritz LS, Koltun WA. Percutaneous drainage and ileocolectomy for spontaneous intraabdominal abscess in Crohn's disease. J Gastrointest Surg. 2007 Feb; 11(2):204-8.
  View in: PubMed
 
36. Poritz LS. Research in academic colon and rectal surgery: keys to success. Clin Colon Rectal Surg. 2006 Aug; 19(3):148-55.
  View in: PubMed
 
37. Poritz LS. How should complex perianal Crohn's disease be treated in the Remicade era. J Gastrointest Surg. 2006 May; 10(5):633-4.
  View in: PubMed
 
38. Poritz LS, Rowe WA, Swenson BR, Hollenbeak CS, Koltun WA. Intravenous cyclosporine for the treatment of severe steroid refractory ulcerative colitis: what is the cost? Dis Colon Rectum. 2005 Sep; 48(9):1685-90.
  View in: PubMed
 
39. Swenson BR, Hollenbeak CS, Poritz LS, Koltun WA. Modified two-stage ileal pouch-anal anastomosis: equivalent outcomes with less resource utilization. Dis Colon Rectum. 2005 Feb; 48(2):256-61.
  View in: PubMed
 
40. Galka E, Thompson JL, Zhang WJ, Poritz LS, Koltun WA. Stat6(null phenotype) human lymphocytes exhibit increased apoptosis. J Surg Res. 2004 Nov; 122(1):14-20.
  View in: PubMed
 
41. Poritz LS, Gagliano GA, McLeod RS, MacRae H, Cohen Z. Surgical management of entero and colocutaneous fistulae in Crohn's disease: 17 year's experience. Int J Colorectal Dis. 2004 Sep; 19(5):481-5; discussion 486.
  View in: PubMed
 
42. Zhang WJ, Koltun WA, Thompson JL, Tilberg AF, Galka E, Poritz LS, Chorney MJ. Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma. Int J Oncol. 2004 Feb; 24(2):447-53.
  View in: PubMed
 
43. Poritz LS, Garver KI, Tilberg AF, Koltun WA. Tumor necrosis factor alpha disrupts tight junction assembly. J Surg Res. 2004 Jan; 116(1):14-8.
  View in: PubMed
 
44. Poritz LS, Koltun WA. Surgical management of ulcerative colitis in the presence of primary sclerosing cholangitis. Dis Colon Rectum. 2003 Feb; 46(2):173-8.
  View in: PubMed
 
45. Evans J, Poritz L, MacRae H. Influence of experience on laparoscopic ileocolic resection for Crohn's disease. Dis Colon Rectum. 2002 Dec; 45(12):1595-600.
  View in: PubMed
 
46. Page MJ, Poritz LS, Kunselman SJ, Koltun WA. Factors affecting surgical risk in elderly patients with inflammatory bowel disease. J Gastrointest Surg. 2002 Jul-Aug; 6(4):606-13.
  View in: PubMed
 
47. Poritz LS, Rowe WA, Koltun WA. Remicade does not abolish the need for surgery in fistulizing Crohn's disease. Dis Colon Rectum. 2002 Jun; 45(6):771-5.
  View in: PubMed
 
48. Poritz LS, Blackstein M, Berk T, Gallinger S, McLeod RS, Cohen Z. Extended follow-up of patients treated with cytotoxic chemotherapy for intra-abdominal desmoid tumors. Dis Colon Rectum. 2001 Sep; 44(9):1268-73.
  View in: PubMed
 
49. Page MJ, Poritz LS, Tilberg AF, Zhang WJ, Chorney MJ, Koltun WA. Cd1d-restricted cellular lysis by peripheral blood lymphocytes: relevance to the inflammatory bowel diseases. J Surg Res. 2000 Aug; 92(2):214-21.
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50. Poritz LS, Page MJ, Tilberg AF, Koltun WA. Amelioration of graft versus host disease with anti-ICAM-1 therapy. J Surg Res. 1998 Dec; 80(2):280-6.
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51. Koltun WA, Tilberg AF, Page MJ, Poritz LS. Bowel permeability is improved in Crohn's disease after ileocolectomy. Dis Colon Rectum. 1998 Jun; 41(6):687-90.
  View in: PubMed
 
52. Page MJ, Dreese JC, Poritz LS, Koltun WA. Cytomegalovirus enteritis: a highly lethal condition requiring early detection and intervention. Dis Colon Rectum. 1998 May; 41(5):619-23.
  View in: PubMed
 
53. Poritz LS, Page MJ, Tilberg AF, Olt G, Ruggiero FM, Koltun WA. Monoclonal antibody to lymphocyte function associated antigen-1 improves graft-versus-host disease. Dis Colon Rectum. 1998 Mar; 41(3):299-309.
  View in: PubMed
 
54. Poritz LS, Olt GJ, Ruggiero FM, Colony P, Tilberg AF, Koltun WA. Increased LFA-1 expression in intestines of rats with GVHD after small bowel transplantation. Dig Dis Sci. 1998 Feb; 43(2):221-8.
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55. Poritz LS, Tilberg AF, Koltun WA. Decreased expression of LFA-1 on peripheral blood lymphocytes in graft versus host disease. J Surg Res. 1997 May; 69(2):316-20.
  View in: PubMed
 
56. Sharma P, Page MJ, Poritz LS, Koltun WA, Chorney MJ. An increased gamma delta T cell population in the intestine of thymus-leukemia antigen transgenic mice. Cell Immunol. 1997 Mar 15; 176(2):153-7.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Crohn Disease
Inflammatory Bowel Diseases
Colitis, Ulcerative
Colectomy
Tight Junctions
See all (277) keywords
Co-Authors  
Berg, Arthur
Koltun, Walter
Lin, Zhenwu
Mckenna, Kevin
Stewart, David
See all (21) people
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