Assistant Professor of Medicine
M.D., Nanjing University School of Medicine, Nanjing, China (1997)
Ph.D., Nanjing University School of Medicine, Nanjing, China (2001)
Dr. Hu's laboratory is interested in understanding the molecular pathogenesis of chronic kidney disease (CKD) and developing therapeutic strategies to retard and/or reverse the progression of CKD.
The hallmark of CKD is renal interstitial fibrosis and inflammation, which is characterized by proliferation and activation of interstitial cells, extensive deposition of extracellular matrix (ECM) components, and the eventual destruction of normal kidney structure. Members of plasminogen activator system including tissue-type plasminogen activator (tPA) are the key regulators in the homeostasis of ECM. In addition to its protease activities, Dr. Hu's lab demonstrated that tPA is actually a cytokine promoting renal fibrosis and inflammation through its receptors-mediated activation of different cascades of intracellular signal transduction.
Dr. Hu's laboratory is currently exploring the diversified roles of plasminogen activator system and the possible signaling transduction mechanisms in the pathogenesis of CKD, and developing novel therapeutic remedies to retard or even reverse the progression of CKD.