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Kevin Staveley-O'Carroll
Title Professor
Institution College of Medicine
Department Surgery
Division Surgery Oncology
Address 500 University Drive Hershey PA 17033
Telephone 7175315965
Email
Other Positions
Title Professor
Institution College of Medicine
Department Medicine
Background
PREFERRED TITLE/ROLE:

Physician, Assoc. Professor of Surgery, and Microbiology & Immunology, Dir.; Program for Liver, Pancreas & Foregut Tumors, PSCI

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Microbiology and Immunology

EDUCATION:

Fellowship, Surgical Oncology, Johns Hopkins Hospital (Maryland) (2000)
Residency, Surgery, General, Johns Hopkins Hospital (Maryland) (1999)
M.D., University of Oklahoma College of Medicine (Oklahoma City) (1990)
Publications
1. Hamed O, Kimchi ET, Sehmbey M, Gusani NJ, Kaifi JT, Staveley-O'Carroll K. Impact of genetic targets on cancer therapy: hepatocellular cancer. Adv Exp Med Biol. 2013; 779:67-90.
  View in: PubMed
 
2. Kaifi JT, Kibbe MR, Lemaire SA, Staveley-O'Carroll KF, Kao LS, Sosa JA, Kimchi ET, Pawlik TM, Gusani NJ. Scientific impact of Association for Academic Surgery and Society of University Surgeons plenary session abstracts increases in the era of the Academic Surgical Congress from 2006 to 2010. J Surg Res. 2013 Jun 1; 182(1):6-10.
  View in: PubMed
 
3. Pauli EM, Staveley-O'Carroll KF, Brock MV, Efron DT, Efron G. A handy tool to teach segmental liver anatomy to surgical trainees. Arch Surg. 2012 Aug; 147(8):692-3.
  View in: PubMed
 
4. Clawson GA, Kimchi E, Patrick SD, Xin P, Harouaka R, Zheng S, Berg A, Schell T, Staveley-O'Carroll KF, Neves RI, Mosca PJ, Thiboutot D. Circulating tumor cells in melanoma patients. PLoS One. 2012; 7(7):e41052.
  View in: PubMed
 
5. Kaifi JT, Kavuturu S, Judelson D, Staveley-O'Carroll KF. Budd-Chiari syndrome and post-traumatic diaphragmatic hernia. J Thorac Cardiovasc Surg. 2012 Apr; 143(4):e21-2.
  View in: PubMed
 
6. Avella DM, Li G, Schell TD, Liu D, Zhang SS, Lou X, Berg A, Kimchi ET, Tagaram HR, Yang Q, Shereef S, Garcia LS, Kester M, Isom HC, Rountree CB, Staveley-O'Carroll KF. Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model. Hepatology. 2012 Jan; 55(1):141-52.
  View in: PubMed
 
7. Jiang Y, DiVittore NA, Kaiser JM, Shanmugavelandy SS, Fritz JL, Heakal Y, Tagaram HR, Cheng H, Cabot MC, Staveley-O'Carroll KF, Tran MA, Fox TE, Barth BM, Kester M. Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer. Cancer Biol Ther. 2011 Oct 1; 12(7):574-85.
  View in: PubMed
 
8. Kaifi JT, Toth JW, Gusani NJ, Kimchi ET, Staveley-O'Carroll KF, Belani CP, Reed MF. Multidisciplinary management of malignant pleural effusion. J Surg Oncol. 2012 Jun 1; 105(7):731-8.
  View in: PubMed
 
9. Avella DM, Podany A, Staveley-O'Carroll KF, Kaifi JT. Laparoscopic repair of post-esophagectomy diaphragmatic hernias using human acellular dermal matrix. Interact Cardiovasc Thorac Surg. 2011 Aug; 13(2):248-9.
  View in: PubMed
 
10. Kaifi JT, Gusani NJ, Jiang Y, Mackley HB, Dye CE, Mathew A, Kimchi ET, Reed MF, Staveley-O'Carroll KF. Multidisciplinary management of early and locally advanced esophageal cancer. J Clin Gastroenterol. 2011 May-Jun; 45(5):391-9.
  View in: PubMed
 
11. Tagaram HR, Divittore NA, Barth BM, Kaiser JM, Avella D, Kimchi ET, Jiang Y, Isom HC, Kester M, Staveley-O'Carroll KF. Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma. Gut. 2011 May; 60(5):695-701.
  View in: PubMed
 
12. Deshaies I, Cherenfant J, Gusani NJ, Jiang Y, Harvey HA, Kimchi ET, Kaifi JT, Staveley-O'Carroll KF. Gastrointestinal stromal tumor (GIST) recurrence following surgery: review of the clinical utility of imatinib treatment. Ther Clin Risk Manag. 2010; 6:453-8.
  View in: PubMed
 
13. Kaifi JT, Gusani NJ, Deshaies I, Kimchi ET, Reed MF, Mahraj RP, Staveley-O'Carroll KF. Indications and approach to surgical resection of lung metastases. J Surg Oncol. 2010 Aug 1; 102(2):187-95.
  View in: PubMed
 
14. Schubart JR, Wise J, Deshaies I, Kimchi ET, Staveley-O'Carroll KF, Gusani NJ. Quality of life assessment in postoperative patients with upper GI malignancies. J Surg Res. 2010 Sep; 163(1):40-6.
  View in: PubMed
 
15. Nikfarjam M, Kimchi ET, Gusani NJ, Staveley-O'Carroll KF. Complete surgical resection of giant mucinous hepatic cystadenomas. Am Surg. 2010 May; 76(5):E17-9.
  View in: PubMed
 
16. Avella DM, Kimchi ET, Donahue RN, Tagaram HR, McLaughlin PJ, Zagon IS, Staveley-O'Carroll KF. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. Am J Physiol Regul Integr Comp Physiol. 2010 Feb; 298(2):R459-66.
  View in: PubMed
 
17. Gusani NJ, Schubart JR, Wise J, Farace E, Green MJ, Jiang Y, Kimchi ET, Staveley-O'Carroll KF. Cancer survivorship: a new challenge for surgical and medical oncologists. J Gen Intern Med. 2009 Nov; 24 Suppl 2:S456-8.
  View in: PubMed
 
18. Kimchi ET, Nikfarjam M, Gusani NJ, Avella DM, Staveley-O'Carroll KF. Combined pancreaticoduodenectomy and extended right hemicolectomy: outcomes and indications. HPB (Oxford). 2009 Nov; 11(7):559-64.
  View in: PubMed
 
19. Avella D, Garcia LJ, Gusani NJ, Nikfarjam M, Shereef S, Kimchi ET, Staveley-O'Carroll KF. Human acellular dermal matrix: an innovative tool for diaphragmatic reconstruction in patients with large intra-abdominal tumors. Am J Surg. 2010 Jan; 199(1):e12-6.
  View in: PubMed
 
20. Jiang Y, Kimchi ET, Staveley-O'Carroll KF, Cheng H, Ajani JA. Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer. Cancer. 2009 Aug 15; 115(16):3609-17.
  View in: PubMed
 
21. Nikfarjam M, Kimchi ET, Gusani NJ, Shah SM, Sehmbey M, Shereef S, Staveley-O'Carroll KF. A reduction in delayed gastric emptying by classic pancreaticoduodenectomy with an antecolic gastrojejunal anastomosis and a retrogastric omental patch. J Gastrointest Surg. 2009 Sep; 13(9):1674-82.
  View in: PubMed
 
22. Nikfarjam M, Kimchi ET, Gusani NJ, Avella DM, Shereef S, Staveley-O'Carroll KF. Reduction of surgical site infections by use of pulsatile lavage irrigation after prolonged intra-abdominal surgical procedures. Am J Surg. 2009 Sep; 198(3):381-6.
  View in: PubMed
 
23. Cherenfant J, Nikfarjam M, Mathew A, Kimchi ET, Staveley-O'Carroll KF. Completion pancreatectomy for treatment of a Clostridium perfringens pancreatic infection. Arch Surg. 2009 Apr; 144(4):368-70.
  View in: PubMed
 
24. Nikfarjam M, Staveley-O'Carroll KF, Kimchi ET, Hardacre JM. Pancreaticoduodenectomy in patients with a history of Roux-en Y gastric bypass surgery. JOP. 2009; 10(2):169-73.
  View in: PubMed
 
25. Nikfarjam M, Sehmbey M, Kimchi ET, Gusani NJ, Shereef S, Avella DM, Staveley-O'Carroll KF. Additional organ resection combined with pancreaticoduodenectomy does not increase postoperative morbidity and mortality. J Gastrointest Surg. 2009 May; 13(5):915-21.
  View in: PubMed
 
26. Choudry HA, Nikfarjam M, Liang JJ, Kimchi ET, Conter R, Gusani NJ, Staveley-O'Carroll KF. Diagnosis and management of retroperitoneal ancient schwannomas. World J Surg Oncol. 2009; 7:12.
  View in: PubMed
 
27. Gusani NJ, Jiang Y, Kimchi ET, Staveley-O'Carroll KF, Cheng H, Ajani JA. New pharmacological developments in the treatment of hepatocellular cancer. Drugs. 2009; 69(18):2533-40.
  View in: PubMed
 
28. Nikfarjam M, Shereef S, Kimchi ET, Gusani NJ, Jiang Y, Avella DM, Mahraj RP, Staveley-O'Carroll KF. Survival outcomes of patients with colorectal liver metastases following hepatic resection or ablation in the era of effective chemotherapy. Ann Surg Oncol. 2009 Jul; 16(7):1860-7.
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29. Ryan CM, Staveley-O'Carroll K, Schell TD. Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors. J Immunother. 2008 Nov-Dec; 31(9):906-20.
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30. Garcia LJ, Avella DM, Hartman B, Kimchi E, Staveley-O'Carroll KF. Thoracoabdominal incision: a forgotten tool in the management of complex upper gastrointestinal complications. Am J Surg. 2009 Feb; 197(2):e28-31.
  View in: PubMed
 
31. Jiang Y, Ming L, Montero AJ, Kimchi E, Nikfarjam M, Staveley-O'Carroll KF. Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors. Gastrointest Cancer Res. 2008 Sep; 2(5):245-50.
  View in: PubMed
 
32. Avella D, Garcia L, Hartman B, Kimchi E, Staveley-O'Carroll K. Esophageal extension encountered during transhiatal resection of gastric or gastroesophageal tumors: attaining a negative margin. J Gastrointest Surg. 2009 Feb; 13(2):368-73.
  View in: PubMed
 
33. Nikfarjam M, Gusani NJ, Kimchi ET, Mahraj RP, Staveley-O'Carroll KF. Combined right nephrectomy and pancreaticoduodenectomy. Indications and outcomes. JOP. 2008; 9(4):449-55.
  View in: PubMed
 
34. Nikfarjam M, Staveley-O'Carroll KF, Gusani NJ, Kimchi E. Education and Imaging. Hepatobiliary and pancreatic: isolated pancreatic metastases. J Gastroenterol Hepatol. 2008 Jul; 23(7 Pt 1):1161.
  View in: PubMed
 
35. Nikfarjam M, Kimchi E, Shereef S, Gusani NJ, Jiang Y, Liang J, Sehmbey M, Staveley-O'Carroll KF. Surgical outcomes of patients with gastrointestinal stromal tumors in the era of targeted drug therapy. J Gastrointest Surg. 2008 Nov; 12(11):2023-31.
  View in: PubMed
 
36. Jiang Y, Kimchi ET, Montero AJ, Staveley-O'Carroll KF, Ajani JA. Upper gastrointestinal tumors: current status and future perspectives. Expert Rev Anticancer Ther. 2008 Jun; 8(6):975-91.
  View in: PubMed
 
37. Liang JJ, Kimchi ET, Staveley-O'Carroll KF, Tan D. Diagnostic and prognostic biomarkers in pancreatic carcinoma. Int J Clin Exp Pathol. 2009; 2(1):1-10.
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38. Tagaram HR, Watson AM, Lemonnier FA, Staveley-O'Carroll K, Tevethia SS, Schell TD. An SV40 VP1-derived epitope recognized by CD8+ T cells is naturally processed and presented by HLA-A*0201 and cross-reactive with human polyomavirus determinants. Virology. 2008 Jun 20; 376(1):183-90.
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39. Choudry H, Avella D, Garcia L, Han D, Staveley-O'Carroll K, Kimchi E. Use of the left renal vein as a practical conduit in superior mesenteric vein reconstruction. J Surg Res. 2008 May 1; 146(1):117-20.
  View in: PubMed
 
40. Jiang Y, Montero AJ, Staveley-O'Carroll KF. Adjuvant and preoperative therapy for localized gastric cancer. Gastrointest Cancer Res. 2007 Jul; 1(4):139-45.
  View in: PubMed
 
41. Fulchiero GJ, Salvaggio H, Drabick JJ, Staveley-O'Carroll K, Billingsley EM, Marks JG, Helm KF. Eruptive latent metastatic melanomas after initiation of antitumor necrosis factor therapies. J Am Acad Dermatol. 2007 May; 56(5 Suppl):S65-7.
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42. Staveley-O'Carroll K, Pan M, Meier A, Han D, McFadden D, Souba W. Developing the young academic surgeon. J Surg Res. 2005 Oct; 128(2):238-42.
  View in: PubMed
 
43. Koniaris LG, Staveley-O'Carroll KF, Zeh HJ, Perez E, Jin XL, Maley WR, Zabari G, Bartlett DL, Khanna A, Franceschi D, Schoeniger LO. Pancreaticoduodenectomy in the presence of superior mesenteric venous obstruction. J Gastrointest Surg. 2005 Sep-Oct; 9(7):915-21.
  View in: PubMed
 
44. Purow B, Staveley-O'Carroll K. Targeting of vaccinia virus using biotin-avidin viral coating and biotinylated antibodies. J Surg Res. 2005 Jan; 123(1):49-54.
  View in: PubMed
 
45. Koniaris LG, Spector SA, Staveley-O'Carroll KF. Complete esophageal diversion: a simplified, easily reversible technique. J Am Coll Surg. 2004 Dec; 199(6):991-3.
  View in: PubMed
 
46. Staveley-O'Carroll K, Pan M, Meier A, Han D, McFadden D, Souba W. Developing the young academic surgeon. J Surg Res. 2004 May 15; 118(2):109-13.
  View in: PubMed
 
47. Staveley-O'Carroll K, Schell TD, Jimenez M, Mylin LM, Tevethia MJ, Schoenberger SP, Tevethia SS. In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice. J Immunol. 2003 Jul 15; 171(2):697-707.
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48. Sotomayor EM, Borrello I, Rattis FM, Cuenca AG, Abrams J, Staveley-O'Carroll K, Levitsky HI. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood. 2001 Aug 15; 98(4):1070-7.
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49. Ewend MG, Thompson RC, Anderson R, Sills AK, Staveley-O'Carroll K, Tyler BM, Hanes J, Brat D, Thomas M, Jaffee EM, Pardoll DM, Brem H. Intracranial paracrine interleukin-2 therapy stimulates prolonged antitumor immunity that extends outside the central nervous system. J Immunother. 2000 Jul-Aug; 23(4):438-48.
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50. Hamm RM, Loemker V, Reilly KL, Johnson G, Dubois P, Staveley-O'Carroll K, Brand J, Owens T, Smith K. A clinical decision analysis of cryotherapy compared with expectant management for cervical dysplasia. J Fam Pract. 1998 Sep; 47(3):193-201.
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51. Staveley-O'Carroll K, Sotomayor E, Montgomery J, Borrello I, Hwang L, Fein S, Pardoll D, Levitsky H. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proc Natl Acad Sci U S A. 1998 Feb 3; 95(3):1178-83.
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52. Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT. The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway. J Biol Chem. 1997 Mar 28; 272(13):8671-8.
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53. Levitsky HI, Montgomery J, Ahmadzadeh M, Staveley-O'Carroll K, Guarnieri F, Longo DL, Kwak LW. Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity. J Immunol. 1996 May 15; 156(10):3858-65.
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54. Lin KY, Guarnieri FG, Staveley-O'Carroll KF, Levitsky HI, August JT, Pardoll DM, Wu TC. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Res. 1996 Jan 1; 56(1):21-6.
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55. Wu TC, Guarnieri FG, Staveley-O'Carroll KF, Viscidi RP, Levitsky HI, Hedrick L, Cho KR, August JT, Pardoll DM. Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proc Natl Acad Sci U S A. 1995 Dec 5; 92(25):11671-5.
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56. Rowell JF, Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Lin X, Tang J, August JT, Siliciano RF. Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells. J Immunol. 1995 Aug 15; 155(4):1818-28.
  View in: PubMed
 
 
Keyword
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Institution
    
 
 
 
Co-Authors  
Gusani, Niraj
Jiang, Yixing
Kaifi, Jussuf
Kimchi, Eric
Schell, Todd
See all (35) people
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