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1.
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Bergoglio V, Boyer AS, Walsh E, Naim V, Legube G, Lee MY, Rey L, Rosselli F, Cazaux C, Eckert KA, Hoffmann JS. DNA synthesis by Pol ? promotes fragile site stability by preventing under-replicated DNA in mitosis. J Cell Biol. 2013 Apr 29; 201(3):395-408.
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2.
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Baptiste BA, Ananda G, Strubczewski N, Lutzkanin A, Khoo SJ, Srikanth A, Kim N, Makova KD, Krasilnikova MM, Eckert KA. Mature microsatellites: mechanisms underlying dinucleotide microsatellite mutational biases in human cells. G3 (Bethesda). 2013 Mar; 3(3):451-63.
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3.
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Ananda G, Walsh E, Jacob KD, Krasilnikova M, Eckert KA, Chiaromonte F, Makova KD. Distinct mutational behaviors differentiate short tandem repeats from microsatellites in the human genome. Genome Biol Evol. 2013 Jan; 5(3):606-20.
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4.
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Walsh E, Wang X, Lee MY, Eckert KA. Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication. J Mol Biol. 2013 Jan 23; 425(2):232-43.
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5.
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Eckert KA, Sweasy JB. Dna polymerases and their role in genomic stability. Environ Mol Mutagen. 2012 Dec; 53(9):643-4.
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6.
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Baptiste BA, Eckert KA. DNA polymerase kappa microsatellite synthesis: Two distinct mechanisms of slippage-mediated errors. Environ Mol Mutagen. 2012 Dec; 53(9):787-96.
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7.
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Wang N, Eckert KA, Zomorrodi AR, Xin P, Pan W, Shearer DA, Weisz J, Maranus CD, Clawson GA. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS One. 2012; 7(6):e39446.
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8.
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Fungtammasan A, Walsh E, Chiaromonte F, Eckert KA, Makova KD. A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome? Genome Res. 2012 Jun; 22(6):993-1005.
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9.
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Donigan KA, Hile SE, Eckert KA, Sweasy JB. The human gastric cancer-associated DNA polymerase ß variant D160N is a mutator that induces cellular transformation. DNA Repair (Amst). 2012 Apr 1; 11(4):381-90.
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10.
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Hile SE, Wang X, Lee MY, Eckert KA. Beyond translesion synthesis: polymerase ? fidelity as a potential determinant of microsatellite stability. Nucleic Acids Res. 2012 Feb; 40(4):1636-47.
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11.
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Kelkar YD, Eckert KA, Chiaromonte F, Makova KD. A matter of life or death: how microsatellites emerge in and vanish from the human genome. Genome Res. 2011 Dec; 21(12):2038-48.
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12.
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Abdulovic AL, Hile SE, Kunkel TA, Eckert KA. The in vitro fidelity of yeast DNA polymerase d and polymerase e holoenzymes during dinucleotide microsatellite DNA synthesis. DNA Repair (Amst). 2011 May 5; 10(5):497-505.
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13.
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Damerla RR, Knickelbein KE, Kepchia D, Jackson A, Armitage BA, Eckert KA, Opresko PL. Telomeric repeat mutagenicity in human somatic cells is modulated by repeat orientation and G-quadruplex stability. DNA Repair (Amst). 2010 Nov 10; 9(11):1119-29.
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14.
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Kelkar YD, Strubczewski N, Hile SE, Chiaromonte F, Eckert KA, Makova KD. What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats. Genome Biol Evol. 2010; 2:620-35.
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15.
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Prakasha Gowda AS, Polizzi JM, Eckert KA, Spratt TE. Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. Biochemistry. 2010 Jun 15; 49(23):4833-40.
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16.
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Shah SN, Hile SE, Eckert KA. Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes. Cancer Res. 2010 Jan 15; 70(2):431-5.
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17.
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Shah SN, Opresko PL, Meng X, Lee MY, Eckert KA. DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D. Nucleic Acids Res. 2010 Mar; 38(4):1149-62.
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18.
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Duncan KJ, Eckert KA, Clawson GA. Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone. J Pharmacol Exp Ther. 2009 Jul; 330(1):359-66.
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19.
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Eckert KA, Hile SE. Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome. Mol Carcinog. 2009 Apr; 48(4):379-88.
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20.
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Shah SN, Eckert KA. Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequences. Cancer Res. 2009 Feb 1; 69(3):1143-9.
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21.
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Lin GC, Jaeger J, Eckert KA, Sweasy JB. Loop II of DNA polymerase beta is important for discrimination during substrate binding. DNA Repair (Amst). 2009 Feb 1; 8(2):182-9.
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22.
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Hile SE, Eckert KA. DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. Nucleic Acids Res. 2008 Feb; 36(2):688-96.
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23.
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Jacob KD, Eckert KA. Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles. Mutat Res. 2007 Jun 1; 619(1-2):93-103.
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24.
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Yu C, Gestl E, Eckert K, Allara D, Irudayaraj J. Characterization of human breast epithelial cells by confocal Raman microspectroscopy. Cancer Detect Prev. 2006; 30(6):515-22.
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25.
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Sweasy JB, Lauper JM, Eckert KA. DNA polymerases and human diseases. Radiat Res. 2006 Nov; 166(5):693-714.
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26.
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Dalal S, Hile S, Eckert KA, Sun KW, Starcevic D, Sweasy JB. Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator. Biochemistry. 2005 Dec 6; 44(48):15664-73.
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27.
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Hamid S, Eckert KA. Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate. Biochemistry. 2005 Aug 2; 44(30):10378-87.
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28.
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Gestl EE, Eckert KA. Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis. Biochemistry. 2005 May 10; 44(18):7059-68.
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29.
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Maneval ML, Eckert KA. Effects of oxidative and alkylating damage on microsatellite instability in nontumorigenic human cells. Mutat Res. 2004 Feb 26; 546(1-2):29-38.
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30.
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Hile SE, Eckert KA. Positive correlation between DNA polymerase alpha-primase pausing and mutagenesis within polypyrimidine/polypurine microsatellite sequences. J Mol Biol. 2004 Jan 16; 335(3):745-59.
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31.
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Meehan WJ, Samant RS, Hopper JE, Carrozza MJ, Shevde LA, Workman JL, Eckert KA, Verderame MF, Welch DR. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. J Biol Chem. 2004 Jan 9; 279(2):1562-9.
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32.
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Khare V, Eckert KA. The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. Mutat Res. 2002 Dec 29; 510(1-2):45-54.
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33.
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Eckert K, Zielinski F, Lo Leggio L, Schneider E. Gene cloning, sequencing, and characterization of a family 9 endoglucanase (CelA) with an unusual pattern of activity from the thermoacidophile Alicyclobacillus acidocaldarius ATCC27009. Appl Microbiol Biotechnol. 2002 Dec; 60(4):428-36.
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34.
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Eckert KA, Mowery A, Hile SE. Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay. Biochemistry. 2002 Aug 20; 41(33):10490-8.
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35.
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Maitra M, Gudzelak A, Li SX, Matsumoto Y, Eckert KA, Jager J, Sweasy JB. Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site. J Biol Chem. 2002 Sep 20; 277(38):35550-60.
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36.
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Eckert KA, Yan G, Hile SE. Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells. Mol Carcinog. 2002 Jul; 34(3):140-50.
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37.
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Khare V, Eckert KA. The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions. J Biol Chem. 2001 Jun 29; 276(26):24286-92.
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38.
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Opresko PL, Shiman R, Eckert KA. Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis. Biochemistry. 2000 Sep 19; 39(37):11399-407.
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39.
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Eckert KA, Yan G. Mutational analyses of dinucleotide and tetranucleotide microsatellites in Escherichia coli: influence of sequence on expansion mutagenesis. Nucleic Acids Res. 2000 Jul 15; 28(14):2831-8.
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40.
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Grünberg E, Eckert K, Karsten U, Maurer HR. Effects of differentiation inducers on cell phenotypes of cultured nontransformed and immortalized mammary epithelial cells: a comparative immunocytochemical analysis. Tumour Biol. 2000 Jul-Aug; 21(4):211-23.
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41.
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Hile SE, Yan G, Eckert KA. Somatic mutation rates and specificities at TC/AG and GT/CA microsatellite sequences in nontumorigenic human lymphoblastoid cells. Cancer Res. 2000 Mar 15; 60(6):1698-703.
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42.
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Eckert KA, Opresko PL. DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions. Mutat Res. 1999 Mar 8; 424(1-2):221-36.
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43.
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Eckert KA, Hile SE. Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases alpha and beta. Mutat Res. 1998 Dec 3; 422(2):255-69.
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44.
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Grünberg E, Eckert K, Maurer HR. Prothymosin alpha1 antagonizes the inhibitory effects of transforming growth factor-beta1 on the adhesion of peripheral blood lymphocytes to human umbilical vein endothelial cells. Int J Mol Med. 1998 Apr; 1(4):741-6.
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45.
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Opresko PL, Sweasy JB, Eckert KA. The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. Biochemistry. 1998 Feb 24; 37(8):2111-9.
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46.
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Eckert KA, Hile SE, Vargo PL. Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions. Nucleic Acids Res. 1997 Apr 1; 25(7):1450-7.
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47.
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Bell JB, Eckert KA, Joyce CM, Kunkel TA. Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. J Biol Chem. 1997 Mar 14; 272(11):7345-51.
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48.
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Washington SL, Yoon MS, Chagovetz AM, Li SX, Clairmont CA, Preston BD, Eckert KA, Sweasy JB. A genetic system to identify DNA polymerase beta mutator mutants. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1321-6.
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49.
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Hite JM, Eckert KA, Cheng KC. Factors affecting fidelity of DNA synthesis during PCR amplification of d(C-A)n.d(G-T)n microsatellite repeats. Nucleic Acids Res. 1996 Jun 15; 24(12):2429-34.
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50.
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Eckert KA, Kunkel TA. Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH. Nucleic Acids Res. 1993 Nov 11; 21(22):5212-20.
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51.
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Eckert KA, Kunkel TA. Effect of reaction pH on the fidelity and processivity of exonuclease-deficient Klenow polymerase. J Biol Chem. 1993 Jun 25; 268(18):13462-71.
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52.
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Lacey SF, Reardon JE, Furfine ES, Kunkel TA, Bebenek K, Eckert KA, Kemp SD, Larder BA. Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine. J Biol Chem. 1992 Aug 5; 267(22):15789-94.
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53.
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Eckert KA, Kunkel TA. DNA polymerase fidelity and the polymerase chain reaction. PCR Methods Appl. 1991 Aug; 1(1):17-24.
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54.
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Eckert KA, Kunkel TA. High fidelity DNA synthesis by the Thermus aquaticus DNA polymerase. Nucleic Acids Res. 1990 Jul 11; 18(13):3739-44.
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55.
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Eckert KA, Ingle CA, Drinkwater NR. N-ethyl-N-nitrosourea induces A:T to C:G transversion mutations as well as transition mutations in SOS-induced Escherichia coli. Carcinogenesis. 1989 Dec; 10(12):2261-7.
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56.
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Eckert KA, Ingle CA, Klinedinst DK, Drinkwater NR. Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea. Mol Carcinog. 1988; 1(1):50-6.
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57.
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Eckert KA, Drinkwater NR. recA-dependent and recA-independent N-ethyl-N-nitrosourea mutagenesis at a plasmid-encoded herpes simplex virus thymidine kinase gene in Escherichia coli. Mutat Res. 1987 May; 178(1):1-10.
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