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Jianhua Li
Title Associate Professor
Institution College of Medicine
Department Medicine
Address 500 University Drive Hershey PA 17033
Mailbox: H047
Telephone 7175318407
Email
Background
PREFERRED TITLE/ROLE:

Professor of Medicine

EDUCATION:

M.D., Norman Bethune University of Medical Sciences, 1986
Ph.D., Norman Bethune University of Medical Sciences, 1993

NARRATIVE:

The global aim of my research effort has been to explore the sympathetic nervous mechanisms that govern control of the circulation in cardiovascular diseases, such as heart failure (HF) and hypertension etc. Specifically, research programs have focused on understanding the central and muscular mechanisms of cardiovascular responses to exercise in those cardiovascular disorders. Our recent work has shown that in HF ATP enhances muscle afferent mediated cardiovascular responses via P2X receptor (Circulation 110: 3049, 2004) and also stimulates this receptor and increase norepinephrine release from the sympathetic nerves in active muscle (Circulation 111: 2748, 2005). The results suggest that the augmented P2X-mediated responsiveness may influence the processing of muscle afferent and sympathetic signals in HF. Work from our lab has also demonstrated that muscle metabolites, i.e. lactate acid and phosphate stimulate acid sensing ion channels (ASIC) and evoke muscle afferent engagement cardiovascular responses. ASIC and TRPV1 may play a coordinated and interactive role in processing the muscle afferent response to metabolites. In HF, cardiovascular responses to activation of metabolite-sensitive TRPV1 are blunted as compared with healthy control. These data suggest that abnormalities in those receptors in primary afferent nerve may initiate the development of an exaggerated sympathetic activity in HF. The long-term goal of our research is to extend investigations on the cellular and molecular mechanisms of neural control and cardiovascular regulation in heart failure.
Publications
1. Lu J, Xing J, Li J. Bradykinin B2 receptor contributes to the exaggerated muscle mechanoreflex in rats with femoral artery occlusion. Am J Physiol Heart Circ Physiol. 2013 Apr; 304(8):H1166-74.
  View in: PubMed
 
2. Xing J, Lu J, Li J. Augmented P2X response and immunolabeling in dorsal root ganglion neurons innervating skeletal muscle following femoral artery occlusion. J Neurophysiol. 2013 Apr; 109(8):2161-8.
  View in: PubMed
 
3. Li J, Gao Z, Lu J, Xing J. Exaggerated Pressor Response in Relation to Attenuated Muscle Temperature Response during Contraction in Ischemic Heart Failure. Front Physiol. 2012; 3:443.
  View in: PubMed
 
4. Li J, Xing J. Muscle afferent receptors engaged in augmented sympathetic responsiveness in peripheral artery disease. Front Physiol. 2012; 3:247.
  View in: PubMed
 
5. Xing J, Lu J, Li J. J Physiol. Acid-sensing ion channel subtype 3 function and immunolabelling increases in skeletal muscle sensory neurons following femoral artery occlusion. 2012; 590(5):1261-1272.
 
6. Liu J, Li JD, Lu J, Xing J, Li J. Contribution of nerve growth factor to upregulation of P2X3 expression in DRG neurons of rats with femoral artery occlusion. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H1070-9.
  View in: PubMed
 
7. Koba S, Xing J, Sinoway LI, Li J. Bradykinin receptor blockade reduces sympathetic nerve response to muscle contraction in rats with ischemic heart failure. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1438-44.
  View in: PubMed
 
8. Liu J, Gao Z, Li J. Am J Physiol Heart Circ Physiol. Femoral artery occlusion increases expression of ASIC3 in dorsal root ganglion neurons. 2010; 299:H1357-H1364.
 
9. Xing J, Lu J, Li J. Contribution of nerve growth factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery occlusion. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1380-7.
  View in: PubMed
 
10. Li J, Lu J, Gao Z, Koba S, Xing J, King N, Sinoway L. Spinal P2X receptor modulates muscle pressor reflex via glutamate. J Appl Physiol. 2009 Mar; 106(3):865-70.
  View in: PubMed
 
11. Xing J, Lu J, Li J. Neurosci Lett. Angiotensin II inhibits GABAergic synpatic transmission in dorsolateral periaqueductal gray neurons. 2009; 455:8-13.
 
12. Li J, Gao Z, Kehoe V, Xing J, King N, Sinoway L. Interstitial adenosine triphosphate modulates muscle afferent nerve-mediated pressor reflex. Muscle Nerve. 2008 Aug; 38(2):972-7.
  View in: PubMed
 
13. Xing J, Sinoway L, Li J. Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin. J Physiol. 2008 Jul 1; 586(13):3245-52.
  View in: PubMed
 
14. Gao Z, Koba S, Sinoway L, Li J. 20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents. J Physiol. 2008 May 15; 586(10):2581-91.
  View in: PubMed
 
15. Xing J, Lu J, Li J. Purinergic P2X receptors presynaptically increase glutamatergic synaptic transmission in dorsolateral periaqueductal gray. Brain Res. 2008 May 7; 1208:46-55.
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16. Xing J, Li DP, Li J. Role of GABA receptors in nitric oxide inhibition of dorsolateral periaqueductal gray neurons. Neuropharmacology. 2008 Mar; 54(4):734-44.
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17. Xing J, Gao Z, Lu J, Sinoway LI, Li J. Am J Physiol Heart Circ Physiol. Femoral artery occlusion augments TRPV1-mediated sympathetic responsiveness. 2008; 295:H1262-H1269.
 
18. Koba S, Xing J, Sinoway LI, Li J. Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H311-21.
  View in: PubMed
 
19. Lu J, Xing J, Li J. Prostaglandin E2 (PGE2) inhibits glutamatergic synaptic transmission in dorsolateral periaqueductal gray (dl-PAG). Brain Res. 2007 Aug 8; 1162:38-47.
  View in: PubMed
 
20. Koba S, Xing J, Sinoway LI, Li J. Differential sympathetic outflow elicited by active muscle in rats. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2335-43.
  View in: PubMed
 
21. Xing J, Koba S, Kehoe V, Gao Z, Rice K, King N, Sinoway L, Li J. Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2007 Aug; 293(2):H1190-5.
  View in: PubMed
 
22. Gao Z, Li JD, Sinoway LI, Li J. Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response. J Appl Physiol. 2007 Jun; 102(6):2288-93.
  View in: PubMed
 
23. Li J, Sinoway LI. Current Cardiology Reviews. Norepinephrine and autonomic modulation in heart failure. 2007; 3(4):264-273.
 
24. Xing J, Li J. TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons. J Neurophysiol. 2007 Jan; 97(1):503-11.
  View in: PubMed
 
25. Gao Z, Xing J, Sinoway L, Li J. P2X receptor-mediated muscle pressor reflex in myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H939-45.
  View in: PubMed
 
26. Li J, Gao Z, Kehoe V, Sinoway LI. Interstitial K+ concentration in active muscle after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H808-13.
  View in: PubMed
 
27. Koba S, Gao Z, Xing J, Sinoway LI, Li J. Sympathetic responses to exercise in myocardial infarction rats: a role of central command. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2735-42.
  View in: PubMed
 
28. Gao Z, Kehoe V, Xing J, Sinoway L, Li J. Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation. Am J Physiol Heart Circ Physiol. 2006 Sep; 291(3):H1255-61.
  View in: PubMed
 
29. Li J, Sinoway LI, Ng YC. Aging augments interstitial K+ concentrations in active muscle of rats. J Appl Physiol. 2006 Apr; 100(4):1158-63.
  View in: PubMed
 
30. Gao Z, Henig O, Kehoe V, Sinoway LI, Li J. Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats. J Appl Physiol. 2006 Feb; 100(2):421-6.
  View in: PubMed
 
31. Sinoway LI, Li J. A perspective on the muscle reflex: implications for congestive heart failure. J Appl Physiol. 2005 Jul; 99(1):5-22.
  View in: PubMed
 
32. Gao Z, Li J, Kehoe V, Davidson WR, Sinoway L, Pu M. An initial application of transesophageal Doppler echocardiography in experimental small animal models. J Am Soc Echocardiogr. 2005 Jun; 18(6):626-31.
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33. Li J, King NC, Sinoway LI. Interstitial ATP and norepinephrine concentrations in active muscle. Circulation. 2005 May 31; 111(21):2748-51.
  View in: PubMed
 
34. Pu M, Gao Z, Li J, Sinoway L, Davidson WR. Development of a new animal model of chronic mitral regurgitation in rats under transesophageal echocardiographic guidance. J Am Soc Echocardiogr. 2005 May; 18(5):468-74.
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35. Li J, Sinoway LI. Current Cardiology Reviews. Heart failure modulates the muscle reflex. 2005; 1(1):7-16.
 
36. Li J, King NC, Sinoway LI. Circulation. Interstitial ATP and norepinephrine concentrations in active muscle. 2005; 111:2748-2751.
 
37. Smith SA, Mitchell JH, Li J. Am J Physiol Heart Circ Physiol. Independent modification of baroreceptor and exercise pressor reflex function by nitric oxide in nucleus tractus solitarius. 2005; 288:H2068-H2076.
 
38. Gao Z, Kehoe V, Sinoway LI, Li J. Spinal P2X receptor modulates reflex pressor response to activation of muscle afferents. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2238-43.
  View in: PubMed
 
39. Li J, Sinoway AN, Gao Z, Maile MD, Pu M, Sinoway LI. Muscle mechanoreflex and metaboreflex responses after myocardial infarction in rats. Circulation. 2004 Nov 9; 110(19):3049-54.
  View in: PubMed
 
40. Li J, Maile MD, Sinoway AN, Sinoway LI. Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. J Appl Physiol. 2004 Nov; 97(5):1709-14.
  View in: PubMed
 
41. Li J. Central integration of muscle reflex and arterial baroreflex in midbrain periaqueductal gray: roles of GABA and NO. Am J Physiol Heart Circ Physiol. 2004 Sep; 287(3):H1312-8.
  View in: PubMed
 
42. Li J, King NC, Sinoway LI. ATP concentrations and muscle tension increase linearly with muscle contraction. J Appl Physiol. 2003 Aug; 95(2):577-83.
  View in: PubMed
 
43. Li J, Mitchell JH. Glutamate release in midbrain periaqueductal gray by activation of skeletal muscle receptors and arterial baroreceptors. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1):H137-44.
  View in: PubMed
 
44. Li J, Sinoway LI. ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2636-43.
  View in: PubMed
 
45. Li J. Nitric oxide synthase (NOS) coexists with activated neurons by skeletal muscle contraction in the brainstem of cats. Life Sci. 2002 Nov 1; 71(24):2833-43.
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46. Li J, Mitchell J. Effect of nitric oxide on release of glutamate in the subretrofacial nucleus (SRF) during the exercise pressor reflex in cats. Brain Res. 2002 Sep 20; 950(1-2):195-202.
  View in: PubMed
 
47. Li J, Mitchell JH. Role of NO in modulating neuronal activity in superficial dorsal horn of spinal cord during exercise pressor reflex. Am J Physiol Heart Circ Physiol. 2002 Sep; 283(3):H1012-8.
  View in: PubMed
 
 
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Co-Authors  
Gao, Zhaohui
Sinoway, Lawrence
Xing, Jihong
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