|
1.
|
Liu Y, Leo LF, McGregor C, Grivitishvili A, Barnstable CJ, Tombran-Tink J. Pigment Epithelium-Derived Factor (PEDF) Peptide Eye Drops Reduce Inflammation, Cell Death and Vascular Leakage in Diabetic Retinopathy in Ins2(Akita) Mice. Mol Med. 2012; 18:1387-401.
|
|
|
|
|
2.
|
He Y, Ge J, Burke JM, Myers RL, Dong ZZ, Tombran-Tink J. Mitochondria impairment correlates with increased sensitivity of aging RPE cells to oxidative stress. J Ocul Biol Dis Infor. 2010 Sep; 3(3):92-108.
|
|
|
|
|
3.
|
Leung KW, Gvritishvili A, Liu Y, Tombran-Tink J. ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium. J Mol Neurosci. 2012 Jan; 46(1):122-37.
|
|
|
|
|
4.
|
Gvritishvili AG, Leung KW, Tombran-Tink J. Codon preference optimization increases heterologous PEDF expression. PLoS One. 2010; 5(11):e15056.
|
|
|
|
|
5.
|
Tombran-Tink J. PEDF in angiogenic eye diseases. Curr Mol Med. 2010 Apr; 10(3):267-78.
|
|
|
|
|
6.
|
He Y, Tombran-Tink J. Mitochondrial decay and impairment of antioxidant defenses in aging RPE cells. Adv Exp Med Biol. 2010; 664:165-83.
|
|
|
|
|
7.
|
Angayarkanni N, Selvi R, Pukhraj R, Biswas J, Bhavesh SJ, Tombran-Tink J. Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. J Ocul Biol Dis Infor. 2009; 2(1):20-8.
|
|
|
|
|
8.
|
Leung KW, Leung FP, Mak NK, Tombran-Tink J, Huang Y, Wong RN. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb; 156(4):626-37.
|
|
|
|
|
9.
|
Volpert KN, Tombran-Tink J, Barnstable C, Layer PG. PEDF and GDNF are key regulators of photoreceptor development and retinal neurogenesis in reaggregates from chick embryonic retina. J Ocul Biol Dis Infor. 2009; 2(1):1-11.
|
|
|
|
|
10.
|
Leung KW, Barnstable CJ, Tombran-Tink J. Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol. 2009 Apr; 46(7):1374-86.
|
|
|
|
|
11.
|
He Y, Ge J, Tombran-Tink J. Mitochondrial defects and dysfunction in calcium regulation in glaucomatous trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4912-22.
|
|
|
|
|
12.
|
He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J. Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1447-58.
|
|
|
|
|
13.
|
Leung KW, Liu M, Xu X, Seiler MJ, Barnstable CJ, Tombran-Tink J. Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1221-31.
|
|
|
|
|
14.
|
Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran-Tink J, Wong AS. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol. 2007 Sep; 152(2):207-15.
|
|
|
|
|
15.
|
Pina AL, Kubitza M, Brawanski A, Tombran-Tink J, Kloth S. Expression of pigment-epithelium-derived factor during kidney development and aging. Cell Tissue Res. 2007 Aug; 329(2):329-38.
|
|
|
|
|
16.
|
Xu X, Zhang SS, Barnstable CJ, Tombran-Tink J. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. BMC Genomics. 2006; 7:248.
|
|
|
|
|
17.
|
Chen L, Zhang SS, Barnstable CJ, Tombran-Tink J. PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases. Biochem Biophys Res Commun. 2006 Oct 6; 348(4):1288-95.
|
|
|
|
|
18.
|
Li H, Tran VV, Hu Y, Mark Saltzman W, Barnstable CJ, Tombran-Tink J. A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Exp Eye Res. 2006 Oct; 83(4):824-33.
|
|
|
|
|
19.
|
Cheung LW, Au SC, Cheung AN, Ngan HY, Tombran-Tink J, Auersperg N, Wong AS. Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells. Endocrinology. 2006 Sep; 147(9):4179-91.
|
|
|
|
|
20.
|
Barnstable CJ, Tombran-Tink J. Molecular mechanisms of neuroprotection in the eye. Adv Exp Med Biol. 2006; 572:291-5.
|
|
|
|
|
21.
|
Tombran-Tink J, Barnstable CJ. Space flight environment induces degeneration in the retina of rat neonates. Adv Exp Med Biol. 2006; 572:417-24.
|
|
|
|
|
22.
|
Patel JI, Tombran-Tink J, Hykin PG, Gregor ZJ, Cree IA. Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles. Exp Eye Res. 2006 May; 82(5):798-806.
|
|
|
|
|
23.
|
Tombran-Tink J. The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling. Front Biosci. 2005; 10:2131-49.
|
|
|
|
|
24.
|
Tombran-Tink J, Aparicio S, Xu X, Tink AR, Lara N, Sawant S, Barnstable CJ, Zhang SS. PEDF and the serpins: phylogeny, sequence conservation, and functional domains. J Struct Biol. 2005 Aug; 151(2):130-50.
|
|
|
|
|
25.
|
Tombran-Tink J, Barnstable CJ. Space shuttle flight environment induces degeneration in the retina of rat neonates. Gravit Space Biol Bull. 2005 Jun; 18(2):97-8.
|
|
|
|
|
26.
|
Aparicio S, Sawant S, Lara N, Barnstable CJ, Tombran-Tink J. Expression of angiogenesis factors in human umbilical vein endothelial cells and their regulation by PEDF. Biochem Biophys Res Commun. 2005 Jan 14; 326(2):387-94.
|
|
|
|
|
27.
|
Uchida H, Hayashi H, Kuroki M, Uno K, Yamada H, Yamashita Y, Tombran-Tink J, Kuroki M, Oshima K. Vitamin A up-regulates the expression of thrombospondin-1 and pigment epithelium-derived factor in retinal pigment epithelial cells. Exp Eye Res. 2005 Jan; 80(1):23-30.
|
|
|
|
|
28.
|
Sawant S, Aparicio S, Tink AR, Lara N, Barnstable CJ, Tombran-Tink J. Regulation of factors controlling angiogenesis in liver development: a role for PEDF in the formation and maintenance of normal vasculature. Biochem Biophys Res Commun. 2004 Dec 10; 325(2):408-13.
|
|
|
|
|
29.
|
Barnstable CJ, Tombran-Tink J. Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Retin Eye Res. 2004 Sep; 23(5):561-77.
|
|
|
|
|
30.
|
Tombran-Tink J, Lara N, Apricio SE, Potluri P, Gee S, Ma JX, Chader G, Barnstable CJ. Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells. Exp Eye Res. 2004 May; 78(5):945-55.
|
|
|
|
|
31.
|
Tombran-Tink J, Barnstable CJ. Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone. Biochem Biophys Res Commun. 2004 Apr 2; 316(2):573-9.
|
|
|
|
|
32.
|
Tombran-Tink J, Barnstable CJ. PEDF: a multifaceted neurotrophic factor. Nat Rev Neurosci. 2003 Aug; 4(8):628-36.
|
|
|
|
|
33.
|
Tombran-Tink J, Barnstable CJ. Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor. Trends Mol Med. 2003 Jun; 9(6):244-50.
|
|
|
|
|
34.
|
Tombran-Tink J, Lara N, Chappa A, Tink AR, Johnson LV, Staples M. Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling. Adv Exp Med Biol. 2003; 533:315-26.
|
|
|
|
|
35.
|
Hutchings H, Maitre-Boube M, Tombran-Tink J, Plouët J. Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes. Biochem Biophys Res Commun. 2002 Jun 21; 294(4):764-9.
|
|
|
|
|
36.
|
Sakharova NIu, Kostanian IA, Lepikhova TN, Lepikhov KA, Malashenko AM, Navolotskaia EV, Tombran-Tink J, Lipkin VM. [Effect of homologous peptides of differentiation factors HLDF and PEDF on preimplantation development of mice in vitro]. Ontogenez. 2002 May-Jun; 33(3):195-200.
|
|
|
|
|
37.
|
Ogata N, Wada M, Otsuji T, Jo N, Tombran-Tink J, Matsumura M. Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2002 Apr; 43(4):1168-75.
|
|
|
|
|
38.
|
Ohno-Matsui K, Morita I, Tombran-Tink J, Mrazek D, Onodera M, Uetama T, Hayano M, Murota SI, Mochizuki M. Novel mechanism for age-related macular degeneration: an equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol. 2001 Dec; 189(3):323-33.
|
|
|
|
|
39.
|
Ogata N, Tombran-Tink J, Nishikawa M, Nishimura T, Mitsuma Y, Sakamoto T, Matsumura M. Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am J Ophthalmol. 2001 Sep; 132(3):378-82.
|
|
|
|
|
40.
|
Ogata N, Tombran-Tink J, Jo N, Mrazek D, Matsumura M. Upregulation of pigment epithelium-derived factor after laser photocoagulation. Am J Ophthalmol. 2001 Sep; 132(3):427-9.
|
|
|
|
|
41.
|
Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A. Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. Glia. 2001 Jul; 35(1):14-25.
|
|
|
|
|
42.
|
Cao W, Tombran-Tink J, Elias R, Sezate S, Mrazek D, McGinnis JF. In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1646-52.
|
|
|
|
|
43.
|
Ogata N, Wang L, Jo N, Tombran-Tink J, Takahashi K, Mrazek D, Matsumura M. Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury. Curr Eye Res. 2001 Apr; 22(4):245-52.
|
|
|
|
|
44.
|
Abul-Hassan K, Walmsley R, Tombran-Tink J, Boulton M. Regulation of tyrosinase expression and activity in cultured human retinal pigment epithelial cells. Pigment Cell Res. 2000 Dec; 13(6):436-41.
|
|
|
|
|
45.
|
Jablonski MM, Tombran-Tink J, Mrazek DA, Iannaccone A. Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. J Neurosci. 2000 Oct 1; 20(19):7149-57.
|
|
|
|
|
46.
|
Kostanian IA, Zhokhov SS, Astapova MV, Dranitsyna SM, Bogachuk AP, Baidakova LK, Rodionov IL, Baskin II, Golubeva ON, Tombran-Tink J, Lipkin VM. [Biological role of a neurotrophic factor fragment from pigment epithelium: structure-functional homology with a differentiation factor for the HL-60 cell line]. Bioorg Khim. 2000 Aug; 26(8):563-70.
|
|
|
|
|
47.
|
Effects of synthetic peptides TQVEHR and TGENHR on early mouse embryo development in vitro. Dokl Biochem. 2000 May-Jun; 372(1-6):84-6.
|
|
|
|
|
48.
|
Cao W, Tombran-Tink J, Chen W, Mrazek D, Elias R, McGinnis JF. Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death. J Neurosci Res. 1999 Sep 15; 57(6):789-800.
|
|
|
|
|
49.
|
Koenekoop R, Pina AL, Loyer M, Davidson J, Robitaille J, Maumenee I, Tombran-Tink J. Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis. Mol Vis. 1999 Jul 2; 5:10.
|
|
|
|
|
50.
|
Bilak MM, Corse AM, Bilak SR, Lehar M, Tombran-Tink J, Kuncl RW. Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J Neuropathol Exp Neurol. 1999 Jul; 58(7):719-28.
|
|
|
|
|
51.
|
DeCoster MA, Schabelman E, Tombran-Tink J, Bazan NG. Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons. J Neurosci Res. 1999 Jun 15; 56(6):604-10.
|
|
|
|
|
52.
|
Malchiodi-Albedi F, Feher J, Caiazza S, Formisano G, Perilli R, Falchi M, Petrucci TC, Scorcia G, Tombran-Tink J. PEDF (pigment epithelium-derived factor) promotes increase and maturation of pigment granules in pigment epithelial cells in neonatal albino rat retinal cultures. Int J Dev Neurosci. 1998 Aug; 16(5):423-32.
|
|
|
|
|
53.
|
Tombran-Tink J, Mazuruk K, Rodriguez IR, Chung D, Linker T, Englander E, Chader GJ. Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin. Mol Vis. 1996 Nov 4; 2:11.
|
|
|
|
|
54.
|
Goliath R, Tombran-Tink J, Rodriquez IR, Chader G, Ramesar R, Greenberg J. The gene for PEDF, a retinal growth factor is a prime candidate for retinitis pigmentosa and is tightly linked to the RP13 locus on chromosome 17p13.3. Mol Vis. 1996 Jun 19; 2:5.
|
|
|
|
|
55.
|
Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D. Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activity. J Neurosci. 1995 Jul; 15(7 Pt 1):4992-5003.
|
|
|
|
|
56.
|
Li A, Lane WS, Johnson LV, Chader GJ, Tombran-Tink J. Neuron-specific enolase: a neuronal survival factor in the retinal extracellular matrix? J Neurosci. 1995 Jan; 15(1 Pt 1):385-93.
|
|
|
|
|
57.
|
Jones BE, Moshyedi P, Gallo S, Tombran-Tink J, Arand G, Reid DA, Thompson EW, Chader GJ, Waldbillig RJ. Characterization and novel activation of 72-kDa metalloproteinase in retinal interphotoreceptor matrix and Y-79 cell culture medium. Exp Eye Res. 1994 Sep; 59(3):257-69.
|
|
|
|
|
58.
|
Tombran-Tink J, Pawar H, Swaroop A, Rodriguez I, Chader GJ. Localization of the gene for pigment epithelium-derived factor (PEDF) to chromosome 17p13.1 and expression in cultured human retinoblastoma cells. Genomics. 1994 Jan 15; 19(2):266-72.
|
|
|
|
|
59.
|
Seigel GM, Tombran-Tink J, Becerra SP, Chader GJ, Diloreto DA, del Cerro C, Lazar ES, del Cerro M. Differentiation of Y79 retinoblastoma cells with pigment epithelial-derived factor and interphotoreceptor matrix wash: effects on tumorigenicity. Growth Factors. 1994; 10(4):289-97.
|
|
|
|
|
60.
|
Steele FR, Chader GJ, Johnson LV, Tombran-Tink J. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1526-30.
|
|
|
|
|
61.
|
Klaidman LK, Tombran-Tink J, Adams JD, Johnson LV. Effects of medium conditioned by retinal pigmented epithelial cells on neurotransmitter phenotype in retinoblastoma cells. Cancer Lett. 1993 Feb; 68(2-3):207-13.
|
|
|
|
|
62.
|
Tombran-Tink J, Li A, Johnson MA, Johnson LV, Chader GJ. Neurotrophic activity of interphotoreceptor matrix on human Y79 retinoblastoma cells. J Comp Neurol. 1992 Mar 8; 317(2):175-86.
|
|
|
|
|
63.
|
Tombran-Tink J, Chader GG, Johnson LV. PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res. 1991 Sep; 53(3):411-4.
|
|
|
|
|
64.
|
Tombran-Tink J, Johnson LV. Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells. Invest Ophthalmol Vis Sci. 1989 Aug; 30(8):1700-7.
|
|
|
|
|
65.
|
Tombran-Tink J, Johnson LV. Collagen-induced alterations in intercellular adhesion and antigen expression in retinoblastoma cells. Exp Eye Res. 1989 Apr; 48(4):549-59.
|
|
|
|