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Joseph Sassani
Title Professor
Institution College of Medicine
Department Ophthalmology
Division Ophthalmology
Address 500 University Drive Hershey PA 17033
Telephone 7175318783
Email
Background
PREFERRED TITLE/ROLE:

Physician, Professor of Ophthalmology and Pathology

EDUCATION:

Fellowship, Ophthalmic Pathology, Hospital of the University of Pennsylvania (1980)
Residency, Ophthalmology, Hospital of the University of Pennsylvania (1979)
M.D., Jefferson Medical College (1974)
Publications
1. Zagon IS, Campbell AM, Sassani JW, McLaughlin PJ. Spontaneous episodic decreased tear secretion in rats is related to opioidergic signaling pathways. Invest Ophthalmol Vis Sci. 2012 May; 53(6):3234-40.
  View in: PubMed
 
2. Ebrahimi KB, Miller NR, Sassani JW, Iliff NT, Green WR. Failure of radiation therapy in orbital xanthogranuloma. Ophthal Plast Reconstr Surg. 2010 Jul-Aug; 26(4):259-64.
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3. Klocek MS, Sassani JW, Donahue RN, McLaughlin PJ, Zagon IS. Regulation of Tenon's capsule fibroblast cell proliferation by the opioid growth factor and the opioid growth factor receptor axis. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5054-61.
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4. Sassani J. The wages of CIN research. Ophthalmology. 2010 Apr; 117(4):647-8.
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5. Aldave AJ, Rosenwasser GO, Yellore VS, Papp JC, Sobel EM, Pham MN, Chen MC, Dandekar S, Sripracha R, Rayner SA, Sassani JW, Gorin MB. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4006-12.
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6. Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ. Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus. Arch Ophthalmol. 2009 Nov; 127(11):1468-73.
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7. Zagon IS, Sassani JW, Carroll MA, McLaughlin PJ. Topical application of naltrexone facilitates reepithelialization of the cornea in diabetic rabbits. Brain Res Bull. 2010 Feb 15; 81(2-3):248-55.
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8. McLaughlin PJ, Sassani JW, Klocek MS, Zagon IS. Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review. Brain Res Bull. 2010 Feb 15; 81(2-3):236-47.
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9. Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS. Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats. Exp Eye Res. 2009 Nov; 89(5):686-92.
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10. Zagon IS, Klocek MS, Griffith JW, Sassani JW, Komáromy AM, McLaughlin PJ. Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone. Arch Ophthalmol. 2008 Apr; 126(4):501-6.
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11. Ziegenfuss JT, Sassani JW. Health administration education for physicians: why? Am J Med Qual. 2008 Jan-Feb; 23(1):5-6.
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12. Zagon IS, Klocek MS, Sassani JW, McLaughlin PJ. Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus. Arch Ophthalmol. 2007 Aug; 125(8):1082-8.
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13. Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS. Topically applied naltrexone restores corneal reepithelialization in diabetic rats. J Ocul Pharmacol Ther. 2007 Apr; 23(2):89-102.
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14. Zagon IS, Sassani JW, Myers RL, McLaughlin PJ. Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium. Brain Res Bull. 2007 Apr 2; 72(1):18-24.
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15. Zagon IS, Sassani JW, Malefyt KJ, McLaughlin PJ. Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA. Arch Ophthalmol. 2006 Nov; 124(11):1620-4.
  View in: PubMed
 
16. Zagon IS, Klocek MS, Sassani JW, Mauger DT, McLaughlin PJ. Corneal safety of topically applied naltrexone. J Ocul Pharmacol Ther. 2006 Oct; 22(5):377-87.
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17. Kim DY, Neely KA, Sassani JW, Vrabec TR, Tantri A, Frost A, Donoso LA. X-linked retinoschisis: novel mutation in the initiation codon of the XLRS1 gene in a large family. Retina. 2006 Oct; 26(8):940-6.
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18. Zagon IS, Sassani JW, McLaughlin PJ. Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone. Cornea. 2006 Aug; 25(7):821-9.
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19. Zagon IS, Sassani JW, McLaughlin PJ. Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats. Diabetes. 2006 Apr; 55(4):1141-7.
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20. Zagon IS, Sassani JW, Verderame MF, McLaughlin PJ. Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium. Cornea. 2005 Jul; 24(5):614-9.
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21. Quraishi SA, Orkin FK, Weitekamp MR, Khalid AN, Sassani JW. The Health Policy and Legislative Awareness Initiative at the Pennsylvania State University College of Medicine: theory meets practice. Acad Med. 2005 May; 80(5):443-7.
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22. Webster R, Sassani J, Shenk R, Harris M, Gerber J, Benson A, Blumenstock J, Billman C, Haluck R. Simulating the continuous curvilinear capsulorhexis procedure during cataract surgery on the EYESI system. Stud Health Technol Inform. 2005; 111:592-5.
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23. Webster R, Sassani J, Shenk R, Good N. A haptic surgical simulator for the continuous curvilinear capsulorhexis procedure during cataract surgery. Stud Health Technol Inform. 2004; 98:404-6.
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24. Sassani JW, Zagon IS, McLaughlin PJ. Opioid growth factor modulation of corneal epithelium: uppers and downers. Curr Eye Res. 2003 May; 26(5):249-62.
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25. Zagon IS, Ruth TB, Leure-duPree AE, Sassani JW, McLaughlin PJ. Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea. Brain Res. 2003 Mar 28; 967(1-2):37-47.
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26. Zagon IS, Jenkins JB, Sassani JW, Wylie JD, Ruth TB, Fry JL, Lang CM, McLaughlin PJ. Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat. Diabetes. 2002 Oct; 51(10):3055-62.
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27. Zagon IS, Sassani JW, Ruth TB, McLaughlin PJ. Epithelial adhesion complexes and organ culture of the human cornea. Brain Res. 2001 May 11; 900(2):205-13.
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28. Zagon IS, Sassani JW, Ruth TB, McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. III. Mitotic activity. Brain Res. 2000 Nov 3; 882(1-2):169-79.
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29. Johnson LN, Sassani JW, Aminlari A. Supervision during automated perimetry. Ophthalmology. 2000 Aug; 107(8):1439-40.
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30. Zagon IS, Sassani JW, McLaughlin PJ. Reepithelialization of the human cornea is regulated by endogenous opioids. Invest Ophthalmol Vis Sci. 2000 Jan; 41(1):73-81.
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31. Zagon IS, Sassani JW, McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. II. DNA synthesis of the ocular surface epithelium following wounding. Brain Res. 1999 Aug 28; 839(2):243-52.
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32. Lewis PR, Phillips TG, Sassani JW. Topical therapies for glaucoma: what family physicians need to know. Am Fam Physician. 1999 Apr 1; 59(7):1871-9, 1882.
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33. Zagon IS, Sassani JW, McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. I. Fate of ocular surface epithelial cells synthesizing DNA prior to wounding. Brain Res. 1999 Mar 20; 822(1-2):149-63.
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34. Zagon IS, Sassani JW, McLaughlin PJ. Re-epithelialization of the rabbit cornea is regulated by opioid growth factor. Brain Res. 1998 Aug 24; 803(1-2):61-8.
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35. Zagon IS, Sassani JW, McLaughlin PJ. Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptors. Brain Res. 1998 Jul 6; 798(1-2):254-60.
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36. Zagon IS, Sassani JW, Wu Y, McLaughlin PJ. The autocrine derivation of the opioid growth factor, [Met5]-enkephalin, in ocular surface epithelium. Brain Res. 1998 May 4; 792(1):72-8.
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37. Zagon IS, Sassani JW, Kane ER, McLaughlin PJ. Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor. Brain Res. 1997 Jun 6; 759(1):92-102.
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38. Campanella PC, Rosenwasser GO, Sassani JW, Goldberg SH. Herpes simplex blepharoconjunctivitis presenting as complete acquired ankyloblepharon. Cornea. 1997 May; 16(3):360-1.
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39. Kansupada KB, Sassani JW. Sushruta: the father of Indian surgery and ophthalmology. Doc Ophthalmol. 1997; 93(1-2):159-67.
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40. DuBiner HB, Hill R, Kaufman H, Keates EU, Zimmerman TJ, Mandell AI, Mundorf TK, Bahr RL, Schwartz LW, Towey AW, Hurvitz LM, Starita RJ, Sassani JW, Ropo A, Gunn R, Stewart WC. Timolol hemihydrate vs timolol maleate to treat ocular hypertension and open-angle glaucoma. Am J Ophthalmol. 1996 May; 121(5):522-8.
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41. Zagon IS, Sassani JW, McLaughlin PJ. Opioid growth factor modulates corneal epithelial outgrowth in tissue culture. Am J Physiol. 1995 Apr; 268(4 Pt 2):R942-50.
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42. Zagon IS, Sassani JW, Allison G, McLaughlin PJ. Conserved expression of the opioid growth factor, [Met5]enkephalin, and the zeta (zeta) opioid receptor in vertebrate cornea. Brain Res. 1995 Feb 6; 671(1):105-11.
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43. Sassani JW. A history of low vision and blind rehabilitation in the United States. Doc Ophthalmol. 1995; 89(1-2):145-52.
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44. Wolner B, Liebmann J, Ritch R, Speaker M, Marmor M, Sassani J. Treatment of bleb infection after glaucoma surgery. Arch Ophthalmol. 1994 Oct; 112(10):1277-8.
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45. Sassani JW, Blankenship G. Disciform choroidal melanoma. Retina. 1994; 14(2):177-80.
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46. Rosenwasser GO, Sucheski BM, Rosa N, Pastena B, Sebastiani A, Sassani JW, Perry HD. Phenotypic variation in combined granular-lattice (Avellino) corneal dystrophy. Arch Ophthalmol. 1993 Nov; 111(11):1546-52.
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47. Sassani JW, Ritch R, McCormick S, Liebmann JM, Eagle RC, Lavery K, Koster HR. Histopathology of argon laser peripheral iridoplasty. Ophthalmic Surg. 1993 Nov; 24(11):740-5.
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48. Quillen DA, Cantore WA, Schwartz SR, Brod RD, Sassani JW. Choroidal nonperfusion in giant cell arteritis. Am J Ophthalmol. 1993 Aug 15; 116(2):171-5.
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49. Quillen DA, Goldberg SH, Rosenwasser GO, Sassani JW. Basal cell carcinoma of the conjunctiva. Am J Ophthalmol. 1993 Aug 15; 116(2):244-5.
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50. Parnes RE, Goldberg SH, Sassani JW. Renal cell carcinoma metastatic to the orbit: a clinicopathologic report. Ann Ophthalmol. 1993 Mar; 25(3):100-2.
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51. Aminlari A, Sassani JW. Simultaneous bilateral malignant glaucoma following laser iridotomy. Graefes Arch Clin Exp Ophthalmol. 1993; 231(1):12-4.
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52. Johnson LN, Aminlari A, Sassani JW. Effect of intermittent versus continuous patient monitoring on reliability indices during automated perimetry. Ophthalmology. 1993 Jan; 100(1):76-84.
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53. Sassani JW, Smith SG, Rabinowitz YS. Keratoconus and bilateral lattice-granular corneal dystrophies. Cornea. 1992 Jul; 11(4):343-50.
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54. Miller ML, Sassani JW, Sexton FM. Diffuse histiocytosis X involving the eyelid of a 65-year-old woman. Am J Ophthalmol. 1992 Apr 15; 113(4):458-9.
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55. Sponsler TA, Sassani JW, Johnson LN, Towfighi J. Ocular invasion in mucormycosis. Surv Ophthalmol. 1992 Mar-Apr; 36(5):345-50.
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56. Goldberg SH, Sassani JW, Parnes RE. Traumatic intraconal hematic cyst of the orbit. Arch Ophthalmol. 1992 Mar; 110(3):378-80.
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57. Wolner B, Liebmann JM, Sassani JW, Ritch R, Speaker M, Marmor M. Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. Ophthalmology. 1991 Jul; 98(7):1053-60.
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58. Sassani JW, Rosenwasser GO. Fungal contact lens infiltration simulating crystalline deposits. CLAO J. 1991 Jul; 17(3):205-6.
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59. Sassani JW. Punch biopsy technique for the ophthalmologist. Arch Ophthalmol. 1991 Apr; 109(4):464-5.
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60. Hill RA, Aminlari A, Sassani JW, Michalski M. Use of a symblepharon ring for treatment of over-filtration and leaking blebs after glaucoma filtration surgery. Ophthalmic Surg. 1990 Oct; 21(10):707-10.
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61. Palm DE, Keil LC, Sassani JW, Severs WB. Immunoreactive atrial natriuretic peptide in the retina of rats and rabbits. Brain Res. 1989 Dec 11; 504(1):142-4.
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62. Kahlenborn C, Sassani JW, Sherrard M, Frankel CA. A mannequin for teaching ocular fundus examination skills. Arch Ophthalmol. 1989 Dec; 107(12):1725-6.
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63. Smith SG, Rabinowitz YS, Sassani JW, Smith RE. Keratoconus and lattice and granular corneal dystrophies in the same eye. Am J Ophthalmol. 1989 Nov 15; 108(5):608-10.
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64. Stankeiwicz PJ, Metz KR, Sassani JW, Briggs RW. Nuclear magnetic resonance study of free and bound water fractions in normal lenses. Invest Ophthalmol Vis Sci. 1989 Nov; 30(11):2361-9.
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65. Sassani JW, Frankel CA. Treatment of conjunctival lesions. Am Fam Physician. 1988 Oct; 38(4):69, 72.
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66. Rabinowitz YS, Ladda RL, Sassani JW, Eyster ME. Cosegregation of X-linked retinitis pigmentosa and hemophilia A. Am J Ophthalmol. 1988 Jan 15; 105(1):46-56.
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67. Griffith JW, Sassani JW, Bowman TA, Lang CM. Osseous choristoma of the ciliary body in guinea pigs. Vet Pathol. 1988 Jan; 25(1):100-2.
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68. Rabinowitz YS, Sassani JW, Ladda R, Eyster ME. An approach to a genetic eye disorder. Trans Pa Acad Ophthalmol Otolaryngol. 1988; 40:701-5.
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69. Grunwald GB, Kornguth SE, Towfighi J, Sassani J, Simmonds MA, Housman CM, Papadopoulos N. Autoimmune basis for visual paraneoplastic syndrome in patients with small cell lung carcinoma. Retinal immune deposits and ablation of retinal ganglion cells. Cancer. 1987 Aug 15; 60(4):780-6.
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70. Metz KR, Stankiewicz PJ, Sassani JW, Briggs RW. Pulse techniques for the suppression of individual components in multiexponential relaxation curves. Magn Reson Med. 1986 Aug; 3(4):575-89.
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71. Sassani JW, Weinstein JM, Graham WP. Massively invasive diffuse choroidal melanoma. Arch Ophthalmol. 1985 Jul; 103(7):945-8.
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72. Sassani JW, John T, Cameron JD, Yanoff M, Eagle RC. Electron microscopic study of corneal epithelial-endothelial interactions in organ culture. Ophthalmology. 1984 Jun; 91(6):553-7.
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73. Sassani JW, Osbakken MD. Anatomic features of the eye disclosed with nuclear magnetic resonance imaging. Arch Ophthalmol. 1984 Apr; 102(4):541-6.
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74. Sassani JW, Peart RE, Haak NW, Hodes BL. Combined use of A-scan ultrasound, plain roentgenograms, and computerized axial tomography in the evaluation of a pseudo-intraocular foreign body. J Clin Ultrasound. 1984 Mar-Apr; 12(3):171-3.
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75. Towfighi J, Sassani JW, Suzuki K, Ladda RL. Cerebro-ocular dysplasia-muscular dystrophy (COD-MD) syndrome. Acta Neuropathol. 1984; 65(2):110-23.
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76. John T, Sassani JW, Eagle RC. The myofibroblastic component of rubeosis iridis. Ophthalmology. 1983 Jun; 90(6):721-8.
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77. Towfighi J, Young R, Sassani J, Ramer J, Horoupian DS. Alexander's disease: further light-, and electron-microscopic observations. Acta Neuropathol. 1983; 61(1):36-42.
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78. Sassani JW, Brucker AJ, Cobbs W, Campbell C. Progressive chloroquine retinopathy. Ann Ophthalmol. 1983 Jan; 15(1):19-22.
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79. Weinstein JM, Sattler FA, Towfighi J, Sassani J, Page RB. Optic neuropathy and paratrigeminal syndrome due to Aspergillus fumigatus. Arch Neurol. 1982 Sep; 39(9):582-5.
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80. Sassani JW, Nichols C, Kimball R, Yanoff M. Subconjunctival phacocele: an unusual complication of cataract surgery. Can J Ophthalmol. 1982 Jun; 17(3):128-31.
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81. John T, Sassani JW, Eagle RC. Scanning electron microscopy of rubeosis iridis. Trans Pa Acad Ophthalmol Otolaryngol. 1982; 35(2):119-21.
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82. Sassani JW, Cutler J. Notes, cases and instruments. Am J Ophthalmol. 1981 Nov; 92(5):737.
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83. Sassani JW, Yanoff M. Inverted follicular keratosis. Am J Ophthalmol. 1979 Jun; 87(6):810-3.
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84. Scheie HG, Yanoff M, Sassani JW. Inverted follicular keratosis clinically mimicking malignant melanoma. Ann Ophthalmol. 1977 Aug; 9(8):949-52.
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85. Sassani JW. Anophthalmos in an infant with multiple congenital anomalies. Am J Ophthalmol. 1977 Jan; 83(1):43-8.
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86. SASSANI J, GENNETT RA. ROLE OF A PODIATRIST IN A COUNTY INFIRMARY. J Am Podiatry Assoc. 1965 Jun; 55:445-7.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Epithelium, Corneal
Cornea
Naltrexone
Narcotic Antagonists
Wound Healing
See all (394) keywords
Co-Authors  
Aminlari, Ali
Eyster, M
Ladda, Roger
McLaughlin, Patricia
Zagon, Ian
See all (18) people
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