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1.
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Phelps DS, Umstead TM, Floros J. Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A. Proteome Sci. 2012; 10(1):44.
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2.
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Macneill C, de Guzman G, Sousa GE, Umstead TM, Phelps DS, Floros J, Ahn K, Weisz J. Cyclic changes in the level of the innate immune molecule, surfactant protein-a, and cytokines in vaginal fluid. Am J Reprod Immunol. 2012 Sep; 68(3):244-50.
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3.
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Silveyra P, Floros J. Air pollution and epigenetics: effects on SP-A and innate host defence in the lung. Swiss Med Wkly. 2012; 142:w13579.
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4.
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Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection. Exp Lung Res. 2012 May; 38(4):165-72.
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5.
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Mikerov AN, Hu S, Durrani F, Gan X, Wang G, Umstead TM, Phelps DS, Floros J. Impact of sex and ozone exposure on the course of pneumonia in wild type and SP-A (-/-) mice. Microb Pathog. 2012 Apr; 52(4):239-49.
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6.
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Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 2012 Jan; 71(1):107-14.
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7.
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Silveyra P, Floros J. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci. 2012; 17:407-29.
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8.
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Phelps DS, Umstead TM, Quintero OA, Yengo CM, Floros J. In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement. Proteome Sci. 2011; 9:67.
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9.
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Mikerov AN, Cooper TK, Wang G, Hu S, Umstead TM, Phelps DS, Floros J. Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions. Int J Physiol Pathophysiol Pharmacol. 2011 Sep 30; 3(3):176-90.
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10.
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Silveyra P, Raval M, Simmons B, Diangelo S, Wang G, Floros J. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L795-803.
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11.
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Lin Z, John G, Hegarty JP, Berg A, Yu W, Wang Y, Kelly AA, Peterson BZ, Poritz LS, Floros J, Koltun WA. Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel disease. Ann Hum Genet. 2011 Sep; 75(5):559-68.
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12.
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Wang Y, Voelker DR, Lugogo NL, Wang G, Floros J, Ingram JL, Chu HW, Church TD, Kandasamy P, Fertel D, Wright JR, Kraft M. Surfactant protein A is defective in abrogating inflammation in asthma. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L598-606.
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13.
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Floros J, Thomas NJ. Surfactant protein genetics in community-acquired pneumonia: balancing the host inflammatory state. Crit Care. 2011; 15(2):156.
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14.
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Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L523-34.
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15.
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Ali M, Umstead TM, Haque R, Mikerov AN, Freeman WM, Floros J, Phelps DS. Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice. Proteome Sci. 2010; 8:34.
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16.
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Wang G, Guo X, Diangelo S, Thomas NJ, Floros J. Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. J Biol Chem. 2010 Apr 16; 285(16):11998-2010.
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17.
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Undar A, Pauliks L, Clark JB, Zahn J, Rosenberg G, Kunselman AR, Sun Q, Pekkan K, Saliba K, Carney E, Thomas N, Freeman W, Vrana K, El-Banayosy A, Ural SH, Wilson R, Umstead TM, Floros J, Phelps DS, Weiss W, Snyder A, Yang S, Kimatian S, Cyran SE, Chinchilli VM, Guan Y, Rider A, Haines N, Rogerson A, Alkan-Bozkaya T, Akcevin A, Sun K, Wang S, Cun L, Myers JL. Penn State Hershey--center for pediatric cardiovascular research. Artif Organs. 2009 Nov; 33(11):883-7.
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18.
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Thomas NJ, DiAngelo S, Hess JC, Fan R, Ball MW, Geskey JM, Willson DF, Floros J. Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatr Res. 2009 Jul; 66(1):70-3.
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19.
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Haque R, Umstead TM, Freeman WM, Floros J, Phelps DS. The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome. Proteome Sci. 2009; 7:12.
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20.
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Wang G, Guo X, Silveyra P, Kimball SR, Floros J. Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol. 2009 Apr; 296(4):L635-47.
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21.
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Vaid M, Floros J. Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review). Oncol Rep. 2009 Jan; 21(1):3-11.
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22.
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Floros J, Wang G, Mikerov AN. Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function. Crit Rev Eukaryot Gene Expr. 2009; 19(2):125-37.
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23.
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Haque R, Umstead TM, Ahn K, Phelps DS, Floros J. Effect of low doses of lipopolysaccharide prior to ozone exposure on bronchoalveolar lavage: Differences between wild type and surfactant protein A-deficient mice. Pneumon. 2009; 22(2):143-155.
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24.
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Mikerov AN, Haque R, Gan X, Guo X, Phelps DS, Floros J. Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences. Respir Res. 2008; 9:77.
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25.
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Mikerov AN, Gan X, Umstead TM, Miller L, Chinchilli VM, Phelps DS, Floros J. Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infection. Respir Res. 2008; 9:24.
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26.
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Mikerov AN, Umstead TM, Gan X, Huang W, Guo X, Wang G, Phelps DS, Floros J. Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L121-30.
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27.
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Wang G, Taneva S, Keough KM, Floros J. Differential effects of human SP-A1 and SP-A2 variants on phospholipid monolayers containing surfactant protein B. Biochim Biophys Acta. 2007 Sep; 1768(9):2060-9.
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28.
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Lin Z, Thomas NJ, Bibikova M, Seifart C, Wang Y, Guo X, Wang G, Vollmer E, Goldmann T, Garcia EW, Zhou L, Fan JB, Floros J. DNA methylation markers of surfactant proteins in lung cancer. Int J Oncol. 2007 Jul; 31(1):181-91.
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29.
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Wang G, Myers C, Mikerov A, Floros J. Effect of cysteine 85 on biochemical properties and biological function of human surfactant protein A variants. Biochemistry. 2007 Jul 17; 46(28):8425-35.
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30.
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Pavlovic J, Floros J, Phelps DS, Wigdahl B, Welsh P, Weisz J, Shearer DA, Leure du Pree A, Myers R, Howett MK. Differentiation of xenografted human fetal lung parenchyma. Early Hum Dev. 2008 Mar; 84(3):181-93.
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31.
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Thomas NJ, Fan R, Diangelo S, Hess JC, Floros J. Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome. Acta Paediatr. 2007 Jul; 96(7):985-9.
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32.
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Mikerov AN, White M, Hartshorn K, Wang G, Floros J. Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells. Med Microbiol Immunol. 2008 Mar; 197(1):9-12.
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33.
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Stagos D, Umstead TM, Phelps DS, Skaltsounis L, Haroutounian S, Floros J, Kouretas D. Inhibition of ozone-induced SP-A oxidation by plant polyphenols. Free Radic Res. 2007 Mar; 41(3):357-66.
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34.
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Mikerov AN, Wang G, Umstead TM, Zacharatos M, Thomas NJ, Phelps DS, Floros J. Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. Infect Immun. 2007 Mar; 75(3):1403-12.
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35.
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Haque R, Umstead TM, Ponnuru P, Guo X, Hawgood S, Phelps DS, Floros J. Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice. Toxicol Appl Pharmacol. 2007 Apr 1; 220(1):72-82.
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36.
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Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J. Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1052-63.
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37.
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Floros J, Thomas NJ, Liu W, Papagaroufalis C, Xanthou M, Pereira S, Fan R, Guo X, Diangelo S, Pavlovic J. Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS. Pediatr Res. 2006 Apr; 59(4 Pt 1):616-21.
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38.
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Bibikova M, Lin Z, Zhou L, Chudin E, Garcia EW, Wu B, Doucet D, Thomas NJ, Wang Y, Vollmer E, Goldmann T, Seifart C, Jiang W, Barker DL, Chee MS, Floros J, Fan JB. High-throughput DNA methylation profiling using universal bead arrays. Genome Res. 2006 Mar; 16(3):383-93.
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39.
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Pavlovic J, Papagaroufalis C, Xanthou M, Liu W, Fan R, Thomas NJ, Apostolidou I, Papathoma E, Megaloyianni E, DiAngelo S, Floros J. Genetic variants of surfactant proteins A, B, C, and D in bronchopulmonary dysplasia. Dis Markers. 2006; 22(5-6):277-91.
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40.
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Seifart C, Lin HM, Seifart U, Plagens A, DiAngelo S, von Wichert P, Floros J. Rare SP-A alleles and the SP-A1-6A(4) allele associate with risk for lung carcinoma. Clin Genet. 2005 Aug; 68(2):128-36.
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41.
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Lin Z, Thomas NJ, Wang Y, Guo X, Seifart C, Shakoor H, Floros J. Deletions within a CA-repeat-rich region of intron 4 of the human SP-B gene affect mRNA splicing. Biochem J. 2005 Jul 15; 389(Pt 2):403-12.
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42.
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Wang G, Guo X, Floros J. Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes. Am J Physiol Lung Cell Mol Physiol. 2005 Sep; 289(3):L497-508.
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43.
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Lin Z, Wang Y, Zhu K, Floros J. Differential allele expression of host defense genes, pulmonary surfactant protein-A and osteopontin, in rat. Mol Immunol. 2004 Nov; 41(12):1155-65.
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44.
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Janic B, Umstead TM, Phelps DS, Floros J. Modulatory effects of ozone on THP-1 cells in response to SP-A stimulation. Am J Physiol Lung Cell Mol Physiol. 2005 Feb; 288(2):L317-25.
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45.
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Mikerov AN, Umstead TM, Huang W, Liu W, Phelps DS, Floros J. SP-A1 and SP-A2 variants differentially enhance association of Pseudomonas aeruginosa with rat alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L150-8.
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46.
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Ding J, Umstead TM, Floros J, Phelps DS. Factors affecting SP-A-mediated phagocytosis in human monocytic cell lines. Respir Med. 2004 Jul; 98(7):637-50.
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47.
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Wang G, Bates-Kenney SR, Tao JQ, Phelps DS, Floros J. Differences in biochemical properties and in biological function between human SP-A1 and SP-A2 variants, and the impact of ozone-induced oxidation. Biochemistry. 2004 Apr 13; 43(14):4227-39.
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48.
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MacNeill C, Umstead TM, Phelps DS, Lin Z, Floros J, Shearer DA, Weisz J. Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid. Immunology. 2004 Jan; 111(1):91-9.
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49.
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Bernhard W, Haslam PL, Floros J. From birds to humans: new concepts on airways relative to alveolar surfactant. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):6-11.
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50.
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Huang W, Wang G, Phelps DS, Al-Mondhiry H, Floros J. Human SP-A genetic variants and bleomycin-induced cytokine production by THP-1 cells: effect of ozone-induced SP-A oxidation. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L546-53.
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51.
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Hu B, Jennings JH, Sonstein J, Floros J, Todt JC, Polak T, Curtis JL. Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes. Am J Respir Cell Mol Biol. 2004 May; 30(5):687-93.
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52.
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Selman M, Lin HM, Montaño M, Jenkins AL, Estrada A, Lin Z, Wang G, DiAngelo SL, Guo X, Umstead TM, Lang CM, Pardo A, Phelps DS, Floros J. Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis. Hum Genet. 2003 Nov; 113(6):542-50.
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53.
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Liu W, Bentley CM, Floros J. Study of human SP-A, SP-B and SP-D loci: allele frequencies, linkage disequilibrium and heterozygosity in different races and ethnic groups. BMC Genet. 2003 Aug 11; 4:13.
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54.
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Matthay MA, Zimmerman GA, Esmon C, Bhattacharya J, Coller B, Doerschuk CM, Floros J, Gimbrone MA, Hoffman E, Hubmayr RD, Leppert M, Matalon S, Munford R, Parsons P, Slutsky AS, Tracey KJ, Ward P, Gail DB, Harabin AL. Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med. 2003 Apr 1; 167(7):1027-35.
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55.
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Floros J, Pavlovic J. Genetics of acute respiratory distress syndrome: challenges, approaches, surfactant proteins as candidate genes. Semin Respir Crit Care Med. 2003 Apr; 24(2):161-8.
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56.
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Janic B, Umstead TM, Phelps DS, Floros J. An in vitro cell model system for the study of the effects of ozone and other gaseous agents on phagocytic cells. J Immunol Methods. 2003 Jan 15; 272(1-2):125-34.
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57.
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Wang G, Guo X, Floros J. Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L738-48.
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58.
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Wang G, Christensen ND, Wigdahl B, Guttentag SH, Floros J. Differences in N-linked glycosylation between human surfactant protein-B variants of the C or T allele at the single-nucleotide polymorphism at position 1580: implications for disease. Biochem J. 2003 Jan 1; 369(Pt 1):179-84.
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59.
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Lin Z, Floros J. Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues. Physiol Genomics. 2002 Dec 3; 11(3):235-43.
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60.
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García-Verdugo I, Wang G, Floros J, Casals C. Structural analysis and lipid-binding properties of recombinant human surfactant protein a derived from one or both genes. Biochemistry. 2002 Nov 26; 41(47):14041-53.
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61.
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Huang W, Wang G, Phelps DS, Al-Mondhiry H, Floros J. Combined SP-A-bleomycin effect on cytokines by THP-1 cells: impact of surfactant lipids on this effect. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L94-L102.
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62.
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Fan R, Floros J, Xiong M. Models and tests of linkage and association studies of quantitative trait locus for multi-allele marker Loci. Hum Hered. 2002; 53(3):130-45.
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63.
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Wang G, Umstead TM, Phelps DS, Al-Mondhiry H, Floros J. The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production. Environ Health Perspect. 2002 Jan; 110(1):79-84.
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64.
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Seifart C, Plagens A, Brödje D, Müller B, von Wichert P, Floros J. Surfactant protein B intron 4 variation in German patients with COPD and acute respiratory failure. Dis Markers. 2002; 18(3):129-36.
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65.
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Umstead TM, Phelps DS, Wang G, Floros J, Tarkington BK. In vitro exposure of proteins to ozone. Toxicol Mech Methods. 2002; 12(1):1-16.
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66.
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Floros J, Hoover RR. Genetics of the hydrophilic surfactant proteins A and D. Biochim Biophys Acta. 1998 Nov 19; 1408(2-3):312-22.
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67.
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Geschwind HJ, Kern MJ, Vandormael MG, Blair JD, Deligonul U, Kennedy HL. Efficiency and safety of optically modified fiber tips for laser angioplasty. J Am Coll Cardiol. 1987 Sep; 10(3):655-61.
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68.
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Hardwick JP, Song BJ, Huberman E, Gonzalez FJ. Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family. J Biol Chem. 1987 Jan 15; 262(2):801-10.
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69.
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Leopold NA, Kagel MC. Dysphagia in Huntington's disease. Arch Neurol. 1985 Jan; 42(1):57-60.
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