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James Griffith
Title Professor Emeritus
Institution College of Medicine
Department Comparative Medicine
Address 500 University Drive Hershey PA 17033
Mailbox: H054
Telephone 7175318460
Email
Background
PREFERRED TITLE/ROLE:

Professor Emeritus of Comparative Medicine

GRADUATE PROGRAM AFFILIATIONS:

Lab Animal Medicine

EDUCATION:

D.V.M., University of Missouri, 1976
Postdoctoral Training, University of Pennsylvania, 1981
Member of the American College of Veterinary Pathologists
Member of the American College of Laboratory Animal Medicine

NARRATIVE:

Veterinary Pathology, Comparative and Experimental Pathology, Pathobiology of mice

Research interests include the pathology of: spontaneous diseases of laboratory animals, genetically modified animal models of cancer, genetic studies of aging in mice, particulate induced pulmonary fibrosis, cardiovascular and respiratory pathology.
Publications
1. Coldwell SE, Mennella JA, Duffy VB, Pelchat ML, Griffith JW, Smutzer G, Cowart BJ, Breslin PA, Bartoshuk LM, Hastings L, Victorson D, Hoffman HJ. Gustation assessment using the NIH Toolbox. Neurology. 2013 Mar 12; 80(11 Suppl 3):S20-4.
  View in: PubMed
 
2. Dunn W, Griffith JW, Morrison MT, Tanquary J, Sabata D, Victorson D, Carey LM, Gershon RC. Somatosensation assessment using the NIH Toolbox. Neurology. 2013 Mar 12; 80(11 Suppl 3):S41-4.
  View in: PubMed
 
3. Zecker SG, Hoffman HJ, Frisina R, Dubno JR, Dhar S, Wallhagen M, Kraus N, Griffith JW, Walton JP, Eddins DA, Newman C, Victorson D, Warrier CM, Wilson RH. Audition assessment using the NIH Toolbox. Neurology. 2013 Mar 12; 80(11 Suppl 3):S45-8.
  View in: PubMed
 
4. Cook KF, Dunn W, Griffith JW, Morrison MT, Tanquary J, Sabata D, Victorson D, Carey LM, Macdermid JC, Dudgeon BJ, Gershon RC. Pain assessment using the NIH Toolbox. Neurology. 2013 Mar 12; 80(11 Suppl 3):S49-53.
  View in: PubMed
 
5. Salsman JM, Butt Z, Pilkonis PA, Cyranowski JM, Zill N, Hendrie HC, Kupst MJ, Kelly MA, Bode RK, Choi SW, Lai JS, Griffith JW, Stoney CM, Brouwers P, Knox SS, Cella D. Emotion assessment using the NIH Toolbox. Neurology. 2013 Mar 12; 80(11 Suppl 3):S76-86.
  View in: PubMed
 
6. Cooper TK, Griffith JW, Reibson J, Peterson R, Roush EP, Zhong Q, Weiss WJ, Rosenberg G. Antibiotic-associated eosinophilic and occlusive arteritis in calves complicating preclinical studies of left ventricular assist devices. Toxicol Pathol. 2013; 41(3):519-27.
  View in: PubMed
 
7. Lang DH, Gerhard GS, Griffith JW, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, Lakoski JM, McClearn GE. Quantitative trait loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice. Aging Clin Exp Res. 2010 Feb; 22(1):8-19.
  View in: PubMed
 
8. Foreman JE, Lionikas A, Lang DH, Gyekis JP, Krishnan M, Sharkey NA, Gerhard GS, Grant MD, Vogler GP, Mack HA, Stout JT, Griffith JW, Lakoski JM, Hofer SM, McClearn GE, Vandenbergh DJ, Blizard DA. Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav. 2009 Oct; 8(7):714-27.
  View in: PubMed
 
9. Blizard DA, Lionikas A, Vandenbergh DJ, Vasilopoulos T, Gerhard GS, Griffith JW, Klein LC, Stout JT, Mack HA, Lakoski JM, Larsson L, Spicer JM, Vogler GP, McClearn GE. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics. 2009 Feb 2; 36(3):158-66.
  View in: PubMed
 
10. Zagon IS, Klocek MS, Griffith JW, Sassani JW, Komáromy AM, McLaughlin PJ. Prevention of exuberant granulation tissue and neovascularization in the rat cornea by naltrexone. Arch Ophthalmol. 2008 Apr; 126(4):501-6.
  View in: PubMed
 
11. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2008 Jan; 107(1):33-40.
  View in: PubMed
 
12. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2007 Sep; 105(1):29-36.
  View in: PubMed
 
13. Zapanta CM, Griffith JW, Hess GD, Doxtater BJ, Khalapyan T, Pae WE, Rosenberg G. Microtextured materials for circulatory support devices: preliminary studies. ASAIO J. 2006 Jan-Feb; 52(1):17-23.
  View in: PubMed
 
14. Peterson SL, Purvis RS, Griffith JW. Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. Neurotoxicology. 2005 Dec; 26(6):969-79.
  View in: PubMed
 
15. Wilgenburg BJ, Budgeon LR, Lang CM, Griffith JW, Christensen ND. Characterization of immune responses during regression of rabbit oral papillomavirus infections. Comp Med. 2005 Oct; 55(5):431-9.
  View in: PubMed
 
16. Foreman JE, Blizard DA, Gerhard G, Mack HA, Lang DH, Van Nimwegen KL, Vogler GP, Stout JT, Shihabi ZK, Griffith JW, Lakoski JM, McClearn GE, Vandenbergh DJ. Serum alkaline phosphatase activity is regulated by a chromosomal region containing the alkaline phosphatase 2 gene (Akp2) in C57BL/6J and DBA/2J mice. Physiol Genomics. 2005 Nov 17; 23(3):295-303.
  View in: PubMed
 
17. Manni A, Washington S, Hu X, Griffith JW, Bruggeman R, Demers LM, Mauger D, Verderame MF. Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells. Clin Exp Metastasis. 2005; 22(3):255-63.
  View in: PubMed
 
18. Peterson SL, Purvis RS, Griffith JW. Differential neuroprotective effects of the NMDA receptor-associated glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine in lithium-pilocarpine status epilepticus. Neurotoxicology. 2004 Sep; 25(5):835-47.
  View in: PubMed
 
19. Manni A, Washington S, Craig L, Cloud M, Griffith JW, Verderame MF, Texter LJ, Mauger D, Demers LM, Harms JF, Welch DR. Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Clin Exp Metastasis. 2003; 20(4):321-5.
  View in: PubMed
 
20. McLaughlin PJ, Wylie JD, Bloom G, Griffith JW, Zagon IS. Chronic exposure to the opioid growth factor, [Met5]-enkephalin, during pregnancy: maternal and preweaning effects. Pharmacol Biochem Behav. 2002 Jan-Feb; 71(1-2):171-81.
  View in: PubMed
 
21. Manni A, Washington S, Griffith JW, Verderame MF, Mauger D, Demers LM, Samant RS, Welch DR. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. Clin Exp Metastasis. 2002; 19(2):95-105.
  View in: PubMed
 
22. Peng X, Griffith JW, Lang CM. Reinitiated expression of EJras transgene in targeted epidermal cells of transgenic rabbits by cottontail rabbit papillomavirus infection. Cancer Lett. 2001 Oct 10; 171(2):193-200.
  View in: PubMed
 
23. Manni A, Fischer S, Franks M, Washington S, De Arment R, Griffith J, Demers L, Verderame M, Leiby B, Mauger D. S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells. Int J Oncol. 2001 Aug; 19(2):317-23.
  View in: PubMed
 
24. Wilson RP, Griffith JW. Endocarditis and meningitis caused by Streptococcus suis after cardiac surgery in a sheep. Contemp Top Lab Anim Sci. 2000 Jul; 39(4):43-6.
  View in: PubMed
 
25. Peng X, Griffith JW, Han R, Lang CM, Kreider JW. Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis. Am J Pathol. 1999 Jul; 155(1):315-24.
  View in: PubMed
 
26. Jayawant AM, Stephenson ER, Matte GS, Prophet GA, LaNoue KF, Griffith JW, Damiano RJ. Potassium-channel opener cardioplegia is superior to St. Thomas' solution in the intact animal. Ann Thorac Surg. 1999 Jul; 68(1):67-74.
  View in: PubMed
 
27. Hopper KD, Gilchrist IC, Landis JR, Localio AR, Wilson RP, Pae WE, Kunselman AR, Griffith JW, Pierce WS, Potok PS, TenHave TR. Detection of Björk-Shiley convexo-concave heart valve outlet strut single leg separations: consensus image acquisition and interpretation using two different cineradiographic imaging technologies. Cardiology. 1999; 91(2):96-101.
  View in: PubMed
 
28. Johnson CA, Griffith JW, Tenorio P, Hytrek S, Lang CM. Fatal trematodiasis in research turtles. Lab Anim Sci. 1998 Aug; 48(4):340-3.
  View in: PubMed
 
29. Dennis JU, Dean NM, Bennett CF, Griffith JW, Lang CM, Welch DR. Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha. Cancer Lett. 1998 Jun 5; 128(1):65-70.
  View in: PubMed
 
30. Harvey SB, Cladel NM, Budgeon LR, Welsh PA, Griffith JW, Lang CM, Christensen ND. Rabbit genital tissue is susceptible to infection by rabbit oral papillomavirus: an animal model for a genital tissue-targeting papillomavirus. J Virol. 1998 Jun; 72(6):5239-44.
  View in: PubMed
 
31. Hopper KD, Gilchrist IC, Landis JR, Abolfathi AH, Localio AR, Wilson RP, Pae WE, Kunselman AR, Wieting DW, Griffith JW, Pierce WS, Potok PS, TenHave TR, Chandler JG. In vivo accuracy of two radiographic systems in the detection of Björk-Shiley convexo-concave heart valve outlet strut single leg separations. J Thorac Cardiovasc Surg. 1998 Mar; 115(3):582-90.
  View in: PubMed
 
32. Tevethia MJ, Bonneau RH, Griffith JW, Mylin L. A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. J Virol. 1997 Nov; 71(11):8157-66.
  View in: PubMed
 
33. Wilson RP, Griffith JW. Mycotic thromboses in sheep implanted with biomedical cardiac devices. Lab Anim Sci. 1997 Oct; 47(5):554-6.
  View in: PubMed
 
34. Follansbee MH, Beyer KH, Griffith JW, Vesell ES. Studies on pyrazinoylguanidine. 5. Temporal effects over 24 weeks demonstrating attenuation of diabetic nephropathy in STZ-diabetic rats. Pharmacology. 1997 May; 54(5):241-55.
  View in: PubMed
 
35. Post JH, Cardella JF, Wilson RP, Griffith JW, Fox PS, Waybill PN, Hills JR. Experimental nonsurgical transcervical sterilization with a custom-designed platinum microcoil. J Vasc Interv Radiol. 1997 Jan-Feb; 8(1 Pt 1):113-8.
  View in: PubMed
 
36. Griffith JW, Brasky KM, Lang CM. Experimental pneumonia virus of mice infection of guineapigs spontaneously infected with Bordetella bronchiseptica. Lab Anim. 1997 Jan; 31(1):52-7.
  View in: PubMed
 
37. Hargaden M, Goldberg SH, Cunningham D, Breton ME, Griffith JW, Lang CM. Optic neuropathy following simulation of orbital hemorrhage in the nonhuman primate. Ophthal Plast Reconstr Surg. 1996 Dec; 12(4):264-72.
  View in: PubMed
 
38. O'Farrell L, Griffith JW. Comparative anatomy of the cranial vena cava in laboratory animals. Lab Anim Sci. 1996 Aug; 46(4):448-9.
  View in: PubMed
 
39. O'Farrell L, Griffith JW, Lang CM. Histologic development of the sheath that forms around long-term implanted central venous catheters. JPEN J Parenter Enteral Nutr. 1996 Mar-Apr; 20(2):156-8.
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40. Skopets B, Wilson RP, Griffith JW, Lang CM. Ivermectin toxicity in young mice. Lab Anim Sci. 1996 Feb; 46(1):111-2.
  View in: PubMed
 
41. O'Farrell L, Griffith JW, Hargaden M, Dennis JU, Höglund AU, Johnson CA, Tobias SW, Lang CM. Diagnostic exercise: megacolon in a cynomolgus monkey. Lab Anim Sci. 1996 Feb; 46(1):96-7.
  View in: PubMed
 
42. Sharma P, Joyce S, Chorney KA, Griffith JW, Bonneau RH, Wilson FD, Johnson CA, Flavell RA, Chorney MJ. Thymus-leukemia antigen interacts with T cells and self-peptides. J Immunol. 1996 Feb 1; 156(3):987-96.
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43. Robuccio JA, Griffith JW, Chroscinski EA, Cross PJ, Light TE, Lang CM. Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in guinea pigs. Lab Anim Sci. 1995 Aug; 45(4):420-6.
  View in: PubMed
 
44. Luo Y, Russell GB, Griffith JW, Lang CM. Comparison of anesthesia induced by ketamine-fentanyl combination and maintained by propofol or etomidate in New Zealand white rabbits. Lab Anim Sci. 1995 Jun; 45(3):269-75.
  View in: PubMed
 
45. Cardella JF, Wilson RP, Fox PS, Griffith JW. Evaluation of a second-generation tantalum biliary stent in a canine model. J Vasc Interv Radiol. 1995 May-Jun; 6(3):397-403.
  View in: PubMed
 
46. Schengrund CL, Chi X, Sabol J, Griffith JW. Long-term effects of instilled mineral dusts on pulmonary surfactant isolated from monkeys. Lung. 1995; 173(3):197-208.
  View in: PubMed
 
47. Mack PA, Griffith JW, Riling S, Lang CM. N-acetyl-beta-D-glucosaminidase activity within BAL from macaques exposed to generic coal dusts. Lung. 1995; 173(1):1-11.
  View in: PubMed
 
48. Schabdach DG, Goldberg SH, Breton ME, Griffith JW, Lang CM, Cunningham D. An animal model of visual loss from orbital hemorrhage. Ophthal Plast Reconstr Surg. 1994 Sep; 10(3):200-5.
  View in: PubMed
 
49. Kuhn DC, Griffith JW, Stauffer JL, Riling S, Demers LM. Characterization of alveolar macrophage eicosanoid production in a non-human primate model of mineral dust exposure. Prostaglandins. 1993 Sep; 46(3):207-20.
  View in: PubMed
 
50. Devaraj H, Griffith JW, Sheykhnazari M, Naziruddin B, Sachdev GP, Bhavanandan VP. Purification and characterization of monkey (Macaca nemestrina) tracheobronchial mucin. Arch Biochem Biophys. 1993 Apr; 302(1):285-93.
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51. Salkin IF, Dixon DM, Kemna ME, Danneman PJ, Griffith JW. Fatal encephalitis caused by Dactylaria constricta var. gallopava in a snowy owl chick (Nyctea scandiaca). J Clin Microbiol. 1990 Dec; 28(12):2845-7.
  View in: PubMed
 
52. Borkowski GL, Griffith JW. Diagnostic exercise: pneumonia and pleuritis in a rat. Lab Anim Sci. 1990 May; 40(3):323-5.
  View in: PubMed
 
53. Peng X, Griffith JW, Lang CM. Cystitis, urolithiasis and cystic calculi in ageing guineapigs. Lab Anim. 1990 Apr; 24(2):159-63.
  View in: PubMed
 
54. Field KJ, Griffith JW, Lang CM. Spontaneous reproductive tract leiomyomas in aged guinea-pigs. J Comp Pathol. 1989 Oct; 101(3):287-94.
  View in: PubMed
 
55. Wixson SK, Griffith JW. Diagnostic exercise: posterior paralysis in a nude mouse. Lab Anim Sci. 1988 Jun; 38(3):323-4.
  View in: PubMed
 
56. Griffith JW, White WJ, Danneman PJ, Lang CM. Cilia-associated respiratory (CAR) bacillus infection of obese mice. Vet Pathol. 1988 Jan; 25(1):72-6.
  View in: PubMed
 
57. Griffith JW, Sassani JW, Bowman TA, Lang CM. Osseous choristoma of the ciliary body in guinea pigs. Vet Pathol. 1988 Jan; 25(1):100-2.
  View in: PubMed
 
58. Griffith JW, Lang CM. Vitamin E and selenium status of guinea pigs with myocardial necrosis. Lab Anim Sci. 1987 Dec; 37(6):776-9.
  View in: PubMed
 
59. Keller LS, Griffith JW, Lang CM. Reproductive failure associated with cystic rete ovarii in guinea pigs. Vet Pathol. 1987 Jul; 24(4):335-9.
  View in: PubMed
 
60. Griffith JW, Frey RA, Sharkey FE. Synovial sarcoma of the jaw in a dog. J Comp Pathol. 1987 May; 97(3):361-4.
  View in: PubMed
 
61. Bowman TA, Griffith JW. Comparison of treatments for Psorergates mites in stumptailed macaques (Macaca arctoides). Lab Anim Sci. 1987 Feb; 37(1):100-2.
  View in: PubMed
 
62. Griffith JW, Hobbs BA, Manders EK. Cleft palate, brachygnathia inferior, and mandibular oligodontia in a Holstein calf. J Comp Pathol. 1987 Jan; 97(1):95-9.
  View in: PubMed
 
63. Moody KD, Griffith JW, Lang CM. Fungal meningoencephalitis in a laboratory rat. J Am Vet Med Assoc. 1986 Nov 1; 189(9):1152-3.
  View in: PubMed
 
64. Wixson SK, Griffith JW. Nutritional deficiency anemias in nonhuman primates. Lab Anim Sci. 1986 Jun; 36(3):231-6.
  View in: PubMed
 
65. Young JD, Griffith JW. Spontaneous Pasteurella pneumonia in adult laboratory goats complicated by superinfection with Corynebacterium pseudotuberculosis and Muellerius capillaris. Lab Anim Sci. 1985 Aug; 35(4):409-11.
  View in: PubMed
 
66. Murray KA, Hobbs BA, Griffith JW. Acute meningoencephalomyelitis in a rabbit infected with Pasteurella multocida. Lab Anim Sci. 1985 Apr; 35(2):169-71.
  View in: PubMed
 
67. Hobbs BA, Griffith JW. Cor pulmonale and cardiac failure in a skunk. J Am Vet Med Assoc. 1984 Dec 1; 185(11):1438-9.
  View in: PubMed
 
68. Griffith JW, Dubielzig RR, Riser WH, Jezyk P. Parosteal osteosarcoma with pulmonary metastases in a cat. Vet Pathol. 1984 Jan; 21(1):123-5.
  View in: PubMed
 
69. Griffith JW, White WJ, Pergrin PA, Darrigrand AA. Proliferative pleuritis associated with Bacteroides melaninogenicus subsp asaccharolyticus infection in a river otter. J Am Vet Med Assoc. 1983 Dec 1; 183(11):1287-8.
  View in: PubMed
 
70. Dubielzig RR, Griffith JW. An odontoameloblastoma in an adult sheep. Vet Pathol. 1982 May; 19(3):318-20.
  View in: PubMed
 
 
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Co-Authors  
Demers, Laurence
Lang, Carol
Manni, Andrea
Verderame, Michael
Wilson, Ronald
See all (34) people
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Lang, Carol
Cooper, Timothy
Peng, Xuwen
Wilson, Ronald
Whitcomb, Tiffany
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