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Jianxun Song
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Title Assistant Professor
Institution College of Medicine
Department Microbiology and Immunology
Division Microbiology & Immunology
Address 500 University Drive Hershey PA 17033
 Mailbox: H107
Telephone 7175310003
Email
Background
PREFERRED TITLE/ROLE:

Assistant Professor of Microbiology and Immunology

GRADUATE PROGRAM AFFILIATIONS:

Microbiology and Immunology, Cell and Molecular Biology

EDUCATION:

Ph.D., Third Military Medical University, China
Postdoctoral Training, La Jolla Institute for Allergy and Immunology, San Diego, CA

NARRATIVE:

Costimulation in T lymphocyte memory
Costimulatory signals expressed by professional antigen presenting cells (APCs) are capable of promoting the formation of highly active effector T cells, which are able to develop into memory populations. However, the mechanisms by which constimlation regulate T lymphocyte memory remain uncertain. Several molecular targets of costimulation (e.g., aurora B, survivin, bcl-xL, PKB) have been identified to sustain T cell proliferation or survival, and their cooperation in promoting T cell persistence as well as tumor regression is being investigated. Findings related to this project will provide new insights into why costimulatory signals might need to be sustained over time and suggest a potential novel approach to augment cellular immunotherapy for cancer.

Immune cell differentiation from induced pluripotent stem cells
Most effort is being expended to generate and characterize highly reactive immune cells from induced pluripotent stem (iPS) cells. Because of the plasticity and potentially unlimited capacity for self-renewal, iPS cell-derived immune cells have great potential in the treatment of disease (e.g., cancer, autoimmune disease, infectious disease, aging-related disease). Antigen-specific highly reactive T cells can be generated by genetic modification of iPS cells with specific T cell receptor and costimulation and stimulation with in vitro Notch signaling, and their therapeutic potential in the treatments of cancer and autoimmune disease are being determined. Findings related to this project will contribute important information to the areas of vaccine design, autoimmune therapy, and immune-based anti-cancer strategies.
Publications
1. Lei F, Song J, Haque R, Xiong X, Fang D, Wu Y, Lens SM, Croft M, Song J. Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol. 2013 Apr 25.
  View in: PubMed
 
2. Haque R, Lei F, Xiong X, Bian Y, Zhao B, Wu Y, Song J. Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol. 2012 Aug 1; 189(3):1228-36.
  View in: PubMed
 
3. Lei F, Haque R, Xiong X, Song J. Directed differentiation of induced pluripotent stem cells towards T lymphocytes. J Vis Exp. 2012; (63):e3986.
  View in: PubMed
 
4. Haque R, Lei F, Xiong X, Song J. The regulation of FoxP3-expressing regulatory T cells. Endocr Metab Immune Disord Drug Targets. 2011 Dec; 11(4):334-46.
  View in: PubMed
 
5. Lei F, Zhao B, Haque R, Xiong X, Budgeon L, Christensen ND, Wu Y, Song J. In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. Cancer Res. 2011 Jul 15; 71(14):4742-7.
  View in: PubMed
 
6. Haque R, Lei F, Xiong X, Wu Y, Song J. FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther. 2010; 12(2):R66.
  View in: PubMed
 
7. Lei F, Haque R, Weiler L, Vrana KE, Song J. T lineage differentiation from induced pluripotent stem cells. Cell Immunol. 2009; 260(1):1-5.
  View in: PubMed
 
8. Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, Wu Y, Croft M, Song J. Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol. 2009 Jun 1; 182(11):6744-52.
  View in: PubMed
 
9. Song J, Lei FT, Xiong X, Haque R. Intracellular signals of T cell costimulation. Cell Mol Immunol. 2008 Aug; 5(4):239-47.
  View in: PubMed
 
10. Song J, So T, Croft M. Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol. 2008 Jun 1; 180(11):7240-8.
  View in: PubMed
 
11. Song J, Salek-Ardakani S, So T, Croft M. The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol. 2007 Jan; 8(1):64-73.
  View in: PubMed
 
12. So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A. 2006 Mar 7; 103(10):3740-5.
  View in: PubMed
 
13. Song J, So T, Cheng M, Tang X, Croft M. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity. 2005 May; 22(5):621-31.
  View in: PubMed
 
14. Song J, Salek-Ardakani S, Rogers PR, Cheng M, Van Parijs L, Croft M. The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol. 2004 Feb; 5(2):150-8.
  View in: PubMed
 
15. Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, Croft M. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med. 2003 Jul 21; 198(2):315-24.
  View in: PubMed
 
16. Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001 Sep; 15(3):445-55.
  View in: PubMed
 
 
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Co-Authors  
Christensen, Neil
Vrana, Kent
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