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Jeffery Sample
Title Professor
Institution College of Medicine
Department Microbiology and Immunology
Division Microbiology & Immunology
Address 500 University Drive Hershey PA 17033
Mailbox: H107
Email
Background
PREFERRED TITLE/ROLE:

Professor of Microbiology and Immunology

GRADUATE PROGRAM AFFILIATIONS:

Biomedical Sciences (BMS)
Virology and Immunology (BMS VIRIM Option)
Biochemistry and Molecular Genetics (BMS BMG Option)
Immunology and Infectious Diseases
Molecular Medicine
MD/PhD Degree Program

EDUCATION:

BS, Florida Institute of Technology, 1979
PhD, University of South Florida College of Medicine, 1985
Postdoctoral training, University of Chicago, 1985-1987
Postdoctoral training, Harvard Medical School, 1987-1990

FACULTY POSITIONS:

Departments of Virology & Molecular Biology and Biochemistry, St. Jude Children's Research Hospital, 1990-2006
Department of Pathology (adjunct), University of Tennessee College of Medicine, 1994-2006
Department of Microbiology & Immunology, Penn State College of Medicine, 2006-present
Penn State Hershey Cancer Institute, 2006-present
Publications
1. Hughes DJ, Kipar A, Leeming G, Sample JT, Stewart JP. Experimental infection of laboratory-bred bank voles (Myodes glareolus) with murid herpesvirus 4. Arch Virol. 2012 Nov; 157(11):2207-12.
  View in: PubMed
 
2. Stevens HC, Cham KS, Hughes DJ, Sun R, Sample JT, Bubb VJ, Stewart JP, Quinn JP. CTCF and Sp1 interact with the Murine gammaherpesvirus 68 internal repeat elements. Virus Genes. 2012 Oct; 45(2):265-73.
  View in: PubMed
 
3. Hughes DJ, Marendy EM, Dickerson CA, Yetming KD, Sample CE, Sample JT. Contributions of CTCF and DNA methyltransferases DNMT1 and DNMT3B to Epstein-Barr virus restricted latency. J Virol. 2012 Jan; 86(2):1034-45.
  View in: PubMed
 
4. Hughes DJ, Dickerson CA, Shaner MS, Sample CE, Sample JT. trans-Repression of protein expression dependent on the Epstein-Barr virus promoter Wp during latency. J Virol. 2011 Nov; 85(21):11435-47.
  View in: PubMed
 
5. Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson JA, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP. Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host. PLoS Pathog. 2011 Mar; 7(3):e1001321.
  View in: PubMed
 
6. Hughes DJ, Kipar A, Sample JT, Stewart JP. Pathogenesis of a model gammaherpesvirus in a natural host. J Virol. 2010 Apr; 84(8):3949-61.
  View in: PubMed
 
7. Hughes DJ, Kipar A, Milligan SG, Cunningham C, Sanders M, Quail MA, Rajandream MA, Efstathiou S, Bowden RJ, Chastel C, Bennett M, Sample JT, Barrell B, Davison AJ, Stewart JP. Characterization of a novel wood mouse virus related to murid herpesvirus 4. J Gen Virol. 2010 Apr; 91(Pt 4):867-79.
  View in: PubMed
 
8. Ruf IK, Houmani JL, Sample JT. Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma. PLoS One. 2009; 4(6):e6023.
  View in: PubMed
 
9. Garrison SP, Jeffers JR, Yang C, Nilsson JA, Hall MA, Rehg JE, Yue W, Yu J, Zhang L, Onciu M, Sample JT, Cleveland JL, Zambetti GP. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol. 2008 Sep; 28(17):5391-402.
  View in: PubMed
 
10. Sample JT, Marendy EM, Hughes DJ, Sample CE. The EBV viral genome. In: Pipas JM, Damania B, eds. DNA tumor viruses. Springer. 2008; 241-258.
 
11. Sample JT, Sample CE. Epstein-Barr virus: Molecular biology. In: Mahy BWJ, Van Regenmortel MHV, eds. Encyclopedia of virology, 3rd edition. Elsevier Ltd., Oxford. 2008; 157-167.
 
12. Yoshioka M, Crum MM, Sample JT. Autorepression of Epstein-Barr virus nuclear antigen 1 expression by inhibition of pre-mRNA processing. J Virol. 2008 Feb; 82(4):1679-87.
  View in: PubMed
 
13. Han Z, Marendy E, Wang YD, Yuan J, Sample JT, Swaminathan S. Multiple roles of Epstein-Barr virus SM protein in lytic replication. J Virol. 2007 Apr; 81(8):4058-69.
  View in: PubMed
 
14. Sample JT, Ruf IK. Burkitt lymphoma. In: Tselis A, Jenson HB, eds. Epstein-Barr virus. Taylor & Francis Group, LLC. 2006; 187-221.
 
15. Ruf IK, Lackey KA, Warudkar S, Sample JT. Protection from interferon-induced apoptosis by Epstein-Barr virus small RNAs is not mediated by inhibition of PKR. J Virol. 2005 Dec; 79(23):14562-9.
  View in: PubMed
 
16. Macrae AI, Usherwood EJ, Husain SM, Flaño E, Kim IJ, Woodland DL, Nash AA, Blackman MA, Sample JT, Stewart JP. Murid herpesvirus 4 strain 68 M2 protein is a B-cell-associated antigen important for latency but not lymphocytosis. J Virol. 2003 Sep; 77(17):9700-9.
  View in: PubMed
 
17. Zhao B, Dalbiès-Tran R, Jiang H, Ruf IK, Sample JT, Wang F, Sample CE. Transcriptional regulatory properties of Epstein-Barr virus nuclear antigen 3C are conserved in simian lymphocryptoviruses. J Virol. 2003 May; 77(10):5639-48.
  View in: PubMed
 
18. Woodland DL, Flaño E, Usherwood EJ. Antigen expression during murine gamma-herpesvirus infection. Immunobiology. 2001 Dec; 204(5):649-58.
  View in: PubMed
 
19. Ruf IK, Rhyne PW, Yang H, Borza CM, Hutt-Fletcher LM, Cleveland JL, Sample JT. EBV regulates c-MYC, apoptosis, and tumorigenicity in Burkitt's lymphoma. Curr Top Microbiol Immunol. 2001; 258:153-60.
  View in: PubMed
 
20. Ruf IK, Rhyne PW, Yang C, Cleveland JL, Sample JT. Epstein-Barr virus small RNAs potentiate tumorigenicity of Burkitt lymphoma cells independently of an effect on apoptosis. J Virol. 2000 Nov; 74(21):10223-8.
  View in: PubMed
 
21. Swart R, Ruf IK, Sample J, Longnecker R. Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway. J Virol. 2000 Nov; 74(22):10838-45.
  View in: PubMed
 
22. Flaño E, Husain SM, Sample JT, Woodland DL, Blackman MA. Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages. J Immunol. 2000 Jul 15; 165(2):1074-81.
  View in: PubMed
 
23. Ruf IK, Sample J. Repression of Epstein-Barr virus EBNA-1 gene transcription by pRb during restricted latency. J Virol. 1999 Oct; 73(10):7943-51.
  View in: PubMed
 
24. Husain SM, Usherwood EJ, Dyson H, Coleclough C, Coppola MA, Woodland DL, Blackman MA, Stewart JP, Sample JT. Murine gammaherpesvirus M2 gene is latency-associated and its protein a target for CD8(+) T lymphocytes. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7508-13.
  View in: PubMed
 
25. Ruf IK, Moghaddam A, Wang F, Sample J. Mechanisms that regulate Epstein-Barr virus EBNA-1 gene transcription during restricted latency are conserved among lymphocryptoviruses of Old World primates. J Virol. 1999 Mar; 73(3):1980-9.
  View in: PubMed
 
26. Ruf IK, Rhyne PW, Yang H, Borza CM, Hutt-Fletcher LM, Cleveland JL, Sample JT. Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. Mol Cell Biol. 1999 Mar; 19(3):1651-60.
  View in: PubMed
 
27. Torii T, Konishi K, Sample J, Takada K. The truncated form of the Epstein-Barr virus LMP-1 is dispensable or complimentable by the full-length form in virus infection and replication. Virology. 1998 Nov 25; 251(2):273-8.
  View in: PubMed
 
28. Srinivas SK, Sample JT, Sixbey JW. Spontaneous loss of viral episomes accompanying Epstein-Barr virus reactivation in a Burkitt's lymphoma cell line. J Infect Dis. 1998 Jun; 177(6):1705-9.
  View in: PubMed
 
29. Chodosh J, Holder VP, Gan YJ, Belgaumi A, Sample J, Sixbey JW. Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype. J Infect Dis. 1998 May; 177(5):1194-201.
  View in: PubMed
 
30. Nonkwelo C, Ruf IK, Sample J. Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma. J Virol. 1997 Sep; 71(9):6887-97.
  View in: PubMed
 
31. Nonkwelo C, Ruf IK, Sample J. The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element. J Virol. 1997 Jan; 71(1):354-61.
  View in: PubMed
 
32. Nonkwelo C, Skinner J, Bell A, Rickinson A, Sample J. Transcription start sites downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein. J Virol. 1996 Jan; 70(1):623-7.
  View in: PubMed
 
33. Nonkwelo C, Henson EB, Sample J. Characterization of the Epstein-Barr virus Fp promoter. Virology. 1995 Jan 10; 206(1):183-95.
  View in: PubMed
 
34. Sample J, Kieff EF, Kieff ED. Epstein-Barr virus types 1 and 2 have nearly identical LMP-1 transforming genes. J Gen Virol. 1994 Oct; 75 ( Pt 10):2741-6.
  View in: PubMed
 
35. Sample J, Henson EB, Sample C. The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated. J Virol. 1992 Aug; 66(8):4654-61.
  View in: PubMed
 
36. Sample J, Brooks L, Sample C, Young L, Rowe M, Gregory C, Rickinson A, Kieff E. Restricted Epstein-Barr virus protein expression in Burkitt lymphoma is due to a different Epstein-Barr nuclear antigen 1 transcriptional initiation site. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6343-7.
  View in: PubMed
 
37. Sample J, Young L, Martin B, Chatman T, Kieff E, Rickinson A, Kieff E. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J Virol. 1990 Sep; 64(9):4084-92.
  View in: PubMed
 
38. Sample J, Kieff E. Transcription of the Epstein-Barr virus genome during latency in growth-transformed lymphocytes. J Virol. 1990 Apr; 64(4):1667-74.
  View in: PubMed
 
39. Lieberman PM, Hardwick JM, Sample J, Hayward GS, Hayward SD. The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions. J Virol. 1990 Mar; 64(3):1143-55.
  View in: PubMed
 
40. Birkenbach M, Liebowitz D, Wang F, Sample J, Kieff E. Epstein-Barr virus latent infection membrane protein increases vimentin expression in human B-cell lines. J Virol. 1989 Sep; 63(9):4079-84.
  View in: PubMed
 
41. Sample J, Liebowitz D, Kieff E. Two related Epstein-Barr virus membrane proteins are encoded by separate genes. J Virol. 1989 Feb; 63(2):933-7.
  View in: PubMed
 
42. Tanner J, Whang Y, Sample J, Sears A, Kieff E. Soluble gp350/220 and deletion mutant glycoproteins block Epstein-Barr virus adsorption to lymphocytes. J Virol. 1988 Dec; 62(12):4452-64.
  View in: PubMed
 
43. Heineman T, Gong M, Sample J, Kieff E. Identification of the Epstein-Barr virus gp85 gene. J Virol. 1988 Apr; 62(4):1101-7.
  View in: PubMed
 
44. Petti L, Sample J, Wang F, Kieff E. A fifth Epstein-Barr virus nuclear protein (EBNA3C) is expressed in latently infected growth-transformed lymphocytes. J Virol. 1988 Apr; 62(4):1330-8.
  View in: PubMed
 
45. Pearson GR, Luka J, Petti L, Sample J, Birkenbach M, Braun D, Kieff E. Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex. Virology. 1987 Sep; 160(1):151-61.
  View in: PubMed
 
46. Liebowitz D, Kopan R, Fuchs E, Sample J, Kieff E. An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Mol Cell Biol. 1987 Jul; 7(7):2299-308.
  View in: PubMed
 
47. Sample J, Hummel M, Braun D, Birkenbach M, Kieff E. Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5096-100.
  View in: PubMed
 
48. Sample J, Lancz G, Nonoyama M. Mapping of genes in BamHI fragment M of Epstein-Barr virus DNA that may determine the fate of viral infection. J Virol. 1986 Jan; 57(1):145-54.
  View in: PubMed
 
49. Lancz G, Sample J. Thermal-pH inactivation of herpes simplex virus: interdependence of the medium composition and the pH on the rate of virus inactivation. Brief report. Arch Virol. 1985; 84(1-2):141-6.
  View in: PubMed
 
50. Sample J, Tanaka A, Lancz G, Nonoyama M. Identification of Epstein-Barr virus genes expressed during the early phase of virus replication and during lymphocyte immortalization. Virology. 1984 Nov; 139(1):1-10.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Co-Authors  
Sample, Clare
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