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Jeffrey Shenberger
Title Associate Professor
Institution College of Medicine
Department Pediatrics
Address 500 University Drive Hershey PA 17033
Telephone 7175318413
Email
Other Positions
Title Associate Professor
Institution College of Medicine
Department Cellular and Molecular Physiology
Background
PREFERRED TITLE/ROLE:

Staff neonatologist
Associate Professor of Pediatrics and Cellular and Molecular Physiology
Medical Director, Neonatal ECMO Program

GRADUATE PROGRAM AFFILIATIONS:

MD/PhD Degree Program, Physiology
CHILD Research
Penn State Eye Research Group

EDUCATION:

Fellowship, University of Minnesota Medical School (1995)
Residency, Pediatrics, University of Minnesota Medical School (1992)
M.D., Penn State Hershey College of Medicine (1989)

NARRATIVE:

Research conducted by our laboratory focuses on the ability of oxidative stress to regulate protein synthesis during development. Our goal is to understand how modulatation of translational regulatory signaling by high levels of inspired oxygen (hyperoxia) contributes to the development of bronchopulmonary dysplasia in premature infants in the newborn intensive care unit. We have determined that hyperoxia suppresses global protein synthesis within the lung via the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2a), thereby activating a stress-response program which restores redox homeostasis, modulates the immune response, and facilitates DNA repair. Research design involves use oxygen-induced lung injury and oxygen-induced retinopathy models.
Publications
1. Konsavage WM, Umstead TM, Wu Y, Phelps DS, Shenberger JS. Hyperoxia-induced alterations in the pulmonary proteome of juvenile rats. Exp Lung Res. 2013 Mar; 39(2):107-17.
  View in: PubMed
 
2. Reed-Thurston D, Qiu F, Ündar A, Haidet KK, Shenberger J. Pediatric and neonatal extracorporeal life support technology component utilization: are US clinicians implementing new technology? Artif Organs. 2012 Jul; 36(7):607-15.
  View in: PubMed
 
3. Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 2012 Jan; 71(1):107-14.
  View in: PubMed
 
4. Konsavage WM, Zhang L, Wu Y, Shenberger JS. Hyperoxia-induced activation of the integrated stress response in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1; 302(1):L27-35.
  View in: PubMed
 
5. Reed-Thurston D, Shenberger J, Qiu F, Undar A. Neonatal extracorporeal life support: will the newest technology reduce morbidity? Artif Organs. 2011 Nov; 35(11):989-96.
  View in: PubMed
 
6. Joanna Floros, Douglas Londono, Derek Gordon, Patricia Silveyra, Susan L DiAngelo, Rose M Viscardi, George Scott Worthen, Jeffrey Shenberger, Guirong Wang, Zhenwu Lin, Neal J Thomas. Pediatric Research. IL-18R1 and IL-18RAP SNPs may associate with Bronchopulmonary Dysplasia in African American Infants. 2011; In Press.
 
7. Konsavage W, Zhang L, Vary T, Shenberger JS. Hyperoxia inhibits protein synthesis and increases eIF2a phosphorylation in the newborn rat lung. Am J Physiol Lung Cell Mol Physiol. 2010 May; 298(5):L678-86.
  View in: PubMed
 
8. Zhang L, Kimball SR, Jefferson LS, Shenberger JS. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free Radic Biol Med. 2009 Jun 1; 46(11):1500-9.
  View in: PubMed
 
9. Shenberger JS, Zhang L, Powell RJ, Barchowsky A. Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes. Free Radic Biol Med. 2007 Sep 1; 43(5):844-52.
  View in: PubMed
 
10. Shenberger JS, Zhang L, Hughlock MK, Ueda T, Watanabe-Fukunaga R, Fukunaga R. Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation. Int J Biochem Cell Biol. 2007; 39(10):1828-42.
  View in: PubMed
 
11. McAdams RM, Mustafa SB, Shenberger JS, Dixon PS, Henson BM, DiGeronimo RJ. Cyclic stretch attenuates effects of hyperoxia on cell proliferation and viability in human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Aug; 291(2):L166-74.
  View in: PubMed
 
12. Shenberger JS, Myers JL, Zimmer SG, Powell RJ, Barchowsky A. Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L442-9.
  View in: PubMed
 
13. Shenberger JS, Adams MH, Zimmer SG. Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):250-6.
  View in: PubMed
 
14. Shenberger JS, Dixon PS, Choate J, Helal K, Shew RL, Barth W. Pregnancy and labor increase the capacity of human myometrial cells to secrete parathyroid hormone-related protein. Life Sci. 2001 Feb 16; 68(13):1557-66.
  View in: PubMed
 
15. Shenberger JS, Dixon PS. Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells. Am J Respir Cell Mol Biol. 1999 Sep; 21(3):395-402.
  View in: PubMed
 
16. Shenberger JS, Shew RL, Johnson DE. Hyperoxia-induced airway remodeling and pulmonary neuroendocrine cell hyperplasia in the weanling rat. Pediatr Res. 1997 Oct; 42(4):539-44.
  View in: PubMed
 
17. Shenberger JS, Shew RL, Johnson DE, Kannan MS. Relaxation of porcine tracheal smooth muscle by parathyroid hormone-related protein. Respir Physiol. 1997 Jan; 107(1):59-66.
  View in: PubMed
 
18. Sinoway L, Shenberger J, Leaman G, Zelis R, Gray K, Baily R, Leuenberger U. Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. J Appl Physiol. 1996 Oct; 81(4):1778-84.
  View in: PubMed
 
19. Baily RG, Prophet SA, Shenberger JS, Zelis R, Sinoway LI. Direct neurohumoral evidence for isolated sympathetic nervous system activation to skeletal muscle in response to cardiopulmonary baroreceptor unloading. Circ Res. 1990 Jun; 66(6):1720-8.
  View in: PubMed
 
20. Shenberger JS, Leaman GJ, Neumyer MM, Musch TI, Sinoway LI. Physiologic and structural indices of vascular function in paraplegics. Med Sci Sports Exerc. 1990 Feb; 22(1):96-101.
  View in: PubMed
 
21. Shenberger JS, Prophet SA, Waldhausen JA, Davidson WR, Sinoway LI. Left subclavian flap aortoplasty for coarctation of the aorta: effects on forearm vascular function and growth. J Am Coll Cardiol. 1989 Oct; 14(4):953-9.
  View in: PubMed
 
22. Sinoway L, Prophet S, Gorman I, Mosher T, Shenberger J, Dolecki M, Briggs R, Zelis R. Muscle acidosis during static exercise is associated with calf vasoconstriction. J Appl Physiol. 1989 Jan; 66(1):429-36.
  View in: PubMed
 
23. Sinoway LI, Wilson JS, Zelis R, Shenberger J, McLaughlin DP, Morris DL, Day FP. Sympathetic tone affects human limb vascular resistance during a maximal metabolic stimulus. Am J Physiol. 1988 Oct; 255(4 Pt 2):H937-46.
  View in: PubMed
 
24. Sinoway LI, Shenberger J, Wilson J, McLaughlin D, Musch T, Zelis R. A 30-day forearm work protocol increases maximal forearm blood flow. J Appl Physiol. 1987 Mar; 62(3):1063-7.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Hyperoxia
Lung
Phosphoproteins
Eukaryotic Initiation Factor-4E
Hydrogen Peroxide
See all (193) keywords
Co-Authors  
Kimball, Scot
Konsavage, Wesley
Sinoway, Lawrence
Thomas, Neal
Zelis, Robert
See all (15) people
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