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Jiyue Zhu
Title Associate Professor
Institution College of Medicine
Department Cellular and Molecular Physiology
Address 500 University Drive Hershey PA 17033
Mailbox: H166
Telephone 7175313597
Email
Background
PREFERRED TITLE/ROLE:

Associate Professor of Cellular and Molecular Physiology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Penn State Cancer Institute

GRADUATE PROGRAM AFFILIATIONS:

Cell and Molecular Biology, Physiology, Genetics, Integrative Biosciences, MD/PhD degree program, Molecular Toxicology

EDUCATION:

Ph.D., Dartmouth Medical School, 1991
Postdoctoral Fellow, Harvard Medical School, 1991; Research Associate, 1992
Postdoctoral Fellow, University of California, 1993-1999

NARRATIVE:

Our laboratory studies the epigenetic and chromatin regulation of the human telomerase reverse transcriptase (hTERT) gene, which plays critical roles in stem cell self-renewal, aging, and cancer. Whereas telomerase mutations causes premature aging, its activation leads to limitless cell proliferation, a hallmark of all cancers. The ongoing projects focus on the identification of epigenetic elements and regulatory proteins involved in telomerase regulation during stem cell differentiation, nuclear reprogramming, and tumorigenesis, using models of normal and cancer cells, adult stem cells, embryonic stem cells, induced pluripotent stem cells (iPSCs), and transgenic mice.
Publications
1. Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J. A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J. 2011 Mar; 25(3):979-89.
  View in: PubMed
 
2. Zhao Y, Wang S, Zhu J. A multi-step strategy for BAC recombineering of large DNA fragments. Int J Biochem Mol Biol. 2011; 2(3):199-206.
  View in: PubMed
 
3. Mathew R, Jia W, Sharma A, Zhao Y, Clarke LE, Cheng X, Wang H, Salli U, Vrana KE, Robertson GP, Zhu J, Wang S. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. FASEB J. 2010 Aug; 24(8):2702-15.
  View in: PubMed
 
4. Zhu J, Zhao Y, Wang S. Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell. 2010 Jan; 1(1):22-32.
  View in: PubMed
 
5. Wang S, Hu C, Zhu J. Distinct and temporal roles of nucleosomal remodeling and histone deacetylation in the repression of the hTERT gene. Mol Biol Cell. 2010 Mar 1; 21(5):821-32.
  View in: PubMed
 
6. Zhao Y, Wang S, Popova EY, Grigoryev SA, Zhu J. Rearrangement of upstream sequences of the hTERT gene during cellular immortalization. Genes Chromosomes Cancer. 2009 Nov; 48(11):963-74.
  View in: PubMed
 
7. Wang S, Zhao Y, Leiby MA, Zhu J. Studying human telomerase gene transcription by a chromatinized reporter generated by recombinase-mediated targeting of a bacterial artificial chromosome. Nucleic Acids Res. 2009 Sep; 37(17):e111.
  View in: PubMed
 
8. Wang S, Zhao Y, Hu C, Zhu J. Differential repression of human and mouse TERT genes during cell differentiation. Nucleic Acids Res. 2009 May; 37(8):2618-29.
  View in: PubMed
 
9. Wang S, Zhao Y, Leiby M, Zhu J. A new positive/negative selection scheme for precise BAC recombineering. Mol Biotechnol. 2009 May; 42(1):110-6.
  View in: PubMed
 
10. Wang S, Hu C, Zhu J. Transcriptional silencing of a novel hTERT reporter locus during in vitro differentiation of mouse embryonic stem cells. Mol Biol Cell. 2007 Feb; 18(2):669-77.
  View in: PubMed
 
11. Wang S, Robertson GP, Zhu J. A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers. Gene. 2004 Dec 8; 343(1):69-78.
  View in: PubMed
 
12. Wang S, Zhu J. The hTERT gene is embedded in a nuclease-resistant chromatin domain. J Biol Chem. 2004 Dec 31; 279(53):55401-10.
  View in: PubMed
 
13. Wang S, Zhu J. Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. J Biol Chem. 2003 May 23; 278(21):18842-50.
  View in: PubMed
 
14. Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM. Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10544-8.
  View in: PubMed
 
15. Zhu J, Wang H, Bishop JM, Blackburn EH. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3723-8.
  View in: PubMed
 
16. Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 1998 Oct 1; 12(19):2997-3007.
  View in: PubMed
 
17. Rajan P, Swaminathan S, Zhu J, Cole CN, Barber G, Tevethia MJ, Thimmapaya B. A novel translational regulation function for the simian virus 40 large-T antigen gene. J Virol. 1995 Feb; 69(2):785-95.
  View in: PubMed
 
18. Zhu J, Cunningham JM. Minus-strand DNA is present within murine type C ecotropic retroviruses prior to infection. J Virol. 1993 Apr; 67(4):2385-8.
  View in: PubMed
 
19. Bentivoglio CM, Zhu J, Cole CN. Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen. J Virol. 1992 Jul; 66(7):4209-19.
  View in: PubMed
 
20. Zhu J, Rice PW, Gorsch L, Abate M, Cole CN. Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen. J Virol. 1992 May; 66(5):2780-91.
  View in: PubMed
 
21. Zhu JY, Abate M, Rice PW, Cole CN. The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53. J Virol. 1991 Dec; 65(12):6872-80.
  View in: PubMed
 
22. Zhu JY, Rice PW, Chamberlain M, Cole CN. Mapping the transcriptional transactivation function of simian virus 40 large T antigen. J Virol. 1991 Jun; 65(6):2778-90.
  View in: PubMed
 
23. Zhu JY, Cole CN. Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene. J Virol. 1989 Nov; 63(11):4777-86.
  View in: PubMed
 
 
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Co-Authors  
Grigoryev, Sergei
Gunther, Edward
Popova, Evgenya
Sharma, Arati
Vrana, Kent
See all (7) people
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