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Gordon Kauffman
Title Professor And Vice Chair Of Surgery; Professor Of Cellular And Molecular Physiology
Institution College of Medicine
Department Surgery
Division Surgery Oncology
Address 500 University Drive Hershey PA 17033
Telephone 7175318815
Email
Background
PREFERRED TITLE/ROLE:

Physician, Professor and Vice Chair of Surgery, Professor of Cellular and Molecular Physiology

GRADUATE PROGRAM AFFILIATIONS:

MD/PhD Degree Program, Physiology

EDUCATION:

Fellowship, Veterans Affairs Medical Center - W. Los Angeles (1980)
Postgraduate Training, Center for Ulcer Research and Education, V.A. Wadsworth, 1977-1980
Residency, University of Michigan Hospitals & Health Centers (1977)
M.D., University of Michigan Medical School (1972)


NARRATIVE:

The use of histamine 2-receptor blockers and the discovery of Helicobacter pylori infection in the stomach and subsequent antibiotic therapy have greatly reduced the incidence and recurrence of gastric and duodenal ulcers. However, gastric ulcers (stress gastritis) of varying severity are seen in 15 to 30 percent of patients in hospital critical care units where they can severely complicate the recovery of critically ill patients. To date, the mechanisms responsible for the development of stress ulcers remain to be defined, but the etiology appears to be multifactorial.

The main aim of the research carried out in the laboratory is to understand the central and peripheral cellular and molecular mechanisms involved in the etiology of stress ulcers. The specific focus is on control by the central nervous system of gastric mucosal defence. These mechanisms are studied in a rat model of stress-induced gastric ulcers. Stress is induced by cold water restraint (CWR) which produces macroscopic and microscopic ulceration within two hours. Studies from this and other laboratories have identified neurotensin, a centrally occuring neurotransmitter/neuromodulator, and other components of the mesolimbic system as key elements involved in central control of mucosal defence. Administration of neurotensin into the cerebrospinal fluid or directly into the mesolimbic nuclei protects the mucosa against CWR injury induced in rats by reducing gastric acid secretion, enhancing endogenous gastric mucosal prostaglandin generation, and maintaining mucosal blood flow. The protective effect of neurotensin can be attenuated by depleteing the nuclei of dopamine with 6-hydroxydopamine, or by pharmacological blockade of dopamine and adrenergic receptors. These observations suggest that exogenous neurotensin acts via dopaminergic and adrenergic pathways in the central nervous system. We have recently observed that the level of endogenous neurotensin in the nucleus accumbens (part of the mesolimbic system) is reduced by CWR and that this change is accompanied by a parallel decrease in neurotensin mRNA levels. In addition, during CWR, neurotensin receptors are up-regulated, so that the number of neurotensin specific binding sites in the nucleus accumbens is increased. These changes support the hypothesis that neurotensin is involved in mucosal defence in vivo.

Research is directed toward 1) elucidating the steps/mechanisms linking events that occur in the mesolimbic nuclei during CRW to events in the periphery that result in gastric mucosal injury and 2) identifying the molecular mechanism(s) through which neurotensin exerts its protective effect. Such knowledge would allow identification of therapeutic interventions that may ameliorate gastric injury induced by stress.
Publications
1. Lazarus MD, Chinchilli VM, Leong SL, Kauffman GL. Perceptions of anatomy: critical components in the clinical setting. Anat Sci Educ. 2012 Jul-Aug; 5(4):187-99.
  View in: PubMed
 
2. Adil E, Adil T, Fedok F, Kauffman G, Goldenberg D. Minimally invasive radioguided parathyroidectomy performed for primary hyperparathyroidism. Otolaryngol Head Neck Surg. 2009 Jul; 141(1):34-8.
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3. Hackett DA, Kauffman GL. Historical perspective of parathyroid disease. Otolaryngol Clin North Am. 2004 Aug; 37(4):689-700, vii.
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4. Chinoy MR, Graybill MM, Miller SA, Lang CM, Kauffman GL. Angiopoietin-1 and VEGF in vascular development and angiogenesis in hypoplastic lungs. Am J Physiol Lung Cell Mol Physiol. 2002 Jul; 283(1):L60-6.
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5. Kokoska ER, Kauffman GL. Helicobacter pylori and the gastroduodenal mucosa. Surgery. 2001 Jul; 130(1):13-6.
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6. McGarrity TJ, Ruggiero FM, Chey WY, Bajaj R, Kelly JE, Kauffman GL. Giant fundic polyp complicating attenuated familial adenomatous polyposis. Am J Gastroenterol. 2000 Jul; 95(7):1824-8.
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7. Kauffman GL. Duodenal ulcer disease: treatment by surgery, antibiotics, or both. Adv Surg. 2000; 34:121-35.
  View in: PubMed
 
8. Karinch AM, Schmidt GL, Kauffman GL. Pretreatment with SR48692 has different effects on central neurotensin-induced gastric mucosal defense and inhibition of gastric acid secretion in rats. Brain Res. 1998 Nov 9; 810(1-2):123-9.
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9. Xing L, Karinch AM, Kauffman GL. Mesolimbic expression of neurotensin and neurotensin receptor during stress-induced gastric mucosal injury. Am J Physiol. 1998 Jan; 274(1 Pt 2):R38-45.
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10. Kauffman GL. Stress, the brain, and the gastric mucosa. Am J Surg. 1997 Sep; 174(3):271-5.
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11. Koltun WA, Bloomer MM, Colony P, Kauffman GL. Increased intestinal permeability in rats with graft versus host disease. Gut. 1996 Aug; 39(2):291-8.
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12. Conter RL, Hughes MT, Kauffman GL. Intracerebroventricular secretin enhances pancreatic volume and bicarbonate response in rats. Surgery. 1996 Feb; 119(2):208-13.
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13. Koltun WA, Bloomer MM, Tilberg AF, Seaton JF, Ilahi O, Rung G, Gifford RM, Kauffman GL. Awake epidural anesthesia is associated with improved natural killer cell cytotoxicity and a reduced stress response. Am J Surg. 1996 Jan; 171(1):68-72; discussion 72-3.
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14. Grenko RT, Anderson KM, Kauffman G, Abt AB. Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. Arch Pathol Lab Med. 1995 Nov; 119(11):1072-4.
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15. Martin LF, Tan TL, Horn JR, Bixler EO, Kauffman GL, Becker DA, Hunter SM. Comparison of the costs associated with medical and surgical treatment of obesity. Surgery. 1995 Oct; 118(4):599-606; discussion 606-7.
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16. Koltun WA, Bloomer MM, Colony PC, Ruggiero FM, Kauffman GL. Graft-versus-host disease after small bowel transplantation is associated with host colonic injury. Dig Dis Sci. 1995 Sep; 40(9):1925-33.
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17. Gerstle JT, Kauffman GL, Koltun WA. The incidence, management, and outcome of patients with gastrointestinal carcinoids and second primary malignancies. J Am Coll Surg. 1995 Apr; 180(4):427-32.
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18. Gerstle JT, Seaton J, Kauffman GL, Colony PC. The association between PGE2 activity and mucosal permeability in proximal small bowel. J Surg Res. 1994 Nov; 57(5):579-83.
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19. McKenna KJ, Ligato S, Kauffman GL, Abt AB, Stryker JA, Conter RL. Epidermal growth factor enhances intestinal mitotic activity and DNA content after acute abdominal radiation. Surgery. 1994 May; 115(5):626-32.
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20. Conter RL, Washington JL, Kauffman GL. Stimulated pancreatic exocrine secretion does not require pancreatic hyperemia in rats. Potential cholinergic role. Dig Dis Sci. 1993 Jul; 38(7):1270-7.
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21. Conter RL, Washington JL, Liao CC, Kauffman GL. Gallbladder mucosal blood flow increases during early cholesterol gallstone formation. Gastroenterology. 1992 May; 102(5):1764-70.
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22. Saperas E, Kauffman G, Taché Y. Role of central prostaglandin E2 in the regulation of gastric acid secretion in the rat. Eur J Pharmacol. 1991 Dec 10; 209(1-2):1-7.
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23. Endoh K, Kauffman GL, Leung FW. Mechanism of aggravation of mucosal injury by intravenous nicotine in rat stomach. Am J Physiol. 1991 Dec; 261(6 Pt 1):G1037-42.
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24. Kauffman GL. Putative mediator(s) of adaptive cytoprotection? Prostaglandins. 1991 Mar; 41(3):201-5.
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25. Barocelli E, Impicciatore M, Seaton J, Conter R, Kauffman G. Localization of central prostaglandin E2 antisecretory effects. Gastroenterology. 1991 Feb; 100(2):320-7.
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26. Xing LP, Balaban C, Seaton J, Washington J, Kauffman G. Mesolimbic dopamine mediates gastric mucosal protection by central neurotensin. Am J Physiol. 1991 Jan; 260(1 Pt 1):G34-8.
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27. Xing LP, King JC, Bryan RM, Kauffman GL. Effect of neurotensin on regional cerebral glucose utilization in cold water-restrained rats. Am J Physiol. 1990 Apr; 258(4 Pt 1):G591-5.
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28. Kauffman GL, Zhang L, Xing LP, Seaton J, Colony P, Demers L. Central neurotensin protects the mucosa by a prostaglandin-mediated mechanism and inhibits gastric acid secretion in the rat. Ann N Y Acad Sci. 1990; 597:175-90.
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29. Xing LP, Washington J, Seaton J, Kauffman G. Monoamine oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats. Dig Dis Sci. 1990 Jan; 35(1):61-5.
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30. Gunion MW, Kauffman GL, Taché Y. Intrahypothalamic corticotropin-releasing factor elevates gastric bicarbonate and inhibits stress ulcers in rats. Am J Physiol. 1990 Jan; 258(1 Pt 1):G152-7.
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31. Chen MC, Sanders MJ, Amirian DA, Thomas LP, Kauffman G, Soll AH. Prostaglandin E2 production by dispersed canine fundic mucosal cells. Contribution of macrophages and endothelial cells as major sources. J Clin Invest. 1989 Nov; 84(5):1536-49.
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32. Zhang L, Xing LP, Demers L, Washington J, Kauffman GL. Central neurotensin inhibits gastric acid secretion: an adrenergic mechanism in rats. Gastroenterology. 1989 Nov; 97(5):1130-4.
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33. Kauffman G. Aspirin-induced gastric mucosal injury: lessons learned from animal models. Gastroenterology. 1989 Feb; 96(2 Pt 2 Suppl):606-14.
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34. Zhang L, Colony PC, Washington JH, Seaton JF, Kauffman GL. Central neurotensin affects rat gastric integrity, prostaglandin E2, and blood flow. Am J Physiol. 1989 Jan; 256(1 Pt 1):G226-32.
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35. Kauffman GL, Kolve E, Walfisch S, Mangus J. Role of prostanoids in experimental duodenal ulcer in rat. Dig Dis Sci. 1988 Jun; 33(6):667-72.
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36. Taché Y, Kolve E, Maeda-Hagiwara M, Kauffman GL. Central nervous system action of calcitonin to alter experimental gastric ulcers in rats. Gastroenterology. 1988 Jan; 94(1):145-50.
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37. Mogard MH, Kauffman GL, Pehlevanian M, Reedy TJ, Elashoff JD, Walsh JH. Carbamylcholine, but not somatostatin or neurotensin, stimulates prostaglandin E2 release from the isolated perfused rat stomach. Regul Pept. 1986 Aug; 15(1):71-6.
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38. Leung FW, Washington J, Kauffman GL, Guth PH. Endoscopic measurement of gastric corpus mucosal blood flow in conscious dogs. Dig Dis Sci. 1986 Jun; 31(6):625-30.
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39. Leung FW, Kauffman GL, Washington J, Scremin OU, Guth PH. Blood flow limitation of stimulated gastric acid secretion in the rat. Am J Physiol. 1986 Jun; 250(6 Pt 1):G794-9.
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40. Garrick T, Kolve E, Kauffman GL. Prostaglandin requirements are greater for protection in cold restraint-induced than alcohol-induced gastric mucosal injury. Dig Dis Sci. 1986 Apr; 31(4):401-5.
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41. Mogard M, Böttcher W, Kauffman GL, Washington J, Walsh JH. Neurotensin-like immunoreactivity released into the portal vein by duodenal acidification in the dog. Scand J Gastroenterol. 1986 Jan; 21(1):97-103.
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42. Mogard MH, Maxwell V, Kovacs T, Van Deventer G, Elashoff JD, Yamada T, Kauffman GL, Walsh JH. Somatostatin inhibits gastric acid secretion after gastric mucosal prostaglandin synthesis inhibition by indomethacin in man. Gut. 1985 Nov; 26(11):1189-91.
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43. Kauffman GL. The gastric mucosal barrier. Component control. Dig Dis Sci. 1985 Nov; 30(11 Suppl):69S-76S.
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44. Mogard MH, Kauffman GL, Pehlevanian M, Golanska E, Elashoff JD, Walsh JH. Prostaglandins may not mediate inhibition of gastric acid secretion by somatostatin in the rat. Regul Pept. 1985 Mar; 10(2-3):231-6.
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45. Ligumsky M, Guth PH, Elashoff J, Kauffman GL, Hansen D, Paulsen G. Salicylic acid blocks indomethacin-induced cyclooxygenase inhibition and lesion formation in rat gastric mucosa. Proc Soc Exp Biol Med. 1985 Feb; 178(2):250-3.
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46. Engel E, Peskoff A, Kauffman GL, Grossman MI. Analysis of hydrogen ion concentration in the gastric gel mucus layer. Am J Physiol. 1984 Oct; 247(4 Pt 1):G321-38.
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47. Kauffman GL. Duodenal mucosal protection: the basic truth? Gastroenterology. 1984 Aug; 87(2):438-40.
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48. Bright-Asare P, Kauffman GL. 16-16 dimethyl prostaglandin E2 reduces 5-fluorouracil-induced and mitomycin C-induced gastric mucosal injury in the dog. Cancer. 1984 Jul 1; 54(1):28-31.
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49. Leung FW, Guth PH, Scremin OU, Golanska EM, Kauffman GL. Regional gastric mucosal blood flow measurements by hydrogen gas clearance in the anesthetized rat and rabbit. Gastroenterology. 1984 Jul; 87(1):28-36.
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50. Whittle BJ, Kauffman GL, Boughton-Smith NK. Stimulation of gastric alkaline secretion by stable prostacyclin analogues in rat and dog. Eur J Pharmacol. 1984 May 4; 100(3-4):277-83.
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51. Robert A, Böttcher W, Golanska E, Kauffman GL. Lack of correlation between mucus gel thickness and gastric cytoprotection in rats. Gastroenterology. 1984 Apr; 86(4):670-4.
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52. Kauffman GL. Non-HCl-reducing medications: do they have a place in therapy? Scand J Gastroenterol Suppl. 1984; 105:92-6.
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53. Kauffman GL. Mucosal damage to the stomach: how, when and why? Scand J Gastroenterol Suppl. 1984; 105:19-28.
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54. Bunnett NW, Walsh JH, Debas HT, Kauffman GL, Golanska EM. Measurement of prostaglandin E2 in interstitial fluid from the dog stomach after feeding and indomethacin. Gastroenterology. 1983 Dec; 85(6):1391-8.
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55. Dayton MT, Kauffman GL, Schlegel JF, Code CF, Steinbach JH. Gastric bicarbonate appearance with ethanol ingestion. Mechanism and significance. Dig Dis Sci. 1983 May; 28(5):449-55.
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56. Ligumsky M, Golanska EM, Hansen DG, Kauffman GL. Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat. Gastroenterology. 1983 Apr; 84(4):756-61.
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57. Jensen DM, Machicado GA, Tapia JI, Kauffman G, Franco P, Beilin D. A reproducible canine model of esophageal varices. Gastroenterology. 1983 Mar; 84(3):573-9.
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58. Ligumsky M, Hansen DG, Kauffman GL. Salicylic acid blocks indomethacin- and aspirin-induced cyclo-oxygenase inhibition in rat gastric mucosa. Gastroenterology. 1982 Nov; 83(5):1043-6.
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59. Kauffman GL, Grossman MI. Components of acidification of an amino acid solution bathing oxyntic mucosa. Am J Physiol. 1982 Nov; 243(5):G336-40.
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60. Martindale R, Kauffman GL, Levin S, Walsh JH, Yamada T. Differential regulation of gastrin an somatostatin secretion from isolated perfused rat stomachs. Gastroenterology. 1982 Jul; 83(1 Pt 2):240-4.
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61. Taylor IL, Singer M, Kauffman GL. Time-dependent effects of vagotomy on pancreatic polypeptide release. Dig Dis Sci. 1982 Jun; 27(6):491-4.
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62. Kauffman GL, Whittle BJ. Gastric vascular actions of prostanoids and the dual effect of arachidonic acid. Am J Physiol. 1982 Jun; 242(6):G582-7.
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63. Ligumsky M, Grossman MI, Kauffman GL. Endogenous gastric mucosal prostaglandins: their role in mucosal integrity. Am J Physiol. 1982 Apr; 242(4):G337-41.
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64. Kauffman GL. Blood flow and gastric secretion. Fed Proc. 1982 Apr; 41(6):2080-3.
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65. Kauffman GL, Whittle BJ, Salmon JA. Gastric venous prostaglandin concentrations during basal and stimulated acid secretion in dog. Proc Soc Exp Biol Med. 1982 Feb; 169(2):233-8.
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66. Miller J, Kauffman G, Elashoff J, Ohashi H, Carter D, Meyer JH. Search for resistances controlling canine gastric emptying of liquid meals. Am J Physiol. 1981 Nov; 241(5):G403-15.
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67. Taylor IL, Kauffman GL, Walsh JH, Trout H, Chew P, Harmon JW. Role of the small intestine and gastric antrum in pancreatic polypeptide release. Am J Physiol. 1981 May; 240(5):G387-91.
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68. Bickel M, Kauffman GL. Gastric gel mucus thickness: effect of distention, 16,16-dimethyl prostaglandin e2, and carbenoxolone. Gastroenterology. 1981 Apr; 80(4):770-5.
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69. Kauffman GL, Steinbach JH. Gastric bicarbonate secretion: effect of pH and topical 16-16 dimethyl prostaglandin E2. Surgery. 1981 Mar; 89(3):324-8.
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70. Kauffman GL. Gastric mucus and bicarbonate secretion in relation to mucosal protection. J Clin Gastroenterol. 1981; 3(Suppl 2):45-50.
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71. Kauffman GL. The role of prostaglandins in the regulation of gastric mucosal blood flow. Prostaglandins. 1981; 21 Suppl:33-8.
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72. Kauffman GL, Reeve JJ, Grossman MI. Gastric bicarbonate secretion: effect of topical and intravenous 16,16-dimethyl prostaglandin E2. Am J Physiol. 1980 Jul; 239(1):G44-8.
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73. Kauffman GL, Aures D, Grossman MI. Intravenous indomethacin and aspirin reduce basal gastric mucosal blood flow in dogs. Am J Physiol. 1980 Feb; 238(2):G131-4.
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74. Kauffman GL, Whittle BJ, Aures D, Grossman MI. Gastric antisecretory and cardiovascular actions of a stable 16-phenoxy prostacyclin analog in the dog. Adv Prostaglandin Thromboxane Res. 1980; 8:1521-4.
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75. Kauffman GL, Whittle BJ, Aures D, Vane JR, Grossman MI. Effects of prostacyclin and a stable analogue, 6-beta-PGI1, on gastric acid secretion, mucosal blood flow, and blood pressure in conscious dogs. Gastroenterology. 1979 Dec; 77(6):1301-6.
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76. Kauffman GL, Foley KT, Grossman MI. Cimetidine does not inhibit indomethacin-induced small bowel ulceration in the rat. Proc Soc Exp Biol Med. 1979 Sep; 161(4):512-4.
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77. Kauffman GL, Grossman MI. Serum gastrin during intestinal phase of acid secretion in dogs. Gastroenterology. 1979 Jul; 77(1):26-30.
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78. Kauffman GL, Grossman MI. Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates. Gastroenterology. 1978 Dec; 75(6):1099-1102.
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79. Guth PH, Kauffman GL, Grossman MI. Cimetidine and prostaglandin prevent damage to gastric mucosa. Gastroenterology. 1978 Nov; 75(5):927-8.
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80. Kauffman GL, D'Alecy LG. Redistribution of canine splanchnic blood flow following normotensive hemorrhage. J Surg Res. 1977 May; 22(5):580-4.
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81. Davenport HW, Kauffman GL. Plasma shedding by the canine oxyntic and pyloric glandular mucosa induced by topical action of acetylcholine. Effect of atropine and physostigmine. Gastroenterology. 1975 Jul; 69(1):190-7.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Gastric Mucosa
Neurotensin
Gastric Acid
Prostaglandins
Stomach Ulcer
See all (362) keywords
Co-Authors  
Abt, Arthur
Demers, Laurence
Karinch, Anne
Koltun, Walter
Ruggiero, Francesca
See all (12) people
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