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Anne Karinch
Title Associate Professor Emeritus
Institution College of Medicine
Department Cellular and Molecular Physiology
Address 500 University Drive Hershey PA 17033
Mailbox: H166
Telephone 7175316259
Email
Background
PREFERRED TITLE/ROLE:

Associate Professor Emerita of Surgery

NARRATIVE:

Renal acid-base regulation

Current interest is the role of the System N1 glutamine transporter in renal regulation of metabolic acidosis and regulation of the SN1 gene.
Publications
1. Karinch AM, Martin JH, Vary TC. Acute and chronic ethanol consumption differentially impact pathways limiting hepatic protein synthesis. Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E3-9.
  View in: PubMed
 
2. Choudry HA, Souba WW, Lin C, Meng Q, Karinch AM, Huang J, Pan M. Stimulation of expression of the intestinal glutamine transporter ATB0 in tumor-bearing rats. Ann Surg Oncol. 2006 Dec; 13(12):1747-53.
  View in: PubMed
 
3. Karinch AM, Lin CM, Meng Q, Pan M, Souba WW. Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic acidosis. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F448-55.
  View in: PubMed
 
4. Choudry HA, Pan M, Karinch AM, Souba WW. Branched-chain amino acid-enriched nutritional support in surgical and cancer patients. J Nutr. 2006 Jan; 136(1 Suppl):314S-8S.
  View in: PubMed
 
5. Meng Q, Choudry HA, Souba WW, Karinch AM, Huang J, Lin C, Vary TC, Pan M. Regulation of amino acid arginine transport by lipopolysaccharide and nitric oxide in intestinal epithelial IEC-6 cells. J Gastrointest Surg. 2005 Dec; 9(9):1276-85; discussion 1285.
  View in: PubMed
 
6. Pan M, Choudry HA, Epler MJ, Meng Q, Karinch A, Lin C, Souba W. Arginine transport in catabolic disease states. J Nutr. 2004 Oct; 134(10 Suppl):2826S-2829S; discussion 2853S.
  View in: PubMed
 
7. Pan M, Meng Q, Choudry HA, Karinch AM, Lin C, Souba WW. Stimulation of intestinal glutamine absorption in chronic metabolic acidosis. Surgery. 2004 Aug; 136(2):127-34.
  View in: PubMed
 
8. Meng Q, Epler MJ, Lin C, Karinch AM, Vary TC, Pan M. Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases. J Gastrointest Surg. 2004 Jan; 8(1):40-7.
  View in: PubMed
 
9. Epler MJ, Souba WW, Meng Q, Lin C, Karinch AM, Vary TC, Pan M. Metabolic acidosis stimulates intestinal glutamine absorption. J Gastrointest Surg. 2003 Dec; 7(8):1045-52.
  View in: PubMed
 
10. Wolfgang CL, Lin C, Meng Q, Karinch AM, Vary TC, Pan M. Epidermal growth factor activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases. J Gastrointest Surg. 2003 Jan; 7(1):149-56.
  View in: PubMed
 
11. Karinch AM, Lin CM, Wolfgang CL, Pan M, Souba WW. Regulation of expression of the SN1 transporter during renal adaptation to chronic metabolic acidosis in rats. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1011-9.
  View in: PubMed
 
12. Pan M, Meng QH, Wolfgang CL, Lin CM, Karinch AM, Vary TC, Souba WW. Activation of intestinal arginine transport by protein kinase C is mediated by mitogen-activated protein kinases. J Gastrointest Surg. 2002 Nov-Dec; 6(6):876-82.
  View in: PubMed
 
13. Pan M, Wolfgang CA, Karinch AM, Lin C, Meng Q, Vary TC, Souba WW. Protein kinase C activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases. J Surg Res. 2002 Jul; 106(1):137-44.
  View in: PubMed
 
14. Pan M, Souba WW, Wolfgang CL, Karinch AM, Stevens BR. Posttranslational alanine trans-stimulation of zwitterionic amino acid transport systems in human intestinal Caco-2 cells. J Surg Res. 2002 May 1; 104(1):63-9.
  View in: PubMed
 
15. Pan M, Souba WW, Karinch AM, Lin CM, Stevens BR. Specific reversible stimulation of system y(+) L-arginine transport activity in human intestinal cells. J Gastrointest Surg. 2002 May-Jun; 6(3):379-86.
  View in: PubMed
 
16. Pan M, Souba WW, Karinch AM, Lin CM, Stevens BR. Epidermal growth factor regulation of system L alanine transport in undifferentiated and differentiated intestinal Caco-2 cells. J Gastrointest Surg. 2002 May-Jun; 6(3):410-7.
  View in: PubMed
 
17. Karinch AM, Pan M, Lin CM, Strange R, Souba WW. Glutamine metabolism in sepsis and infection. J Nutr. 2001 Sep; 131(9 Suppl):2535S-8S; discussion 2550S-1S.
  View in: PubMed
 
18. Karinch AM, Schmidt GL, Kauffman GL. Pretreatment with SR48692 has different effects on central neurotensin-induced gastric mucosal defense and inhibition of gastric acid secretion in rats. Brain Res. 1998 Nov 9; 810(1-2):123-9.
  View in: PubMed
 
19. Karinch AM, Deiter G, Ballard PL, Floros J. Regulation of expression of human SP-A1 and SP-A2 genes in fetal lung explant culture. Biochim Biophys Acta. 1998 Jun 16; 1398(2):192-202.
  View in: PubMed
 
20. Xing L, Karinch AM, Kauffman GL. Mesolimbic expression of neurotensin and neurotensin receptor during stress-induced gastric mucosal injury. Am J Physiol. 1998 Jan; 274(1 Pt 2):R38-45.
  View in: PubMed
 
21. Karinch AM, deMello DE, Floros J. Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humans. Biochem J. 1997 Jan 1; 321 ( Pt 1):39-47.
  View in: PubMed
 
22. Floros J, DiAngelo S, Koptides M, Karinch AM, Rogan PK, Nielsen H, Spragg RG, Watterberg K, Deiter G. Human SP-A locus: allele frequencies and linkage disequilibrium between the two surfactant protein A genes. Am J Respir Cell Mol Biol. 1996 Oct; 15(4):489-98.
  View in: PubMed
 
23. Stuempfle KJ, Koptides M, Karinch AM, Floros J. Preparation of transcriptionally active nuclear extracts from mammalian tissues. Biotechniques. 1996 Jul; 21(1):48-50, 52.
  View in: PubMed
 
24. Karinch AM, Floros J. Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A. Biochem J. 1995 Apr 15; 307 ( Pt 2):327-30.
  View in: PubMed
 
25. Floros J, Karinch AM. Human SP-A: then and now. Am J Physiol. 1995 Feb; 268(2 Pt 1):L162-5.
  View in: PubMed
 
26. Floros J, Veletza SV, Kotikalapudi P, Krizkova L, Karinch AM, Friedman C, Buchter S, Marks K. Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome. Biochem J. 1995 Jan 15; 305 ( Pt 2):583-90.
  View in: PubMed
 
27. Karinch AM, Floros J. 5' splicing and allelic variants of the human pulmonary surfactant protein A genes. Am J Respir Cell Mol Biol. 1995 Jan; 12(1):77-88.
  View in: PubMed
 
28. Kimball SR, Karinch AM, Feldhoff RC, Mellor H, Jefferson LS. Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver. Biochim Biophys Acta. 1994 Dec 15; 1201(3):473-81.
  View in: PubMed
 
29. Vary TC, Jurasinski CV, Karinch AM, Kimball SR. Regulation of eukaryotic initiation factor-2 expression during sepsis. Am J Physiol. 1994 Feb; 266(2 Pt 1):E193-201.
  View in: PubMed
 
30. Feldhoff RC, Karinch AM, Kimball SR, Jefferson LS. Purification of eukaryotic initiation factors eIF-2, eIF-2B and eIF-2 alpha kinase from bovine liver. Prep Biochem. 1993 Aug; 23(3):363-74.
  View in: PubMed
 
31. Kouretas D, Karinch AM, Rishi A, Melchers K, Floros J. Conservation analysis of rat and human SP-A gene identifies 5' flanking sequences of rat SP-A that bind rat lung nuclear proteins. Exp Lung Res. 1993 Jul-Aug; 19(4):485-503.
  View in: PubMed
 
32. Karinch AM, Kimball SR, Vary TC, Jefferson LS. Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. Am J Physiol. 1993 Jan; 264(1 Pt 1):E101-8.
  View in: PubMed
 
33. Karinch AM, Zimmer WE, Goodman SR. The identification and sequence of the actin-binding domain of human red blood cell beta-spectrin. J Biol Chem. 1990 Jul 15; 265(20):11833-40.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Proteolipids
Pulmonary Surfactants
Acidosis
Glutamine
Amino Acid Transport Systems, Neutral
See all (203) keywords
Co-Authors  
Kauffman, Gordon
Kimball, Scot
See all (2) people
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