|
1.
|
Gowda R, Madhunapantula SV, Desai D, Amin S, Robertson GP. Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma. Mol Cancer Ther. 2013 Jan; 12(1):3-15.
|
|
|
|
|
2.
|
Crampsie MA, Pandey MK, Desai D, Spallholz J, Amin S, Sharma AK. Phenylalkyl isoselenocyanates vs phenylalkyl isothiocyanates: Thiol reactivity and its implications. Chem Biol Interact. 2012 Oct 25; 200(1):28-37.
|
|
|
|
|
3.
|
Hahm ER, Chandra-Kuntal K, Desai D, Amin S, Singh SV. Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration. PLoS One. 2012; 7(9):e44957.
|
|
|
|
|
4.
|
Gowda R, Madhunapantula SV, Desai D, Amin S, Robertson GP. Selenium-containing histone deacetylase inhibitors for melanoma management. Cancer Biol Ther. 2012 Jul; 13(9):756-65.
|
|
|
|
|
5.
|
Emmert SW, El-Bayoumy K, Das A, Sun YW, Amin S, Desai D, Aliaga C, Richie JP. Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2. Free Radic Biol Med. 2012 May 15; 52(10):2064-71.
|
|
|
|
|
6.
|
Crampsie MA, Jones N, Das A, Aliaga C, Desai D, Lazarus P, Amin S, Sharma AK. Phenylbutyl isoselenocyanate modulates phase I and II enzymes and inhibits 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced DNA adducts in mice. Cancer Prev Res (Phila). 2011 Nov; 4(11):1884-94.
|
|
|
|
|
7.
|
Liao A, Broeg K, Fox T, Tan SF, Watters R, Shah MV, Zhang LQ, Li Y, Ryland L, Yang J, Aliaga C, Dewey A, Rogers A, Loughran K, Hirsch L, Jarbadan NR, Baab KT, Liao J, Wang HG, Kester M, Desai D, Amin S, Loughran TP, Liu X. Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. Blood. 2011 Sep 8; 118(10):2793-800.
|
|
|
|
|
8.
|
Krishnegowda G, Sharma AK, Krzeminski J, Gowda AS, Lin JM, Desai D, Spratt TE, Amin S. Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides. Chem Res Toxicol. 2011 Jun 20; 24(6):960-7.
|
|
|
|
|
9.
|
Chung CY, Madhunapantula SV, Desai D, Amin S, Robertson GP. Melanoma prevention using topical PBISe. Cancer Prev Res (Phila). 2011 Jun; 4(6):935-48.
|
|
|
|
|
10.
|
Nguyen N, Sharma A, Nguyen N, Sharma AK, Desai D, Huh SJ, Amin S, Meyers C, Robertson GP. Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4. Cancer Prev Res (Phila). 2011 Feb; 4(2):248-58.
|
|
|
|
|
11.
|
Desai D, Kaushal N, Gandhi UH, Arner RJ, D'Souza C, Chen G, Vunta H, El-Bayoumy K, Amin S, Prabhu KS. Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib. Chem Biol Interact. 2010 Dec 5; 188(3):446-56.
|
|
|
|
|
12.
|
Karelia N, Desai D, Hengst JA, Amin S, Rudrabhatla SV, Yun J. Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells. Bioorg Med Chem Lett. 2010 Nov 15; 20(22):6816-9.
|
|
|
|
|
13.
|
Desai D, Sinha I, Null K, Wolter W, Suckow MA, King T, Amin S, Sinha R. Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells. Int J Cancer. 2010 Jul 1; 127(1):230-8.
|
|
|
|
|
14.
|
Luo W, Li J, Zhang D, Cai T, Song L, Yin XM, Desai D, Amin S, Chen J, Huang C. Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure. Curr Cancer Drug Targets. 2010 Feb; 10(1):96-106.
|
|
|
|
|
15.
|
Emmert SW, Desai D, Amin S, Richie JP. Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane. Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2675-9.
|
|
|
|
|
16.
|
Desai D, Madhunapantula SV, Gowdahalli K, Sharma A, Chandagaludoreswamy R, El-Bayoumy K, Robertson GP, Amin S. Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2038-43.
|
|
|
|
|
17.
|
Desai D, Salli U, Vrana KE, Amin S. SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2044-7.
|
|
|
|
|
18.
|
Xiao D, Powolny AA, Antosiewicz J, Hahm ER, Bommareddy A, Zeng Y, Desai D, Amin S, Herman-Antosiewicz A, Singh SV. Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species. Pharm Res. 2009 Jul; 26(7):1729-38.
|
|
|
|
|
19.
|
Das A, Bortner J, Desai D, Amin S, El-Bayoumy K. The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer. Chem Biol Interact. 2009 Jul 15; 180(2):158-64.
|
|
|
|
|
20.
|
Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res. 2009 Mar 1; 69(5):2117-25.
|
|
|
|
|
21.
|
Sharma A, Sharma AK, Madhunapantula SV, Desai D, Huh SJ, Mosca P, Amin S, Robertson GP. Targeting Akt3 signaling in malignant melanoma using isoselenocyanates. Clin Cancer Res. 2009 Mar 1; 15(5):1674-85.
|
|
|
|
|
22.
|
Sharma AK, Sharma A, Desai D, Madhunapantula SV, Huh SJ, Robertson GP, Amin S. Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates. J Med Chem. 2008 Dec 25; 51(24):7820-6.
|
|
|
|
|
23.
|
Madhunapantula SV, Desai D, Sharma A, Huh SJ, Amin S, Robertson GP. PBISe, a novel selenium-containing drug for the treatment of malignant melanoma. Mol Cancer Ther. 2008 May; 7(5):1297-308.
|
|
|
|
|
24.
|
Chen KM, Spratt TE, Stanley BA, De Cotiis DA, Bewley MC, Flanagan JM, Desai D, Das A, Fiala ES, Amin S, El-Bayoumy K. Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit. Cancer Res. 2007 Nov 1; 67(21):10475-83.
|
|
|
|
|
25.
|
Guttenplan J, Chen KM, Khmelnitsky M, Kosinska W, Hennessy J, Bruggeman R, Desai D, Amin S, Sun YW, Spratt TE, El-Bayoumy K. Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide. Mutat Res. 2007 Dec 1; 634(1-2):146-55.
|
|
|
|
|
26.
|
Ouyang W, Hu Y, Li J, Ding M, Lu Y, Zhang D, Yan Y, Song L, Qu Q, Desai D, Amin S, Huang C. Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells. Carcinogenesis. 2007 Oct; 28(10):2218-26.
|
|
|
|
|
27.
|
Trempus CS, Morris RJ, Ehinger M, Elmore A, Bortner CD, Ito M, Cotsarelis G, Nijhof JG, Peckham J, Flagler N, Kissling G, Humble MM, King LC, Adams LD, Desai D, Amin S, Tennant RW. CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res. 2007 May 1; 67(9):4173-81.
|
|
|
|
|
28.
|
Pinto JT, Sinha R, Papp K, Facompre ND, Desai D, El-Bayoumy K. Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells. Int J Cancer. 2007 Apr 1; 120(7):1410-7.
|
|
|
|
|
29.
|
Nelson G, Ross JA, Pimentel M, Desai D, Sharma AK, Amin S, Nesnow S. Characterization of naphtho[1,2-a]pyrene and naphtho[1,2-e]pyrene DNA adducts in C3H10T1/2 fibroblasts. Cancer Lett. 2007 Mar 18; 247(2):309-17.
|
|
|
|
|
30.
|
Richie JP, Kleinman W, Desai DH, Das A, Amin SG, Pinto JT, El-Bayoumy K. The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. Chem Biol Interact. 2006 Jun 10; 161(2):93-103.
|
|
|
|
|
31.
|
Ding J, Li J, Chen J, Chen H, Ouyang W, Zhang R, Xue C, Zhang D, Amin S, Desai D, Huang C. Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. J Biol Chem. 2006 Apr 7; 281(14):9093-100.
|
|
|
|
|
32.
|
Herzog CR, Desai D, Amin S. Array CGH analysis reveals chromosomal aberrations in mouse lung adenocarcinomas induced by the human lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochem Biophys Res Commun. 2006 Mar 17; 341(3):856-63.
|
|
|
|
|
33.
|
El-Bayoumy K, Das A, Narayanan B, Narayanan N, Fiala ES, Desai D, Rao CV, Amin S, Sinha R. Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer. Carcinogenesis. 2006 Jul; 27(7):1369-76.
|
|
|
|
|
34.
|
Sharma AK, Lin JM, Desai D, Amin S. Convenient syntheses of dibenzo[c,p]chrysene and its possible proximate and ultimate carcinogens: in vitro metabolism and DNA adduction studies. J Org Chem. 2005 Jun 24; 70(13):4962-70.
|
|
|
|
|
35.
|
Hooven LA, Mahadevan B, Keshava C, Johns C, Pereira C, Desai D, Amin S, Weston A, Baird WM. Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. Bioorg Med Chem Lett. 2005 Mar 1; 15(5):1283-7.
|
|
|
|
|
36.
|
Sohn OS, Desai DH, Das A, Rodriguez JG, Amin SG, El-Bayoumy K. Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate. Chem Biol Interact. 2005 Feb 10; 151(3):193-202.
|
|
|
|
|
37.
|
Fiala ES, Sohn OS, Wang CX, Seibert E, Tsurutani J, Dennis PA, El-Bayoumy K, Sodum RS, Desai D, Reinhardt J, Aliaga C. Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E. Carcinogenesis. 2005 Mar; 26(3):605-12.
|
|
|
|
|
38.
|
Narayanan BA, Narayanan NK, Desai D, Pittman B, Reddy BS. Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. Carcinogenesis. 2004 Dec; 25(12):2443-9.
|
|
|
|
|
39.
|
Singh SV, Varma V, Zimniak P, Srivastava SK, Marynowski SW, Desai D, Amin S, Ji X. Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide. Biochemistry. 2004 Aug 3; 43(30):9708-15.
|
|
|
|
|
40.
|
Schwartz J, Baker V, Larios E, Desai D, Amin S. Inhibition of experimental tobacco carcinogen induced head and neck carcinogenesis. Oral Oncol. 2004 Jul; 40(6):611-23.
|
|
|
|
|
41.
|
Guttenplan JB, Spratt TE, Khmelnitsky M, Kosinska W, Desai D, El-Bayoumy K. Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice. Mutat Res. 2004 Apr 11; 559(1-2):199-210.
|
|
|
|
|
42.
|
Li J, Chen H, Tang MS, Shi X, Amin S, Desai D, Costa M, Huang C. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol. 2004 Apr; 165(1):77-86.
|
|
|
|
|
43.
|
Boyiri T, Guttenplan J, Khmelnitsky M, Kosinska W, Lin JM, Desai D, Amin S, Pittman B, El-Bayoumy K. Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene. Carcinogenesis. 2004 Apr; 25(4):637-43.
|
|
|
|
|
44.
|
El-Bayoumy K, Das A, Boyiri T, Desai D, Sinha R, Pittman B, Amin S. Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells. Chem Biol Interact. 2003 Oct 25; 146(2):179-90.
|
|
|
|
|
45.
|
El-Bayoumy K, Narayanan BA, Desai DH, Narayanan NK, Pittman B, Amin SG, Schwartz J, Nixon DW. Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray. Carcinogenesis. 2003 Sep; 24(9):1505-14.
|
|
|
|
|
46.
|
Amin S, Lin JM, Krzeminski J, Boyiri T, Desai D, El-Bayoumy K. Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats. Chem Res Toxicol. 2003 Feb; 16(2):227-31.
|
|
|
|
|
47.
|
Desai D, Das A, Cohen L, el-Bayoumy K, Amin S. Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice. Anticancer Res. 2003 Jan-Feb; 23(1A):499-503.
|
|
|
|
|
48.
|
Das A, Desai D, Pittman B, Amin S, El-Bayoumy K. Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse. Nutr Cancer. 2003; 46(2):179-85.
|
|
|
|
|
49.
|
Boyiri T, Leszczynska J, Desai D, Amin S, Nixon DW, El-Bayoumy K. Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines. Int J Cancer. 2002 Aug 1; 100(4):395-400.
|
|
|
|
|
50.
|
Desai D, Sharma AK, Lin JM, Krzeminski J, Pimentel M, El-Bayoumy K, Nesnow S, Amin S. Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene. Chem Res Toxicol. 2002 Jul; 15(7):964-71.
|
|
|
|
|
51.
|
El-Bayoumy K, Desai D, Boyiri T, Rosa J, Krzeminski J, Sharma AK, Pittman B, Amin S. Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland. Chem Res Toxicol. 2002 Jul; 15(7):972-8.
|
|
|
|
|
52.
|
Cohen LA, Marks PA, Rifkind RA, Amin S, Desai D, Pittman B, Richon VM. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors. Anticancer Res. 2002 May-Jun; 22(3):1497-504.
|
|
|
|
|
53.
|
Prokopczyk B, Hoffmann D, Bologna M, Cunningham AJ, Trushin N, Akerkar S, Boyiri T, Amin S, Desai D, Colosimo S, Pittman B, Leder G, Ramadani M, Henne-Bruns D, Beger HG, El-Bayoumy K. Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol. 2002 May; 15(5):677-85.
|
|
|
|