Search Edit My Profile Login to Profiles FAQs / About
Cheng Dong
Institution College of Engineering
Department Bioengineering
Address 233 Hallowell Bldg
University Park, PA 16802
Telephone 8148658091
Email
Other Positions
Institution Huck Institutes of the Life Sciences
Background
PREFERRED TITLE/ROLE:

Department Head and Distinguished Professor, Bioengineering

EDUCATION:

Ph.D. Applied Mechanics and Bioengineering, Columbia University, 1988

NARRATIVE:

Dr. Dong's research focuses on elucidating biomechanical, biophysical and biochemical aspects of cellular function in the circulatory systems, with particular interest in cellular biomechanics, cell adhesion, cell migration, cell signaling, systems biology, and multi-scale modeling of biological systems. His current research includes studies of micro-hemodynamics, leukocyte rheology, intercellular and intracellular signaling, cancer immunology and metastases. In particular, Dr. Dong is investigating how fluid dynamics, adhesion kinetics and tumor microenvironment change leukocyte and/or endothelial immune functions which subsequently affect tumor cell extravasation in the microcirculation and subsequent metastasis.
Publications
1. Ozdemir T, Zhang P, Fu C, Dong C. Fibrin serves as a divalent ligand that regulates neutrophil-mediated melanoma cells adhesion to endothelium under shear conditions. Am J Physiol Cell Physiol. 2012 Apr 15; 302(8):C1189-201.
  View in: PubMed
 
2. Fu, Y., Kunz, R., Wu, J., and Dong, C. . Study of local hydrodynamic environment in cell-substrate adhesion using side-view µPIV technology. PLoS ONE. 2012; 7(2):e30721.
 
3. Fu, C., Tong, C., Wang, M., Gao, Y., Zhang, Y., Lu, S., Liang, S., Dong, C. and Long, M. . Determining beta2-integrin and ICAM-1 binding kinetics in tumor cells adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay. J. Biol. Chem. 2011; 286(40):34777.
 
4. Thein M, Cheng A, Khanna P, Zhang C, Park EJ, Ahmed D, Goodrich CJ, Asphahani F, Wu F, Smith NB, Dong C, Jiang X, Zhang M, Xu J. Site-specific sonoporation of human melanoma cells at the cellular level using high lateral-resolution ultrasonic micro-transducer arrays. Biosens Bioelectron. 2011 Sep 15; 27(1):25-33.
  View in: PubMed
 
5. Dong, C. Adhesion and signaling of tumor cells to leukocytes and endothelium in cancer metastasis. Stud. Mechanobiol. Tissue Eng. Biomater. Springer-Verlag, Berlin Heidelberg. 2011; 4:477.
 
6. Zhang, P., Ozdemir, T., Chung, C.-Y., Robertson, G.P. and Dong, C. . Sequential binding of avß3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophil. J. Immunology. 2011; 186:242.
 
7. Zhang P, Ozdemir T, Chung CY, Robertson GP, Dong C. Sequential binding of aVß3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils. J Immunol. 2011 Jan 1; 186(1):242-54.
  View in: PubMed
 
8. Huh, S.J., Liang, S., Dong, C. and Robertson, G.P. . Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res. 2010; 70(14):6071.
 
9. Huh SJ, Liang S, Sharma A, Dong C, Robertson GP. Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development. Cancer Res. 2010 Jul 15; 70(14):6071-82.
  View in: PubMed
 
10. Liang S, Hoskins M, Dong C. Tumor cell extravasation mediated by leukocyte adhesion is shear rate dependent on IL-8 signaling. Mol Cell Biomech. 2010 Jun; 7(2):77-91.
  View in: PubMed
 
11. Khanna P, Yunkunis T, Muddana HS, Peng HH, August A, Dong C. p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly. Am J Physiol Cell Physiol. 2010 May; 298(5):C1140-50.
  View in: PubMed
 
12. Hoskins, M.H. Kunz, R.F., Bistline, J. and Dong, C. . Coupled flow-structure-biochemistry simulations of dynamic systems of blood cells using an adaptive surface tracking method. J. Fluids and Structures. 2009; 25:936.
 
13. Mao X, Lin SC, Dong C, Huang TJ. Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing. Lab Chip. 2009 Jun 7; 9(11):1583-9.
  View in: PubMed
 
14. Dong C, Robertson GP. Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development. Biorheology. 2009; 46(4):265-79.
  View in: PubMed
 
15. Peng, H.H. and Dong, C. . Systemic analysis of tumor cell-induced endothelial calcium signaling and junction disassembly. Cellular and Molecular Bioengineering. 2009; 2(3):375.
 
16. Liang S, Dong C. Integrin VLA-4 enhances sialyl-Lewisx/a-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C701-7.
  View in: PubMed
 
17. Liang S, Slattery MJ, Wagner D, Simon SI, Dong C. Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation. Ann Biomed Eng. 2008 Apr; 36(4):661-71.
  View in: PubMed
 
18. Liang S, Fu C, Wagner D, Guo H, Zhan D, Dong C, Long M. Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C743-53.
  View in: PubMed
 
19. Liang, S. and Dong, C. Integrin VLA-4 enhances sialyl-negative melanoma adhesion to and extravasation through the endothelium under low flow conditions. Am. J. Physiol. – Cell Physiol. 2008; 295(3):C701.
 
20. Liang, S., Fu, C., Wagner, D., Guo, H., Zhan, D., Dong, C., and Long, M. 2D Kinetics of ß2 integrin-ICAM-1 bindings between neutrophils and melanoma cells. Am. J. Physiol. 2008; 294:C743.
 
21. Liang, S., Slattery, M., Wagner, D., Simon, S.I., and Dong, C. Hydrodynamic shear rate regulates melanoma-leukocyte aggregations, melanoma adhesion to the endothelium and subsequent extravasation. Ann. Biomed. Eng. 2008; 36:661.
 
22. Liang S, Sharma A, Peng HH, Robertson G, Dong C. Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Res. 2007 Jun 15; 67(12):5814-20.
  View in: PubMed
 
23. Peng, H.H., Liang, S., Henderson, A.J. and Dong, C. . Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. Experimental Cell Research. 2007; 313:551.
 
24. Liang, S., Sharma, A., Peng, H.H., Robertson, G. and Dong C. . Targeting mutant (V600E) B-raf in melanoma disrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Research. 2007; 67:5814.
 
25. Peng HH, Liang S, Henderson AJ, Dong C. Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response. Exp Cell Res. 2007 Feb 1; 313(3):551-9.
  View in: PubMed
 
26. Sharma A, Tran MA, Liang S, Sharma AK, Amin S, Smith CD, Dong C, Robertson GP. Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases. Cancer Res. 2006 Aug 15; 66(16):8200-9.
  View in: PubMed
 
27. Hoskins MH, Dong C. Kinetics analysis of binding between melanoma cells and neutrophils. Mol Cell Biomech. 2006 Jun; 3(2):79-87.
  View in: PubMed
 
28. Leyton-Mange J, Yang S, Hoskins MH, Kunz RF, Zahn JD, Dong C. Design of a side-view particle imaging velocimetry flow system for cell-substrate adhesion studies. J Biomech Eng. 2006 Apr; 128(2):271-8.
  View in: PubMed
 
29. Liang S, Slattery MJ, Dong C. Shear stress and shear rate differentially affect the multi-step process of leukocyte-facilitated melanoma adhesion. Exp Cell Res. 2005 Nov 1; 310(2):282-92.
  View in: PubMed
 
30. Dong C, Slattery MJ, Liang S, Peng HH. Melanoma cell extravasation under flow conditions is modulated by leukocytes and endogenously produced interleukin 8. Mol Cell Biomech. 2005 Sep; 2(3):145-59.
  View in: PubMed
 
31. Peng HH, Hodgson L, Henderson AJ, Dong C. Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly. Front Biosci. 2005; 10:1597-606.
  View in: PubMed
 
32. Slattery MJ, Liang S, Dong C. Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation. Am J Physiol Cell Physiol. 2005 Apr; 288(4):C831-9.
  View in: PubMed
 
33. Slattery MJ, Dong C. Neutrophils influence melanoma adhesion and migration under flow conditions. Int J Cancer. 2003 Sep 20; 106(5):713-22.
  View in: PubMed
 
34. Hodgson L, Henderson AJ, Dong C. Melanoma cell migration to type IV collagen requires activation of NF-kappaB. Oncogene. 2003 Jan 9; 22(1):98-108.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Melanoma
Neutrophils
Cell Movement
Cell Adhesion
Interleukin-8
See all (119) keywords
Co-Authors  
Amin, Shantu
Robertson, Gavin
Sharma, Arati
Sharma, Arun
See all (4) people
Same Department  
Lipowsky, Herbert
Hancock, William
Butler, Peter
Abidian, Mohammad
Zheng, Siyang
Search for (202) people
Site Index | Privacy and Legal Statements | Copyright Information | The Pennsylvania State University © 2011